Uyisebenzisa kanjani i-drug Trental 100?

I-Trental 100 mg isiza kusebenze ukujikeleza kwegazi futhi ithuthukise isimo semithambo yegazi. Lokhu kunomthelela omuhle kwizakhiwo ezahlukahlukene futhi kuvumela ukusetshenziswa kwalesi sidakamizwa hhayi nje njenge-angioprotector, kodwa futhi kufakwe ekwelashweni okuyinkimbinkimbi ukuze kuthuthukiswe izicubu zomzimba, ukuqinisa ukushintshaniswa kwegesi, futhi kuthuthukise ukusebenza kahle kwemicu yezinzwa. Ithuluzi lisetshenziswa kabanzi ukwelapha izifo eziningi, ukuqeda izimo ezithile ezingekho emthethweni kanye nezinhloso zokuthibela.

Igama Lezwe elingafanele

I-Trental igama lokuhweba lesidakamizwa. I-INN yayo ngokuya ngemithetho ye-WHO yiPentoxifylline.

I-Trental ikhiqizwa ngohlobo lwemikhiqizo yethebhulethi kanye nokugxilisa uketshezi ukuze kusetshenziswe ukumnika.

I-ATX

Iqembu lezemithi lama-vasodilators ane-ATX code AC04A D03.

Khipha amafomu nokwakheka

I-Trental ikhiqizwa ngohlobo lwemikhiqizo yethebhulethi kanye nokugxilisa uketshezi ukuze kusetshenziswe ukumnika.

Amaphilisi

Amathebhulethi amhlophe amancanyana anomumo oyindilinga we-convex Ingaphezulu lawo limboza okuhlanganayo okufaka ukungathandeki kamuthi futhi kunciphise imiphumela emibi yeTrental esiswini. Isenzo somuthi sinikezwa isakhi esiyinhloko se-pentoxifylline. Kulelo ngalinye lamathebhulethi iqukethe inani le-100 mg. Ukulungiswa kokukhishwa okunwetshiwe okutholakalayo kutholakala lapho okuqukethwe yikhompiyutha eyisisekelo kungama-400 mg. Ukuqanjwa okwengeziwe kuyangezwa:

• isitashi sommbila;
• i-talcum powder;
• ifomu le-anhydrous le-colloidal silicon dioxide;
• i-magnesium stearate;
• lactose mahhala.

Amacwecwe ahlanganiswe kuma-pc ayi-10. ezimangeni.

Ukuhlanganiswa kwefilimu kwakhiwa nge-methacrylate, polyethylene glycol, sodium hydroxide, talc, additive E 171 (titanium dioxide).

Amacwecwe ahlanganiswe kuma-pc ayi-10. ezimangeni. Ukufakwa kwangaphandle kungamakhadibhodi, kuqukethe iziqeshana ezi-6 kanye nepheshana lokufundisa.

Isixazululo

Uhlobo loketshezi lomuthi luyisixazululo esingenamibala, esitholakala kuma-ampoule ayisi-5 ml, afakwe emaphaketheni amakhadibhodi ama-5 ama-pcs. Into esebenzayo lapha nayo i-pentoxifylline. Ukuhlushwa kwayo kungu-2% (20 mg ku-1 ml wesidakamizwa). Ingxenye esetshenziswayo iyisisombululo se-sodium chloride.

Umuthi uvame ukuphathwa njengengxenye ye-dropper, kepha futhi ungasetshenziselwa imijovo ye-intravenous. Ukuqokwa kweTrental intramuscularly kuvunyelwe.

Isenzo se-Pharmacological

I-Trental inemiphumela eminingana yokwelashwa:

• ukungqubuzana
• i-vasodilating;
• i-adenosinergic;
• i-angioprotective;
• ukulungiswa kwe-microcirculation.

I-Trental inomphumela we-vasodilating Therapeutic.

