ICocaarboxylase iyi-estamine ye-thiamine phosphate. Inezihlanganisi eziningi, isibonelo: Kotiamin, Berolase, njll. Vitamin B, engena emzimbeni wesiguli, iphosphorylated ibe yi-coenzyme enomphumela wokwelapha.
Igama
NgesiLatini, isidakamizwa sinamagama amaningana: Cocarboxylasum, B-Neuran, Cocarbosyl, Cocarboxylase.
I-ATX
Isimilo se-anatomical nesokwelapha sifanelana nekhodi A11DA01.
Khipha amafomu nokwakheka
Umuthi ukhiqizwa ngezinhlobo eziningana:
- i-powder yokulungiselela isixazululo (i-ampoules eyi-0.05 g, i-2 ml solvent);
- i-lyophilisate yomjovo we-i / m;
- into eyomile yokuphathwa kwe-intravenous (ampoules ka-0,025 no-0,005 g, i-solvent ye-2 ml).
Kunama-ampoules ayi-10 kwiphakethe.
Umuthi uthinta kahle isimo sesiguli esiye saphethwe yi-myocardial infaration.
Isenzo se-Pharmacological
Umuthi wenza kusebenze ukwakheka kwama-nucleotide, kuthinta izinqubo ze-metabolic emzimbeni, kuthuthukisa ukuhamba kwegazi emithanjeni ye-coronary. Kuyasiza ukwehlisa i-cholesterol egazini, kunciphisa ingozi yokuthola isifo sokuqina kwezinzwa nesifo senhliziyo.
I-Pharmacokinetics
Isisekelo somuthi yinto esetshenziswayo ngesimo se-porous, mass eyomile enephunga elintekenteke. I-Lyophilisate inyibilika kalula emanzini. ICoenzyme thiamine ikhangiswe emgodini wokugaya ukudla.
Okubaluleke kakhulu inqubo yokudla izidakamizwa esibindini. Uma usezinso, umuthi ukhishwa emchameni ngenani elincane. Umuthi uyiqembu le-Vitamin B, uthinta ukulinganisela kwamandla ku-myocardium, uvikela izinso ku-ischemia ngesikhathi sokuhlinzwa. Ukushoda kweCoenzyme kudala i-acidosis.
Okunqunyelwe
Umuthi uthinta kahle isimo sesiguli esibe ne-myocardial infaration, sinciphise i-acidosis, futhi sibuyisele i-homeostasis. Ezigulini ezithola umuthi, ukubonakaliswa kokuhluleka kwenhliziyo kuyancishiswa, ukubekezelela umsebenzi womzimba kuyanda.
Isiguli esibi kakhulu asinconywa ukuthi siphuze umuthi emathebhulethi.
Ukwelashwa kwezifo zenhliziyo ezi-coronary, isiguli sinqunywe i-metabolite ye-vithamini B1, kepha ukubola kwayo kwenzeka emizuzwini embalwa ngemuva komjovo.
Phakathi kwezinkomba zokunqunywa kwemithi, lezi zimo ezilandelayo ziyahlukaniswa:
- isifo sikashukela mellitus;
- ukwehluleka kokuphefumula okungamahlalakhona;
- kubani;
- arrhythmia;
- i-sclerosis eminingi;
- i-neuritis;
- i-eclampsia;
- sepsis
- i-acidosis ezinganeni ezisanda kuzalwa;
- ukuphazamiseka kwe-endocrine.
Umuthi lo usetshenziswa njenge-antioxidant ukwelapha iziguli ngesikhathi sokuqala kwe-ischemic stroke.
Umuthi ubamba iqhaza kulezi zinqubo ezilandelayo:
- ikhuthaza ukuguqulwa kwe-lactic acid ibe yichemicals yamakhemikhali ye-pyruvic;
- ubamba iqhaza ekuphenduleni kwe-decarboxylation;
- kuqeda i-metabolic acidosis.
Umuthi ukhonjiswa ezigulini ezinesifo sikashukela i-mellitus, ngoba umuthi ubuyisela i-carbohydrate metabolism, wehlise ukuwohloka kwamafutha, futhi usebenze ukugcinwa kwe-bile.
I-Coenzyme thiamine inomphumela we-antioxidant.
