I-Histochrome ibhekisela ekuqineni kwezitho zokuqalwa kwamangqamuzana.
Igama Lezwe elingafanele
IPentahydroxyethylnaphthoquinone.
I-Histochrome ibhekisela ekuqineni kwezitho zokuqalwa kwamangqamuzana.
I-ATX
Ikhodi ye-ATX yi-S03D. Inombolo yokubhalisa umuthi yi-P N002363 / 01-2003.
Khipha amafomu nokwakheka
Isixazululo somjovo siqukethe i-echinochrome ekuqoqweni okungu-1%. Izakhi ezisizayo: i-sodium carbonate, i-sodium chloride. Isixazululo sokwelashwa kwezilonda zamehlo siqukethe into eyi-0.02% ne-sodium chloride.
Kutholakala kuma-ampoule ayi-5 ml, ekupakweni kwamaseli. Kuthengiswe emabhokisini amakhadibhodi.
Kutholakala kuma-ampoule ayi-5 ml, ekupakweni kwamaseli. Kuthengiswe emabhokisini amakhadibhodi.
Isenzo se-Pharmacological
Iqinisa ukwakheka kodonga lweseli, ivikela ngokumelene ne-lipid peroxidation, isuse oksijini wamahhala, i-peroxide kanye nama-radicals wamahhala. Ibuyisa ukushaya kwenhliziyo, kwehlise ukuwohloka kwe-necrotic yomsipha wenhliziyo ngemuva kokufakelwa kwe-myocardial. Kuthuthukisa ukuzimela kwenhliziyo, kuncibilikise izingxenyana zegazi emithanjeni yemithambo yegazi. Ngama-hemorrhages ku-retina, intuthuko ibonwa emaphesenti angama-43 wamacala. Ukopha okuncane, isilonda siqhuma kungakapheli izinsuku ezingama-30 ngaphandle komkhondo.
I-Pharmacokinetics
Umuthi ubonakala ngokushintsha okungeyona ejwayelekile ekuqoqweni kwengxenye eyinhloko kwiplasma yegazi. 2 amahora emva kokuphathwa, ukwehla kokuxakeka kuyabonakala, khona-ke kungakapheli amahora ayi-6 ukwanda. Isigamu sempilo singamahora ayi-10-12. Ukuhoxiswa komuthi kwehlisa ukusetshenziswa kwe-ascorbic acid. It is metabolized in the isibindi, okukhishwa ikakhulukazi izinso. Ngemuva kokuthi ukuhlukunyezwa sekuyekelele, izinga layo ligcinwa isikhathi eside.
Izinkomba zokusetshenziswa
Kunqunyelwe izifo zenhliziyo ezihambisana ne-myocardial hypoxia:
- Isifo senhliziyo.
- Angina pectoris.
- Ukwehluleka kwenhliziyo kwehlulekile kwenhliziyo.
- I-coronary thrombosis yenhliziyo.
- Ukwelashwa kwe-vascular thrombosis yeso, ukuphuma kwesibindi ku-cornea, i-retina, umzimba we-vitreous.
- Ama-pathologies wokubuka okubangelwa yisifo sikashukela.
Ekushayweni kwenhliziyo okukhulu njengengxenye yokwelapha okuyinkimbinkimbi.
I-histochrome imiselwe izifo ezithinta inhliziyo ezihambisana ne-myocardial hypoxia.
Contraindication
- Hypersensitivity kwento esemqoka esebenzayo.
- Ukukhulelwa, ukuncelisa ibele.
- Iminyaka engu-18.
Ngokunakekela
Ukwehluleka okungapheli kwezinso noma kwesibindi. Akukho miphumela enobuthi esibindini noma ezinsoni ezitholakele, noma kunjalo, uma kungasebenzi umsebenzi, kudingeka ukubhekwa kwezokwelashwa. Uma kunesidingo, isiguli sinikezwa usizo oluphuthumayo lwezokwelapha.
Umuthi uyaphikiswa ngesikhathi sokukhulelwa futhi awusetshenziselwa ukwelapha izingane ezingaphansi kweminyaka engu-18.
