Ungasisebenzisa kanjani isidakamizwa i-Neurontin?

I-Neurontin ilungiselelo elifanayo nesakhiwo sendawo ku-neurotransmitter GABA (gamma-aminobutyric acid). Ekuqaleni, into esebenzayo yesidakamizwa ibibhekwa njenge-anticonvulsant. Futhi eminyakeni embalwa kuphela kamuva, ukusebenza ngempumelelo kwayo ekwelapheni ama-syndromes amaningi obuhlungu be-neurogenic kwembulwa.

Igama Lezwe elingafanele

INN - UGabapentin.

I-Neurontin ilungiselelo elifanayo nesakhiwo sendawo ku-neurotransmitter GABA (gamma-aminobutyric acid).

Igama lokuhweba ngesiLatini yiNeurontin.

I-ATX

Ikhodi ye-ATX yi-N03AX12.

Khipha amafomu nokwakheka

Akhiqizwa ngohlobo lwamathebulethi namaphilisi, into esebenzayo yayo yi-gabapentin.

Funda futhi ngeminye imithamo:

I-Neurontin 600 - imiyalo esetshenzisiwe.

Qeda i-300 - ibekelwe ini?

Amaphilisi

Umumo we-Ellipse, ophekwe ngesinothi nokuqoshwa kwe-NT. Ngakolunye uhlangothi lwethebhulethi, ngokuya ngethamo lento esebenzayo, izinombolo ziyahlelwa:

• ezibhebheni ezinezinombolo ezingama-600 mg ze-gabapentin 16;
• 800 mg - 26.

Amathebulethi e-elliptical

Ukwakheka, ngaphezu kwento esebenzayo, kufaka phakathi izakhi ezisizayo:

• poloxamer-407;
• isitashi;
• E572.

Ubungako babo buye kuncike ekuhlakazweni kwento eyisisekelo.

Amakhandlela

Amakhandlela akhiqizwa ngenombolo ye-gabapentin:

• 100 mg
• 300 mg;
• 400 mg

Amakhandlela ahluka ngokubukeka (umbala we-gelatin capsule) kanye nelebuli.

Ziyahluka ngokubukeka (umbala we-gelatin capsule) kanye nelebuli. Amaphilisi ama-100 mg amhlophe, ama-300 mg aphuzi aphuzi, kuthi ama-400 mg angawolintshi. Phezu kwe-gabapentin, amakhompiyutha afaka izimbongi:

• i-monohydrate kashukela;
• isitashi;
• i-magnesium hydroxylate.

Amakhandlela nawo ayahluka ngosayizi - Cha. 3, 1, 0 ngokuhleleka okuphambene nomthamo.

Isenzo se-Pharmacological

Ngaphandle kokufana nokwakheka kwe-GABA, i-gabapentin ayibopheleli ku-GABAA ne-GABAA receptors. Izici ze-analgesic zichazwa yikhono lezinto zokubopha kwamanye amayunithi we-calcium tubule ion etholakala emgodini we-Presynaptic cleft we-nerve fibers yezimpondo zangemuva zentambo yomgogodla.

Uma izinzwa ze-distal (kude) zilimele, inani le-α2-δ subunits lenyuka kakhulu. Ukwenza kusebenze kwabo kukhulisa ukugeleza kwe-Ca2 + esitokisini ngokusebenzisa ulwelwesi, okubangela ukuncipha kwalo futhi kunciphise amandla esikhathi esingahle sisebenze. Kulesi simo, izinto ezisebenzayo ezivusa amadlingozi (ama-neurotransmitters) - glutamate nezidakamizwa P - ziyakhishwa noma zihlanganiswe, ama-receptors we-ionotropic glutamate acushiwe.

Umphumela we-analgesic weNeurontin ubangelwa ukuvimba ukudluliswa kwezimpawu zobuhlungu ezingeni lentambo yomgogodla.

IGabapentin isebenza kuphela kuma-receptors acushiwe, ngaphandle kokuthinta ukuhamba kwe-calcium kuma-receptors angasebenzi. Umphumela we-analgesic weNeurontin ubangelwa ukuvimba ukudluliswa kwezimpawu zobuhlungu ezingeni lentambo yomgogodla. Ngaphezu kwalokho, umuthi uthinta ezinye izinhlelo:

• Ama-receptors e-NMDA;
• iziteshi ze-sodium ion;
• uhlelo lwe-opioid;
• izindlela ze-monoaminergic.

