I-Mildronate 250 ibandakanyeka kwinqubo ye-metabolic; Kuyi-analogue yokwakheka yento yemvelo etholakala kumaseli womzimba womuntu. Ngenxa yaleli thuluzi, imetabolism iyabuyiselwa, umsebenzi wezitho zangaphakathi uyathuthuka.
Ngesikhathi sokwelashwa kwe-MP, inqubo yokulethwa kwe-oxygen kumaseli iyasheshiswa, ethuthukisa i-myocardium futhi isize ekuvimbeleni izinkinga eziningi. Kunemikhawulo embalwa ekusebenziseni umuthi, imiphumela emibi ayivelakali. Ngokubizwa, umthamo wengxenye eyinhloko ubethelwe - 250 mg.
Igama Lezwe elingafanele
IMeldonium.
Ngenxa yeMildronate, imetabolism iyabuyiselwa, umsebenzi wezitho zangaphakathi uyathuthuka.
I-ATX
I-C01EB, nezinye izidakamizwa zokwelapha izifo zenhliziyo.
Khipha amafomu nokwakheka
Umkhiqizo uyatholakala ngefomu eliqinile nelingamanzi. Isithako esisebenzayo yi-meldonium hydrochloride. Umthamo wayo ungahluka, othintwa ukwakheka komuthi. Isibonelo, i-250 mg ne-500 mg ingaqukatha ku-1 capsule, kanye ne-100 mg ku-1 ml yesisombululo somjovo. Ezinye izinto ezakhiwayo azisebenzi. Ukuthola umuthi ofunekayo wesidakamizwa, kufakwa amanzi wokujova kusisombululo.
Ezinye izinto zomkhiqizo ngesimo samaphilisi asetshenziselwa ukuthola ukungaguquguquki okudingakalayo kwento:
- i-silicon dioxide colloidal;
- isitashi samazambane;
- i-calcium stearate.
Ukwakheka kwegobolondo yamathebhulethi i-Mildronate 250: udayi kanye ne-gelatin.
Ukwakheka kwe-Shell: udayi kanye ne-gelatin.
Umkhiqizo uhlinzekwa ngamaphakethe ama-ampoules ayi-10 no-20 (5 ml ngamunye), kanye namaphilisi angama-40 no-60.
Isenzo se-Pharmacological
Umsebenzi oyinhloko wento esebenzayo ukulengiswa kwe-metabolism ezingeni lamaselula. Isidingo saso sivela nge-ischemia, ukuntuleka kwe-oksijini kanye nokunye ukuphazamiseka okubangelwa ushintsho ekulinganiseni kwezakhi eziseleni.
I-Carnitine yenziwa nge-gamma-butyrobetaine. Isakhi esiyinhloko ekwakhekeni kwalo muthi yi-analogue ehlelekile yale nto. Ngaphansi kwethonya lazo, inqubo yokukhiqiza i-carnitine ivinjelwe, ngenxa yokuvinjwa komsebenzi we-enzyme gamma-butyrobetaine hydroxylase. Ngenxa yalezi zigameko, ukuhanjiswa kwamafutha acid ngama-membranes weseli kuyaphazamiseka.
Umenzeli okukhulunywa ngaye uphazamisa ukumuncwa kwe-carnitine ngama-membrane angaphakathi esibeletho.
Ngenxa yalokhu, ama-acid anamafutha adlula kancane ngenkuthalo ngamangqamuzana enhliziyo. Ngokushoda komoya-mpilo, i-oxidation yamafutha acid iyathuthuka.
Umphumela wale nqubo ukwakheka kwezinto ezinobuthi ezithinta kabi ukusebenza kohlelo lwethambo nenhliziyo. Ngokuphikisana nesizinda sokuphendula okuchaziwe, i-metabolism yama-carbohydrate iya ishesha. Kulokhu, ukukhiqizwa kwe-ATP okusebenza kahle kwenzeka.
Umuthi futhi ulusizo kuma-diabetes, ngoba asiza ukwehlisa amazinga kashukela egazini. Inzuzo yethuluzi yikhono lokuguqula lesi sikhombisi ngaphandle kokuthuthukisa ukukhiqizwa kwe-insulin.