Ungayithatha kanjani i-Histochrome
Sebenzisa umuthi kuphela ngokuya ngemiyalo. I-ampoule eyodwa iyoncibilika ku-20 ml we-sodium carbon dioxide, ofakwe ngaphakathi kwemizuzu engu-3-5 ngaphakathi. Umuthi ungalawulwa ngokudonsa, ngoba lokhu udinga ukuncibilikisa i-50-100 mg yesidakamizwa ku-100 ml yesisombululo somzimba we-sodium. Umthamo kanye nesikhathi sokwelashwa kubalwa udokotela.
Ngoshukela
Esikhathini sikashukela, isixazululo somuthi sisetshenziselwa ukwelapha i-retinopathy. Umjovo wenziwa i-parabulbarno ekuhlakazweni okungu-0,03%. Isikhathi sesifundo siyizinqubo eziyi-7-10.
Umuthi ungalawulwa ngokudonsa noma ngokuqina.
Imiphumela emibi ye-Histochrome
Mhlawumbe ukuthuthukiswa kokuphendula kokungezwani kokuqina okuhlukahlukene kuze kufinyelele ekuqhekekeni kwe-anaphylactic.
Kungakapheli usuku ngemuva kokuphathwa umuthi, kwavela umchamo obomvu obomvu. Esizeni somjovo, kubuhlungu izinhlungu, kuyilapho i-thrombophlebitis ingakhuli.
Umthelela ekhonweni lokulawula izindlela
Ngesikhathi sokwelashwa, akunconywa ukushayela imoto noma amanye amadivaysi obuchwepheshe ayinkimbinkimbi.
Ngemuva kokusebenzisa umuthi, kungenzeka ukuthuthukisa ukungezwani komzimba kwamandla ahlukahlukene kuze kufinyelele ekuqhekekeni kwe-anaphylactic.
Imiyalo ekhethekile
Lapho wenza imijovo ye-parabulbar, i-cornea yeso ingahle ibe mnyama.
Sebenzisa ebudaleni
Kubekelwe iziguli esezikhulile ngokuthuthukiswa kokuhluleka kwenhliziyo. Njengoba unesifo senhliziyo, sibekelwe ukuvimbela ukuhlaselwa yinhliziyo. Kufanele kukhunjulwe ukuthi umuthi ukhishwa kancane lapho usumdala, kungadingeka ukulungiswa komthamo.
Lapho wenza imijovo ye-parabulbar, i-cornea yeso ingahle ibe mnyama.
Isabelo sezingane
Izifundo zemitholampilo ngokusetshenziswa kwe-antioxidant emithini yezingane ayenziwanga ngamanani anele. Umuthi awubekelwe izingane nentsha.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Akukho zivivinyo ezenziwayo zokuthola ukuthi umuthi uthinta kangakanani umbungu. Sebenzisa kunoma iyiphi i-trimester yokukhulelwa kuvinjelwe. Ukwelashwa kukamama ngesikhathi sokuqunjelwa kwenziwa kuphela ngokwezinkomba ezibalulekile, kuyilapho ingane kufanele idluliselwe kwingxube yokondla.
Ukweqisa kwe-Histochrome
Akuzange kube namacala okweqisa izidakamizwa, ngoba ukwethulwa kwenziwa kuphela ngochwepheshe ezikhungweni zezokwelapha.
Ukuxhumana nezinye izidakamizwa
Akunconywa ukusebenzisa usawoti we-iron noma ukulungiswa kwe-calcium. Kuyahlanganiswa ukuze kuhlanganiswe namalungiselelo wamaprotheni.
Ukuhambisana notshwala
Ngesikhathi sokulashwa, ukusetshenziswa kotshwala akwemukeleki, ngoba utshwala be-ethyl bukhulisa isimo semithambo. Lapho uphuza iziphuzo eziqukethe utshwala, i-hypoxia iyanda futhi umthwalo emikhunjini uyakhuphuka.
Ukuphuza utshwala ngezifo ze-myocardial nakho kuphikisiwe.
Ekwelapheni isifo sikashukela se-retinopathy nezifo zamehlo, inhlanganisela yomuthi ne-ethanol yehlisa umphumela wokwelapha futhi kungaholela ekulahlekelweni kombono okungaphenduki.
Ngesikhathi sokulashwa, ukusetshenziswa kotshwala akwemukeleki, ngoba utshwala be-ethyl bukhulisa isimo semithambo.
