Ungayisebenzisa kanjani i-Atorvastatin-Teva?

I-Atorvastatin-Teva isizukulwane esisha sama-statin. Umuthi ubhekwa njengosebenza ekwelapheni izimpawu ze-cholesterol ephezulu yegazi.

Ngaphambi kokusebenzisa umkhiqizo, isiguli kufanele sizijwayeze nolwazi olujwayelekile ngomkhiqizo, sinake izici, futhi sinake imininingwane ngemiphumela emibi.

Igama Lezwe elingafanele

I-Atorvastatin, Atorvastatin.

I-ATX

C10AA05.

Khipha amafomu nokwakheka

Ezikhungweni zezokwelapha nasemaphoyiseni ekhemisi, umuthi uhlinzekwa ngendlela yamathebulethi. Lezi zokugcina zigcwele emabhulashini bese kuthi emaphaketheni amaphepha aminyene.

Ifomu lomthamo lihlanganiswa nefilimu futhi liqoshwe ezinhlangothini zombili zomkhiqizo. Amacwecwe alethwa nezinombolo ezilandelayo:

• I-93 ne-7310 ezinhlangothini eziphambene zefomu lomthamo (amaphilisi ayi-10 mg);
• I-93 ne-7311 (20 mg ngayinye);
• I-93 ne-7312 (40 mg ngayinye);
• I-93 ne-7313 (80 mg ngayinye).

Into esebenzayo yesidakamizwa yi-atorvastatin calcium.

I-Atorvastatin-Teva isizukulwane esisha sama-statin.

Izingxenye ezisizayo:

• indawo kashukela esetshenziselwa imikhiqizo yemithi;
• ifomu elingabonakali lesisindo se-polyvinylpyrrolidone ephansi yamangqamuzana;
• I-Eudragit E100;
• alpha tocopherol macrogol ukunikela;
• usawoti we-cellulose;
• i-antihypoxant ethinta ikhwalithi yokuguqulwa kwamaseli uma kunokushoda komoya-mpilo.

Ungqimba oluphezulu lwethebhulethi luqukethe i-opadray YS-1R-7003: polysorbate-80, hypromellose 2910 3cP (E464), titanium dioxide, hypromellose 2910 5cP (E464), macrogol-400.

Isenzo se-Pharmacological

Umuthi ngumenzeli onciphisa i-lipid ovimbela isenzo sokunciphisa kabusha i-enzyme HMG-CoA. Into esebenzayo ekwakhiweni kwethebhulethi ithinta isilinganiso se-cholesterol biosynthesis, elawula izinga lama-lipoprotein ku-plasma yegazi, inyusa inani lama-receptors wesibindi.

Into esebenzayo ekwakhiweni kwethebhulethi ithinta inani le-cholesterol biosynthesis.

Ngesikhathi esifanayo, umuthi uthinta ukwehla kwe-apolipoprotein B egazini (ophethe i-cholesterol engadingekile) nama-triglycerides (akha amafutha omzimba).

Ngakho-ke, umuthi wehlisa amathuba okuba nezifo zesistimu yokujikeleza kwegazi, uvimbela ubungozi bokuhlaselwa yinhliziyo nemivimbo.

Ngokwezifundo zobudokotela, umuthi wehlisa inani le-cholesterol ye-LDL ngo-41-61%, i-apolipoprotein B - ngo-34-50%, triglycerides - ngo-14-33%.

I-Pharmacokinetics

Into esebenzayo yesidakamizwa igxilwe ku-plasma yegazi ngemizuzu engama-30-60.

Izinto ezisethebhulekweni zitholwa ngesibindi bese zigqitshwa kuyi-bile amahora angama-14, ngenkathi kugcinwa umphumela wengxenye ye-inhibitory (kufika emahoreni angama-30).

Ingxenye esebenzayo ayisusiwe emzimbeni ngokuhlanzwa kwegazi ngokweqile.

Ezikhungweni zezokwelapha nasemaphoyiseni ekhemisi, umuthi uhlinzekwa ngendlela yamathebulethi. Lezi zokugcina zigcwele emabhulashini bese kuthi emaphaketheni amaphepha aminyene.