Konke kungenxa yomsebenzi we-pentoxifylline, onomthelela ovimbela i-phosphodiesterase (PDE), okuholela ekuqokeleleni kwe-cAMP kumaseli wegazi nasemithanjeni ye-vascular. Ngenxa yalokhu, imithambo iyanda, ukumelana kwenethiwekhi yokuhlinzeka ngegazi kuyancipha, umzuzu nethamo legazi elishaqisayo liyakhuphuka ngenkathi kugcinwa isilinganiso senhliziyo. Ukuhlushwa kwe-ATP nakho kuyanda. Lokhu kunomthelela omuhle ekusebenzeni kobuchopho kanye nokusebenza kwe-bioelectric kohlelo lwezinzwa oluphakathi.

Namanje i-pentoxifylline inyusa ukuqina kwamangqamuzana abomvu egazi nokugeleza kwegazi. Yehlisa ukuqina kwe-fibrinogen, inciphisa ukusebenza kwe-leukocyte kanye nethuba lokunamathela kweplatelet. Ngenxa yokwanda kwemikhumbi ye-pulmonary kanye nokwenyuka kwezwi lemisipha yokuphefumula, ukushintshaniswa kwegesi ezingeni lamaseli, izicubu zomzimba wonke kuyathuthukiswa.

I-Pharmacokinetics

Ihora eli-1 ngemuva kokuphathwa ngomlomo kwalo muthi, cishe udlulela ngokuphelele ku-plasma. Ngemuva kokuhlunga okuyinhloko esibindini, i-bioavailability ye-pentoxifylline imaphakathi ne-19%. Kodwa-ke, imikhiqizo yayo yokubola, ikakhulukazi i-metabolite I, nayo ikhombisa umsebenzi omkhulu wemithi okwenzeka kusakhiwo sokuqala. Kulokhu, kukholelwa ukuthi i-bioavailability yomuthi ingaphezulu kwenani elibekiwe.

Emzimbeni, i-pentoxifylline isetshenziswe ngokuphelele emzimbeni. Emahoreni angama-4, cishe wonke umthamo othathwe (kuze kufinyelele ku-96%) ukhishwa ezinso. Ngokuhluleka okukhulu kwezinso, le nkathi iyanda, futhi ngomonakalo omkhulu wesibindi, kuphawulwa i-bioavailability ephakeme yesidakamizwa.

Ihora eli-1 ngemuva kokuphathwa ngomlomo kwalo muthi, cishe udlulela ngokuphelele ku-plasma.

Izinkomba zokusetshenziswa

I-Trental imiselwe ukuthuthukisa izicubu zomzimba kanye nokubuyisa i-microcirculation nge-pathologies enjalo:

• ukwehlukaniswa kwe-atherosclerosis yemikhumbi yemilenze, ukucacisa okuthile ngezikhathi ezithile;
• isifo sikashukela i-angiopathy;
• ukwephulwa kokugeleza kwegazi kwe-peripheral ngenxa yokuvuvukala;
• angiotrophoneurosis;
• ukuphazamiseka kwe-angioneuropathic, i-paresthesia;
• ukulimala kwezicubu ngenxa yokuhluleka kwe-microcirculatory (frostbite, gangrene, trophic ulceration, varicose veins);
• ukuphazamiseka kokujikeleza kwegazi ngenxa ye-osteochondrosis;
• ukonakala kwe-hemodynamic ku-retina ne-choroid;
• izifo zokuphefumula ezihambisana nezinto ezivimbayo (i-asthma, i-emphysema, izinhlobo ezinzima ze-bronchitis);
• i-ischemia, isimo sasemuva kwe-infarction;
• i-otossteosis, ukulahleka kwezindlebe ngenxa yama-pathologies we-vascular;
• i-microcirculation engasebenzi kahle emzimbeni kanye nemiphumela yayo (isiyezi, i-migraines, ukuphambuka kwengqondo kanye ne-mnemonic);
• ukungasebenzi ngocansi okuvuswa ukonakala komthambo.

