Ithebhulethi ye-rosuvastatin ye-cholesterol: imiyalo yokusebenzisa

I-Rosuvastatin isidakamizwa esenza ukuthi i-lipid metabolism, okuyiqembu lama-statins. Isebenza kumgomo wokuphikisana nokuncintisana - ama-statin abopha engxenyeni ye-coenzyme receptor enamathela kwi-enzyme. Ingxenye yesibili ibandakanyeka ekuguqukeni kwento eyisisekelo ibe yi-mevalonate, okuyi-Mediumediate synthesis ku-cholesterol. Ukuvinjwa komsebenzi wezinto ezithile kuholela ezinqubweni ezithile, umphumela wazo ukuthi ngaphakathi kwamangqamuzana izinga le-cholesterol liyancipha. Ngemuva kokusabela okunjalo, umsebenzi wama-lipoproteins aphansi kakhulu uyanda, i-cholesterol catabolism ijwayelekile.

Umphumela wokunciphisa izinga le-cholesterol ephelele itholakala ngokusebenza kwe-lipoprotein esezingeni eliphansi, futhi lo mphumela, utholakala ngenxa yomthamo onqunywe ngokufanele womuthi ongenhla. Ukuthuthuka kubangelwa ukwanda kosayizi wento esetshenzisiwe. Ukubuyekezwa okuhle okwedlula okukodwa kukhuluma ngesenzo sakhe esihle.

Izimo zithinta amazinga e-triglyceride ngokungaqondile ngokunciphisa inani le-cholesterol. Futhi, umuthi uthinta ukuvimbela ukwakheka kokuqala kwe-atherossteosis. Ngokubamba iqhaza kwakhe, i-prophylaxis iyenziwa, ethuthukisa ukukhipha amathoni emithanjeni yemithambo yegazi, futhi ithuthukise nezindawo zegazi.

Ngemuva kokuqala kokwelashwa, umphumela uyabonakala ngemuva kwezinsuku eziyisikhombisa, futhi ngemuva kwamasonto ambalwa umphumela ufinyelela isilinganiso sawo. Ngemuva kwenyanga yokwelashwa, i -apogee yesenzo iqala ukusebenza, bese iqhubeka njalo. Inani elikhulu lezinto ezisegazini nezicubu zingabhekwa ngemuva kwamahora angama-5 okusebenza emzimbeni. Iqongelela esibindini, ngemuva kwalokho isuka nokugcwala. Cishe i-10% ayibonisiwe.

Isithako esiyinhloko somuthi yi-rosuvavstatin.

Njengezinto ezengeziwe, ukwakheka kwalo muthi kufaka phakathi:

• i-hypromellose;
• isitashi;
• titanium dioxide;
• udayi we-carmine;
• i-microcrystalline cellulose;
• i-colloidal silicon dioxide;
• unxantin;
• i-magnesium stearate.

Intengo yesidakamizwa eRussia isuka kuma-ruble angama-330 ngephakeji ngalinye. Ungayithenga kunoma iyiphi ikhemisi lekhemisi, emadolobheni amaningi, kodwa ngomuthi kuphela. Amathebhulethi angagcinwa iminyaka engu-2 kusukela ngosuku lokukhishwa. Gcina endaweni eyomile ingenakufinyeleleka ezinganeni.

Ukudliwa kwamathebhulethi e-rosuvastatin kufanele kususelwe ngokuqinile kwizincomo zokwelashwa.

Kufanele zinikezwe uchwepheshe ojwayele umlando kanye nempilo ejwayelekile yeziguli.

Ngakho-ke, kubalulekile ukuthi uvakashele udokotela wakho.

Izinkomba zifaka:

1. Isimo se-cholesterol ephezulu ephezulu ebizwa nge-hypercholesterolemia eyisisekelo.
2. Izindlela zokuvimbela ukumelana nokwakhiwa kwe-atherosclerosis kanye nezinkinga zayo. Lokhu kufaka phakathi ukushaya kwenhliziyo, unhlangothi, i-angina pectoris, isifo senhliziyo. Esikhathini esiningi, laba ngabantu besigaba seminyaka engu-50+.
3. I-Hypertriglyceridemia - inani elikhulayo lama-triglycerides (amafutha wamahhala) egazini.
4. I-Hereditary (yomndeni) i-homozygous hypercholesterolemia.
5. Isifo senhliziyo esibangelwa i-cholesterol ephezulu. Kulokhu, isetshenziswa ngokuhlanganiswa nezinye izindlela.

