Ukucindezela okwandayo kufaka imiphumela emibi eminingi. Lesi simo siholela ekukhathaleni okuhlala njalo, impilo engeyinhle, umthwalo omkhulu kumisipha yenhliziyo kanye nengozi enkulu yokuhlaselwa yinhliziyo. I-antihypertensive drug Lozap izosiza ukubhekana ne-pathology.
I-ATX
Ikhodi ye-ATX yi-C09CA01.
Umuthi ukhiqizwa ngendlela yamaphilisi e-biconvex.
Khipha amafomu nokwakheka
Umuthi ukhiqizwa ngendlela yamaphilisi e-biconvex. Iphakheji liqukethe amaphilisi angama-30, 60 noma angama-90.
Njengoba isithako esisebenzayo, i-losartan potassium (100 mg) isetshenziswa. Izinto ezisizayo yilezi:
- udayi ophuzi;
- I-MCC
- i-povidone;
- dimethicone;
- i-talc;
- i-croscarmellose sodium;
- i-macrogol;
- mannitol.
Indlela yokusebenza
Ithuluzi lihloselwe ukwehlisa ingcindezi. Umphumela we-pharmacological uhambisana nomphumela we-angiotensin 2, ngenxa yalokho ongeke ubophele kuma-receptors e-AT1. Lokhu kuholela ekunciphiseni kwemiphumela elandelayo ye-AT2:
- i-hypertrophic yesokunxele;
- ukukhishwa kwe-catecholamines, vasopressin, aldosterone ne-renin;
- umfutho wegazi ophakeme
Ithuluzi lihloselwe ukwehlisa ingcindezi.
I-Pharmacokinetics
Into esebenzayo ayinciphisi kuphela ukuqoqwa kwe-adrenaline egazini, kodwa futhi nezinga le-aldosterone. Inani eliphakeme lokwelashwa livela ngemuva kwamahora ayi-6. Uma umuthi usetshenziswa njalo, khona-ke umphumela omkhulu kakhulu wokwelapha utholakala ngemuva kwamaviki ama-3-6.
Ukuqunjelwa kwenzeka ngokushesha okuphuma emgodini wokugaya ukudla. Ukuqoqwa okuphezulu kwengxenye esebenzayo ku-plasma yegazi kuvela ihora ngemuva kokuphathwa, kanye ne-metabolite ngemuva kwamahora ama-3.
I-Bioavailability ingama-33%. Iningi lomuthi lukhishwa emathunjini, kodwa cishe u-35% wezidakamizwa ukhishwa emchanjeni.
Yini edingekayo
Umuthi usetshenziselwa ukufeza izinhloso ezilandelayo:
- ukuqedwa kohlobo lwesifo sikashukela se-nephropathy esenzeka ngokumelene nesizinda sokukhula kohlobo lwesifo sikashukela sohlobo 2 esinomfutho wegazi ophakeme;
- ukunciphisa amathuba okuba nesifo senhliziyo;
- ukuqedwa kokuhluleka kwenhliziyo okungalapheki;
- ukwelashwa kwe-hypertension ebalulekile.
Contraindication
Umuthi awuvunyelwe ukusetshenziswa phambi kwe-hypersensitivity kuzakhi. Sebenzisa ngokuqapha ezimweni ezilandelayo:
- ngesikhathi se-stenosis semithambo yezinso;
- ngokwephulwa kwebhalansi ye-electrolyte;
- ngokwehla kwe-bcc.
Ungayithatha kanjani
Ukuthatha umuthi akuxhomekile esikhathini sokudla kokudla. Ithuluzi lisebenzisa 1 isikhathi ngosuku. Iziguli ezine-hypertension ye-arterial zinqunywa umuthi ngenani lama-50 mg. Uma umphumela onamandla uyadingeka, umthamo unyuka uye ku-100 mg.
Inani eliqondile lomuthi linqunywe udokotela, ngakho-ke ukubonisana kuyadingeka.