I-Trental imiselwe ukuthuthukisa izicubu zomzimba kanye nokubuyisa i-microcirculation nge-pathologies efana nokuqothula i-atherosclerosis yemithambo yemilenze, ukulamula ngezikhathi ezithile.

I-Trental imiselwe ukuthuthukisa izicubu zomzimba kanye nokubuyisa i-microcirculation ku-pathologies efana ne-angiopathy yesifo sikashukela.

I-Trental imiselwe ukuthuthukisa izicubu zomzimba kanye nokubuyisa i-microcirculation kuma-pathologies anjenge-ischemia.

I-Trental imiselwe ukuthuthukisa izicubu zomzimba kanye nokubuyisa i-microcirculation ku-pathologies efana nokuphazamiseka kokujikeleza ngenxa ye-osteochondrosis.

I-Trental imiselwe ukuthuthukisa izicubu zomzimba kanye nokubuyisa i-microcirculation ku-pathologies efana nokulahleka kwezindlebe ngenxa ye-vascular pathologies.

Umuthi futhi ungasetshenziswa ukuvikela ukwenzeka kwengozi ye-cerebrovascular phambi kwe-neuroinfection yegciwane.

Contraindication

I-Trental ine-contraindication eminingi eqinile:

1. Ukusongela okukhulu kwe-pentoxifylline noma okunye okuphathelene ne-xanthine.
2. Ukungabekezeleli ezingxenyeni ezisizayo zomuthi.
3. Ukuba khona kokuphuma kwegazi noma ukuthambekela kwalo, i-hemorrhagic diathesis, hemorrhage ebuchosheni noma i-retina ye-visual visual.
4. Ukuqunjelwa esiswini.
5. Porphyria.
6. Ukuhlasela kwenhliziyo esigabeni esibi.
7. Isikhathi sokukhulelwa.
8. Ukuncelisa.
9. Iminyaka engu-18.

Umuthi awusetshenziselwa ukwelapha izingane ezingaphansi kweminyaka yobudala obuningi.

Ngaphezu kwalokho, umuthi akufanele uphathwe ukumnika lapho kukhona i-arrhythmia, i-hypotension ye-arterial, i-atherosulinosis yemithambo yenhliziyo nobuchopho (ngaphandle kwesigaba sokuqala).

Ngokunakekela

Iziguli ezinokulimala kwe-renal kanye ne-hepatic kanye neziguli ezilulama ekuhlinzeni zidinga ukunakwa okukhethekile. I-Trental inqunywa ngokuqapha ekwehlulekeni kwenhliziyo okungapheli nokusetshenziswa okufanayo kwezidakamizwa ezithile.

Ungayithatha kanjani iTrental 100?

Uhlobo lwemithi nomuthi wayo kunqunywa udokotela ngawodwana. Amathebulethi akufanele alunywe. Zidliwa ngemuva kokudla, zigezwe phansi ngevolumu edingekayo yamanzi. Kuyadingeka ukunciphisa umthamo ube ubuncane ezifweni ezinzima ze-renal noma hepatic. Ngokuncipha kwangemuva kwengcindezi yegazi, ezimweni eziyinkimbinkimbi zesifo sokuqina kwenhliziyo ne-ischemia, ukwelashwa kufanele kuqalwe ngomthamo omncane, kancane kancane kukhulisa inani lemithi elithathiwe.

Thatha amaphilisi ngemuva kokudla, uphuze inani elidingekayo lamanzi.

Njengomuntu osetshenziselwa ukugxilisa ukusetshenziselwa ukugxilisa ingqondo:

• Isisombululo se-0.9% sodium chloride;
• ushukela 5%;
• Isixazululo sika-ringer.

Ukuphatha ngokubambisana nezinye izinto zotshwala kungenzeka kuphela uma kutholakala isisombululo esicacile. Ukuhlushwa kwe-pentoxifylline kule ngxube kunqunywa izinkomba ngazinye.

