UWessel Douai F 600 yiqembu lezidakamizwa eziyingxenye eyodwa. Umuthi yi-anticoagulant. Lokhu kusho ukuthi umsebenzi wayo oyinhloko ukuguqula ukubukeka kwegazi ukuze kunciphise ingozi yokwakheka kwesibalo segazi esiningi. Umuthi umuthi, ngoba unomphumela omubi emzimbeni futhi awunakusetshenziswa ngokubona kwawo - ubungozi bokopha buyanda.
Igama Lezwe elingafanele
I-Sulodexide
I-ATX
B01AB11 Sulodexide
UWessel Douai F 600 yiqembu lezidakamizwa eziyingxenye eyodwa.
Khipha amafomu nokwakheka
Isakhi esiyinhloko umsebenzi we-anticoagulant - i-sulodexide ye-izidakamizwa. Umuthi wenziwa ngefomu eqinile newuketshezi. Ezinye izinto ezakhiwe ekwakhiweni kwe-capsule:
- sodium lauryl sarcosinate;
- triglycerides;
- i-silicon dioxide colloidal.
Ukwakheka kwe-Shell:
- glycerol;
- i-gelatin;
- sodium ethyl paraoxybenzoate;
- i-iron oxide ebomvu;
- sodium propyl paraoxybenzoate;
- titanium dioxide.
Iqoqo lesakhi esiyinhloko ku-1 ampoule yi-600 LU. Kutholakala ngesimo sesisombululo semijovo ngaphakathi nangaphakathi.
Iqoqo lesakhi esiyinhloko ku-1 ampoule yi-600 LU. Ukulungiswa kuhlongozwa ngomthamo onjalo wento ngendlela yesisombululo sokwenza imijovo ngaphakathi nangokomzimba. Kodwa-ke, kukhona enye inguqulo: i-1 capsule iqukethe i-250 LU ye-sodebide. Izakhi ezincane ekwakhekeni kwekhambi:
- i-sodium chloride (0.9%);
- amanzi ngomjovo.
Umuthi okuqinile unikezwa emabhulini angama-25 ama-pcs. Iphakethe liqukethe ama-2 blims. Isixazululo singathengwa kuma-ampoules we-2 ml. Inani labo eliphelele kwiphakethe li-10 ama-pcs.
Isenzo se-Pharmacological
Isithako esisebenzayo sitholakala emzimbeni wengulube. Umthombo wayo yizinto zokwakha eziqukethwe ulwelwesi lwamafinya esiswini esincane. Umphumela uba yindawo yemvelo equkethe ama-glycosaminoglycans: i-daltone, efana ne-heparin ephansi yesisindo kanye ne-dermatan sulfate.
Umuthi yi-anticoagulant ebonakala ngomphumela oqondile. Lokhu kusho ukuthi ngenxa yayo, umsebenzi we-thrombin kanye ne-coagulation factor uyancipha. Umphumela uba umphumela we-antithrombotic. Ezinye izakhiwo:
- profibrinolytic;
- angioprotective.
Ngaphansi kwethonya le-sulodexide, indices zegazi zenziwa zenziwe ngokwejwayelekile, izakhiwo zalo zokuphamba zithuthukiswa.
Amandla okucindezela i-X-factor eyenziwe isebenze, athuthukise ukukhiqizwa kwe-prostacyclin, futhi anciphise inani le-fibrinogen kwiplasma yegazi futhi kusiza ekwehliseni ubukhulu bokwakheka kwegazi. Ngasikhathi sinye, izinga lomlungisi we-izicubu ze-plasminogen lishintsha liye phezulu, ngenxa yokuncipha kokuxineka kwe-inhibitor yale nto.
Ngaphezu kwalokho, ukubuyiselwa kwesakhiwo sezindonga zemithambo yegazi kuyaphawulwa, ngenkathi kusebenza kangcono. Ngaphansi kwethonya le-sulodexide, indices zegazi zenziwa zenziwe ngokwejwayelekile, izakhiwo zalo zokuphamba zithuthukiswa. Lokhu kungenxa yokwehla kweqoqo lama-triglycerides.
