Umuthi i-Ciprofloxacin: Imiyalo yokusebenzisa

Umuthi yiqembu lezidambisigciwane, elingelama-fluoroquinolones. Igama ngesiLatini lithi ciprofloxacin. Injongo yayo eyinhloko ukunciphisa umsebenzi kanye nokubhujiswa kwama-pathogenic agents ezinhlobo ezahlukahlukene. Izinzuzo zalo muthi zifaka phakathi amandla wokuthenga umuthi wokwelapha ngendlela elula: uqinile, uketshezi. Kodwa-ke, okokuqala, izinga elanele lokusebenza liyaphawulwa.

I-ATX

S01AE03 Ciprofloxacin.

Umuthi yiqembu lezidambisigciwane, elingelama-fluoroquinolones. Igama ngesiLatini lithi ciprofloxacin.

Khipha amafomu nokwakheka

Umuthi ukhiqizwa ezinhlotsheni eziningana. Umehluko phakathi kwalokhu ezimbili ngesakhiwo. Umsebenzi wokuboniswa wokuhlanganiswa uhlanganisa imali. Kulesi sikhundla, isisetshenziswa segama elifanayo siyasetshenziswa. Kanye ne-ciprofloxacin, izici ezincane nazo ziyaphawulwa.

Amaphilisi

Dose ku-1 pc: 250 noma 500 mg yento esemqoka. Ezinye izinto:

• isitashi sommbila;
• crospovidone M;
• i-lactose;
• i-microcrystalline cellulose;
• i-magnesium stearate;
• i-talcum powder.

Umuthi uhlanganiswa (amaphilisi ayi-10).

Umuthi ubekwe njenge-bactericidal, i-antimicrobial agent. Inokufana kakhulu ne-antibiotic, kepha ngokungafani neyokugcina, umuthi okukhulunywa ngawo awunayo indawo yemvelo.

Isixazululo

Ingasetshenziselwa izinhloso zokungenelela. Isixazululo sivame ukuphathwa ngokuhlinzwa nangokomzimba. I-100 ml yento ewuketshezi iqukethe ama-200 mg we-ciprofloxacin. Ukwakheka komuthi o-antimicrobial kufaka enye ingxenye esebenzayo - i-sodium chloride. I-100 ml yomkhiqizo owuketshezi uqukethe ama-900 ml ale nto. Kutholakala emabhodleleni (100 ml).

Amaconsi

Umthamo we-ciprofloxacin ku-1 ml wesisombululo ngu-3 mg. Izinto ezinezinga eliphansi lomsebenzi, nazo eziyingxenye:

• i-ethylenediaminetetraacetic acid disodium usawoti;
• i-mannitol;
• i-sodium acetate i-anhydrous noma i-3-amanzi;
• i-glacial acetic acid;
• i-benzalkonium chloride;
• amanzi ahlanziwe.

Lo mkhiqizo ubekwe umakhi njengoba amaconsi endlebe / iso. Zitholakala ebhodleleni (5 ml).

Umuthi ukhiqizwa ezinhlotsheni eziningana. Umehluko phakathi kwalokhu ezimbili ngesakhiwo. Umsebenzi wokuboniswa wokuhlanganiswa uhlanganisa imali.

I-100 ml yento ewuketshezi iqukethe ama-200 mg we-ciprofloxacin. Ukwakheka komuthi o-antimicrobial kufaka enye ingxenye esebenzayo - i-sodium chloride.

Lo mkhiqizo ubekwe umakhi njengoba amaconsi endlebe / iso. Zitholakala ebhodleleni (5 ml).

Indlela yokusebenza

Umuthi ubekwe njenge-bactericidal, i-antimicrobial agent. Inokufana kakhulu ne-antibiotic, kepha ngokungafani neyokugcina, umuthi okukhulunywa ngawo awunayo indawo yemvelo. Umuthi uhlukaniswa njengomuthi wesizukulwane sesibili. Isenzo se-pharmacological se-ciprofloxacin sisuselwa ekuvinjelweni kwama-enzyme, athathwa njengabaluleke kakhulu empilweni yamagciwane. Lawa yi-DNA gyrase ne-topoisomerase-4.