I-Intravenous infusion ingaba yi-jet noma i-drip. Ngesikhathi senqubo, isiguli kufanele silale phansi. Ukuphatha kancane kuyadingeka: isikhathi senqubo yokulimala yimizuzu emi-5, ukuvuza kwesidakamizwa kufanele kugcinwe ezingeni elingeqi i-100 mg ngehora eli-1. Ekuphazamisekeni kakhulu kokujikeleza kwegazi, isikhathi sokufakwa singaba amahora angama-24. Ukubalwa komthamo kuleli cala kusekelwe kwisisindo somzimba sesiguli ngaphakathi kobukhulu bomuthi nsuku zonke.

Ngokuphazamiseka okusebenzayo kwezinso noma kwesibindi, ukwethulwa kwekhambi lokufakwa kuncishisiwe. Uma isiguli sithambekele ekuqothulweni kwe-hypotension, ukwelashwa kuqala ngemithamo ephansi, kuyikhulise kancane kancane, kucatshangelwa ukusabela komuntu ngamunye.

Ngokukhubazeka okusebenzayo kokusebenza kwezinso, ukwethulwa kwekhambi lokufakwa kungenziwa kancane.

I-Trental ingabekwa nge-intramuscularly, le ndlela idinga isingeniso esijulile. Inhlanganisela yokuphathwa komlomo nobuzali kweTrental kuvunyelwe ukubheka umthamo ophelele we-pentoxifylline. Ukwelashwa kokuvimbela nokunakekela, kusetshenziswa ifomu lethebhulethi kuphela lesidakamizwa.

Ukuthatha umuthi wesifo sikashukela

Ngokuhlanganiswa neTrental, isenzo se-Insulin neminye imishanguzo ye-antidiabetes siyathuthukiswa. Ngakho-ke, phambi kwesifo sikashukela i-mellitus, inani elikhulu le-pentoxifylline kufanele liphathwe ngokuncipha komthamo wama-ejenti we-hypoglycemic ngaphansi kwezimo zokulawulwa okwandayo kwesimo sesiguli.

Yiliphi izinga likashukela wegazi elijwayelekile emadodeni? Funda kabanzi esihlokweni.

Yiziphi izinkomba zesifo sikashukela kubantu besifazane?

Ingabe i-parsley ilusizo kushukela wohlobo 2? Funda kabanzi esihlokweni.

Zingaki izinsuku?

Isikhathi sokwelashwa sinqunywa udokotela ngokuya ngesithombe sonke, izici zomuntu ngamunye kanye ne-Dynamics ebonakalayo. Amapharamitha we-rheological yegazi nawo ayabhekwa. Inkambo yokwelapha ingaba ngezinsuku eziyi-10-14 iye ezinyangeni ezimbalwa.

Isikhathi sokwelashwa sinqunywa udokotela ngokuya ngesithombe sonke, izici zomuntu ngamunye kanye ne-Dynamics ebonakalayo.

Imiphumela emibi yeTrental 100

Umuthi ezimweni eziningi ubekezelelwa kahle. Kepha kungenzeka kube nemiphumela emibi evela ezinhlakeni ezihlukene zomzimba.

Amapheshana wesisu

Ukwehla kwesifiso sokudla, umthamo owengeziwe wamathe noma ulwelwesi lwamafinyela olomile, ukugabha, i-atony lamathumbu, umuzwa wokugcwala kwesisu, ukuphakama kokugaya ukudla.

Umphumela wecala lesipheshana emathunjini kungaba ukungathandi ukudla.

Izitho zeHematopoietic

Izinguquko ezibalulekile ekwakhiweni kwegazi, okuqukethwe kwe-fibrinogen kwehlile

Isistimu yezinzwa ephakathi

Isiyezi, i-migraine, ukubonakaliswa okukholisayo, ukhubazeka okubonakalayo kwesikhashana, ukukhathazeka, ukuqwasha.

Kusuka ohlelweni lomchamo

Ukuvuvukala.

Kusuka ohlelweni lokuphefumula

Ukopha kwe-nasal, bronchospasm.

Imiphumela emibi evela ohlelweni lokuphefumula - ukopha kwamakhala.

