I-Acorta isidakamizwa esingeqembu le-pharmacological elibizwa ngokuthi ama-statins. Imvamisa, odokotela bayayinikeza abantu abanenkinga ye-atherosulinosis kanye nanoma yikuphi okunye ukuphazamiseka kwe-lipid metabolism emzimbeni. Lo muthi uyatholakala ngesimo samathebulethi amancane ekuhlanganiseni ifilimu. Umbala wamathebulethi ungaba phakathi kwawo wonke ama-pink apinki. Ziyindilinga ngesimo, ziqhakambisa ezinhlangothini zombili, futhi lapho zephukile ngaphakathi, zimhlophe noma zibomvu.
Isithako esikhulu esisebenzayo se-Akorta yi-rosuvastatin. Futhi, ngaphezu kwe-rosuvastatin, ukwakheka komuthi kufaka izinto ezisizayo njenge-lactose, cellulose, calcium, magnesium, crospovidone. Igobolondo lefilimu lamathebulethi ngokwalo liqukethe i-lactose, hypromellose, titanium dioxide, i-triacetin nodayi ngendlela eyakheke ngayo insimbi. Wonke amaphilisi atholakala kumaphakeji ajwayelekile wezingcezu eziyi-10.
Ukusebenza kwesenzo se-acorta
I-Akorta, noma kunalokho, isithako sayo esiyisisekelo, i-rosuvastatin, isithinteli esithile esikhethiwe se-enzyme ekhethekile - hydroxymethylglutaryl-coenzyme A reductase, okuyindlela efushanisiwe izwakala njenge-HMG-CoA. I-HMG-CoA iyi-enzyme ebaluleke kakhulu ebhekele ukuguqulwa kwe-hydroxy-3-methylglutaryl-coenzyme A entweni ebizwa ngokuthi yi-mevalonate, noma i-mevalonic acid.
I-Mevalonate iyisendlalelo esiqondile se-cholesterol, okwedlulele okuyisici esiyinhloko sengozi ye-atherossteosis. Ukuvela kwe-cholesterol kanye nokuqhekeka kwama-low density lipoproteins (LDL) kwenzeka esibindini. Ukusuka lapha kungashiwo ngokunemba ukuthi isibindi siyisisulu esiyinhloko sesenzo somuthi.
Umuthi usiza ukwandisa inani lama-receptors ama-lipoprotein aphansi ebusweni bamaseli wesibindi, okuholela ekukhupheni okukhulu ekubanjweni kwemikhiqizo yawo yokubola, futhi ama-lipoprotein amahhala awangeni egazini. Ngaphezu kwalokho, esibindini, elinye iqembu lama-lipoproteins nalo lakhiwe - kwabantu abaphansi kakhulu (VLDL). Yi-Akorta evimbela ukwakheka kwabo futhi iholele ekunciphiseni kwezinga labo egazini lomuntu.
I-Rosuvastatin isiza ukunciphisa inani le-cholesterol ephansi nephansi kakhulu, futhi ngasikhathi sinye inyusa izinga le-cholesterol "enhle" - evela ku-HDL. Inani eliphelele le-cholesterol, i-apolipoproteins B (kodwa-ke, likhulisa ukugcwala kwama-apolipoproteins A), i-triglycerides nayo incishiswa kakhulu, izinga le- "atherogenic" cholesterol lehlisiwe ngokuphelele.
Le ndlela yokusebenza isebenza ichaza umphumela oyinhloko wesidakamizwa - ukwehliswa kwe-lipid (ngokweqiniso - ukunciphisa inani lamafutha). Lo mphumela ngokuqondile uncike kumthamo wesidakamizwa onqunywe udokotela ohambelayo. Ukufinyelela ekwelapheni, okuwukuthi, umphumela ojwayelekile wokusekela, kuyadingeka ukuthatha lo muthi isonto elilodwa. Ukuthola umphumela ophelele, "wokushaqisayo", kuthatha okungenani amaviki amane okudla njalo kanye nokunakekelwa okuthe xaxa komthamo kanye nerejimeni.