Kwezinye izimo, umuthi unomphumela olinganiselayo, njengoba uthathwa ngokuhambisana nezinye izidakamizwa. Umphumela omuhle oqondile ubonwa kushukela; ukukhuluphala; hyperchilomicronemia.

Kwesinye isikhathi isetshenziswa njengesengezo ekudleni esilwa ne-atherosulinosis.

Kukhona okungaphezu kokukodwa kokukhwabanisa emthini, kunezinkomba ezingaphezu kokukodwa. Lokhu kungenxa yezici ezithile zesenzo sezingxenye ezisebenzayo. Onke ama-pathologies anganqunywa kuphela ngudokotela, ngakho-ke ukuzelapha kungalimaza isimo sempilo.

Odokotela babhekisa kuma-contraindication ngokuphelele:

• Iminyaka engu-18.
• Ukungabekezelelani komuntu ngamunye kwizakhi.
• Isikhathi sokuzala nengane.
• Abesifazane beminyaka yokuzala izingane abangazisebenzisi izindlela zokuvimbela inzalo ezinokwethenjelwa, okwandisa amathuba okukhulelwa ngesikhathi sokulashwa kwezidakamizwa.
• Ama-pathologies wesibindi okwenzeka ngendlela ebukhali futhi ehambisana nokungasebenzi kahle kwesitho, ngendlela yomonakalo kuma-hepatocytes kanye nokwanda kwama-hepatic transaminases egazini.
• Ukusetshenziswa okufanayo kwe-cyclosporine.
• Isifo se-Myopathy, noma ukuthambekela kwendabuko kukho.

Umuthi ongu-40 mg awunqatshelwe kubantu abathambekele kwi-myopathy, kanye nophuzo oludakayo, izinqubo ezikhulisa ukunambitheka kwe-rosuvastatin egazini, nomsebenzi wokuphazamiseka wezinso. Kubantu bohlanga lwamaMongoloid, le dosage nayo ayemukeleki, ngenxa yokuthambekela kwe-myopathy.

Lapho enquma ikhambi, udokotela kufanele aqinisekise ukuthi akukho ukwephulwa kweziguli.

Umuthi uyatholakala ngesimo samaphilisi we-5, 10, 20, 40 mg. Ngayinye yazo imbozwe ngegobolondo elikhethekile.

Kunqunyelwe esigulini kuphela uma kungaphumeleli ukwelashwa ngaphandle kwezidakamizwa, ubude besikhathi saso okungenani izinyanga ezintathu.

Kuyasiza ukukhulisa ukuqina kwemithambo yegazi nokuqina kwabo. Umkhiqizo onjengeRosuvastatin unemiyalo emisiwe yokusetshenziswa, intengo enengqondo nokubuyekezwa okuhle kweziguli.

Ukuze umuthi usebenze ngokufanele ngangokunokwenzeka, kunemigomo eminingana yokwamukelwa:

1. Ithebhulethi iyageza ngamanzi amaningi (hhayi ngaphansi kwama-60 ml). Musa ukuhlafuna amaphilisi, ukuwaphula noma ukuwohloka ukuze wehlise umthamo. Izenzo ezinjalo zingadala ukuphazamiseka komgudu wesisu, kanye nokwehla kokufakwa kwezinto.
2. Uma usebenzisa iRosuvastatin, awudingi ukuzulazula kokudla, kepha awukwazi ukuphuza amaphilisi ngokudla. Ukwemukelwa kufanele kube ngasiphi isikhathi esinqunyelwe nsuku zonke. Odokotela bathi isikhathi esihle kunazo zonke ekuseni.
3. Ukulungisa isikhathi kubaluleke kakhulu, okungenani amahora angama-24 kufanele kudlule kusukela esikhathini sokusebenzisa.
4. Ukungezelela inani lezinto ezisetshenziswa ngesikhathi kufanele zenziwe kancane kancane ukuze umzimba uvumelane nezinguquko. Ukusebenza kokuqala akufanele kungabi ngaphezu kwama-10 amagremu. Izinguquko kufanele zenziwe ngokuhamba kwamasonto amabili, uma isikhathi singagcinwanga, ubungozi bemiphumela emibi buphakeme.