Ngenxa yethonya enqubweni yokukhiqizwa kwe-gamma-butyrobetaine, ukwehla kwesilinganiso sokukhuphuka kwendawo yendawo ethintekile ngokuqanjwa kwe-myocardial infarction kuyaphawulwa. Ngenxa yalokhu, isikhathi sokululama ngemuva kokuqedwa kwezimpawu ezibucayi sinciphile.
Esizeni esinezimpawu ze-ischemic, ukugeleza kwegazi kuyabuyiselwa.
Uma ukuhluleka kwenhliziyo kukhula, umuthi uyasiza ekuvumelaniseni ukusebenza kwe-myocardial. Ngaso leso sikhathi, kukhona ukwehla kwesibalo sezimpawu ze-angina pectoris.
Umzimba umelana kakhulu nokuxineka ngokomzimba. Ngaphezu kwalokho, ukujwayeza ukusebenza kwangaphakathi kohlelo lwezinzwa kuyabonakala, okubangelwa kakhulu ukubuyiselwa kokujikeleza komoya.
Ngemuva kokuthatha umuthi, ukujwayeza ukujwabuzwa kohlelo lwezinzwa oluphakathi kuyaqapheleka, okubangelwa ukubuyiselwa kokujikeleza komgogodla.
Ngenxa yokwelashwa nge-meldonium, amandla okusebenza akhuphuka, isimo sengqondo somguli sibuyele kokujwayelekile. Ngosizo lwaleli thuluzi, izinkomba zezimpawu zokuhoxa ngokuphuza utshwala ziyaqedwa.
I-Pharmacokinetics
Umgomo wokusebenza nesilinganiso sokusakazeka kwawo emzimbeni wonke kuya ngesakhiwo se-MP. Umuthi osefomini eluketshezi uqala ukusebenza ngokushesha ngemuva kokulethwa egazini / izicubu. Isixazululo semijovo siphathwa ngaphakathi, ngaphakathi nange-parrambarno. Ngaphezu kwalokho, i-bioavailability yesidakamizwa esinjalo ifinyelela ku-100%. Inani eliphakeme lomsebenzi livela ngokushesha uma into ingeniswa egazini. Okubi ukususwa okusuka emzimbeni (amahora angama-3-6), okuandisa imvamisa yokusetshenziswa.
I-Mildronate ivame ukusungulwa; ngenxa yalokho, kukhishwa izingxenye ezi-2 ezisebenzayo ezidalulwe yizinso.
Uma amaphilisi athathwe, i-bioavailability iyancishiswa futhi ingu-78%. Umsebenzi wethamo lomuthi wezidakamizwa utholakala ngemuva kwemizuzu engama-60-120 ngokulawulwa komlomo.
Umsebenzi wethamo lomuthi wezidakamizwa utholakala ngemuva kwemizuzu engama-60-120 ngokulawulwa komlomo.
Uhlobo lwamuva lwesidakamizwa luthuthukisile izakhiwo: i-hygroscopic encane, lubekezelela amazinga okushisa aphezulu. Muva nje, kusetshenziswe indlela ye-mitterionic ye-meldonium. Lapho ukufuthelana, ilahlekelwa yizakhiwo zayo, kushintsha isakhiwo sayo: ngenxa yokuthambekela kokungenisa umswakama, iLungu le-MP lidlula kwifomu eliwuketshezi, lifana nesiraphu ngokuvumelana.
Okunqunyelwe
I-Mildronate ingasetshenziselwa ama-pathologies alandelayo:
- izifo zenhliziyo ezi-coronary (kanye neminye imithi); ngenkathi kuthuthukiswa i-myocardial infarction, i-angina pectoris;
- izifo ngesimo esingelapheki ezibangelwa izingozi ze-cerebrovascular: stroke, ukulamba kwe-oksijini kwemithambo yegazi;
- ukwehluleka kwenhliziyo okungapheli, isifo senhliziyo, ukucasulwa yizinguquko ze-pathological futhi ezihlala zingenakuphikiswa ekwakhiweni kwemisipha, okuvame ukuba ngumphumela wokuphazamiseka kwehomoni;
- izimo ze-pathological ezibangelwa ukuwohloka ekunikezelweni kwegazi ezingxenyeni zombono: i-hemorrhage, i-venous thrombosis, i-retinopathy yama-etiologies ahlukahlukene;
- ukululama ezimpawu zokuhoxa ezenziwa ngenxa yokudakwa kotshwala;
- ukusebenza okuncishisiwe.