Ngokungeziwe kokuvinjezelwa kokufika komgogodla, umphumela we-supraspinal wembulwa. Isidakamizwa sisebenza ebhulohweni, i-cerebellum kanye ne-vestibular nuclei, echaza hhayi kuphela umphumela we-analgesic, kodwa futhi nempahla ye-anticonvulsant, isusa umlutha kuma-opioid futhi isivele yathuthukisa ukungazwani.

Ngakho-ke, umuthi awusebenzi kuphela ekuqedeni ubuhlungu obungamahlalakhona, kepha futhi nokusiza ubuhlungu obukhulu.

I-Pharmacokinetics

Ukusebenza kweNeurontin kuncike kumthamo. Ngemuva kokuphathwa ngomlomo okungu-300 no-600 mg wento, ukugaya kwayo kungama-60% no-40%, ngokulandelana, futhi kuyehla ngobuningi obukhulayo. Umuthi uxhumana kancane namaprotheni e-plasma (3-5%). Umthamo wokusabalalisa ngu ~ 0,6-0.8 l / kg. Ngemuva kokuthatha i-300 mg ye-gabapentin, i-saturation ephezulu (2.7 μg / ml) ye-plasma yegazi ifinyelelwa ngemuva kwamahora we-2-3.

Umuthi uxhumana kancane namaprotheni e-plasma (3-5%).

UGabapentin udlula ngokushesha umgoqo-wegazi-ingqondo. Umsebenzi wayo kulamanzi we-cerebrospinal ngu-5-35% we-plasma, nasebuchosheni - ufike kuma-80%. Emzimbeni, into ayihlanganisi i-biotransformation futhi ichithwa yizinso ezingashintshiwe. Izinga le-excretion lincike ekuthini imvume ye-creatinine (inani leplasma yegazi lisusiwe kusuka ku-creatinine ngomzuzu 1). Ezigulini ezinomsebenzi ojwayelekile wezinso, impilo yengxenye yento ngemuva komthamo owodwa ngamahora angama-4,7-8.7.

Yini esiza?

Yabela ukukhululeka kobuhlungu obukhulu nobungapheli kanye:

• isifo sokuqaqanjelwa;
• i-postherpetic neuralgia;
• ukuvuvukala kwe-nerve ye-trigeminal;
• isifo sikashukela nomsebenzi we-polyneuropathy;
• ama-syndromes ama-discogenic pain syndromes ane-osteochondrosis, i-radiculopathy;
• i-carpal tun tun syndrome;
• ukulungela okukhulu kwe-spasmodic of the brain;
• syringomyelia;
• izinhlungu zangemva kokushaywa unhlangothi.

Umuthi ubekelwe ukukhululeka kobuhlungu obukhulu futhi obungamahlalakhona nobuhlungu be-post-stroke.

Umuthi ubekelwe ukukhululeka kobuhlungu obukhulu futhi obungamahlalakhona ku-osteochondrosis.

Umuthi ubekelwe ukukhululeka kobuhlungu obukhulu futhi obungamahlalakhona ngesifo se-rheumatic.

Lapho uthatha i-Neurontin, hhayi kuphela ubuhlungu be-neuropathic abumiswa. Umuthi usetshenziselwa i-prophylactic analgesia ngaphambi kokuhlinzwa okuyinkimbinkimbi nokwanda. Ukwethulwa kwayo kusiza ukunciphisa inani lama-anesthetics asetshenziswe esikhathini se-postoperative, futhi kunciphisa kakhulu ubukhulu bezinhlungu.

Umuthi awukwazi ukuyeka kuphela (ngqo endaweni yokungenelela kokuhlinzwa) ubuhlungu be-postoperative, kodwa futhi uthinte nobuhlungu besibili (buqamama kude nenkambu yokuhlinzwa) obangelwa isenzo sokwenza emicubeni.

Umuthi usetshenziselwa isithuthwane njenge-anticonvulsant. Ngendlela umuthi owodwa osetshenziselwa ukudambisa ukubanjwa okuyingxenye.

Contraindication

Ukuxhumana kokusetshenziswa kweNeurinu yilezi:

• ukuthambekela kokungezwani komzimba;
• iminyaka efinyelela kwayi-3.

Ukuphambana ngokusetshenziswa kweNeurontin kuwukuthambekela kokungezwani komzimba.

Ngokunakekela

Iziguli zokwehluleka kwezinso kufanele zinikezwe umuthi ngokuqapha ngaphansi kokulawulwa komsebenzi we-creatine. Njengoba ikhishwa ngenkathi i-hemodialysis, ukulungiswa kwamthamo kuyadingeka.

Ungayithatha kanjani i-neurontin?