Contraindication
Imiyalo yokusebenzisa umuthi ayikuvumeli ukusetshenziswa kwayo uma kwenzeka kungabekezelelani. Ukwelashwa kwe-Metabolic akunconyelwe iziguli ezinokuqina kwe-angina pectoris.
Ukusetshenziswa kwomuthi kungadala ukungezwani komzimba.
I-postinfarction cardiossteosis iphathwa ngezidakamizwa zenhliziyo, kanye ne-coenzyme thiamine, i-ATP, uRiboxin akazange abhekane nokuhlolwa kwesikhathi. Ngokuphikisana nesizinda sokwelashwa okujwayelekile, ukuqokwa kwesidakamizwa akuholeli ekwandeni kokuvivinya umzimba.
Ngemuva kokusebenzisa i-coenzyme thiamine, isiguli sivame ukukhula:
- ukungahambi kahle komzimba;
- dyspepsia
- ukuvuka.
Ngohlobo 2 lwesifo sikashukela, i-cardiac autonomic neuropathy iyenzeka. Ukusetshenziswa kwezithako zamavithamini kwezinye iziguli kuholela ekwandeni kwesimo, futhi izinkomba zokuphinda zisebenze kwesistimu yethambo yengqondo ijwayele ukuhamba kancane.
Akunconyelwe ukuphatha lo muthi ezigulini ezisesimweni se-hepatic coma uma isiguli sike saba nokungezwani komzimba ngaphambili. Kulesi sifo sesibindi, umuthi ubekelwe ukuvikela i-glycemia nanjengesondlo sabazali abane-5% glucose solution.
Iziguli ezine-pathology engalapheki yohlelo lwe-hepatobiliary and allergies azidingi ukuthatha umuthi, ngoba imiphumela engeke iguqulwe emzimbeni iba lapho ingekho ukunakekelwa okukhulu.
Ukulungiselela isisombululo esinqunyelwe i-intramuscularly, okuqukethwe i-ampoule eyi-1 kuyoncibilika kumamililitha amaningi amanzi wokujova.
Ukuzalela
Ukulungiselela isisombululo esinqunyelwe i-intramuscularly, okuqukethwe i-ampoule eyi-1 kuyoncibilika kumamililitha amaningi amanzi wokujova. Ukulawulwa kokudonsa, kusetshenziswa i-solvent ekhethekile - isisombululo se-0.9% sodium chloride. Kwezinye izimo, kusetshenziswa isisombululo se-dextrose.
I-ampoule ejwayelekile iqukethe 2 ml wamanzi wokujova. Ngomjovo we-jet, i-10-20 ml yesixazululo yanele, ngoba ukumiliselwa kwe-intravenous okwenziwa nge-Drip, kusetshenziswa ama-200-400 ml. I-powder yokulungiswa kwekhambi ihlinzekwa iphelele ngama-ampoules aqukethe i-sodium acetate. Iphakethe elilodwa lifaka amasethi ama-3, ngalinye liqukethe ama-ampoules we-0,05 g no-2 ml.
Ungayithatha kanjani
Umuthi uphathwa nge-intramuscularly, kwesinye isikhathi ngaphansi kwesikhumba noma kufakwe kulabo abawela phansi. Esikhathini sikashukela, umthamo wokwelapha u-0.1-1.0 g ngosuku. Inani lempahla elungiselelwe abantu abadala isuka ku-50 mg iye ku-1 g kanye ngosuku. Ukwelashwa kwezifundo kuthatha izinsuku ezi-15 kuye kwezingama-30.
Esifo sesibindi, umuthi ubekelwe ukuvikela i-glycemia.
Okwezingane
Imijovo yezidakamizwa ebekwe udokotela ukuvusa izivikeli mzimba ezigulini ezinamathela emithonjeni yemidiya ifakwa ekwelashweni eliyinkimbinkimbi ngasikhathi sinye nokwelashwa kwe-physiotherapy kanye ne-mechanotherapy. Umuthi lo uphathwa ngokuhlinzekile ngemithamo ye-50-100 mg ngosuku.
Ukwelashwa kwesifo se-hemolytic zezinsana, amavithamini E, B1, B2, B6, i-thiamine phosphate ester asetshenziswa, athuthukisa ukusebenza kwamapheshana we-biliary kanye nezinqubo ze-metabolic. Ukwelashwa kwe-cirrhosis ezinganeni kufaka phakathi ukuqokwa kwezifundo eziningana zekhambi le-vitamin.