Inani eliqondile lomuthi linqunywe udokotela, ngakho-ke ukubonisana kuyadingeka. Umuthi usetshenziswa kuphela uma kunezinkomba zokuwusebenzisa. Ukwenza ukwelashwa kukodwa akunconywa.
Ngoshukela
Ukwelashwa kweziguli ezinesifo sikashukela sohlobo 2 kuqala ngo-50 mg. Umthamo uthathwa isikhathi esingu-1 ngosuku. Ngokobufakazi bukadokotela, inani lemithi yokwelashwa lingakhuphuka lifinyelele ku-100 mg ngosuku, ukuhlukanisa umuthi emugomweni we-1-2.
Imiphumela emibi
Amapheshana wesisu
Izimpawu ezivele zivela eceleni yilezi:
- isicanucanu
- izinhlungu
- umuzwa wokugcwala kwesisu (dyspepsia);
- isifo sohudo
Okuncane okuvamile ukubonakaliswa:
- izinkinga ngesibindi;
- umsebenzi owengeziwe wama-enzyme wesibindi;
- ukuthopha;
- umlomo owomile
- ukunciphisa umzimba;
- ukuqunjelwa
- ukuhlanza
Izitho zeHematopoietic
Izimpawu ezilandelayo zokuphendula okungesihle ziyakhiwa:
- ukwehla kwenombolo yama-eosinophils;
- i-anemia
- i-thrombocytopenia;
- ukulimala kwemikhumbi emincane (hemorrhagic vasculitis).
I-anemia ingaba wumphumela ongemuhle.
Isistimu yezinzwa ephakathi
Isiguli sinezimpawu:
- ukukhathala;
- ukuthuthumela
- umuzwa wokukhathazeka;
- Ukudana
- i-peripheral nerve neuropathies;
- i-hypersthesia
- i-paresthesia - ukuvela okuzenzakalelayo okubonakaliswa yikugunda noma ukuvutha;
- ukukhubazeka kwenkumbulo;
- ukuphazamiseka kokulala;
- ukulahleka kokuxhumana.
Izitho zomzimba
Imiphumela emibi ingathinta izinzwa, ezizobangela izimpawu ezilandelayo:
- ukuvuvukala kwe-conjunctiva yeso;
- ukungaboni kahle
- ukunambitheka kwezinguquko;
- tinnitus.
Uhlelo lokuphefumula
Ukwehlulwa kohlelo lokuphefumula lubonakala ngokuboniswa okusohlwini:
- i-sinusitis
- ukuvela kwe-pharyngitis;
- ukucinana kwamakhala;
- i-bronchitis;
- ukukhwehlela
- ukunqotshwa ukutheleleka kwepheshana eliphezulu.
Ukulimala ohlelweni lokuphefumula kubonakala ngokubonakala kokhwehlela.
Izitho zangasese
Ukuphendula kohlelo lwe-genitourinary kwimiphumela emibi kuvezwe yizimpawu ezilandelayo:
- ukuchama njalo;
- ukungabi namandla;
- kwehla i-libido;
- umsebenzi wezinso ongonakalisiwe;
- izifo ezithinta umchamo;
Kusuka emasosheni omzimba
Izimpawu ezilandelayo zenzeka:
- i-angioedema;
- ukuvuvukala kwemithambo (vasculitis).
Imiphumela emibi iholele ku-angioneurotic edema ethinta ubuso.
Allergies
Imiphumela emibi iholela kulezi zimpawu ezilandelayo zokusabela komzimba:
- i-angioedema, ethinta izindebe, i-pharynx, ulimi, i-larynx, ubuso nepheshana lokuphefumula;
- imivimbo yesikhumba;
- ukulunywa.
Imiyalo ekhethekile
Uma ngaphambi kokuqala ukwelashwa isiguli sithathe ama-diuretics kumthamo omkhulu, khona-ke inani le-Lozap kufanele lehliselwe ku-25 mg.