Okunqunyelwe

Umuthi ufakwa ekwelashweni kulezi zimo ezilandelayo:

1. Ushintsho lwe-pathological oluhambisana nokukhuphuka kwezinga lotshwala be-polycyclic lipophilic ku-plasma yegazi: eyinhloko, i-heterozygous yomndeni kanye ne-non-Famal hypercholesterolemia.
2. Ukwanda okungajwayelekile kuzinga le-lipids nama-lipoproteins egazini: i-hyperlipidemia exubile noma ehlangene yohlobo IIa ne-IIb ngokusho kukaFredrickson. Ukwelashwa kunqunyelwe kanye nokudla, okulandela lapho ukudla kuhlose khona ukwehlisa i-LDL-cholesterol, apolipoprotein B kanye ne-triglycerides kanye nokwandisa cholesterol ye-HDL.
3. Ukwehla kwamazinga we-beta-lipoprotein nama-chylomicrons ku-plasma yegazi, okubangela ukushoda kwamavithamini A no-E: hlobo lwe-dysbetalipoproteinemia ngokusho kukaFredrickson.
4. I-triglycerides ephakanyisiwe (thayipha IV ngokusho kukaFredrickson). Umuthi ubekiwe uma ukudla okwelapha kungaphumeleli.
5. I-Homozygous yomndeni hypercholesterolemia, ukuze kuqedwe lapho indlela yokwelapha yokudla ingasebenzi khona.
6. Ingozi eyandayo yokushaywa unhlangothi, i-myocardial infarction, i-angina pectoris.
7. Ukuba khona kwezinto ezibalelwa engcupheni ezi-3 noma ngaphezulu: ubulili besilisa, inkomba yomzimba eyandayo, iminyaka yobudala engaphezulu kweminyaka engama-55, i-hypertrophy ye-ventricular, i-mellitus yesifo sikashukela, izinkinga zomsebenzi wezinso, i-angiopathy ye-peripheral, isifo senhliziyo esiyindlalifa.

Umuthi ufakwa ekwelashweni usengozini enkulu yokuhlaselwa yisifo sohlangothi, i-myocardial infarction, i-angina pectoris.

Contraindication

Umuthi unokuphikisana okulandelayo:

• ukungabekezelelani komuntu ngamunye ezingxenyeni zomuthi;
• ukungakwazi komzimba ukumunca i-lactose;
• ukuntuleka kwe-enzyme ye-Lapp-lactase, i-pathology yeprotheni ethwala ye-glucose ne-galactose;
• ama-enzyme aphezulu wesibindi;
• isifo sesibindi esibuhlungu noma esingamahlalakhona;
• ukwehluleka kwesibindi;
• ukuhlela ukukhulelwa, isikhathi sokuzala ingane noma ukuncelisa;
• izifo ze-neuromuscular (myopathy);
• encane.

Ukuntuleka kwe-Hepatic ukungqubuzana nokuthatha umuthi.

Ngokunakekela

Umuthi kufanele uthathwe ngokuqapha lapho:

• izifo zesibindi;
• ukushintshana okungalungile kwezinto zomkhondo;
• ukuba khona kokuphazamiseka ohlelweni lokugaya ukudla kanye nokugaya ukudla;
• izifo ezithinta i-acute (sepsis);
• ukubanjwa kwesithuthwane okungalawuleki;
• ukuba khona kokulimala okuningi;
• ukungasebenzi komzimba kwesistimu ye-musculoskeletal;
• ukusetshenziswa kabi kotshwala.

Lapho kukhona ukwephulwa ohlelweni lwe-endocrine, umuthi kufanele uthathwe ngokuqapha.

Umuntu owenze ukuhlinzwa okuningi ngesikhathi sokwelashwa okujwayelekile ngamaphilisi kufanele aqashelwe njalo uchwepheshe ukuthola imiphumela engahle ingafuneki.

Owesifazane osebenzisa umuthi udinga ukusebenzisa izindlela zokuvimbela inzalo ezisebenzayo.

Ungayithatha kanjani i-Atorvastatin-Teva

Umuthi unconywa ukusetshenziswa kuphela uma kukhonjisiwe.

Ukwelashwa kufaka ukusetshenziswa kwamathebulethi ngokuhambisana nokudla okujwayelekile kwe-hypocholesterolemic.

Lapho ukhetha umthamo ophelele (10-80 mg), udokotela uthatha njengesisekelo izinkomba zokuhlaziya, ebheka imininingwane mayelana nezinga le-cholesterol ye-LDL. Ukuhlolwa kokulawula ukulungisa indlela ekhethiwe yokwelashwa kwenziwa njalo ezinsukwini eziyi-14-28.

Kwi-hypercholesterolemia eyisisekelo ne-hyperlipidemia ehlanganisiwe, umthamo ojwayelekile ngu-10 mg ngamahora angama-24.

Nge-homozygous yomndeni hypercholesterolemia - 80 mg ngosuku.

