I-Aspicor yezidakamizwa: imiyalelo yokusetshenziswa

I-Aspicor antiplatelet agent yenzelwe ukusetshenziswa isikhathi eside yiziguli ezisengozini yokuqhamuka nezinkinga ze-thromboembolic.

Igama Lezwe elingafanele

NgesiLatin - Aspicor

I-Aspicor antiplatelet agent yenzelwe ukusetshenziswa isikhathi eside yiziguli ezisengozini yokuqhamuka nezinkinga ze-thromboembolic.

I-ATX

B01AC06

Khipha amafomu nokwakheka

Umuthi, umuthi osebenzayo wawo yi-acetylsalicylic acid, uyatholakala ngesimo sethebhulethi ngokuhlanganiswa okukhethekile kwe-enteric. Ithebhulethi eyi-1 iqukethe u-100 mg wento esebenzayo.

Umumo wamatafula yi-biconvex, mhlophe. Kutholakala emabhulashini izingcezu eziyi-10. 3, 9 amabhliki nemiyalo yokusetshenziswa efakwe kwiphakethe lekhadibhodi. Ama-analoggues wezidakamizwa ayatholakala ngesimo samathebulethi e-sebetsa.

Isenzo se-Pharmacological

Izici ze-antiplatelet zomuthi zinikezwa ngento eseqenjini lama-salicylates. Ekwenzeni i-enzyme cycloo oxygenase, i-acetylsalicylic acid inegalelo ekuphazamisweni kokuhlanganiswa kwezicubu zama-enzyme okuvuvukala kwe-prostaglandin. Njengomphumela wokuvezwa okunjalo, ama-platelet alahlekelwa amandla abo okuhlanganisa i-thromboxane. Ngaphandle kwale enzymme, amaseli egazi awakwazi ukuhlanganisa futhi ahlangane ne-fibrin.

Umphumela wokuvezwa ugcinwa kukho konke impilo yamaseli.
Inomphumela wokuvimbela ekwakhekeni kwe-prostacyclin ngamangqamuzana emithambo yegazi. Le enzyme ivimbela ukuhlanganiswa kwezinto ezakhiwe. Ukuvinjwa kokuqamba kwenzeka kuphela lapho kukhona into emzimbeni. Imithamo emincane yesidakamizwa ayivimbi ukwakheka kobugqila.

Ekwenzeni i-enzyme cycloo oxygenase, i-acetylsalicylic acid inegalelo ekuphazamisweni kokuhlanganiswa kwezicubu zama-enzyme okuvuvukala kwe-prostaglandin. Njengomphumela wokuvezwa okunjalo, ama-platelet alahlekelwa amandla abo okuhlanganisa i-thromboxane.

Ukusebenza kwamakhambi aphansi kufakazelwe. Lokhu kwenza ukuthi sikwazi ukusebenzisa umuthi wokwelapha ngezinhloso ze-prophylactic. Akuzithinti izingqimba zegazi ezakhekile, kepha zivimbela ukwakheka kwazo.
Ukushintsha ukwakheka kwe-fibrin, kukhulula i-plasminogen, kukhuthaza ukwenziwa kwe-fibrinolysis.

I-Pharmacokinetics

Kucasulwe ukuphathwa ngomlomo. Yakhelwe ukufakwa emathunjini amancane. Kufika kuma-90% kungenxa yamaprotheni. Kuthatha cishe amahora angama-3 ukufinyelela okuhlushwa phezulu.

Njengomphumela we-hydrolysis, kwakhiwa ama-anions e-salicylic acid, asatshalaliswa ngokukhululekile emzimbeni. Ibhekana nokushayeka kokuqina kwenhliziyo. Ixakwe kakhulu endaweni ene-asidi.

Kucasulwe ukuphathwa ngomlomo.

Ngodonga lwemithambo yegazi kuphela ama-molecule e-acid angena ngaphakathi kwezicubu, amandla athile adonsela phansi akhuphuka endaweni ene-asidi. Ukusetshenziswa kwomuthi esimweni se-acidosis kuyingozi ngenxa yokuba khona kwezinto eziyingozi zokuphuza ngisho nasemithanjeni yokwelapha.

Kuba ngaphansi kwe-metabolism, kwakheka izinhlanganisela ezibhangqiwe nge-glycine, i-glucuronic acid. Kuyakhishwa emchameni. Ama-rebu tubules asebenzisa cishe ama-60% wezithako ezisebenzayo nama-metabolites. Ukuqedwa kwesigamu sempilo kuya ngesilinganiso esamukelwe, i-acidity yaphakathi.