Kulesi sifo ngasinye, kune-algorithm efanelekile kanye nethamo lemithi. Udinga ukunaka ngamunye wabo, ngoba umzimba usabela ngokuhlukile ngama-pathologies ahlukile. Imithetho yokuthola imali:

• phambi kwe-hyperlipidemia, i-10 mg kufanele ithathwe kanye ngosuku, inkambo yokwelashwa iyizinyanga eziyi-12-18, kuya ngamandla wokuqalwa kokuqina kwe-pathology;
• ukwelashwa kwe-atherosclerosis kwenziwa ngengxenye yokuqala ye-5 mg, kanye nenani eliphakeme lama-60 mg, ngakho-ke kuyadingeka ukuphathwa ngale ndlela, unyaka owodwa nohhafu;
• ukwelashwa kwezifo zenhliziyo ezi-coronary kwenziwa ngengxenye yokuqala ye-5 milligram yepilisi, isikhathi sokwelashwa sineminyaka eyodwa nesigamu;
• ekwelapheni ezinye izifo zesistimu yezinhliziyo, thatha kuqala inani le-5 mg, ukusetshenziswa okwengeziwe kulungiswa nguchwepheshe, kuye ngobungozi namandla abo;
• ekuvinjelweni kwezifo zenhliziyo nge-cholesterol ephezulu, i-5 mg kufanele ithathwe nsuku zonke, futhi udokotela ukhetha isikhathi ngokuya ngezimpawu zesiguli;
• ekuvinjelweni kwesifo sikashukela i-mellitus, i-10 mg yesidakamizwa kufanele sithathwe, isikhathi sokwelashwa siyizinyanga eziyi-18, ngokuhlolwa njalo ezinyangeni eziyisithupha.

Akunconyelwe ukuthi izingane nentsha ziluthathe, ngoba ucwaningo kule ndawo alukaqedwa futhi nomphumela emzimbeni wezingane awuqondakali ngokuphelele.

Umphumela wecala ungenzeka ikakhulukazi ngenxa yokwephulwa komthamo ovunyelwe.

Iningi lazo aliphikiswa futhi lihlala isikhashana.

Ukusetshenziswa ngokungafanele komuthi kukhuthaza ukuthuthukiswa kwale mibandela echazwe ngezansi.

Ngokuya ngomphumela ohlelweni oluthile lomzimba, imiphumela emibi eminingana ingavela, okungukuthi:

1. Isistimu yokugaya: isisu sokuphazamiseka kwengqondo, isicanucanu, ukuhlanza, ubuhlungu besisu, i-pancreatitis.
2. Uhlelo lwezinzwa: ikhanda, ukucindezelwa, ukungazinzi ngokomzwelo, isiyezi, umuzwa wobuthakathaka obungapheli emzimbeni, kwandise ukukhathazeka.
3. Isistimu ye-musculoskeletal: Ubuhlungu obuphikelelayo bemisipha, ukuvuvukala kwezicubu zomzimba kanye nokubhujiswa kwalo.
4. Uhlelo lwe-genitourinary: i-hematuria ne-proteinuria kungenzeka.
5. Allergies: ukulunywa kanzima, ukuqhuma kwesikhumba, urticaria.
6. Uhlelo lwe-Endocrine: ukuthuthukiswa kwesifo sikashukela sohlobo 2.

Ngaphezu kwalokhu kukhubazeka okungenhla, inyumoniya, ukukhwehlela, ubuhlungu obuphansi besisu, i-asthma ye-bronchial, i-sinusitis, i-gastritis, ukunyuka kwengcindezi yegazi, i-angina pectoris, i-arrhythmia, i-palpitations yenhliziyo, i-bronchitis, isifo samathambo, izinhlungu emuva, ubuhlungu besifuba, i-ecchymosis, i-periodontal abscess akuvamile.

Uma umphumela wecala uqalile ukuvela, kufanele uwuthathe ngokungathi sína futhi uguqule ukwamukela, noma ukhansele. Udinga futhi ukuqala ukwelashwa okuhlose ukuqeda izimpawu ukuze uthuthukise impilo yakho.