Ukuvuselela ukuvikela umzimba, izidakamizwa ezilandelayo zidluliselwa enganeni:
- Umzila;
- i-riboflavin;
- i-folic acid.
Ukwelapha i-nephritis engokwemvelo enganeni, umuthi unqunywe ku-intramuscularly. Umuthi usetshenziselwa ukwelashwa okwenziwa ngezikhathi ezithile kabili ngonyaka. Ngokuthuthukiswa kokutheleleka nge-meningococcal, i-thiamine coenzyme iphathwe kahle ngaphakathi.
Iziguli ezine-allergies akufanele zivunyelwe ukujova ikhambi ukugwema ukucasuka nokuxhuma.
Kwabadala
Ngokumisela, i-100-150 mg yesidakamizwa isetshenziswa amahlandla ama-3 ngosuku. Ekwehlulekeni kwesibindi okukhulu, i-lyophilisate iphathwa ngokudonsa ngendlela eyi-5% isixazululo se-dextrose. Inani eliphelele lomuthi wezidakamizwa akufanele lidlule i-150 mg / ngosuku.
Ukusetshenziswa kwe-cocarboxylase yezidakamizwa ye-peripheral neuritis kwiziguli esezikhulile kubandakanya ukuphathwa kwemishanguzo yomuthi umthamo we-100 mg ngosuku izinsuku ezingama-30.
Ekwelapheni ukukhubazeka komzimba komndeni kwe-Strumpel, kusetshenziswa amaphilisi e-coenzyme anomthelela ojwayelekile wokuhlanganisa ukuphathwa kwawo ne-ATP, Cerebrolysin ne-Aminalon.
Kuboniswa amaphilisi we-Thiamine phosphorus ester, amaphilisi wePanangin ne-Anaprilin ngokwephula izinqubo ezihambisana nokugula kwenhliziyo. Ukwelashwa kwe-hypovitaminosis emgodleni womlomo, kusetshenziswa ama-ampoules ama-vithamini aqukethe u-0,05 g wesithako esisebenzayo.
Umuthi uphathwa nge-intramuscularly, kwesinye isikhathi ngaphansi kwesikhumba noma kufakwe kulabo abawela phansi.
Imiphumela emibi
Umkhiqizo we-Vitamin onikezwe isiguli njengomjovo ungadala imiphumela emibi:
- ubomvu kwesikhumba endaweni yomjovo;
- ukuvuvukala
- ukulunywa
- izinhlungu
Ngaphambi kokusebenzisa umuthi ukwelashwa kwesimo esiyingozi njenge-metabolic acidosis, udokotela uthola lokho esigulini uma egula ngesifo somoya (i-asthma) noma i-atopic dermatitis.
Isiguli esiphethwe yi-allergies asinconywa ukuthi siphuze umuthi ezibhebheni; ukujova kwesisombululo akufanele kuvunyelwe ukugwema ukubonakala kokucasuka kanye nokuqhuma.
Allergies
Isiguli singaba nemivimbo eminingi esikhumbeni:
- amaqhubu;
- ama-buble agcwele okuqukethwe okusobala.
Imvamisa isiguli sikhononda ngamabala amancane abomvu. Ngokuqhubeka kwesifo isikhathi eside, inqubo yokuvuvukala imboza izindawo ezinkulu zesikhumba. Imishayo ye-allergic ihambisana nokulunywa kanzima.
Imishayo ye-allergic eyenzeka ngenkathi uthatha umuthi ihambisana nokulunywa kanzima.
Uma wenqaba imijovo yesidakamizwa, ukululama ngokuphelele kungenzeka. Ukungezwani komgogodla kuthuthukisa izimpawu zokungezwani ezenzeka ngemuva kokuphathwa komuthi. Ezinganeni, ubomvu busakazekela ezindaweni ezinkulu zesikhumba.
Imiyalo ekhethekile
Kumele kukhunjulwe ukuthi i-cofactor dehydrogenase ithinta isenzo se-glycosides ye-cardiac. Umuthi unomthelela ekubekezelelekeni okungcono kwe-Digoxin, Strofantin, Korglikon, i-normal metabolism metabolism ku-myocardium. Akuvumelekile ukuyihlanganisa nemithi equkethe i-paracetamol.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukuvimbela i-toxicosis ne-metabolic acidosis ku-trimester yokuqala, owesifazane unqunywa i-cofactor ye-dehydrogenase, ebandakanyeka ekwakhiweni kwama-nucleic acid, acetylcholine, ne-nucleotides.