Ngenxa yalomgomo wokusebenza, kuphulwa umthetho wenqubo yokwenziwa kabusha kwama-pathogenic agents. Izinto ezivela eqenjini le-fluoroquinolones, kanye ne-ejenti okukhulunywa ngayo, zivimbela ukwakheka kwama-microorganisms ayingozi. Ngemuva kwalokhu, ukuthuthukiswa kokutheleleka kuyamiswa.

Ngaphezu kwalokho, umphumela osusa umuthi ku-RNA yamagciwane uyaphawulwa. Ngenxa yalokhu, ama-membrane amaseli alahlekelwa ukuqina. Ngaphezu kwalokho, ukwephulwa kwezinqubo eziningi ze-biochemical kuphawuliwe. Ngokwalo mgomo, amaseli wamagciwane wamaqembu ahlukene ayabhujiswa. Phakathi kwazo okuphawuliwe:

• ama-bacterium a-gram-positive, phakathi kwawo ajwayelekile kakhulu yi-staphylococci, streptococci;
• Isifo sofuba se-Mycobacterium;
• amagciwane angenalo igciwane lezinhlobo eziningi.

Inzuzo yalesi sidakamizwa imiphumela yaso emibi kuma-aerobic agents. Inani lama-microorganisms ahlukanisiwe alwa nemiphumela ye-ciprofloxacin. Umphumela wesidakamizwa okukhulunywa ngaso ku-Treponema pallidum awukafundwa. Ngalesi sizathu, kunzima ukubikezela ukuthi ukutheleleka kuzoziphatha kanjani.

I-Pharmacokinetics

Izinga le-bioavailability lomuthi lapho lifakwe alihambi ngaphezu kwe-50-85%. Lapho ungenwa, ithebhulethi iyabanjwa. Izinga eliphakeme lomsebenzi litholakala ngemuva kwemizuzu engama-60-90. Ukuqhathanisa, ngesikhathi sokwelashwa nge-Ciprofloxacin emaconsi, isixazululo sokungeniswa, izinga lomsebenzi ophakeme lifinyelelwa ngokushesha - emva kwemizuzu engama-60.

Emzimbeni womuntu, umuthi uthola inqubo ye-metabolic. Noma kunjalo, izinto ezikhishwe zingaphansi komsebenzi ophansi. Ikhwalithi enhle ye-ciprofloxacin ukusatshalaliswa komfaniswano emzimbeni wonke. Ihlukahluka kwi-tropism kuya kwezicubu ze-prostate gland, izicubu zamathambo nezitho ezahlukahlukene.

Ukuqhathanisa, ngesikhathi sokwelashwa nge-Ciprofloxacin emaconsi, isixazululo sokungeniswa, izinga lomsebenzi ophakeme lifinyelelwa ngokushesha - emva kwemizuzu engama-60.

Okusizayo

Amathebulethi, uhlobo oluwuketshezi lomuthi (lokufaka), kutuswa ukuthi usebenzise izifo ezivela kumthelela wokutheleleka ngomonakalo ezingxenyeni ezahlukene zomzimba:

• Izitho ze-ENT (ikhala, amehlo, izindlebe);
• ipheshana lokuphefumula (ngokwesibonelo, nge-angina);
• izinso (pyelonephritis);
• abahlaseli;
• umgogodla womlomo;
• isisu, amathumbu, njll;
• i-gadder kanye nepheshana le-biliary;
• izitho zangasese, ngokwesibonelo, ne-prostatitis emadodeni, i-cystitis;
• i-integument yangaphandle (ulwelwesi nolwelwesi lwamafinyila) ezingxenyeni ezihlukene zomzimba;
• uhlelo lwe-musculoskeletal.