Noma yimuphi umuthi kufanele unqunywe ngudokotela kuphela, ngoba unomphumela oqondile ezinhlelweni zomzimba.

Uma kusetshenziswa kabi, ukuphuza lo muthi kungavusa izinkinga eziningi.

Lapho enquma iRosuvastatin, udokotela kumele acabangele izimfanelo zomzimba futhi anikeze nezincomo zokuphuza umuthi ogulini.

Lezi zincomo zifaka isandla ekwelashweni okusebenzayo. Izici zesidakamizwa:

• uma umuthi uthathwa isikhathi eside futhi ngemithamo emikhulu, khona-ke umsebenzi we-CPK kufanele ubhekwe ngezikhathi ezithile, lokhu kuyadingeka ukuvimbela ukulimala kwezicubu zemisipha, ikakhulukazi kubantu abathambekele kwi-pathology enjalo, uma izinga liphakeme, ukwelashwa kufanele kumiswe ngokushesha;
• ukuphathwa okufanayo kwezidakamizwa ezifanayo kumphumela wazo kufanele kwenziwe ngokucophelela okukhulu;
• udokotela kumele azise isiguli kusenesikhathi ngomthelela omubi emisipheni, ukuze kuthi uma kwenzeka sephulwa aphendule ngokushesha;
• inyanga ngemuva kokulungiswa kwenani elichithwayo, kwenziwa ukuhlolwa kwe-cholesterol ne-lipids;
• isikhathi esithile ngaphambi kokwelashwa kanye namaviki amabili ngemuva, udinga ukuhlola ngokuphelele isibindi, ukubona ukusebenza kwawo;
• kufanele uhlole isiguli ukuthi singabekezelela yini i-lactose, ngoba lesi sakhi sisethuluzi;
• ngezikhathi ezithile, udinga ukuthola izinga le-glucose, ngoba izakhi ezisebenzayo ziphazamisa ukwanda kwe-glucose metabolism, ngenxa yalokho kukhula uhlobo 2 lwesifo sikashukela;
• uma usebenzisa eminye umuthi ngokufana, udokotela ohambelayo kufanele aziswe;
• ubuthakathaka bemisipha kungenzeka ngemuva kokuthatha umuthi, lapho kufanele uthinte uchwepheshe ofanelekile;
• umphumela we-rosuvastatin ku-cortex ye-cerebral ayiqondakali ngokuphelele;
• uma ukhulelwe phakathi nesikhathi sokulashwa, ukwamukela kufanele kumile ukuze kungathinti i-fetus;
• kumithamo ephakeme, kubalulekile ukulawula umsebenzi wezinso;
• ukusetshenziswa okufanayo kwamacwecwe neziphuzo zotshwala kuzodala ushintsho olungapheli lomqondo esibindini, maqondana nalesi simo utshwala kufanele bushiywe, noma ukuhlukunyezwa kufanele kubekelwe umkhawulo;
• ukuvinjelwa kusebenza futhi ekusetshenzisweni okufanayo kwezidakamizwa ze-hormonal;
• ama-anticoagulants abhanqwe ne-rosuvastatin akhipha ukopha kakhulu.

Lo muthi unama-analogue angaphezu kweyodwa asebenzayo, phakathi kwawo kukhona nezidakamizwa ezifanayo kakhulu ezisebenzayo.

Enye indlela ye-rosuvastatin yile:

1. I-Rosucard - ama-ruble angama-560;
2. I-Tevastor - ama-ruble angama-341;
3. I-Roxer - ama-ruble angama-405;
4. I-Krestor - kusuka kuma-ruble ayi-1800;
5. I-Mertenil - kusuka kuma-ruble angama-507;
6. I-Rosart - kusuka kuma-ruble angama-570;
7. Simvastatin - kusuka kuma-ruble ayi-120;
8. ISuvardio - isuka kuma-ruble angama-900 (generic yokungenisa).

Ziyahlukahluka ngezindleko, umenzi negama, futhi ngokuya ngokusebenza kahle cishe ziyefana.

Umuthi iRosuvastatin ubuyekezwa kuvidiyo ekulesi sihloko.