I-overdose yomuthi we-vithamini iyingozi kowesifazane okhulelwe.
Ukusekelwa kwe-Metabolic kwehlisa amathuba okuzalwa ngaphambi kwesikhathi kanye nokuzalwa komntwana osanda kuzalwa anesisindo esiphansi. Umuthi uvimbela izinkinga zokubelethisa:
- preeclampia;
- ukubuyiselwa kokukhula kwengane;
- ukuthathwa kwangaphambi kwesikhathi kwe-placenta.
Ukuthatha umuthi wesifo sikashukela
Ukwelashwa kweMetabolic kwenzelwa isifo sikashukela se-polyneuropathy.
I-Kokarnit yezidakamizwa, ngaphezu kwe-cocarboxylase, iqukethe i-cyanocobalamin ne-nicotinamide ekwakhiweni kwayo.
Isiguli sinqunyelwe ukwelashwa umuthi i-Kokarnit, oqukethe 1 i-ampoule lezinto ezilandelayo:
- i-disodium triphosphadenine trihydrate - 10 mg;
- cyanocobalamin - 0.5 mg,
- nicotinamide - 20 mg.
I-Thiamine phosphate ester inciphisa okuqukethwe kwe-lactic ne-pyruvic acid emzimbeni, ithuthukise umsoco wezicubu zezinzwa.
Ukweqisa
Ezigulini esezikhulile, umuthi unqunywe kumthamo ophansi. I-dropper enomuthi onokuphumula kombhede isikhathi eside uvame ukuba nomphumela ongemuhle wokwelapha.
Kubantu asebekhulile, ukusabela okunzima okubucayi kubonakalisa ngesimo sokuphazamiseka kwengqondo, izinkinga zekhehla, ukufupheka komoya, umuzwa wokuntuleka komoya, i-tachycardia. Kwesinye isikhathi isiguli sikhononda ngokubonakala kwezimpawu ezinjengokuthi:
- ukukhathala
- Isiyezi
- tinnitus;
- ukuvuka.
Kwabakhulile, ukusabela okunzima kokubi kubonakalisa ngesimo se-tachycardia nezinye izifo.
Kuyadingeka ukucabanga ngezici zomzimba wesiguli ukuvikela umuthi owedlula lowo muthi. I-ejenti ye-metabolic kumithamo emincane ilungisa ukuphazamiseka kwe-neuropsychiatric.
Ukuxhumana nezinye izidakamizwa
Umuthi uthuthukisa umphumela wezidakamizwa ezisetshenziselwa ukwelapha ukwehluleka kwenhliziyo okungamahlalakhona. I-Digoxin ngokuhambisana ne-coenzyme thiamine inciphisa ukumuncwa kwento esebenzayo nama-metabolites ayo.
Musa ukunikeza umuthi ngasikhathi sinye nezixazululo ezinokusabela kwe-alkali noma ukungathathi hlangothi. Ama-antidepressants ahambisana ne-vithamini akhulisa umphumela wawo, okungaholela kalula ekuqotheni ngokweqile nasekuthuthukisweni kwemiphumela emibi engafuneki.
Nge-obstetric peritonitis esikhathini sokuzala, ama-glycosides e-cardiac asetshenziselwa ukwenza ngokwejwayelekile i-hemodynamics. Umuthi uthuthukisa isenzo sabo, ungabekwa ngasikhathi sinye neTrental.
Umuthi uthinta kabi ukusetshenziswa kwezindlela zokuvimbela inzalo.
Ama-antidepressants ahambisana neC Cocarboxylase akhuphula ukusebenza kwawo, okungaholela ekwandiseni ngokweqile nasekuthuthukisweni kwemiphumela emibi engathandeki.
Umuthi awunawo umthelela omubi emiphumeleni ye-pharmacological yezidakamizwa ezinjengokuthi:
- I-Kanamycin;
- I-Glutamic acid;
- I-Prednisone;
- Okubalulekile;
- I-Lactulose
Babekelwe ukwelashwa i-hepatic coma. I-Thiamine diphosphate ingathathwa nge-riboflavin, i-nicotinic acid, i-pyridoxine hydrochloride, i-Riboxin, i-vitamin C. Umuthi uqinisa umphumela weKorglikon ekwelapheni ubuthi nge-tranquilizer.