I-Ciprofloxacin nayo ibekelwe i-angina.

Umuthi usiza ngezifo ezahlukahlukene zesikhumba.

I-Ciprofloxacin imiselwe i-prostatitis.

Izifo zomgogodla womlomo ziyinkomba yokusetshenziswa kwomuthi.

I-ejenti ebhekwa njengeyizidambiso isebenza kahle kuma-gynecologists, futhi ngesikhathi sokululama nokwelashwa kwezinkinga ngemuva kokuhlinzwa, ngqo ngesikhathi sokuhlinzwa, ngenqubo yokuhlanza, i-peritonitis, futhi ngaphezu kwalokho isetshenziswa njengezinyathelo zokuvimbela kubantu abanomlando wokungazeleleki.

Umuthi osehla ngamadonsi wenzelwe ekwelapheni kwezimo zempilo njenge:

• abezindaba ze-otitis;
• izifo ezihambisana nokukhubazeka okubukwayo: i-acjunctivitis eyingozi, i-blepharitis, izilonda ze-ulcerative cornea, ukutheleleka kwesibili ngemuva kokulimala, njll;

Isetshenziselwa ukuvikela ukuthuthukiswa kwemiphumela emibi ngaphambi nangemva kokuhlinzwa kwamehlo.

Kungenzeka yini ukuthi uphuze umuthi onesifo sikashukela

Ukusetshenziswa kwe-ciprofloxacin ekwelapheni iziguli ezinalokhu kutholwa kuyavunyelwa. Kodwa-ke, kufanele kwaziwe ukuthi lesi sidakamizwa sisiza ukwehlisa amazinga kashukela. Lokhu kukhulunywa kakhulu ezigulini ezinesifo sikashukela i-mellitus.

I-Ciprofloxacin emaconsi ihloselwe ukwelashwa kwezifo ezinjenge-blepharitis.

Contraindication

Imikhawulo ekuqashweni komuthi inqunywa ngesakhiwo sawo. Ukwephulwa okuvamile kwazo zonke izinhlobo zomuthi ukubalwa kwengqondo engxenyeni eyinhloko, futhi ngaphezu kwalokho ezintweni eziyingxenye yezinye fluoroquinolones. Yazi ngokwehlukile imikhawulo yethuluzi elikhulunywa ngalo:

• izingane nentsha;
• isikhathi sokuncelisa;
• ukuzala ingane.

Kuyenqatshelwa ukusebenzisa umuthi odonsa kwezinye izikhathi:

• nge-keratitis yemvelo yegciwane;
• eminyakeni yeziguli kuze kufike ezinyangeni eziyi-12.

Kukhona nezifo eziningana lapho ukuqaphela kubalulekile ngenkathi uphuza umuthi. Leli qembu lifaka isimo se-pathological, esihambisana nezinguquko ze-atherosclerotic emithanjeni yobuchopho, ukuthambekela kokuthuthukisa ukuqaqamba kokujikeleza kokubeletha. Umuthi wamukelekile ukuwuthatha, kepha udinga ukukwenza lokhu ngaphansi kokuqondisa kukadokotela.

Umuthi uthathwa ngokuqapha ku-atherossteosis kanye neengozi ze-cerebrovascular.

I-Ciprofloxacin icutshaniswe nokuncelisa ibele.

Ithuluzi livinjelwe ukusetshenziswa keratitis yegciwane.