Uma kwenzeka wephula isilinganiso se-lipid - 10 mg ngamahora angama-24. Ngesikhathi sokuhlolwa ngudokotela, umthamo uguqulwa futhi, uma kunesidingo, unyuka uye ku-80 mg.

Umphumela wokuphuza umuthi ubonakala ngemuva kwamasonto amabili.

Umuthi unconywa ukusetshenziswa kuphela uma kukhonjisiwe.

Ukuthatha umuthi wesifo sikashukela

Ngokusetshenziswa kwama-statins, amazinga kashukela egazi ayanda, ngakho-ke ukuthuthukiswa kwe-hyperglycemia kungenzeka.

Imiphumela emibi

Amapheshana wesisu

Imvamisa, imiphumela emibi yenzeka ngendlela yobuhlungu besisu, ukushaya kwenhliziyo, isicanucanu, ukuqhakaza nokuqunjelwa. Lezi zimo ziba buthaka ngesikhathi senqubo yokwelashwa.

Imiphumela emibi eyingozi kakhulu ifaka phakathi ukuvuvukala esiswini, ama-pancreas noma ulwelwesi lwama-mucous we-esophagus, i-intrahepatic cholestasis ne-anorexia.

Isistimu yezinzwa ephakathi

Kwezinye izimo, isiguli singabonakala:

• Isiyezi
• ikhanda
• ubuthakathaka obujwayelekile nokukhubazeka;
• ukulahleka kwenkumbulo yesikhashana;
• ukuzwela kwemizwa (umuzwa wama-goosebumps, umuzwa ovuthayo, umuzwa we-tingling);
• ukuncipha kokuzwela ukuthonya kwangaphandle;
• ukulimala kwezinzwa zepherishi;
• ukuqwasha nobusuku obunzima;
• i-asthenic syndrome.

Kwezinye izimo, isiguli singase sibhekane nokulimala nobuthakathaka obujwayelekile.

Kusuka ohlelweni lokuphefumula

Imiphumela elandelayo emibi kungenzeka:

• isifuba somoya;
• phazamisa ukulimala kwamaphaphu;
• ukuvuvukala mucosa wamakhala;
• inyumoniya

Engxenyeni yesikhumba

Kwezinye izimo, amanxeba namunxeba kugcwala esikhunjeni sesiguli ngenxa yokungezwani komzimba. Mhlawumbe ukwakheka kwesiqalo se-polymorphic kuma-membermes kanye nama-mucous membranes, ukubonakala kwe-eczema ne-seborrhea, ukuthuthukiswa kwe-necrolysis enobuthi.

Kwezinye izimo, amanxeba namunxeba kugcwala esikhunjeni sesiguli ngenxa yokungezwani komzimba.

Kusuka ohlelweni lwezitho zofuzo

Ukusetshenziswa kwomuthi kungadala:

• ukwanda kokuchama;
• ukungasebenzi;
• i-polakiuria;
• ukwanda kokuchama ebusuku ngesikhathi sasemini;
• i-leukocyturia;
• ukubonakala kwegazi emchameni;
• ukungasebenzi kanye nokwephula i-ejaculation;
• ukuvuvukala kwesibindi.

Kusuka ohlelweni lwezinhliziyo

Kwezinye iziguli, lapho uphuza amaphilisi, inani lamaplatelet egazini liyancipha, ukuvuvukala kodonga lwe-venous kwenzeka, i-anemia, arrhythmia ne-angina kukhula.

Kusuka ohlelweni lwe-musculoskeletal

Ezinye iziguli ziyakhanya:

• ukungakhululeki kanye nobuhlungu engxenyeni engezansi yomgogodla;
• imisipha yokuwohloka kanye ne-hypertonicity;
• ukulimala kwemisipha
• ubukhulu be-myopathy;
• isifo samathambo;
• nobuhlungu obuqhubekayo emalungeni.

Imiphumela emibi evela ohlelweni lwe-musculoskeletal: isifo samathambo.

Allergies

Njengoba ukusabela komzimba kungabakhona:

• i-urticaria;
• ukulunywa
• ukuqhuma
• ukwethuka kwe-anaphylactic;
• ukuvuvukala kwesikhumba, izicubu ezithambile noma ulwelwesi lwama-mucous.

Imiyalo ekhethekile

Ukuhambisana notshwala

Ukusetshenziswa kanyekanye kwamathebhulethi anotshwala kuthuthukisa imiphumela emibi, kuthinta kabi inhlala-kahle yesiguli.

Ukusetshenziswa kanyekanye kwamathebhulethi anotshwala kuthuthukisa imiphumela emibi, kuthinta kabi inhlala-kahle yesiguli.