Okunqunyelwe

Umuthi uyatholakala kumthamo, ubalwa ngenxa yokuphatha isikhathi eside. Kuvimbela ukwakheka kwezihibe zegazi uma kwenzeka:

• i-infarction ye-myocardial eyingozi kakhulu;
• i-vascular pathology ye-circbral circulal;
• i-angina pectoris engazinzi.

Kuvimbela ukwakheka kwezigaba zegazi uma kune-angina engazinzile.

Yabela iziguli ezisengozini yokuhlaselwa i-pulmonary embolism, i-acute coronary thrombosis. Ukusetshenziswa kwesidakamizwa kunesizathu esimweni se:

• umfutho wegazi ophakeme
• isifo sikashukela mellitus;
• isifo sokuqina kwemithambo yegazi, i-hyperlipidemia;
• ukukhuluphala
• ukungasebenzi kahle isikhathi eside;
• izimo ngemuva kokuhlinzwa kwemithambo.

Ukusetshenziswa kwesidakamizwa kunesizathu uma sikhuluphele.

Kubekelwe ukuvikela ukuthuthukiswa kokuhlaselwa yinhliziyo okuphindaphindiwe, ukuhlaselwa kwe-ischemic kwesikhashana, i-thrombosis yemikhumbi esemqoka.

Contraindication

Ngenxa yobuntu besenzo se-pharmacological somuthi, ukusetshenziswa kwawo kukhawulelwe uma:

• izilonda zesistimu yokugaya;
• ukopha
• onqobayo beFerian-Vidal;
• ukuvela komzimba wemithi yeqembu le-salicylate;
• i-asthma ye-bronchial, ecasulwa ukusetshenziswa kwezidakamizwa ezingezona ze-steroidal;
• ukukhulelwa
• ukwelashwa kwe-methotrexate.

Umuthi uphulwa phakathi nesikhathi sokukhulelwa.

Ukuphuza umuthi akunqunyelwe uma kuvela ukubonakala kokungezwani komzimba.

Ukusetshenziswa kwesidakamizwa kukhawulelwe ku-asthma ye-bronchial.

Akukwazi ukusetshenziswa ukuphatha izingane nentsha.

Ngokunakekela

Ukunaka okwandisiwe lapho kunqunywa umuthi kudinga:

• isifo esithinta amaphaphu;
• i-polyposis yakhala, umkhuhlane we-hay;
• izifo zesisu nge-acidity eyandayo;
• ukungasebenzi kahle kwesibindi nezinso;
• izifo zegazi;
• ukusetshenziswa kwe-methotrexate;
• izinhlobo zokwelashwa ezihlangene;
• gout, hyperuricemia.

Ukunaka okwengeziwe lapho unquma umuthi kudinga isifo sesisu esine-acidity ephezulu.

Ukwelashwa kudinga ukunakwa uma iziguli zinezifo ezihlangene, isidingo seminye imithi.

Ungayithatha kanjani i-Aspicore

Amathebulethi kufanele aphathwe ephelele, gezwa ngamanzi amaningi. Thatha ngasikhathi sinye ngaphambi kokudla. Umthamo nesikhathi sokulashwa kufanele sinqunywe ngudokotela.

Ukuvimbela i-thrombosis, umuthi unqunywe kusuka ku-100 kuye kuma-300 mg ngosuku. Ekuhlaselweni okukhulu kobuhlungu besifuba, kuyalulekwa ukuhlafuna ithebhulethi yokuqala.

Ngoshukela

Ukuphathwa okuhlanganayo kwe-Aspicore ne-hypoglycemic izidakamizwa kudala ukwanda komphumela wokugcina. Usongo lwe-hypoglycemia lwakhiwe. Isidingo sokulawula ushukela wegazi, umsebenzi wezinso, ukudla kuyadingeka,

Imiphumela emibi ye-Aspicore

Ukusabela okungathandeki okwenzeka lapho usebenzisa umuthi kuboniswa kaningi ngu:

• isikhumba
• umgudu wokugaya ukudla;
• uhlelo lwezinzwa oluphakathi;
• izitho ezakha igazi.

Ukuphendula okungathandeki okwenzeka lapho usebenzisa umuthi kuvame ukubonakaliswa izitho ze-hematopoietic.

Ukuthuthukiswa kwemiphumela emibi kungenxa yethonya lezinto ezisebenzayo kuma-receptors ezikhungweni zobuchopho, ukudalwa kokugxila okuphezulu kwama-salicylates eplasma yegazi.