Ungayithatha kanjani

I-ejenti kumaconsi isetshenziswa kaningi ngosuku. Isikimu: kusuka ezikhathini ezi-2 kuya kwezi-4 ngosuku, ama-1-2 ehla esweni elithintekile. Umthamo ophakeme kakhulu unganconywa ezimweni ezinzima ze-pathological. Lapho kuhlelwa ukusebenzisa amaphilisi, kukhethwe elinye icebo:

• izifo zezinso, ipheshana lokuphefumula: hhayi ngaphezu kwama-500 mg ngosuku, leli nani kufanele lihlukaniswe ngemithamo emibili;
• ukwelashwa kwezifo ezithathelwana ngocansi (ngokwesibonelo, i-gonorrhea): 250-500 mg, udinga ukuthatha umuthi kuleli dosi kuphela isikhathi;
• ngezifo zezitho zangasese zowesifazane, amathumbu, ne-prostatitis, kunconywa ukuphuza ama-250 mg kabili ngosuku.

I-ejenti kumaconsi isetshenziswa kaningi ngosuku. Isikimu: kusuka ezikhathini ezi-2 kuya kwezi-4 ngosuku, ama-1-2 ehla esweni elithintekile.

Umuthi uvame ukuthathwa ngokuhamba kwezinsuku eziyisikhombisa kuya kweziyishumi. Uma isiguli siphazamise umsebenzi wezinso, kubuye kuvezwe umthamo. Uma uhlela ukusebenzisa umuthi ngendlela ye-liquid (ukuphathwa kwemithambo yegazi), lezi zinto ezilandelayo ziyabhekwa:

• iphathwe kancane nge-dropper imizuzu engama-30 uma kusetshenziswa umthamo wama-200 mg;
• ukumnika kwenziwa ngehora eli-1 (inani le-ciprofloxacin ngu-400 mg).

Inkambo yokwelapha iyahluka kusuka ezinsukwini ezi-1 kuye kwezingu-14. Konke kuncike ohlotsheni lwesifo, uhlobo lwayo (ngokwesibonelo, oluyinkimbinkimbi noma olubi).

Ngaphambi noma ngemuva kokudla

Kungcono ukuthatha umuthi emathebuleni esiswini esingenalutho. Uma usebenzisa amaconsi, isixazululo esenzelwe ukufakwa, ayikho imikhawulo enjalo.

Ngoshukela

Ushintsho emazingeni kashukela lubhekelwa eduze.

Kungcono ukuthatha umuthi emathebuleni esiswini esingenalutho.

Imiphumela emibi

Okubi kwomuthi kufaka inani elikhulu lokungaphenduki okuhle. Ezigulini ezahlukahlukene, iqoqo lezimpawu ezinjalo liyahlukahluka, kuya ngesimo somzimba ngesikhathi sokuthatha umuthi, uhlobo nesigaba sokuthuthuka kwalesi sifo.

Amapheshana wesisu

Ukuvela kokuhlanza ngemuva kwesizinda sokucanuzelelwa kwemizwa kuyaphawulwa. Ezinye izimpawu: izihlalo ezikhululekile, ubuhlungu besisu, isifiso sokudla, i-anorexia, ukuthopha. Imvamisa iba ne-hepatitis, jaundice, izinqubo ze-necrotic esibindini.

Izitho zeHematopoietic

Gxila izimo ezinjengokuthi: i-leukopenia, i-granulocytopenia, i-leukocytosis, i-thrombocytopenia, uhlobo lwe-hemolytic hlobo anemia, i-thrombocytosis.

Isistimu yezinzwa ephakathi

Leli qembu lifaka inani elikhulu kakhulu lokubonakaliswa okungalungile:

• isiyezi nekhanda;
• ukukhathala kungena ngokushesha;
• ukulala kabi;
• ukukhuphuka kwengcindezi ye-intracranial;
• ukwazi kuyaphazamiseka;
• isimo sokudangala siyakhula;
• ukubona izikhathi ngezikhathi, njll.

Allergies

Izimpawu: i-urticaria, ukulunywa kanzima, ukopha, ukuqhuma kwemvelo ehlukahlukene, ukuvuvukala komphimbo nobuso, isithombe sokuzwa kwezimpawu, i-erythema, i-epidermal necrosis.

Eminye yemiphumela emibi yesidakamizwa ukuvela kokuqhuma.