Ithuluzi elibhekwayo lisiza ukunciphisa ubukhulu benqubo yokukhula kwezicubu ngenxa yokuqhekeka ngokweqile kweseli kwe-mesangium. Ngasikhathi sinye, ukuncipha kogqinsi kolwelwesi olungaphansi kanye nokuncipha kokukhiqizwa kwe-matrix engaphandle kuyabonakala. Ngenxa yalezi zinqubo, lesi simo sithuthuka nge-angiopathy yesifo sikashukela.
I-Pharmacokinetics
Umuthi udonswa amaseli wobuso bangaphakathi bemikhumbi. Inqubo yokumunca yenzeka emathunjini. Into esemqoka esibindini nasezinso iguquliwe. Kulokhu, inqubo yokuchithwa ayenzeki, ehlukanisa umenzeli ocatshangelwe kuzidakamizwa eziqukethe i-heparin. Ngokuchithwa, ukwehla komsebenzi we-antithrombotic kwenzeka, ngenkathi ukumbumbuluzwa kwento esemqoka evela emzimbeni kushesha. Ngokunikezwe ukuthi ngokuguqulwa kwe-sulodexide le nqubo ayithuthukisi, isikhathi se-igazi sokuqina siyenyuka.
Ngemuva kosuku olungu-1, ama-50% ento atholakala kumchamo. Ngemuva kwezinsuku ezi-2 - ama-67%.
Ngemuva kokuphatha, into esebenzayo ayikhishwa kungakapheli amahora angama-4. ISulodexide isatshalaliswa emzimbeni wonke. Kuboniswa kancane. Ngemuva kosuku olungu-1, ama-50% ento atholakala kumchamo. Ngemuva kwezinsuku ezi-2 - ama-67%.
Izinkomba zokusetshenziswa
Umuthi okukhulunywa ngawo unqunywe emacaleni amaningi:
- ukwephulwa kwemithambo yegazi ngokumelene nesizinda sokuphazamiseka komthethonqubo wezinzwa, okubonakaliswa ngama-spasms, ama-paresis, uma ngabe kukhona ingozi ye-thrombosis;
- ukuwohloka kokujikeleza kwe-cerebral, ikakhulukazi nge-ischemia ekhulayo (nge-exacerbation kanye nasesigabeni sokuthola kabusha);
- i-dyscircular encephalopathy, ehambisana nomonakalo emithanjeni yobuchopho, lokhu kungahle kube ngumphumela wokuwohloka kwemizwa, isifo sikashukela, umfutho wegazi ophakeme noma ushintsho lwe-atherosselotic;
- izilonda zemithambo yethambo, lapho i-lumen ne-patency kuncishisiwe;
- ukuphuma kwegazi okungahambi kahle, i-vein thrombosis;
- izimo zokugula ezimelela izinhlobo ezahlukahlukene ze-microangiopathy: i-neuropathy, i-nephropathy, i-retinopathy, kufaka phakathi lezo ezikhule ngokumelene nesizinda sesifo sikashukela i-mellitus (i-cardiopathy, isifo sikashukela sonyawo, njll.);
- ama-pathologies ahlukahlukene ahambisana nokuvuvukala kodonga lwe-vein kanye nokwehla kwe-lumen yayo ngenxa yejazi legazi;
- izimo ze-thrombophilic;
- ukwelashwa kwe-heparin-indened thrombocytopenia yesimo se-thrombotic.
Contraindication
Izinzuzo zomuthi zifaka inani eliphansi lemikhawulo. Kuvinjelwe ukuyisebenzisa ezimweni ezinjalo:
- ukusabela komuntu kwesimo esingesihle;
- i-diathesis ephelezelwa yi-hemorrhage (ukukhululwa kwegazi ngaphandle komkhumbi) nezinye izifo lapho kunokwehla kobukhulu bokuqina kwegazi.
Ngokunakekela
Ngama-pathologies wezinso nesibindi, umuthi usetshenziswa ngaphansi kokuqondisa udokotela. Lesi sidingo singenxa yokuthi into esebenzayo iba ngaphansi kwenqubo ye-metabolic esibindini, futhi ikhishwa yizinso.
Ungamthatha kanjani uWessel Douai F 600?