Ukuhambisana notshwala
Ukusetshenziswa kophuzo oludakayo phakathi nesikhathi sokwelashwa kuzoholela ekuphendukeni kabi nasekuwohlakalweni kwenempilo yesiguli, njengoba umuthi awuhambisani kahle notshwala.
Ukuphuza utshwala phakathi nesikhathi sokwelashwa kuzoholela ekuwohlokeni kwenhlala kahle yenhliziyo yesiguli.
Isicelo sokusebenza kokulimala kwezinso
Uma kunezinkinga zezinso, asikho isidingo sokulungiswa komthamo. Kodwa-ke, lezi ziguli kufanele zigadwe ngudokotela ukuze kuqashwe ukucaciswa kwe-renal kanye nokuhlushwa kwe-potassium egazini.
Sebenzisa umsebenzi wesibindi okhubazekile
Abantu abaphethwe ukungasebenzi kahle kwesibindi, udinga ukuthatha imishanguzo ngemithamo ephansi.
Ukwehluleka kwenhliziyo
Ukusetshenziswa kwe-Lozap ngendlela engapheli yokuhluleka kwenhliziyo kwenziwa isikhathi esingu-1 ngosuku. Umthamo wokuqala ngu-12,5 mg. Inani lezimali likhuphuka kancane kancane liye ezingeni elidingakalayo.
Ukusetshenziswa kwe-Lozap ngendlela engapheli yokuhluleka kwenhliziyo kwenziwa isikhathi esingu-1 ngosuku.
Umthelela ekhonweni lokulawula izindlela
Ukuvela kwezimpawu eziseceleni kuholela ekunciphiseni komsebenzi wemisebenzi ye-psychomotor, ngenxa yalokho ukunaka kokunaka kwesiguli kuya ngokuya kukhuphuka. Kufanele wenqabe ukushayela izimoto isikhathi sokulashwa.
Ngesikhathi sokukhulelwa nokuqunjelwa
Lapho uncelisa ibele, udinga ukudlulisela ingane ekondleni okungelona okwenziwe ngalo noma ukhethe esinye isidakamizwa esingasetshenziswa ngesikhathi sokuqunjelwa.
Lapho uncelisa ibele, udinga ukudlulisa ingane ekunakekelweni kokudla okwenziwe ngemizwa.
Ukusetshenziswa kwomuthi kungadala iziphazamiso ku-fetus noma ekufeni. Ngesikhathi sokukhulelwa, umuthi awunqunyelwe.
Ukuqokwa kwe-Lozap ezinganeni
Umuthi awubekelwe iziguli ezingaphansi kweminyaka engu-18 ngenxa yokushoda kolwazi ngokuphepha kokuthatha lo muthi ebuntwaneni.
Sebenzisa ebudaleni
Iziguli ezingaphezu kweminyaka engu-75 ubudala zidinga ukukhetha imithamo ephansi.
Ukweqisa
Ukuthatha umuthi ngamanani amakhulu kuholela ekushintsheni kwezinga lesifo senhliziyo noma ukubukeka kwe-hypotension enzima.
Ukuqeda ukubonakaliswa, kufanele uye esibhedlela.
Ukuxhumana nezinye izidakamizwa
Ukusebenzisana kwezidakamizwa kweLozap kunezici ezilandelayo:
- ukuqina kwe-metabolite yesakhi esisebenzayo egazini kuyehla ngenxa yokusebenzisa i-fluconazole noma i-rifampicin;
- impahla ye-hypotensive iyancishiswa lapho kusetshenziswa izidakamizwa ezingezona ze-steroidal anti-inflammatory
- amathuba okukhiqizwa kwe-hyperkalemia lapho usebenzisa imishanguzo ene-potassium ne-diuretic potasium-sparing drug grow;
- ithonya lama-diuretics, ama-block adrenergic ayathuthukiswa.
Lapho uxhumana nezinye izidakamizwa, umphumela we-diuretics, blockers adrenergic uyanda.