Ukusetshenziswa isikhathi eside komuthi kungadala i-anemia.

Ukuphazamiseka kokulala kungenye yemiphumela emibi yokuphuza umuthi.

Imiyalo ekhethekile

Uma umuthi okukhulunywa ngawo uthathelwe, udinga ukusebenzisa uketshezi oluningi kunemodi ejwayelekile. Iziguli zokuxilongwa okuthile (isifo sokuwa kanye nesifo sezinzwa, ukuhlukunyezwa kwenhliziyo, ngokwesibonelo, ukufakwa kwe-myocardial) zinqunywa lesi sidakamizwa kuphela uma sibalulekile. Uma isifo sohudo siqala ukwelashwa nge-Ciprofloxacin, kunconywa ukuthi isiguli singakhuli i-colitis.

Uma umuthi okukhulunywa ngawo uthathelwe, udinga ukusebenzisa uketshezi oluningi kunemodi ejwayelekile.

Ukuhambisana notshwala

Kuyenqatshelwa ukuthatha izidakamizwa zokuvimbela izidakamizwa kanye neziphuzo eziqukethe utshwala ngasikhathi sinye.

Umthelela ekhonweni lokulawula izindlela

Akunemikhawulo eqinile. Kodwa-ke, kucwayiswa lapho ushayela izimoto, ngoba umuthi uyakwazi ukudala ukuvela okungalungile okuyingozi. Okufanayo kusebenza ezimweni lapho isiguli sisebenza kunoma yimuphi umsebenzi odinga ukunakwa okuthe xaxa kokunakwa kanye nejubane lokuphendula kwe-psychomotor.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Amathebulethi nesixazululo (sokuphathwa kwemithambo, imijovo) asetshenziswa ekwelapheni i-ciprofloxacin. Uma amaconsi wamehlo ecatshangelwa, khona-ke umuthi onjalo ubekiwe lapho inzuzo engaba khona iphakeme kakhulu kunokulimaza ingane.

Umthamo we-Ciprofloxacin wezingane

Ukusetshenziswa kwe-ciprofloxacin kumaconsi kuvunyelwe ngenhloso yokwenza inkambo yokwelashwa kweziguli ezingavuthiwe.

Sebenzisa ebudaleni

Kungcono ukusebenzisa umuthi emithanjeni emincane, ngoba iziguli ezikuleli qembu zisengozini enkulu yokuthola ukusabela okungekuhle komuntu ngamunye.

Ukuqwashisa kuyelulekwa lapho ushayela izimoto, ngoba umuthi uyakwazi ukudala ukuvela okungalungile okuyingozi.

Kuyenqatshelwa ukuthatha izidakamizwa zokuvimbela izidakamizwa kanye neziphuzo eziqukethe utshwala ngasikhathi sinye.

Kuyalulekwa ukusebenzisa umuthi ngemithamo emincane, ngoba iziguli esezikhulile zisengozini enkulu yokuthola ukusabela okungekuhle komuntu ngamunye.

Ukweqisa

Uma amanani amaningi we-antimicrobial agent acatshangelwe angeniswe emzimbeni esikhathini eside, ukuqina kwemiphumela emibi echazwe ngenhla kuyanda. Yenza ukwelashwa okuhlose ukuqeda izimpawu. Kubalulekile ukwenza isiqiniseko sokuthi isilinganiso esanele soketshezi singena emzimbeni.

Ukuxhumana nezinye izidakamizwa

Ithuluzi elinjenge-Didanosine lisiza ukunciphisa ubukhulu bokufakwa kwe-koprofloxacin yento. Umphumela ofanayo uyatholakala lapho usebenzisa ama-antacid, imikhiqizo equkethe i-zinc, i-magnesium, i-iron, i-aluminium ion. I-Metoclopramide, kunalokho, yandisa umsebenzi we-ciprofloxacin.