Abenzi
Umuthi ukhiqizwa yizinkampani eziningana:
- Lelfa S.A. EPoland
- I-NPO Microgen Russia, Moskhimpharmpreparaty im. N.A. Semashko.
I-analogue yesidakamizwa isidakamizwa iMilgamma.
Ama-Analog
Umuthi wanamuhla unikeza izidakamizwa ezifanayo ezinkombeni nasezenzakalweni ze-pharmacological:
- Neurorubin;
- Magne Express;
- Milgma
- I-Tsinsil-T;
- Laetrile B17;
- Demoton;
- UZimani;
- I-Neuromax;
- I-Neurobeks.
I-Riboxin iqukethe izinto eziguqula ukuphefumula kwamaselula. Umuthi unomphumela olandelayo:
- umzimba
- antiarrhythmic;
- kwandisa ukushaya kwenhliziyo
I-Mexicoidol, etholakala ngesimo se-ampoules kanye namathebulethi, yehlisa ukugcwala kwama-lipid ezithweni zezicubu kanye noketshezi lomzimba. Umuthi unomphumela we-antioxidant, uqinisa amaseli egazi abomvu namapulatelethi ngesikhathi se-hemolysis, futhi wehlise i-endo native kudakwa.
Imibandela yekhefu lekhemisi
Umuthi uyathengiswa kuwo wonke amakhemisi. Ukuyithenga, kufanele ukhombise usokhemisi umuthi kadokotela.
Intengo ye-Cocarboxylase
Intengo ethandwayo ihambelana nekhwalithi ephezulu. Umuthi ungathengwa ngama-ruble ayi-123, kepha izindleko zomuthi emakhemisi ehlukene zingahluka.
Izimo zokugcina izidakamizwa i-Cocarboxylase
Umuthi ugcina zonke izinto zokwelapha, ngokuya ngemithetho ebekiwe yokugcina - amazinga okushisa angedluli ku + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Ngenxa yokufakwa okhethekile, umuthi ugcinwa iminyaka emi-3. Gcina ungatholakali ezinganeni.
Akuvumelekile ukuhlanganisa umuthi nemithi equkethe i-paracetamol.
Ukubuyekezwa ku-Cocarboxylase
Ochwepheshe babelana ngemibono yabo mayelana nomuthi, ngoba uvame ukubekelwa ekwelapheni i-peritisheritisitis kanye nemivimbo. Odokotela banentshisekelo yocwaningo lwezokwelapha nobufakazi. Imibono yabathengi imi kanjena:
Odokotela
URodion, udokotela wezokwelapha, uNovgorod: "Ngikubheka njengento engenamsebenzi ukwelashwa, hhayi nje ukugwazwa. Kwesinye isikhathi ngiyikhipha njengomuthi wezokwelapha. Emisebenzini yakamuva yemithi esekwe ebufakazini, isidakamizwa sibekwe ohlwini olukhethekile njengesidakamizwa esisebenza ngempumelelo engavunyelwe."
U-Lyudmila, udokotela wezifo zamathambo, uVologda: "Umuthi ubekelwe iziguli ezinomdlavuza noma i-hepatitis yotshwala. Iziguli azizizwa zisetshenziswa ngokuthile, kepha imijovo ibuhlungu. Ukwelashwa nge-coenzyme thiamine kufanelekile nge-acidosis noma ikoma."
Iziguli
U-Alexandra, oneminyaka engama-22, uSevastopol: "Ngesikhathi sokukhulelwa, bafaka i-dropper ene-vitamin, Tivortin ne-Actovegin. I-fetus yalimala, intombazane yashoda ngo-20% wesikhumba sayo (uhlobo lokushiswa kwebanga lesi-3). Ngikholwa ukuthi lesi kwakuyisifo sikaStevens-Johnson. Angiboni inzuzo. kusuka ekusebenziseni umuthi. "
UGrigory, oneminyaka engama-38 ubudala, u-Arkhangelsk: "Indodana yami yahlaselwa isicanucanu, i-acetone emchameni. Ukuqothuka kwengane kumile ngemuva kokuphathwa kokhakhayi okungu-150 mg kokulungiswa kwe-vithamini. Ngenxa yezifundo eziningi zokwelashwa, i-acetone yomchamo yanyamalala."