Amapheshana wesisu

Njengawo wonke ama-salicylates, inamandla okubangela izimpawu ze-dyspeptic. Izithasiselo, ezifaka i-oxygenase inhibitors, azinconywa ukusetshenziswa ngokuhlanganyela. Le nhlanganisela inyusa ingozi yokuvezwa kwe-ulcerogenic. Imiphumela emibi yesidakamizwa ifaka phakathi ukuthuthukiswa kokopha kwe-gastrointestinal.

Izitho zeHematopoietic

I-Thrombocytopenia kungenzeka. Ngokushoda kwe-phosphate dehydrogenase kubangela i-hemolytic anemia.

I-Thrombocytopenia kungenzeka. Ngokushoda kwe-phosphate dehydrogenase kubangela i-hemolytic anemia.

Isistimu yezinzwa ephakathi

Ukuqongelelwa kwento esebenzayo ezicutshini zobuchopho kubonakaliswa ngumsindo wesici ezindlebeni, isiyezi. I-Aspicore metabolites ibangela i-tinnitus yesikhashana lapho ichaza imithamo emikhulu.

Kusuka ohlelweni lokuphefumula

Imiphumela emibi evela ohlelweni lokuphefumula ibonakaliswa ukukhula kwe-bronchospasm, dyspnea ephumayo. Ukuphendula okunjalo kwenza kube nzima ukusebenzisa umuthi ngezinhloso zawo ezihlosiwe.

Imiphumela emibi evela ohlelweni lokuphefumula ibonakaliswa ukukhula kwe-bronchospasm, dyspnea ephumayo.

Allergies

Ukwemukela kungadala ukuvela kwesikhumba, i-edema kaQuincke. Ukuphendula ngokushesha akuvamile, kudinga ukunakekelwa okujulile. Ukuphendula kwe-anaphylactic ku-anamnesis yisikhathi sokuhoxiswa kwezidakamizwa.

Umthelela ekhonweni lokulawula izindlela

Lapho kukhona impendulo emibi evela ohlelweni lwezinzwa, umsebenzi odinga ukunakwa kufanele ushiywe.

Lapho kukhona impendulo emibi evela ohlelweni lwezinzwa, umsebenzi odinga ukunakwa kufanele ushiywe.

Imiyalo ekhethekile

Sebenzisa umuthi uwedwa kubuhlungu kanye ne-hyperthermia kuvunyelwe kungadluli izinsuku ezingama-3.

Amandla okubangela ukopha anciphisa ukusetshenziswa komuthi njenge-agent elwa nokuvuvukala. Ukwelashwa kwe-antiplatelet kufanele kwenziwe ngokuqapha njalo ukubalwa kwegazi. Ukuhlolwa kwezindunduma zegazi lemilingo uma kungenzeka kusetshenziswe isikhathi eside kuyaphoqelelwa.

Ukuze uqinisekise ukulahleka kwegazi okuncane ngesikhathi sokungenelela kokuhlinzwa, kufaka phakathi i-gynecology, umuthi kufanele unqatshelwe isonto ngaphambi kokuhlinzwa.

Ukusetshenziswa kwezindlela ezikhethekile zokukhishwa kwezidakamizwa kusiza ukunciphisa umphumela ocasulayo we-salicylic acid.

Sebenzisa ebudaleni

Ngobudala, i-pharmacokinetics yezidakamizwa iyashintsha:

• i-hepatic metabolism iyancipha;
• izinguquko zokusatshalaliswa kwezicubu;
• isikhathi sokususa siyanda.

Inciphiso ye-albhamu

Ukusetshenziswa kwezidakamizwa ezinobuthi obufanayo ebudaleni akwemukeleki.

Ukuba khona kwezifo ezihambelanayo ngemithi yesikhathi eside kudinga ukubhekwa njalo kwe-serum creatinine nomfutho wegazi. I-overdose iholela emiphumeleni ebulalayo. Ukusetshenziswa kwezidakamizwa ezinobuthi obufanayo ebudaleni akwemukeleki.

Isabelo sezingane

Ayisebenzi ebuntwaneni nasebusheni. Inobungozi obukhulu bezinkinga ze-hemorrhagic. Ukusetshenziswa kwe-Aspicore kudala ukukhula kwegazi, ukuvela kokuhlaselwa i-asthmatic. Awukwazi ukunikeza umuthi ngaphandle kokuqokwa udokotela.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Akucacisiwe esigabeni sokuqala sokukhulelwa. Kukhona usongo oluqondile lokwakheka kokungazalwa kahle kokuzala. Ubungozi bokunquma umuthi ku-trimester yesibili kufanele buvezwe.
Ukungena kwento esebenzayo nge-placenta kudala ukukhula kwe-hemorrhagic syndrome. Ukusetshenziswa kwezidakamizwa okukhona esikhathini esidlule kuyingozi ezimweni ezisongela impilo.