Ukusetshenziswa kweMildronate kwezemidlalo
Ithuluzi elibhekiwe lingasetshenziswa ngabasubathi abanokucindezela ngokweqile ngokomzimba nangokwengqondo. Kodwa-ke, lapho ihlolwa ukuthi i-doping, i-meldonium ithinta umphumela.
Ithuluzi okukhulunywa ngalo lingasetshenziswa ngabasubathi abanokuzivocavoca ngokweqile komzimba.
Contraindication
Kunemikhawulo eminingana lapho umuthi uvinjelwe ngaphansi kokwenza umuthi ngaphandle kokukhetha:
- ukusabela okungekuhle kwesimo somuntu ngamunye kumthelela wanoma yiziphi izinto ezakhiwayo;
- ukuthambekela kokukhulisa ingcindezi ye-intracranial, okuvela ngenxa yokwakheka kwezimila, ukuqina kokuqina kwemithambo, okunzima ukuphuma kuyo kwegazi.
Ngokunakekela
Ukuhlukumeza okuhlobene kufaka phakathi ukungasebenzi kahle kwesibindi nezinso. Njengoba unikezwe ukuthi lezi zitho zomzimba zibandakanyeka ku-metabolism ye-meldonium kanye nokuphuma kwayo, umthwalo owengeziwe uvusa ukuthuthukiswa kokungaphenduki okuhle. Ngenxa yalesi sizathu, kunconywa ukuqapha isimo sesiguli ngama-pathologies anjalo.
Ungayithatha kanjani iMildronate 250
I-MP ingadala ukuthokoza okukhulu, ngakho-ke kunconyelwa ukuyisebenzisa ekuseni, ezimweni ezibucayi - kungakadluli isidlo sasemini. Umthamo wento yomuthi uzonqunywa ngawodwana, kucatshangelwa izinga lokuthuthuka kwe-pathology, isimo sempilo sesiguli. Inkambo yokwelashwa nayo ingaba nesikhathi esingafani.
Kwisifo senhliziyo esiku-coronary, thatha i-500-1000 mg yesidakamizwa ngosuku amaviki ayisithupha.
Imiyalo yokusebenzisa ngokuya nge-pathology:
- izifo zenhliziyo ezi-coronary: 500-1000 mg ngosuku (ihlukaniswe imithamo emi-2), isifundo asiqhubeke isikhathi esingaphezu kwamaviki ayi-6;
- i-cardiomyopathy: 500 mg ngosuku, isikhathi sokwelashwa - kuze kufike ezinsukwini eziyi-12;
- izimo ezingama-subacute nezingama-pathological ezingapheli ezibangelwa ukwephulwa kokujikeleza kwenhliziyo: 500-1000 mg ngosuku, ukwelashwa kuthatha amasonto ayi-6, futhi ifomu lesifo elingelapheki libonisa isidingo sokusebenzisa inani eliphansi kusuka ebangeni elibekiwe (500 mg); ukwelashwa kabusha ngemuva kokuphumula kunconyelwe;
- ukugcwala ngokweqile ngokomzimba kanye nokusebenza kwengqondo okuphansi: ama-500 mg angadluli amahlandla ama-2 ngosuku, inkambo yokwelashwa ingamaviki ayi-1.5-2; uma kunesidingo, kuyaphindwa, kepha hhayi ngaphambili kunasemva kwamaviki ayi-2;
- umthamo ojwayelekile (500-1000 mg) ubekelwe abasubathi, umuthi awuthathwa izikhathi ezingaphezu kwezingu-2 ngosuku, inkambo ihlala kuze kube ngamaviki ama-3 ngesikhathi sokulungiselela ukwenziwa kwemisebenzi efanelekile futhi akukho ngaphezulu kwezinsuku eziyi-14 phakathi nemincintiswano;
- ubuthi obunobuthi: 500 mg amahlandla amane ngosuku, umuthi awuthathi izinsuku ezingaphezu kwezi-10;
- ku-ophthalmology: 50 mg kanye ngosuku, into iphathwa ngokuzwakalayo, isifundo sithatha izinsuku eziyi-10.