Imiphumela emihle inikezwa ukuphathwa okungaguquki komuthi ngezindlela ezahlukahlukene: imijovo yokuqala, bese kuba ngamakhompiyutha. Umuthi uketshezi lusetshenziswa ngokuya ngemiyalo: okuqukethwe i-1 ampoule ngosuku ngokufakwa emzimbeni noma ngaphakathi, le ndlela ingashintshwa ngethonsi, lapho umuthi buhlanjululwe ngaphambilini nge-saline (150-200 ml). Qhubeka nesifundo isikhathi esingadluli izinsuku ezingama-20. Ukuthola umphumela ozinzile, phinda ukwelashwa izikhathi ezimbili ngonyaka.
Kuvunyelwe ukusebenzisa umuthi ushukela.
Ekupheleni kwenkambo yokwelashwa ngesisombululo, aqhubekela esigabeni sesibili - thatha amaphaphu. Isikhathi sokwelashwa siyizinsuku ezingama-30- 40. Imvamisa yokuphatha i-1 capsule kabili ngosuku.
Ngoshukela
Kuvunyelwe ukusebenzisa umuthi kulokhu kutholwa. Umthamo wayo awubalwanga, kepha kufanele kuqashelwe, ngoba iziguli ezinesifo sikashukela sohlobo loku-1 zingakha ezinye iziphazamiso zezitho zangaphakathi, ezizothinta umetabolism kanye nokusebenza kwento esebenzayo.
Imiphumela emibi uWessel Duet F
Njengoba kunikezwe ukuthi ingxenye eyinhloko ithinta ukwakheka kwegazi, kukhona ubungozi bokungaphenduki okuhle. Ukuqina nokuvama kwabo kunqunywa isimo somzimba, ukuba khona kwezinye izifo, ubukhulu bezimpawu. Isibonelo, ngokufakwa kwento ewuketshezi, kuvela izinhlungu, umuzwa ovuthayo, i-hematoma ingakheka endaweni yokubhoboza kwesikhumba.
Ngokwazisa kwento ewuketshezi, umuzwa ovuthayo kwesinye isikhathi uyavela.
Amapheshana wesisu
Ubuhlungu esiswini, obuhambisana nokucanuzelelwa, kuyaphawulwa. Ukuqhafaza kwenzeka kaningi.
Allergies
Ukuqhuma kungavela kunombolo engaphandle yangaphandle.
Umthelela ekhonweni lokulawula izindlela
Akunabo ubungozi bokuthi kuphazamiseke ukusebenza kwezitho zombono, isistimu yezinzwa ephakathi noma i-CCC, kanye nezinye izinqubo eziningi emzimbeni. Ngenxa yalokhu, kuvunyelwe ukushayela izimoto ngesikhathi sokwelashwa.
Imiyalo ekhethekile
Kuyo yonke le nkathi yokwelashwa, kufanele kuhlolwe inani lamapharamitha egazi, lapho kwenziwa khona i-coagulogram. Amapharamitha abaluleke kakhulu:
- antithrombin III;
- isikhathi se-thromboplastin esetshenzisiwe - ukusebenza kahle kwezindlela eziguqukayo zangaphakathi nezijwayelekile;
- ukopha nesikhathi sokujaha.
Kuyo yonke le nkathi yokwelashwa, kufanele kuhlolwe inani lamapharamitha egazi, lapho kwenziwa khona i-coagulogram.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi uphulwe ku-1 trimester. Kuma-trimesters e-2 ne-3, asetshenziswa ngaphansi kokuqondisa kukadokotela. Kunokuhlangenwe nakho okuhle ekwelashweni kweziguli ezitholakala zinesifo sikashukela ngesikhathi sokukhulelwa (ezigabeni zakamuva).
Akunamininingwane ngokusetshenziswa kwesidakamizwa ngesikhathi sokuncelisa ibele.
Umthamo wezingane
Akunconyelwe ukusebenzisa umuthi ukwelashwa kweziguli ezingaphansi kweminyaka engu-12. Kunokuhlangenwe nakho okulinganiselwe ngokusetshenziswa kwalesi sidakamizwa ekwelashweni kwentsha kusuka eminyakeni engu-13 kuye kwengu-17. Kulokhu, umkhiqizo ubekezelelwa kahle. Ekwelapheni kwezingane zalo nyaka, uhlelo olufanayo lusetshenziselwa njengabantu abadala, kepha isikhathi sokwelashwa sincishiswa amahlandla ama-2.