Ukusetshenziswa kwezidakamizwa okukhona esikhathini esidlule kuyingozi ezimweni ezisongela impilo.

Ukusetshenziswa okukodwa komthamo omncane wento akuyona ukungqubuzana kokuncelisa ibele. Ukwelashwa isikhathi eside kule nkathi kuhlotshaniswa nokuqedwa kokuncelisa ibele.

Isicelo sokusebenza kokulimala kwezinso

Ukunquma umuthi ezigulini ezinomsebenzi wezinwele oguquliwe, ukwehluleka kwezinso kuyinto engathandeki. Ukwehla kwe-uric acid okucasulayo kuvusa ukuhlaselwa kwe-gout ngisho nangemithamo emincane.

Sebenzisa umsebenzi wesibindi okhubazekile

Ukwephulwa kwe-hepatic metabolism kunciphisa ukuqashelwa ngu-30%, odinga ukuthathwa ngokulingana komuntu ngamunye. Nikeza umuthi wokuphazamiseka ukusebenza kwesibindi kufanele uqaphele.

Nikeza umuthi wokuphazamiseka ukusebenza kwesibindi kufanele uqaphele.

Ukweqisa kwe-Aspicore

Ubukhulu bezimpawu zobuthi buxhomeke kumthamo womuthi. Ukubonakaliswa komtholampilo kobukhulu obulinganiselwe kubonakaliswa ngu:

• isicanucanu, ukuhlanza;
• isiyezi
• ukungaboni kahle
• ukulahleka kwezindlebe, ukukhala ezindlebeni;
• ukungazi kahle.

Isibonakaliso sobuthi nomuthi singaba isiyezi.

Ukuvela kwezimpawu zobuthi kudinga ukuncishiswa ngokushesha komthamo wezidakamizwa, ukugada okuqinile kwezokwelapha.

Ubuthi obukhulu be-salicylate budinga ukulaliswa esibhedlela ngokushesha, ukunakekelwa okuphuthumayo.

Izimpawu zobuthi obunamandla zivezwa ngu:

• ketoacidosis;
• umkhuhlane;
• hyperventilation;
• i-alkalosis yokuphefumula;
• ukulahleka kwengqondo;
• ukwehla okukhulu kweglucose yegazi;
• ukuhluleka kwenhliziyo, izinhlelo zokuphefumula.

Izimpawu zobuthi obunamandla zibonisa ngokulahlekelwa ukwazi.

Iziguli zidinga ukumfakwa kwemithi ye-alkaline, hemodialysis, ukulungiswa kwe-elektrolyte ibhalansi ne-rheology yegazi. Ukwelashwa okubonakalayo kunqunyelwe njengoba kunesidingo.

Ukugcotshwa okuphezulu kwe-salicylic acid kukhombisa ubuthi obunamandla bobuthi nokulimala okungekuhle.

Ukuxhumana nezinye izidakamizwa

Ukusetshenziswa okuhlangene kwe-salicylic acid ngemithi yamaqembu ahlukene kufanele kube nesizathu. Ukuxhumana kuboniswa ngokuthuthukiswa kokuphendula okulandelayo:

• ukuqinisa noma ukwenza buthaka isenzo sokuqondiwe;
• ukuthuthukiswa kwezinkinga eziyingozi, imiphumela enobuthi.

Ngaphandle kokubonana nodokotela, akunconywa ukusebenzisa umuthi nangezinye izindlela.

Ngaphandle kokubonana nodokotela, akunconywa ukusebenzisa umuthi nangezinye izindlela.

Inhlanganisela ehlanganisiwe

Ukusetshenziswa okuhlangene nemithi elwa namagciwane kuvinjelwe. Izidakamizwa zivimba isenzo somunye nomunye, zivimbela amasosha omzimba.

Ukuphendula okungalungile kubangela ukuhlanganiswa ne-diclofenac, ibuprofen, digoxin ngenxa yokugxila kwe-plasma ephezulu.

Ukuphendula okungalungile kubangela ukuhlanganiswa ne-diclofenac.

Awukwazi ukuthatha lesi sidakamizwa ngasikhathi sinye njenge-ibuprofen ngenxa yokugxila kwe-plasma ephezulu.