Akukho ukusebenzisana okuyingozi lapho kutholakala laba bantu:
- I-Erythromycin;
- EWarfarin;
- IHydrochlorothiazide;
- I-Phenobarbital;
- I-Cimetidine;
- I-Digoxin.
Ama-Analog
Uma kunesidingo, ungawususa umkhiqizo ngama-analogues. Le mithi ifaka phakathi:
- I-Lorista isidakamizwa esinomphumela we-antihypertensive.
- I-Enap ingumuthi one-enalapril. Isiza ukucindezela okuphansi.
- I-Indapamide umuthi lapho into esebenzayo iyi-indapamide hemihydrate. Kusho imishanguzo ye-antihypertensive ne-diuretic.
- I-Mikardis - ithuluzi elihlose ukucindezela ama-angiotensin 2 receptors, okuholela ku-vasodilation kanye nokwejwayelekile kwencindezi.
- I-Telmisartan iyisidakamizwa esinezinto ezifanayo ezisebenzayo. Umuthi usetshenziswa ngesikhathi sokwelapha umfutho wegazi ophakeme.
- I-Candesartan ilungiselelo lomkhiqizo waseRussia naseSwitzerland.
- I-Lozap Plus - isidakamizwa esenziwe nge-losartan. Ngokwengeziwe kuqukethe i-hydrochlorothiazide - into enomphumela wokugaya.
Imibandela yekhefu lekhemisi
Kudingeka umuthi ukuthenga umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Akukho okubhalwe phansi akusatshalwanga.
Intengo ye-Lozap
Izindleko zalo muthi zincike kwinani lamathebulethi asephaketheni nasekhemisi lapho kuthengiswa khona iLozap. Intengo emaphakathi yomuthi ingama-ruble angama-320.
Izimo zokugcina zesidakamizwa i-Lozap
Ukushisa kwesitoreji akumele kudlule + 30 ° C. Kuyadingeka ukuvikela umuthi elangeni eliqondile.
Isikhathi sokuphelelwa yisikhathi
Isikhathi sokugcina yiminyaka emi-2.
Ukubuyekezwa mayelana ne-Lozap
Ukubuyekezwa komuthi kumele kubhekwe iziguli ezihlela ukuwuphuza.
Izazi zezenhliziyo
UVictor Konstantinovich, udokotela wezifo zenhliziyo
Umuthi yi-analogue yeCozaar. Umuthi uyasebenza ngokusetshenziswa okufanele kanye nokwelashwa okwanele.
UVictoria Gennadievna, udokotela wezifo zenhliziyo
Umphumela wokwelapha weLozap ubonakala ngomphumela obuthakathaka. Ngenqubo yokwelashwa, kunzima ukufeza izinkomba zokucindezela ezidingekayo, ezihambisana nobunzima ekukhetheni umthamo: inani elincane lemithi aliholeli emiphumeleni oyifunayo, futhi amavolumu amakhulu angadala izimpawu eziseceleni.
Iziguli
U-Elena, oneminyaka engama-54, uSaransk
Ngosizo lweLozap ngiphathwe iminyaka engaphezu kwengu-4. Ngasikhathi sinye ngisebenzisa i-Concor, ngoba Lolu hlelo lwalunqunywe ngudokotela. Ekuqaleni kwemithi, konke bekuhamba kahle. Ngemuva kwezinyanga ezimbalwa, kwaqala ukubonakala izimpawu: izinhlungu emhlane, isiyezi, ukukhala ezindlebeni. Ngesikhathi sokuhlolwa, akukho lutho olutholakele, futhi izimpawu ezifakiwe ziqhubeka ziqina. Manje ngifuna indawo efanelekile yomuthi.
U-Irina, oneminyaka engama-45 ubudala, uPerkov
Ukuqinisa ingcindezi, uLoap wabekwa. Angibonanga umphumela omuhle. Ikhambi alilimalanga, kepha akubanga khona inzuzo. Izinkomba zokucindezela zahlala zisezingeni elifanayo, futhi i-hypertrophy yesokunxele ayizange inciphe.