Ngaphambi noma ngemuva kokudla
Umuthi uthathwa esiswini esingenalutho noma isigamu sehora ngemuva kokudla.
Umuthi ungathathwa uhhafu wehora ngemuva kokudla.
Umthamo wesifo sikashukela
I-Mildronate ithathwa ngezifundo nokuphazamiseka okuthile. Kulokhu, kuvunyelwe ukunquma umthamo ojwayelekile womuthi. Isikhathi sesifundo, kanye nemvamisa yokusebenzisa umuthi, sinqunywa ngawodwana.
Imiphumela emibi
Imiphumela emibi ayiveli.
Kulokhu, imiphumela elandelayo elandelayo yenzeka:
- ukuguquguquka kwezinga lokucindezela;
- ukwephulwa kwesilinganiso senhliziyo (tachycardia);
- isimo esijabulile, ngenxa yomphumela ohlelweni lwezinzwa oluphakathi;
- Ukugaya ukudla kuyacasuka;
- ukungahambi kahle komzimba, kubonakaliswa ukuvuvukala, ukulunywa, ukuqubuka, i-hyperemia.
Umthelela ekhonweni lokulawula izindlela
Akunamininingwane ngokuphepha kokushayela ngesikhathi sokwelashwa nge-Mildronate. Imiphumela emibi evezwe kakhulu ngesikhathi sokwelapha akuvamile ukuba ikhule. Kodwa-ke, ngenxa yekhono le-meldonium lokuvusa ukuphazamiseka kwenhliziyo nokunciphisa ingcindezi, ukunakekelwa kufanele kuthathwe lapho ushayela imoto.
Lapho uthatha iMildronate 250, kufanele kuqashelwe ngenkathi ushayela imoto.
Imiyalo ekhethekile
I-Mildronate ingasetshenziselwa i-angina pectoris namanye ama-pathologies we-CCC, kepha leli khambi akusona isidakamizwa esiyinhloko. Ngalesi sizathu, i-MP isetshenziswa kuphela neminye imithi.
Sebenzisa ebudaleni
Kuvunyelwe ukusebenzisa ithuluzi okukhulunywa ngalo. Kodwa-ke, kufanele ubheke isimo somzimba, ngoba i-metabolism esegugile iyancipha. Ngaphezu kwalokho, iMildronate ivusa ukuphazamiseka ekusebenzeni kwe-CVS futhi yehlise nomfutho wegazi.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi uvunyelwe ukusetshenziswa. Lokhu kungenxa yokushoda kolwazi ngokuphepha kwayo.
Ukunquma uMildronate ezinganeni ezingama-250
Ithuluzi okukhulunywa ngalo alisetshenziswa. Lokhu kungenxa yokushoda kolwazi ngokuphepha kwayo.
Ukuthatha uMildronate okhulelwe kukhubazekile.
Ukweqisa
Izimpawu ezingahle zibe nokwanda kwenani lemithi elinconyiwe:
- ushintsho olubukhali ezingeni lokucindezela (phansi);
- ikhanda kanye nesiyezi;
- ukuphazamiseka kwenhliziyo, okuhambisana nokushintshwa kwemvamisa yezinkontileka ze-myocardial;
- umuzwa wobuthakathaka.
Ngenxa yobuthi obuphansi besidakamizwa, izimo ezinzima kakhulu ze-pathological azitholakali. Susa izimpawu ngezindlela zokwelashwa zakudala; ukukhethwa kohlelo kuncike esithombeni somtholampilo.
Ukuxhumana nezinye izidakamizwa
I-Mildronate ingahlanganiswa nezinye izidakamizwa ezithinta ngokuqondile noma ngokungaqondile ukusebenza kwesistimu yenhliziyo: izidakamizwa ezisebenza ngokuqondile, i-antiplatelet, i-anticoagulant kanye ne-antiarrhythmic drug.
Azikho izimpawu ezingezinhle ngokusetshenziswa kanyekanye kwama-bronchodilators.
Ama-glycosides e-Cardiac aqala ukusebenza ngokuzikhandla ngaphansi kwethonya lomenzeli okukhulunywa ngalo.