Umuthi uphuzwa ngomlomo, ugezwe ngamanzi, noma ngabe ukudla kungakanani. Ungahlukanisa ithebhulethi ngesigamu, wephule engcupheni. Ukwelashwa esiteji sokuqala kwenziwa ngokwesikimu esilandelayo:

• Usuku 1 - 300 mg kanye ngosuku;
• Usuku 2nd - 300 mg izikhathi 2 ngosuku;
• Usuku 3 - 300 mg izikhathi 3 ngosuku.

Isikimu esinjalo sikhonjiswa kwiziguli zabantu abadala nentsha esukela eminyakeni eyi-12. Uma ukuhoxiswa kwezidakamizwa kuyadingeka, khona-ke kwenziwa kancane kancane, kwehlisa umthamo okungenani izinsuku eziyi-7, ngaphandle kwezinkomba.

Umuthi uphuzwa ngomlomo, ugezwe ngamanzi, noma ngabe ukudla kungakanani.

Kwezinye izimo, iziguli zabantu abadala zingaqala ukwelashwa ngomthamo we-900 mg ngokunyuka kancane kancane (i-titration) okungama-300 mg ngosuku njalo ezinsukwini ezingama-2-3. Umthamo omkhulu wansuku zonke ngu-3600 mg. Itholakala emavikini ama-3. Esimweni esibi sesiguli, umthamo uyandiswa ngamanani amancane noma izikhala ezinkulu phakathi kwezithako.

Ukwelapha isithuthwane, umuthi kumele usetshenziswe ngokuqhubekayo. Kulokhu, umthamo wansuku zonke ubalwa ngudokotela ngokwahlukana.

Ukuthatha umuthi wesifo sikashukela

Isetshenziswa njengomuthi wokuzikhethela wokukhululeka kobuhlungu ku-polyneuropathy yesifo sikashukela. Kunconywa ukunquma umuthi ku-300 mg ngosuku kusihlwa, kancane kancane (njalo ezinsukwini ezingama-2-3) okwandisa umthamo kuya ku-1800 mg ngosuku.

Isetshenziswa njengomuthi wokuzikhethela wokukhululeka kobuhlungu ku-polyneuropathy yesifo sikashukela.

Ngingathatha isikhathi esingakanani?

Umuthi unconyelwa ukuba ungathathwa ungekho ngaphezulu kwezinyanga eziyi-5, ngoba inkambo ende yokwelashwa ayifundwanga. Isikhathi eside, uchwepheshe kufanele ahlole isidingo sokuvezwa isikhathi eside.

Imiphumela emibi yeNeurotin

Ngokuvamile, phakathi kwemiphumela emibi yokuphuza umuthi, isiyezi nokuxineka okweqile kuyabonakala. Kakhulu kaningi, umuthi unomthelela ongemuhle ezinhlelweni ezahlukahlukene.

Amapheshana wesisu

Okuvame ukuphawulwa:

• ukwephulwa kokuhamba kwamathumbu;
• ukomiswa kwe-oropharynx;
• ukwakheka ngokweqile kwegesi;
• isicanucanu, ukuhlanza
• ukuphazamiseka kwe-dyspeptic;
• isifo sezinsini;
• ukonakala kwesifiso sokudla.

Phakathi kwemiphumela emibi, ukwakheka ngokweqile kwegesi kuvame ukubonwa kakhulu.

Phakathi kwemiphumela emibi, i-oropharynx imvamisa ukoma.

Phakathi kwemiphumela emibi, isicanucanu sivame ukubonwa.

Esikhathini sangemva kokulashwa, kwaqoshwa amacala angawodwa we-pancreatitis acute.

Izitho zeHematopoietic

Ngokuvamile kutholakala i-leukopenia, i-hypertension ye-arterial kanye ne-thrombocytopenia.

Isistimu yezinzwa ephakathi

Ngokuvamile kuboniswa:

• ukozela
• discoordination;
• ubuthakathaka
• i-paresthesia;
• ukuthuthumela
• ukulahlekelwa inkumbulo
• ukwephulwa kokuzwela;
• ukucindezelwa kokukhishwa.

Ukusuka ohlangothini lohlelo lwezinzwa oluphakathi, ukulahleka kwememori kuyabonakala.

Kusuka ekuqhaqheni kohlelo lwezinzwa oluphakathi kuyabonakala.

Ukusuka ohlelweni lwezinzwa oluphakathi kuyabonakala.

Imvamisa ukuphuza umuthi kuholela ekulahlekelweni kokungazi, ukuhlukunyezwa kwengqondo, njengobutha, i-phobias, ukukhathazeka, kubangela ukwephula ukucabanga.