Ama-uricosuric agents avimbela ukuphuma kwe-izidakamizwa okulimaza emzimbeni wesiguli. Uma kusetshenziswa izidakamizwa eziningana zesenzo se-bactericidal, ukusebenza ngempumelelo kwezokwelapha kuyathuthukiswa, kepha imiphumela emibi ingavela. Uma usebenzisa i-Ciprofloxacin, kukhona ushintsho ekugxambeni kwe-Theophylline ku-plasma, kanye nama-ejenti angaqondile angaphandle, izidakamizwa ze-hypoclycemic. Lokhu kwandisa ubukhulu be-nephrotoxicity lapho usebenzisa i-cyclosporine.

Uma ngasikhathi sinye nomuthi wokulwelwa ubhekwe phansi, ama-NSAID asetshenziswa, amathuba okuxhuga ayanda. Ukwehla kwezinga le-phenytoin egazini kuyaphawuleka, kepha ukuqina kwe-tizanidine kuyanda.

Ama-Analog

Izidakamizwa ezejwayelekile ezingasetshenziswa ukuthatha indawo ye-ciprofloxacin:

• UCyprolet;
• I-Cypromed;
• I-Ciprinol;
• Idijithali;
• I-Levofloxacin nezinye izidakamizwa zeqembu le-fluoroquinolone (isizukulwane sesithathu).

Ukuthandwa kweCoprofloxacin Eco, Teva no-Akos kuyaphawulwa. Izidakamizwa ezinjalo zinokwakheka okufanayo futhi nomgomo wokusebenza, uhlobo lomkhiqizo kuphela oluhlukile. Indlela yokufaka incike kumenzi.

Imibandela yekhefu lekhemisi

I-antimicrobial okukhulunywa ngayo ingathengwa kuphela ngemithi.

Malini ciprofloxacin

Intengo incike ohlotsheni lomuthi futhi ihluka kusuka kuma-ruble angama-20 kuye kwangama-90.

Izimo zokugcina zesidakamizwa i-Ciprofloxacin

Ukushisa kwekamelo okwamukelekayo - hhayi okuphakeme kuno- + 25 ° С.

Isikhathi sokuphelelwa yisikhathi

Ungasigcina isidakamizwa sinamaconsi iminyaka emi-2. Uma kwenzeka wephula ubuqotho bebhodlela, impilo yeshelufu iyancishiswa ibe yinyanga eyi-1. Isikhathi sokulondolozwa kwamathebhulethi singaba yiminyaka emi-2 neminyaka emi-5. Isikhathi sokusetshenziswa kwekhambi lokungeniswa yiminyaka emi-2 kusukela ngosuku lokukhiqizwa.

Ukubuyekezwa kodokotela neziguli mayelana ne-ciprofloxacin

U-Ilyasov A.R., oneminyaka engama-41, udokotela ohlinzayo, eYekaterinburg

Ngibeka lesi sidakamizwa kaningi, ngoba sinikezwa ngezindlela ezahlukahlukene, sisebenza kakhulu, futhi izindleko ziphansi (okubalulekile kwiziguli). Uma kunesidingo, ungawukhetha umuthi onjalo, ucabangela isimo sesiguli.

U-Eugenia, oneminyaka engama-33, Ukhozi

Umuthi ubekezelelwa kahle, angibonanga imiphumela emibi. Inkambo yokwelashwa imfushane (isonto eli-1), okubalulekile kimi, ngoba angithandi ukuphuza i-chemistry.

U-Olga, oneminyaka engama-35 ubudala, uP Pskov

Angizange ngithande iqiniso lokuthi ngemuva kwalo ngavele ngathuthuka ngokushesha. Konke kubonakala kukuhle: kuyasiza ngokulwa nezifo ezahlukahlukene, kushibhile, kukhona ukukhetha kwamafomu omthamo, kepha lokhu kudonsela phansi kukhipha indiva yonke inzuzo ye-Ciprofloxacin.