I-Mildronate ingahlanganiswa nama-ejenti athinta ukusebenza kohlelo lwethambo nenhliziyo.
Isimo sesiguli sibhekwa njalo ngesikhathi sokwelashwa ngemithi enjalo:
- I-Nitroglycerin;
- INifedipine;
- ama-alpha-blockers;
- izidakamizwa ze-antihypertensive;
- ama-vasodilators aphambili.
Lesi sidingo singenxa yengozi ekhulayo yesenzo esandisiwe.
Ukuhambisana notshwala
Ngaphandle kokuthi umuthi okukhulunywa ngawo usetshenziselwa ekwelapheni i-hangover encomeni yotshwala, akumele isetshenziswe ngasikhathi sinye neziphuzo eziqukethe notshwala, ngoba kukhona ukwehla kwezinga le-MP elifanele.
Ama-Analog
Ukufakwa esikhundleni okusebenzayo:
- IMeldonium;
- I-Meldonium Organics;
- I-Cardionate;
- Idrinol
Ungangena esikhundleni seMildronate ngeMeldonium.
Esikhundleni samaphilisi kanye nesisombululo, amaphilisi angasetshenziswa. Uma kunesidingo, ukulandisa komthamo kuyenziwa.
Izimo zeholide Mildronata 250 kusuka ekhemisi
Umuthi umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Akunakwenzeka lokho.
Intengo yeMildronate 250
Izindleko ezijwayelekile ngama-ruble angama-315.
Izimo zokugcina zomuthi
Endaweni emnyama neyomile. Ukushisa kwekamelo okwamukelekayo - hhayi okuphakeme kuno- + 25 ° ะก.
Isikhathi sokuphelelwa yisikhathi
Amacwecwe angasetshenziswa iminyaka emi-4; ikhambi lingasetshenziswa isikhathi eside - iminyaka emi-5 kusukela ngosuku lokukhishwa.
Amacwecwe angasetshenziswa iminyaka emi-4; ikhambi lingasetshenziswa isikhathi eside - iminyaka emi-5 kusukela ngosuku lokukhishwa.
Umakhi we-Mildronate 250
ISantonica, eLithuania.
Ukubuyekezwa kwe-Mildronate 250
Ngenxa yokuhlolwa kwemibono yabachwepheshe nabathengi, kungenzeka ukuthi kuhlolwe ukusebenza ngempumelelo kwomuthi lapho usebenza.
Izazi zezenhliziyo
Kutina M.A., udokotela wezifo zenhliziyo, oneminyaka engama-32, uSaratov
Umuthi osebenzayo; umphumela omuhle ufinyelelwa ezinsukwini ezingama-7-10 ngemuva kokuqala kokwelashwa. Impumuzo ethile iza ngosuku lokuqala. Yabela ukwephulwa okuhlukahlukene kwesakhiwo sezindonga zemithambo yegazi. Kumkhuba wami, imiphumela emibi ezigulini ayizange ibe khona.
UGerudova, A.I., udokotela wezifo zenhliziyo, oneminyaka engama-39 ubudala, eMoscow
Phezu kokuntuleka kwezifundo ezigcwele ngokuphelele zokuphepha komuthi, uyakhombisa ukuthi muhle kakhulu. Ukuqina kwezimpawu zesifo kwehla nge-monotherapy. Uma umuthi okukhulunywa ngawo usetshenziswa kanye nezidakamizwa ezinamandla, izimpawu zinganyamalala ngokuphelele.
Iziguli
U-Alexandra, oneminyaka engama-33, u-Oryol
UMildronate wabekwa ngemuva kokuhlinzwa: udokotela ohlinzayo wathi kwakudingeka ukuvimbela izinkinga. Angazi ukuthi umuthi udlale yiphi indima ekululameni kwami, kepha ngalulama ngokushesha, azikho izinkinga ezivelile.
U-Eugene, oneminyaka engama-37, uBarnaul
Yamukelwa ngokuwohloka kwekhwalithi yokuzwa (kwakukhona i-hum ezindlebeni). Ngemuva kwamasonto ambalwa, kwaba ngcono kakhulu. Manje ngigcina ngisebenzisa lo muthi ekhaya uma kwenzeka kuvela izimpawu ezingezinhle.