Kusuka ohlelweni lomchamo

Amacala ahlukanisiwe we-hyperacaction of the bladder, ukwehluleka okukhulu kwe-renal. Izilonda zegciwane, kufaka phakathi ukutheleleka kwe-urinary tract, zivame ukubonwa.

Kusuka ohlelweni lwe-musculoskeletal

Imvamisa, ukwelashwa kuhambisana:

• i-myalgia;
• i-arthralgia;
• imisipha iminyene kanye teak.

Engxenyeni yesikhumba

Imvamisa kuba khona okungekuhle ngendlela:

• ukukhohlakala;
• ukulimala;
• induna
• imishayo;
• ukulunywa.

Kusuka esikhunjeni, kuvela imivimbo eminingi.

Engxenyeni yesikhumba, ukulunywa kuvame ukuvela.

Ukusuka esikhunjeni, izinduna zivame ukuvela.

I-Alopecia, ubomvu, nokuqhuma kwezidakamizwa akuvamile.

Allergies

Ukungezwani komzimba kubonakaliswe yi-pathologies yesikhumba, ukushaqeka kwe-anaphylactic akuvamile ukubonwa.

Umthelela ekhonweni lokulawula izindlela

Lapho uthatha umuthi, akukhuthazwa ukuthi ushayele izimoto noma usebenze ngezindlela ezingaba yingozi ngaphambi kokuthi kutholakale ukuthi awukho umphumela omubi wesidakamizwa ekuphenduleni kwe-neuromuscular.

Imiyalo ekhethekile

Iziguli eziphuza umuthi lezi ziqephu zokuziphatha kokuzibulala. Ngakho-ke, kuyadingeka ukuqapha isimo se-psycho-ngokomzwelo seziguli ngokuqokwa kokulungiswa kokuphambuka.

Uma kuboniswa izimpawu zokuqina kwesikhumba se-pancreatitis, isinqumo sokuyeka umuthi siyasikalwa.

Ngokuhoxiswa komuthi ngesikhathi sokwelapha isithuthwane, kuqale ukuquleka.

Ngokuhoxiswa komuthi ngesikhathi sokwelapha isithuthwane, kuqale ukuquleka. Umuthi ubhekwa njengengasebenzi ekwelashweni kokuqunjelwa okujikelele okuyisisekelo futhi kungaholela nasekuqinisweni kwawo. Ngakho-ke, nikeza lo muthi ezigulini ezinama-paroxysms axubile ngokuqapha.

Ngokuphathwa kanyekanye kwama-opioid neNeurinu, ukudangala kwe-CNS kungakhula - ukuqapha isimo sesiguli nokulungiswa kwamthamo okufika kuyadingeka.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ikhambi ngesikhathi sokukhulelwa lichazwa lapho izinzuzo ezikhona ngaphezulu kwengozi yokulimala kumbungu. Asikho isidingo sokulawula umsebenzi wesidakamizwa ku-plasma yegazi.

Ngoba umuthi utholakala emfihlakalweni ye-mammary gland, ngesikhathi sokudla, kuyadingeka ukuphazamisa ukondla okungokwemvelo kwengane bese uyidlulisela kwingxube.

Ikhambi ngesikhathi sokukhulelwa lichazwa lapho izinzuzo ezikhona ngaphezulu kwengozi yokulimala kumbungu.

Ukunquma uNeurontin ezinganeni

Ukwelashwa ngeNeurontin kuze kube yiminyaka emi-3 akunqunyelwe. Eminyakeni engu-3-12 yeminyaka, umthamo wokuqala ngu-10-15 mg / ngosuku. Ihlukaniswe ngemithamo emithathu. Ukufeza umphumela wokwelapha, kancane kancane uyakhuphuka, ufinyelela ku-40 mg / ngosuku. Kuyadingeka ukunamathela ekuphumeni kwamahora ayi-12 phakathi kwama-reception.

Sebenzisa ebudaleni

Eqenjini lobudala obudala (> iminyaka engama-65), ukonakala komsebenzi we-excretory ngenxa yezinqubo ezihlobene nobudala kuvame ukutholakala, ngakho-ke, ezigulini ezinjalo, ukulawula i-creatinine clearance control kuyadingeka.

Ukweqisa kwe-neurotin

Ngokuphathwa okukodwa komthamo omkhulu, kuboniswa okulandelayo:

• ukungaboni kahle
• ukwanda kwenhlala-kahle;
• i-dyspemia (isifo sokuqina);
• i-hypersomnia (ukulala isikhathi sasemini);
• ubuqili;
• ukwephulwa kokuhamba kwamathumbu.

Ngokuphathwa okukodwa komthamo omkhulu, ukonakala kokubonakalayo kuyaphawulwa.