Ama-Analog
Analogs angabekwa:
- I-Neurox, intengo esezingeni lama-ruble angama-300-800;
- I-Emoxibel, izindleko zomuthi zingama-ruble angama-60-100;
- I-Mexicoidol, inani eliphakathi lomuthi ngama-ruble angama-250-490;
- UMexifin, izindleko zivela kuma-ruble angama-350.
Imibandela yekhefu lekhemisi
Kuthengiswe ngomuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi wokuphathwa kwe-intravenous and parabulbar ngaphandle kwencwadi kadokotela awuthengiswa. Kwezinye izifunda, kungenzeka ukuthenga umuthi nge-Intanethi ngaphandle kadokotela. Ngokuthengiswa okungekho emthethweni kwezidakamizwa ukuphatha nezikweletu zobugebengu kufanelekile.
Ungathengi imithi kubahlinzeki abangaqinisekiswanga, lokhu kungadala ukulimala okungalingani empilweni.
Intengo
Izindleko zesisombululo sokwelapha amehlo ziqala kuma-ruble ayi-130. Ukuphathwa kwe-intravenous - kusuka kuma-ruble ayi-1000.
Umuthi umuthi.
Izimo zokugcina zomuthi
Gcina isixazululo at lokushisa lika + 2 ... + 8 ° C. Umuthi ugcinwa endaweni eyomile, uvikelekile emisebeni ye-ultraviolet. Kuyadingeka ukufihla umuthi ezinganeni.
Isikhathi sokuphelelwa yisikhathi
Umuthi ugcinwa iminyaka emi-2 kusukela ngelanga lokwenziwa ngawo. Usuku lokukhiqiza lukhonjisiwe kwiphakheji.
Umkhiqizi
Isikhungo sePacific of Bioorganic Chemistry, IGatsha EliseMpumalanga Ekude YeRussia Academy of Science
I-690022 Vladivostok, ithemba lokugubha iminyaka engu-100 Vladivostok, 159.
Gcina isixazululo at lokushisa lika + 2 ... + 8 ° C.
Ukubuyekezwa
U-Alexey Semenov, udokotela wezifo zenhliziyo, oneminyaka engama-49, eMoscow: "Kufakazelwa ngokomtholampilo ukuthi ukusetshenziswa kwalesi sidakamizwa ngesikhathi sangaphakathi kwe-myocardial infarction kunciphisa usayizi wokugxila kwe-necrotic. Umphumela oyinhloko uba khona uma ukwelashwa kuqalwa ngosuku lokuqala ngemuva kokuhlaselwa yinhliziyo. Uma ukwelashwa kuqalile ngokuhamba kwesikhathi izinsuku, umphumela awubonakali. "
U-Alina Lebedyanova, oneminyaka engama-38 ubudala, udokotela wezifo zamehlo, u-Kislovodsk: "Ezigulini ezine-hemreha hemorrhage, kufaka ne-Cloud of lens, ukugxila kwe-pathology kuyanyamalala ngemuva kwezifundo zokwelapha. Ukopha okukhulu, amathuba okugcina umbono ungama-20%."
UShevchenko Yulia, oneminyaka engama-45 ubudala, udokotela jikelele, iZernograd: "Ukusetshenziswa kwalesi sidakamizwa ezigulini ezinesifo sikashukela kunciphisa ingozi yokulahleka kombono ngamaphesenti angama-40. Umuthi unikezwe umuthi wokubuyisa umbono ngemuva kokushaywa yimichiza. Kunconywa ukusebenzisa i-retina ukwelashwa kokushiswa, kufaka phakathi nalokhu okubangelwa ukuchayeka kumakhemikhali. ukuxhumana. "
U-Ana, oneminyaka engama-34, uSmolensk: "Umama wami wanikezwa umuthi ngemuva kokuhlaselwa yisifo senhliziyo. Impilo yakhe yabuya ngokushesha yayajwayelekile. Wayesatshiswa umbala obomvu womchamo, kepha udokotela wamqinisekisa, wathi lokhu kwakujwayelekile."
U-Oleg, oneminyaka engama-55 ubudala, uKrasnodar: "Uqokwe ngemuva kokuchitheka kwegazi emthanjeni wamehlo. Ilihlo lisindisiwe, umbono uyabuyiselwa kancane."