Umthelela ekhonweni lokulawula izindlela

Uma kwenzeka le miphumela emibi, ukuzishayela kungavunyelwe.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Umuthi akufanele uphuzwe ngenkathi ukhulelwe futhi uncelisa ibele.

Ukuqokwa kwe-Atorvastatin-Teva ezinganeni

Umuthi uphambaniswe nezingane.

Umuthi uphambaniswe nezingane.

Sebenzisa ebudaleni

Ubudala obudala akusikho ukweqa ekusebenziseni komlomo umuthi: ingozi yemiphumela emibi ayikhuphuki, ukusebenza ngempumelelo kwezidakamizwa akwehli.

Isicelo sokusebenza kokulimala kwezinso

Amacwecwe kufanele adliwe ngaphansi kokuqondisa udokotela.

Sebenzisa umsebenzi wesibindi okhubazekile

Ukusetshenziswa kwomuthi kuyenqatshelwa ngezindlela ezinesifo futhi ezingalapheki zezifo zesibindi, kanye nokwanda okungajwayelekile ezingeni lama-transaminases egazini (amahlandla ama-3 noma ngaphezulu kuqhathaniswa nokujwayelekile).

Ukusetshenziswa kwomuthi kuyenqatshelwa ngezindlela ezinesifo ezinesifo esisheshayo nesingamahlalakhona, kanye nokwanda okungajwayelekile ezingeni lama-transaminases egazini.

Ezigulini ezinokwehluleka kwezinso

Kulokhu, udokotela ohamba njalo wenza izivivinyo zesiguli, emva kwalokho umuthi ungabekelwa emithanjeni eyehlisa i-lipid noma eyekwe.

Ukweqisa

Ngokweqile kwento esebenzayo emzimbeni, isiguli sinezimpawu ezilandelayo:

• umuzwa wokoma nobumunyu emlonyeni;
• isicanucanu nokuhlanza
• dyspepsia.

Ngokweqile komzimba osebenzayo emzimbeni, isiguli singathola isicanucanu.

Uma kwenzeka kusetshenziswa i-overdose, i-gastric lavage iyenziwa, kulandelwa ukuqapha izinga le-CPK egazini.

Ukuxhumana nezinye izidakamizwa

Inhlanganisela ehlanganisiwe

Ngesikhathi sokulashwa, kuyadingeka ukukhipha ukusetshenziswa kwe:

• imicu;
• imithi elwa nama-macrolide;
• i-nicotinic acid;
• azole antifungal agents;
• ujusi wamagilebhisi.

Ngesikhathi sokulashwa, kuyadingeka ukukhipha ukusetshenziswa kwejusi yamagilebhisi.

Akuhlanganisiwe ukuhlanganisa

Umuthi awubalulekile ukusisebenzisa ngokuhlangana:

• I-cyclosporine;
• Ama-protease inhibitors e-HIV;
• Nefazodone;
• ama-ejenti anciphisa ukuhanjiswa kwama-hormone ama-endo native steroid.

Inhlanganisela edinga ukuqashelwa

Isiguli sitshelwa ukuthi sibike noma yiziphi izimo zokuwohloka kwempilo kudokotela oholayo uma amaphilisi esetshenziswa kanye kanye:

• I-P-glycoprotein inhibitors;
• I-Digoxin;
• izindlela zokuvimbela inzalo zomlomo eziqukethe i-ethinyl estradiol ne-norethisterone;
• Colestipol;
• I-Warfarin.

Isiguli sitshelwa ukuthi sibike noma yiziphi izimo zokuwohloka kwempilo kudokotela oholayo uma amaphilisi esetshenziswa kanyekanye nama-P-glycoprotein inhibitors.

Ama-Analog

Faka izidakamizwa, ezibandakanya izinto ezifanayo:

• Abendeli
• I-Actastatin;
• I-Astin;
• I-Atomax;
• I-Atocor
• I-Atorem;
• Atoris;
• Atorvastatin;
• Atorvastatin alkaloid;
• Atorvastatin-LEXVM;
• Atorvastatin-SZ;
• I-Vazator;
• Lipoford;
• I-Liprimar;
• INovostat;
• I-Torvazin;
• ITorvacard
• Torvas
• Tulip.

I-Atorvastatin ingelinye lamagama afanayo.

I-Vazator ingesinye sezifanekiso zomuthi.

INovostat ingesinye sezifanekiso zomuthi.

Yini engcono - Atorvastatin noma Atorvastatin-Teva?