Ngokuphathwa okukodwa komthamo omkhulu, ukuwohloka kwempilo kuyaphawulwa.

Ngokuphathwa okukodwa komthamo omkhulu, ukubambeka kuyabonakala.

Uma umthamo udluliwe, ikakhulukazi ngokuhlanganiswa neNeurinu neminye izidakamizwa ze-neurotropic, kungaqalwa ukoma.

Ngomthamo omkhulu, imijovo efanelekile kanye nokuhlanzwa kwegazi okuvame kakhulu kuchazwa kwiziguli ezinokungasebenzi kahle kwezinso.

Ukuxhumana nezinye izidakamizwa

Lapho i-Neurontin isetshenziswa kanyekanye ne-opium poppy derivatives, izimpawu zokucindezela kwe-CNS zingaphawulwa. Izinguquko ku-pharmacodynamics yaseNeurontin lapho kuthathwa izidakamizwa ze-antiepileptic aziphawulwanga.

Ukuhlanganiswa kwezidakamizwa nama-antacid kunciphisa ukwehla kwe-Neurotin cishe nge-1/4.

I-venoruton namanye ama-venotonics ahlanganiswe nento esebenzayo yesidakamizwa futhi angabekwa ukuvimbela ukusabela okungalungile ohlelweni lokujikeleza.

Ngokubonakaliswa okulinganiselayo kokuphendula okwenziwa yi-allergic, ama-antihistamines, anjengeCetrin, asetshenziswa ngokufana nomuthi.

Ngokubonakaliswa okulinganiselayo kokuphendula okwenziwa yi-allergic, ama-antihistamines, anjengeCetrin, asetshenziswa ngokufana nomuthi.

Ukuhambisana notshwala

Akunconywa ukuthatha utshwala nomuthi ngasikhathi sinye, ngoba zombili zinomphumela ohlelweni lwezinzwa oluphakathi. Kodwa-ke, umuthi usetshenziswa ekwelapheni ukuxhomekeka kotshwala. Yehlisa ukufisa ngotshwala, iqeda ukuqwasha nokudangala.

Ama-Analog

Kunezimpawu ezifanayo ezingama-Neurotin:

• Convalis;
• IDroplet;
• I-Egipentin;
• Gabalept;
• I-Wimpat;
• IGabastadine
• Tebantin;
• UGabapentin;
• Katena.

IDroplet ingenye yokufanekisa kweNeurontin.

UKonvalis ungenye yokufanekisa kweNeurontin.

I-Tebantin ingesinye sezifanekiso zeNeurontin.

Imibandela yekhefu lekhemisi

Ngokusebenzisa umuthi.

Ngingakwazi ukuthenga ngaphandle kadokotela?

Imithi esetshenziswe ngaphezulu kwe-counter ayinconywa ukugwema ukuqamba amanga.

Intengo yeNeurontin

Izindleko ezingama-ruble angama-962-1729.

Izimo zokugcina zomuthi

Gcina endaweni yokushisa engeqi ku-25 ° C, lapho izingane zingafinyeleleki khona.

Imithi esetshenziswe ngaphezulu kwe-counter ayinconywa ukugwema ukuqamba amanga.

Isikhathi sokuphelelwa yisikhathi

Hhayi ngaphezulu kweminyaka engu-2.

Umkhiqizi

I-Pfizer (Germany).

Ukubuyekezwa kweNeurinu

U-Alexey Yuryevich, oneminyaka engama-53 ubudala, uKaluga: "Sekuphele isikhathi eside ngihlushwa iminjunju ye-neuropathic. Sekuphele unyaka manje, udokotela wanikeza ukwamukelwa kweNeurinu 300. Ekuqaleni umphumela wawumuhle, kepha manje usebuthakathaka. Ngisaqhubeka nokuthatha lesi sidakamizwa, kepha ngiyasola ukuthi ngenxa yobude bezokwelashwa. ayisebenzi. "

UKonstantin, oneminyaka engama-38, u-Odessa: "Udokotela unqume isifundo seNeurontin. Wathatha umthamo udokotela ayewunqume, wanamathela kulolo hlelo.Ngalesi sikhathi bekungekho miphumela emibi ebisatshiswa, kanti nomuthi usebenza kahle. "

U-Olga, oneminyaka engama-42, uMelitopol: "Ngemuva kokuthatha i-Neurinu, umphumela waphikelela isikhathi eside, angizwanga ngiyanizwa, imilenze yami yalimala kancane. Ngikholwa ukuthi umuthi uyasebenza futhi uyasiza ukuqeda izinhlungu."