I-Akorta yesicelo ihamba kahle ngokuqokwa kwezidakamizwa eqenjini le-pharmacological lezidakamizwa elehlisa i-lipid, kanye ne-nicotinic acid, esiza ukwandisa izinga lama-lipoproteins aphezulu.
I-Pharmacokinetics ne-pharmacodynamics Acorta
I-Pharmacokinetics yilokho okwenzeka nomuthi uqobo emzimbeni womuntu owuphuzile. Umphumela osheshayo ungama-20% womthamo owutholile. Le nto ibizwa ngokuthi yi-bioavailability. Leli inani lemithi lifinyelela lapho lifika lapho lihlala khona. Ukuhlushwa okuphezulu kakhulu kwe-Acorta kugcinwa amahora angama-3-5 ngemuva kokuphathwa ngomlomo. Akumele uphuze amaphilisi ngokudla, ngoba noma yikuphi ukudla kusiza ukwehlisa inani lokutholwa lomuthi. I-Rosuvastatin ingena kahle emgoqweni we-hematoplacental, okufanele icatshangwe njalo lapho kunqunywa lo muthi kwabesifazane abakhulelwe.
Lapho i-aorta ingena emzimbeni wethu, ithinta kakhulu isibindi, futhi isetshenziswe yiyo, kuthinta ukwakheka kwe-cholesterol kanye ne-low density lipoprotein. Futhi, i-rosuvastatin ihlotshaniswa kahle namaprotheni egazi. Ku-metabolism, okungukuthi, ukushintshaniswa kwe-rosuvastatin, ama-enzyme e-hepatic abamba iqhaza ngenkuthalo, ikakhulukazi - i-cytochrome P-450, okungenye yezinto eziphambili ezinikezela inqubo yokuphefumula kwezicubu.
Ukuchithwa, noma ukuqedwa, kwesabelo esiyinhloko somuthi kwenzeka ngohlelo lokugaya, okungukuthi ngamathumbu. Ingxenye encane esele isuswa yizinso. Ukwehla kokuxinaniswa kwezidakamizwa egazini ngesigamu kubizwa ngokuthi yi-half-life. Ukuphila kwengxenye ye-Acorta kungamahora ayishumi nesishiyagalolunye, futhi kuzimele.
I-metabolism ye-rosuvastatin ayiguquki nganoma iyiphi indlela futhi ayincike eminyakeni nobudala beziguli, kepha kuya ngobukhona be-pathologies ezihambisanayo ezinjengokuhluleka kwe-renal nesibindi. Ezigulini ezinenkinga yokwehluleka kakhulu kwe-renal, ukuqina komuthi osegazini kuphakame kathathu kunakubantu abaphilile. Futhi ezigulini zokwehluleka kwesibindi, kuye kwanda ukwanda kwengxenye yempilo ye-rosuvastatin.
Futhi, i-metabolism kanye nomphumela we-Acorta kuncike ekulimazeni kofuzo noma umehluko nje.
Imiyalo yokusebenzisa umuthi
I-Aorta imiselwe ukuphazamiseka okuhlukahlukene kwe-lipid metabolism.
Isibonakaliso esiyinhloko ukuba khona kwe-atherossteosis.
Umuthi usetshenziswa njengokwengeza ekudleni ukuze unciphise i-cholesterol kanye ne-lipoprotein ephansi nephansi kakhulu.