Ngaphambi kokuthatha isinqumo ngokusetshenziswa kwezidakamizwa ezifanayo, kungakhathalekile ukuthi yisiphi isizathu, isiguli kufanele sifunde imininingwane mayelana nezibhebhe futhi sixhumane nodokotela wakho mayelana nokuthi kungenzeka yini ukuthi ungene kwesinye.

Igama elithi Atorvastatin (ngaphandle kokufaka igama lomenzi) libonisa ukuthi umuthi wenziwa yinhlangano okungenzeka ukuthi awunakuba ngumthengisi onokwethenjelwa wemithi.

Imibandela yekhefu lekhemisi

Amacwecwe asatshalaliswa ngokuya ngommiselo, onegama lomuthi ngesiLatini, ubhalwe ebhaleni lesikhungo sezokwelapha futhi ligunyazwe ngophawu.

Ngingakwazi ukuthenga ngaphandle kadokotela

Kunezimo zokuthola umuthi ngaphandle kokuthola umuthi (ngezitolo eziku-inthanethi). Kodwa ukuthatha lo muthi ngaphandle kokuqokwa kukachwepheshe kungadala ukulimala okungalingani empilweni yabantu.

Umuthi kufanele ugcinwe ngaphandle kokutholwa yizingane emazingeni okushisa angaphansi kwama-30 ° C.

Intengo ye-Atorvastatin-Teva

Izindleko zalo muthi ezivela kumenzi wakwa-Israyeli ziyahlukahluka kusuka kuma-ruble angama-95 kuye kwangama-600. kuya ngomthamo nendawo athengiswa kuyo.

Izimo zokugcina zomuthi

Umuthi kufanele ugcinwe ngaphandle kokutholwa yizingane emazingeni okushisa angaphansi kwama-30 ° C.

Isikhathi sokuphelelwa yisikhathi

Akukapheli iminyaka emi-2 kusukela ngosuku lokukhishwa.

Umkhiqizi

Inkampani - Teva Pharmaceutical Industries, Israel.

Ukubuyekezwa kwe-Atorvastatin-Teva

Odokotela

UVitaliy, oneminyaka engama-42, u-Ufa

Umuthi ovela kuTeva ukhiqizwa yinkampani yemithi ethembekile, ngakho-ke lo muthi ubekelwe iziguli ezinokuxilongwa okufanele. Kwesinye isikhathi iziguli zikhononda ngokungasebenzi komuthi. Kodwa-ke, ngemuva kwesicelo sokubonisa iphakheji ethengiwe, kutholakala ukuthi umuthi ukhiqizwa enye inkampani engaziwa kangako.

U-Irina, oneminyaka engama-48, uStavropol

Kuyadingeka ukusebenzisa umuthi njengoba ubekwe ngudokotela futhi kuphela lapho kungekho khona ukungqubuzana. Ezenzweni zomuntu siqu, kukhona icala lapho isiguli esinesifo sesibindi siqala ukuthatha amaphilisi ngaphandle kokuya kuchwepheshe wezokwelapha, okwadala ukulimala okukhulu empilweni yakhe.

URenat, oneminyaka engama-37 ubudala, uRostov-on-Don

Iziguli akufanele zikhohlwe ngemiphumela emibi ebangelwa umuthi. Lapho usebenzisa amaphilisi, iziguli zelulekwa ngokuqinile ukuthi zivame ukuhlolwa igazi nge-biochemical.

Iziguli

U-Ilya, oneminyaka engama-38 ubudala, uSergut

Ezinyangeni ezi-3 zokudla nokusetshenziswa kwezidakamizwa, amazinga we-cholesterol we-LDL ehle afinyelela ku-3 mmol / L. Ngakho-ke, ngingasho ukuthi amaphilisi anomphumela omuhle, ahlukile kule ndleko ephansi. Ngiyayincoma.

U-Alexandra, oneminyaka engama-29, Izhevsk

Umama wanikezwa amaphilisi okwehlisa i-cholesterol. Izinyanga ezi-3 zidlulile, kepha akunamphumela. Kepha isisindo semiphumela emibi - ukuqwasha, ikhanda, nobuhlungu emuva.

UMarina, oneminyaka engama-32, uVoronezh

Ngikholelwa ukuthi uma kunezinkinga nge-cholesterol, khona-ke kungcono ukulandela isidlo bese uhambisa okuningi. Umuthi awuthinti izinga lotshwala be-lipophilic, kepha ubanga ukushisa kwenhliziyo nekhanda elibuhlungu. Ngiphuze amaphilisi ngokunconywa ngudokotela wami futhi angiqondi ukuthi uqondiswa yiphi lapho enquma umuthi onjalo ezigulini. I-Vazator ingesinye sezifanekiso zomuthi.