Engxenyeni yesikhumba

Ukuqhekeka, ukulunywa, i-hyperemia, ukukhuphuka kwezipikili kwezipikili.

Kusuka ohlelweni lwezitho zofuzo

I-Spotting.

Kusuka ohlelweni lwezinhliziyo

Ubuhlungu enhliziyweni, tachycardia, ukuncipha kwengcindezi, i-arrhythmia, i-angina pectoris, ukopha okuvela kulwelwesi lwama-mucous noma emithanjeni yegazi yesikhumba.

Ukusuka ohlelweni lwezinhliziyo, amacala okubonakala kwe-arrhythmia ne-tachycardia akuvamile.

Kusuka emasosheni omzimba

Ukuthuthukiswa kwe-angioedema, ukushaqeka kwe-anaphylactic.

Engxenyeni yesibindi ne-biliary

Ukwanda kwe-cholecystitis, ifomu le-intrahepatic le-cholestasis.

Allergies

Ukusabela okufana ne-urticaria, ukuphefumula, ukuvuvukala, i-anaphylaxis.

Kwezinye izimo, ukusabela komzimba kuba njenge-urticaria.

Umthelela ekhonweni lokulawula izindlela

Ithonya leTrental ekuhlushwa alitholakalanga. Kodwa-ke, kufanele kuqashelwe ngoba kungenzeka kube nesiyezi.

Imiyalo ekhethekile

Ngenkathi uphuza umuthi, udinga ukulawula umfutho wegazi. Esikhathini se-postoperative, kuyadingeka ukulawula inkomba ye-hematocrit ne-hemoglobin. Uma i-retinal hemorrhage yenzeka ngesikhathi sokwelashwa, ukusetshenziswa kweTrental kufanele kumiswe ngokushesha. Ababhemayo bangathola ukwehla kokusebenza kwomuthi kahle.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ngesikhathi sokuzala, iTrental ayinqunyelwe. Isikhathi sokulashwa, ukuncelisa ibele kufanele kushiywe.

Ngesikhathi sokuzala, iTrental ayinqunyelwe.

Ukunquma iTrental ezinganeni eziyi-100

Akukho datha eqinisekisiwe ngemiphumela yesidakamizwa emzimbeni wezingane, ngakho-ke akunconywa ukuthi unikeze umuthi ezigulini ezingaphansi kweminyaka engu-18.

Sebenzisa ebudaleni

Ngenxa yokuwohloka kwesibindi nezinhlaka zezinso, iziguli esezikhulile kufanele zinqunywe imithamo yomuthi futhi ziqaphele isimo sazo.

Isicelo sokusebenza kokulimala kwezinso

Ukwehluleka kwangempela kuholela ekwandeni kwenkathi ye-pentoxifylline, ukukhishwa kungenzeka. Imithamo ye-Trental kufanele incishiswe.

Ukwehluleka kwangempela kuholela ekwandeni kwenkathi yokukhuphuka kwe-pentoxifylline, ukukhishwa kungenzeka, umthamo weTrental kufanele uncishiswe.

Sebenzisa umsebenzi wesibindi okhubazekile

Ukulimala kwizakhiwo zesibindi kukhulisa i-bioavailability yomuthi. Kulokhu, kunconyelwa ukunciphisa umthamo ngama-30-50%.

Ukweqisa kweTrental 100

Izimpawu zomthamo owedlulele:

• ubuthakathaka
• ukuhlanza
• amakhaza;
• ukwehluleka
• hyperemia;
• arrhythmia;
• ukwanda kwesilinganiso senhliziyo;
• ukwehla kwengcindezi yegazi;
• ukwephulwa kokuphendula kwe-Reflex;
• iminyakazo
• ukopha emgodini wokugaya ukudla.

Enye yezimpawu zokuphulwa komthamo ubuthakathaka.

Hlanza isisu bese ufuna ukwelashwa.