Ngaphezu kwalokhu, umuthi unqunyelwe:
- Njenge-prophylactic eyengeziwe yezifo zohlelo lwezinhliziyo ezigulini ngaphandle kwezimpawu zomtholampilo zesifo senhliziyo. Lokhu kufaka phakathi i-myocardial infarction, unhlangothi, umfutho wegazi ophakeme. Kulokhu, iminyaka yeziguli ibalulekile - kwabesilisa yona ingaphezu kweminyaka engama-50, futhi kwabesifazane - ngaphezulu kweminyaka engama-60. Kuyafaneleka futhi ukubheka izinga eliphansi lokuqina kwenhliziyo lipoprotein cholesterol kanye nokuba khona kwezifo zenhliziyo ezi-coronary ezihlotsheni eziseduze;
- I-hypercholesterolemia eyisisekelo ngokusho kukaFredricksen noma uhlobo oluxubekile ukwanda kwe-cholesterol ngaphandle kwezimbangela zangaphandle. Umuthi ubekwe njengethuluzi elingeziwe, ikakhulukazi uma ezinye izidakamizwa, ukudla kanye nokuzivocavoca kwakungelingene ukufeza umphumela oyifunayo;
- Uhlobo lwesine lwe-hypertriglyceridemia ngokusho kukaFredricksen njengesinyathelo esengeziwe ekuhlanganiseni nokwelashwa kokudla.
Contraindication ukusebenzisa i-Akorty kuya ngethamo lomuthi. Ngomthamo wansuku zonke we-10 kuya ku-20 mg, ukusabela komzimba kungukuphikisana; izifo ezibangwa yisibindi noma ezingalapheki esigabeni esibuhlungu, okuthi ekuhlaziyweni kwe-biochemical kwegazi kuchazwa njengokukhuphuka okuphindwe kathathu kumasampula wesibindi uma kuqhathaniswa nezinkomba ezijwayelekile; ukwehluleka okunzima kwezinso; i-hypersensitivity yomuntu ngamunye kushukela wobisi (i-lactose), ukuntuleka kwayo noma ukwephulwa kwezinqubo zokufakwa emzimbeni; ukuba khona emlandweni we-myopathy (kubuthakathaka bemisipha); ukuphathwa kanye kwezidakamizwa okubizwa ngokuthi yi-cyclosporin; isakhi sofuzo ekukhuleni kwe-myopathy; isikhathi sokukhulelwa nokukhulelwa kwabesifazane; iminyaka emincane.
Lapho dosing Akorta 40 mg ngosuku, lokhu okulandelayo contraindication kufanele kufakwe kulokhu contraindication ngenhla:
- Ukushoda kwe-yegilo - i-hypothyroidism;
- Ukuba khona emlandweni womuntu siqu noma esilandelayo senhlobo yamacala wesifo semisipha yemisipha;
- Ukuthuthukiswa kwe-myotoxicity lapho uthatha izidakamizwa ngendlela ethile yokusebenza;
- Ukuphuza ngokweqile
- Noma yiziphi izimo ezingaphumela ekwandeni kwezinga le-rosuvastatin emzimbeni;
- Iziguli ezingomjaho wamaMongoloid;
- Ukusetshenziswa okuhlangene kwama-fibrate;
Ngaphezu kwalokho, i-contraindication ukubakhona komzimba wesiguli kobunzima obulinganiselayo bokuhluleka kwezinso.
Izici zokusebenzisa i-acorta kuma-pathologies ahlukahlukene
Ngokuqapha ngokweqile, i-Akorta kufanele ichazwe kumthamo we-10 no-20 mg lapho kukhona ama-pathologies ahlangana emzimbeni
Ukuqapha kufanele kuthathwe lapho usebenzisa umuthi uma kunengozi yezifo zohlelo lwemisipha
Ngaphezu kwalokho, iziguli ezisebenzisa lo muthi kufanele zigcinwe ngaphansi kolawulo olukhethekile lapho kukhona ukwehluleka kwezinso kwanoma yisiphi isigaba emzimbeni wesiguli.
Ngaphezu kwalokho, ukunemba nokuqapha kufanele kusetshenziswe uma kutholwa isiguli:
- ukungalingani kwe-thyroid;
- ukuba khona emlandweni wakho noma kwesinye isihlobo samacala wesifo semisipha yemisipha;
- ukuthuthukiswa kwe-myotoxicity lapho udla izidakamizwa ngendlela ethile yokusebenza;
- ukuphuza ngokweqile utshwala;
- noma yiziphi izimo ezingaphumela ekwandeni kwezinga le-rosuvastatin emzimbeni;
- ubudala obudala - ngaphezulu kweminyaka engama-65;
- isifo sesibindi sangaphambilini;
- i-septic lesion;
- ingcindezi encishisiwe;
- izinqubo ezibalulekile zokuhlinzwa ezenziwe ngaphambili;
- ukulimala okuxakayo;
- ukuphazamiseka kwe-metabolic, ibhalansi yama-electrolyte yamanzi, amazinga e-hormonal;
- isithuthwane esingalawulwa.