Ngokuhambisana neziphuzo zotshwala kubangela umphumela ongezayo.

Ungasebenzisi ngokuhlanganiswa ne-methotrexate. Ukwelashwa isikhathi eside kusongela ukuthuthukiswa kwemiphumela enobuthi, kuvimbela uhlelo lwe-hematopoietic.

Ngokuhambisana neziphuzo zotshwala kubangela umphumela ongezayo. Usongo oluqondile lokopha, izinkinga eziningi zomzimba.

Akuhlanganisiwe ukuhlanganisa

Gwema ukusetshenziswa ngokuhlangana ne-heparin, amanye ama-anticoagulants, ama-thrombolytics ukuvikela ukopha kwesisu. Ukusetshenziswa nge-valproic acid kudinga ukuqaphela. Ukwanda komphumela omubi kuphephabhuku lesisu kanye nohlelo lwe-hematopoietic kuyabonakala.

Inhlanganisela edinga ukuqashelwa

Lapho kuthathwa ndawonye, ​​ama-corticosteroids aphansi ama-salicylates emzimbeni. Ukukhishwa kwamahomoni kuzodala izimpawu zokweqisa.

Musa ukweqa imithamo ezigulini ezithatha i-insulin, ama-hypoglycemic agents. Ingozi yokuhlakulela i-hypoglycemia idinga ukubhekwa njalo kwezokwelapha.

Ama-antacid, aqukethe i-aluminium ne-magnesium, anciphisa ukusebenza kwama-salicylates.

Ukuhambisana notshwala

Umphumela ongezekayo wotshwala nama-salicylates unomthelela ongemuhle emzimbeni, kungakhathalekile nobudala besifo.

Umphumela ongezekayo wotshwala nama-salicylates unomthelela ongemuhle emzimbeni, kungakhathalekile nobudala besifo.

Inhlanganisela eyingozi iyakhiwa, ibonakaliswa ukusabela okunzima. Ukopha kakhulu kuyenzeka, ukusebenza kwesibindi kukhubazekile, kuvela okukhulu esimisweni sezinzwa. Lokhu kwenza kungakwazi ukuthatha isidakamizwa notshwala ndawonye.

Ama-Analog

Qukethe into efanayo esebenzayo. Okuvame ukusetshenziswa:

• I-Taspir;
• I-CardiASK;
• I-Thromboass;
• Acecardol;

I-Thrombo ACC iyi-analogue ye-aspiric.

Phakathi kokufana kwamanye amazwe, bavame ukusebenzisa iTrombogard 100, iTrombopol, i-Upsarin UPSA. Ukuzikhethela komuthi kufanele kwenziwe ngudokotela.

Imibandela yekhefu lekhemisi

Ngingakwazi ukuthenga ngaphandle kadokotela

Iyatholakala ngokuthengiswa kwamahhala.

Intengo ye-Aspicore

Amaphakethe wamathebulethi angama-30 ayatholakala kuma-ruble angama-63 Kwiphakheji equkethe amaphilisi angama-90, intengo ivela kuma-ruble ayi-105.

Izimo zokugcina zomuthi

Gcina endaweni evikelwe ukukhanya nomswakama. Ukushisa kwesitoreji kungaphakeme kune- + 25̊ С. Gcina kude nezingane.

Isikhathi sokuphelelwa yisikhathi

Impilo yeshelf - kuze kube yiminyaka emi-2. Kuboniswa kwiphakheji. Ungasebenzisi ngemuva kosuku olubekiwe.

Umkhiqizi

IVertex CJSC, eRussia.

Ukubuyekezwa mayelana ne-Aspicore

U-Inna, oneminyaka engama-56, uBelgorod

Kwakunezinkinga zenhliziyo, kwanda ingcindezi. Wathatha lo muthi ngokweseluleko sikadokotela wezenhliziyo amasonto amabili. Umuthi utholakala ngokukhululeka, intengo yanele. Ngizizwa ngingcono.

UNatyaya, oneminyaka engama-27, Kharkov

Umyeni wami unesifo sikashukela. Udokotela ubeke amaphilisi emgodleni ozivikela. Ukuvikela, umthamo ulula, kuthatha ama-200 mg ngosuku. Akukho ukusabela okungekuhle. Isimo siyenelisa.

U-Alina, oneminyaka engama-40, eRussia

Umuthi uyasiza ngesikhumba esinenkinga. Ngenhloso yokuhlanzeka kwesikhumba sobuso, ngenza imaski, okuyingxenye yayo. Ikuvumela ukuthi ulondoloze isikhumba sisesimweni esihle.