Ukuxhumana nezinye izidakamizwa

Kuyadingeka ukubheka ukuhambisana kweTrental nezinye izidakamizwa. Kwezinye izimo, kukhona ukwanda kwesenzo somuthi owodwa noma ingozi yokwanda okungafuneki inyuka. Ukusebenzelana Nezidakamizwa:

1. Nezidakamizwa ze-antihypertensive (ama-nitrate, ama-inhibitors we-ACE, njll.) - ubungozi be-hypotension.
2. Ngama-anticoagulants kanye nemithi elwa namagciwane - amathuba wokopha.
3. Nge-Theophylline, ukwanda kokuhlushwa kwayo.
4. Nge-cimetidine ne-ciprofloxacin - ukwanda kokuqukethwe kwe-plasma ye-pentoxifylline.
5. Ngama-xanthines - ukwanda okukhulu kwenjabulo.
6. Ngamakhompiyutha we-anti-glycemic - agcwele i-hypoglycemia.

Ukuhambisana notshwala

Ngesikhathi sokulashwa, kunconywa ukwenqaba ukuphuza utshwala.

Ngesikhathi sokulashwa, kunconywa ukwenqaba ukuphuza utshwala.

Ama-Analog

Ama-Analogs we-Trental wento esebenzayo:

• I-Pentoxifylline;
• I-Agapurin;
• Pentilin;
• I-Flowerpot;
• I-Pentohexal;
• I-Arbiflex;
• I-Flexital nabanye.

I-Flowerpot - i-analogue yeTrental yento esebenzayo.

Ezinye izidakamizwa zeqembu elifanayo lezokwelapha, ezifana, ngokwesibonelo, iDuzofarm, zinomphumela ofanayo.

Imibandela yekhefu lekhemisi

ITrental ayithengiswa.

Ngingakwazi ukuthenga ngaphandle kadokotela?

Umuthi uhanjiswa ngokuya ngencwadi ethile.

Umuthi uhanjiswa ngokuya ngencwadi ethile.

Intengo Trental 100

Izindleko zesisombululo sokufakwa zimayelana nama-ruble angama-147. Intengo yefomu lethebhulethi yesidakamizwa livela kuma-ruble angama-450.

Izimo zokugcina zomuthi

Umkhiqizo ugcinwe kude nezingane emazingeni okushisa angaphansi kuka + 25 ° C.

Isikhathi sokuphelelwa yisikhathi

Amacwecwe afanele iminyaka eyi-4 kusukela ngosuku lokukhishwa. Impilo yeshalofu yesisombululo yiminyaka emi-5.

Umkhiqizi

Lesi sidakamizwa senziwa yinkampani yezemithi yaseNdiya i-Aventis Pharma Limited.

Ukubuyekezwa kweTrental 100

I-Trental inezibuyekezo ezinhle ezivela kuzo zombili iziguli nodokotela.

Odokotela

U-Otavin P.N., udokotela wezifo zemizwa, iNovosibirsk.

I-Trental ihamba kahle ekwelashweni okuyinkimbinkimbi njengomuthi oyisibonakaliso futhi owelapha. Iningi leziguli linomkhuba omuhle. Ngithanda ukuqaphela ukungabikho kwe-hepatotoxicity nokubekezelela okuhle kulo muthi.

Iziguli

USemen, oneminyaka engama-41 ubudala, idolobha lasePenza.

Ngaba nokulahlekelwa izindlebe kwe-1 degree. Ngemuva kokuthatha uTrental, akagcinanga ngokuzwa kangcono, kepha wezwa nokuqina kwamandla. Izinsuku zokuqala ezimbalwa, ikhanda lami lalinesiyezi, futhi kwakungekho kusabela okukhulu okuphezulu.

U-Alice, oneminyaka engama-26, uSamara.

Ugogo wami wayesolwa ngokuwohloka komqondo, kepha kwakukhona udokotela onekhono owamisela uTrental. Ngemuva kwenkambo yokwelashwa, akazange aqashelwe. Ugogo waphila, wahlekisa futhi waphinda wathatha amaskena.