Ukweqisa kweWessel Duet F
Uma inani elandayo leWessel Duo F lisetshenziswa njalo, ubungozi bokukhipha okwemvelo ehlukile, amandla ayanda. Lapho umthamo ukhishwa ngokwengeziwe, kuba nzima kakhulu ukuqeda izimpawu ezingezinhle.
Lapho kwenzeka izinkinga, inkambo iyaphazamiseka. Uma kunesidingo, ukwelashwa kwenziwa ukuze kuqedwe izimpawu.
Ukuxhumana nezinye izidakamizwa
I-Wessel Duo F ibekezelelwa kahle ngumzimba ngenkathi isetshenziswa nezinye izidakamizwa eziningi. Kodwa-ke, ukusetshenziswa kwalesi sidakamizwa kanye namanye ama-anticoagulants kuvusa ukwanda komsebenzi wesidakamizwa, ngasikhathi sinye, ubungozi bezinkinga buyanda. Futhi kufanele ugweme ukuthatha ama-anticoagulants ezinhlobo ezahlukile: imiphumela eqondile nengaqondile. Lezi zincomo zisebenza nezidakamizwa ze-antiplatelet.
Akukho ukuvimbela okuqinile ekusebenziseni kanyekanye kweziphuzo eziqukethe utshwala kanye nomuthi okukhulunywa ngawo.
Ukuhambisana notshwala
Akukho ukuvimbela okuqinile ekusebenziseni kanyekanye kweziphuzo eziqukethe utshwala kanye nomuthi okukhulunywa ngawo. Kodwa-ke, utshwala bukhulisa umphumela we-anticoagulant, ngaphezu kwalokho buthinta isibindi. Ngalesi sizathu, iziphuzo eziqukethe utshwala kufanele zigwenywe ngesikhathi sokwelashwa.
Ama-Analog
Njengokufaka esikhundleni, izidakamizwa ngezindlela ezahlukahlukene zingasetshenziswa: isixazululo, amaphilisi, amaphilisi, i-lyophilisate. Izithasiselo ezisebenzayo:
- I-Angioflux;
- Fragmin;
- U-Enixum;
- Anfibra.
Lapho ukhetha isidakamizwa, cabanga ngezinhlobonhlobo zezinto ezisebenzayo, umthamo wazo ekubunjweni. Ngaphezu kwalokho, banaka uhlobo lokukhishwa, ngoba kuzoncika kulokhu ukuthi ngabe kuyadingeka yini ukuthi uphinde ulandise inani lomuthi noma cha.
Imibandela yekhefu lekhemisi
Umuthi yiqembu lemithi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Cha.
Umuthi yiqembu lemithi kadokotela.
Intengo
Izindleko ziyehluka kakhulu: kusuka ku-1640 kuya kuma-ruble angama-3000.
Izimo zokugcina zomuthi
Izinga lokushisa elamukelekayo egumbini alikho ngaphezu kuka- + 30 ° ะก.
Isikhathi sokuphelelwa yisikhathi
Kuvunyelwe ukusebenzisa lesi sidakamizwa iminyaka engu-5 kusukela ngosuku lokukhishwa. Ekupheleni kwalesi sikhathi, umphumela womuthi ungaba buthaka noma kungaba nemiphumela emibi engabhalisiwe.
Umkhiqizi
I-Alpha Wassermann S.P.A., Italy. Ukupakisha nokupakisha - I-Farmakor Production (Russia).
Ukubuyekezwa
UMargarita, oneminyaka engama-39, uBarnaul.
Umuthi usize ngomonakalo emithanjeni yengqondo. Ngemuva kwenkambo yokuqala ngabona ukuthuthuka okusobala. Manje ngithola ukwelashwa amahlandla ama-2 ngonyaka ngesincomo sikadokotela. Azange ngibe nemiphumela emibi.
U-Olga, oneminyaka engama-44, uSaratov.
Umuthi uyabiza, kepha ufanelekile. Isiza ngokushesha nangokuthembekile. Ngathatha amaphilisi ngesikhathi sokukhulelwa, ngoba bathola i-hypoxia ye-fetus. Ukwelashwa kuhamba ngaphandle kwezinkinga, izimpawu ezingezinhle zaqedwa. Ngijabule ngomuthi, manje ngiwugcina ubonakele.