Ngomthamo we-40 mg ngosuku, imikhawulo icishe ifane:
- Ukuguga - ngaphezulu kweminyaka engama-65;
- Isifo sesibindi esedlule;
- I-lesic lesion;
- Ukuqina kwengcindezi encishisiwe;
- Izinqubo ezibalulekile zokuhlinzwa ngaphambili;
- Ukulimala kobuhlungu;
- Ukuphazamiseka kwemetabolic, ibhalansi yama-electrolyte yamanzi, amazinga e-hormonal;
- Isithuthwane esingalawulwa;
- Ukwehluleka kwezinso okumnene.
Ukuqapha kufanele futhi kusetshenziswe lapho usebenzisa lo muthi ukuphatha abantu bohlanga lwamaMongoloid kanye nokusetshenziswa okuyinkimbinkimbi kwama-fibrate.
Ukwanda kwemiphumela emibi lapho uthatha i-Acorta kuncike ngqo kwithamo.
Imiphumela emibi ingenzeka ngezinhlelo ezahlukene zomzimba.
Isistimu yezinzwa - izinhlungu ekhanda, umuzwa wokukhathazeka, nobuhlungu kanye nezinzwa, imizwa yomoya ophelile, ukulahleka kwememori.
I-emathunjini esiswini - ukwephulwa kokuhamba kwamathumbu, isicanucanu, isisu esiswini, ukuvuvukala kwamanyikwe, ukuphazamiseka kokugaya, i-gastroenteritis, imiphumela enobuthi esibindini.
Uhlelo lokuphefumula - ukuvuvukala kwe-pharynx, i-noseal, i-sinus, i-bronchi, amaphaphu, i-asthma, ukuphefumula komoya, ukukhwehlela.
Uhlelo lwezinhliziyo - i-angina pectoris (icindezela izinhlungu ngemuva kwe-sternum), ukukhuphuka kwengcindezi yegazi, ubomvu besikhumba, umuzwa wokushaya kwenhliziyo.
Uhlelo lwe-musculoskeletal - Ubuhlungu bemisipha, ukuhlangana, ukuvuvukala okuhlangene, ama-tendon sheaths wemisipha, i-rhabdomyolysis.
Ukubonakaliswa kwe-allergic - ukuqubuka kwesikhumba, ukulunywa, ukuqubuka kwesikhumba ngamacembe abomvu (urticaria), ukuvuvukala kwesikhumba, iStevens-Johnson syndrome - ukusabela okubi kakhulu komzimba.
Izinguquko ekuhlaziyeni - ukwanda koshukela wegazi, i-bilirubin, amasampula wesibindi, i-creatine phosphokinase.
Abanye: thayipha isifo sikashukela esingu-2 mellitus, ukubonakaliswa kwe-anemic, ububele besifuba, ukuncipha kokubala kweplatelet, i-edema, ukuthuthukiswa kwesifuba emadodeni.
Uma kwenzeka kusetshenziswa i-overdose, kukhuphuka ukwenzeka kokungahambi kahle. Ukuyivimbela, kufanele unamathele ngokuqinile emiyalweni.
Intengo ye-Akorta eRussia isukela kuma-ruble angama-500 kuye kwangama-550, ngakho-ke umuthi ubhekwa njengoshibhile. Ama-Analogues we-Akorta afaka izidakamizwa ezinjengeKrestor, Rosuvastatin, Roxer, Tevastor, Fastrong nezimali ezifuywayo aziphansi ekusebenzeni kahle. Ukubuyekezwa kokusetshenziswa kwe-Akorta kulungile kakhulu.
Imininingwane mayelana nama-statin inikezwe kuvidiyo kule ndatshana.
