I-Rosuvastatin Canon iyisidakamizwa esinezindawo eziphansi ze-lipid. Umuthi ungoweqembu lama-statins.
Umuthi umuthi wokuncintisana okhethiwe we-HMG-CoA reductase, obhekele ukuguqulwa kwe-3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, okuyisandulelo se-cholesterol.
Inkomba eyinhloko yesenzo salo muthi isibindi, isitho esenza inqubo yokuqokwa kwe-cholesterol kanye ne-catabolism yamalonda amancane we-lipoprotein.
Umuthi uvimbela umsebenzi we-HMG-CoA reductase. Lapho usebenzisa umuthi, cishe i-90% ye-rosuvastatin ijikeleza eplasma yegazi.
Ukusetshenziswa kwesidakamizwa kusiza ukwandisa isibalo sama-LDL receptors engqukweni olungaphezulu lwe-hepatocytes, okwandisa ukubanjwa kanye ne-catabolism yama-lipoprotein aphansi. Umphumela onjalo emzimbeni uholela ekwehleni kwezinga le-LDL ku-plasma.
Umphumela wokwelapha ukusetshenziswa komuthi ubonwa kakade isonto ngemuva kokuqala kokwelashwa. Ngemuva kwamaviki ama-2, umphumela wokwelapha ufinyelela isilinganiso sawo. Ngemuva kwalesi sikhathi, ukwehla okuphezulu kwezinga le-cholesterol emzimbeni kuyabonakala futhi ngokuphathwa okuqhubekayo kwemithi kugcinwa ezingeni elifinyelelwe isikhathi eside.
Ukusetshenziswa kwomuthi kungaba nomthelela ekwehliseni isisindo ngenxa yokususwa kwama-lipids amaningi kuwo.
Ukukhishwa kwefomu nokwakheka kwamakhemikhali
Umenzi ukhiqiza umuthi ngendlela yamathebulethi. Ingaphezulu lamathebulethi lihlanganiswe nokuhlanganiswa kwefilimu okubomvu.
Ijamo liyindilinga, i-biconvex. On a convex ebusweni, ubungozi kubekwa. Engxenyeni yesiphambano, umuthi unombala ocishe ube mhlophe.
Isithako esikhulu esisebenzayo kulo muthi yi-rauvastatin calcium. Le ngxenye iqukethe isisindo esilingana ne-10.4 mg, okuthi ngokwe-rosuvastatin emsulwa yi-10 mg.
Ngokungezwe kwinhlanganisela enkulu esebenzayo, izinhlanganisela zamakhemikhali ezilandelayo zifakiwe ekwakhiweni kwethebhulethi:
- i-calcium hydrogen phosphate dihydrate;
- isitashi sommbila pregelatinized;
- i-magnesium stearate;
- i-povidone;
- i-microcrystalline cellulose.
Ukwakheka kokuhlanganiswa kwefilimu kwamathebulethi kubandakanya izinto ezilandelayo:
- I-Selecoat AQ-01032 ebomvu.
- IHydroxypropyl methyl cellulose.
- IMacrogol-400.
- IMacrogol-6000.
- I-titanium dioxide
- I-varnish aluminium esekwe kudayi Ponso 4R.
Umenzi wamathebulethi akhiqizwayo uwafaka ekuhlanganisweni kwamaselula kwe-PVC. Ngaphezulu kwephakheji kumbozwe ucwecwe lwe-aluminium. Amaphakeji anjalo abekwa uphawu emabhokisini amakhadibhodi, lapho kubekwa khona imiyalo yokusebenzisa umuthi.
Umuthi uyatholakala kumathebulethi anemithamo ehlukile yesithako esisebenzayo. Kumakhemisi, ngokuya ngesidingo, ungathenga umuthi onemithamo ye-rauvastatin 10, 20 no-40 mg kwithebhulethi eyodwa. Intengo yomuthi incike esifundeni esithengiswayo e-Russian Federation, ukuqoqwa kwezithako ezisebenzayo zokwakheka kwezidakamizwa nenani lamaphilisi kwelinye iphakethe. Izindleko zephakeji elilodwa, ngokuya ngamapharamitha acacisiwe, zingahluka kusuka kuma-ruble angama-350 kuye kwangama-850.
Isiguli singathenga kuphela umuthi uma sinikezwa umuthi kudokotela oholayo.
Umuthi kufanele ugcinwe emazingeni okushisa angadluli kuma-25 degrees Celsius endaweni eyomile engenakutholwa yizingane nezilwane ezifuywayo. Indawo yokubeka kufanele ivikelwe elangeni eliqondile. Impilo yeshalofu yesidakamizwa yiminyaka emibili.
Ngemuva kwalesi sikhathi, ukusetshenziswa komuthi kwenqatshelwe, kufanele kuchithwe.
Izinkomba kanye ne-contraindication ukuze zisetshenziswe
Ngaphambi kokusebenzisa umuthi i-Rosuvastatin Canon, kufanele ufunde ngokucophelela imiyalo esetshenzisiwe, ukubuyekezwa komuthi odokotela kanye neziguli, uzijwayeze ngentengo yomuthi ngomthamo ohlukile wesithako esisebenzayo.
Isiqondiso ngokusetshenziswa kwomuthi sincoma ukuthatha umuthi kuphela ngemuva kokubonisana nodokotela wakho.
Udokotela unquma umthamo ophelele, kucatshangelwa yonke imininingwane etholakalayo ngempilo nezimpawu zomzimba womuntu ngamunye.
Izinkomba eziphambili zokusebenzisa umuthi ngokuya ngemiyalo yokusetshenziswa yilezi zimo ezilandelayo:
- ukuba khona kwe-Fredrickson hypercholesterolemia eyisisekelo (uhlobo IIa, kufaka phakathi i-heterozygous hypercholesterolemia) noma i-hypercholesterolemia (uhlobo IIb) njengesengezo ekudleni, kulezo zimo ukusetshenziswa kwezindlela zokwelapha ezingezona ezokwelapha (ukuvivinya umzimba, ukunciphisa umzimba) akwanele;
- ukuba khona kwe-homozygous hypercholesterolemia yomndeni, njengesengezo sokudla nokunye ukwelashwa okwehlisa i-lipid (ngokwesibonelo, i-LDL apheresis), noma ezimweni lapho ukusetshenziswa kwalezo zinhlungu kungasebenzi ngokwanele;
- ukuba khona kwe-hypertriglyceridemia (uhlobo IV ngokusho kukaFredrickson) njengokungezwa kokudla okusetshenzisiwe.
Ukuxhumana kokusetshenziswa kwesidakamizwa kunokwehluka ngokuya ngokufakwa kumathebulethi wesithako esikhulu esisebenzayo.
Ngakho-ke kumathebulethi aqukethe u-10 no-20 mg we-rosuvastatin, isiguli sinokuphikisana okulandelayo:
- Izifo zesibindi esigabeni esisebenzayo sokuqhubekela phambili, kufaka phakathi umsebenzi owengeziwe we-transaminase.
- Ukulimazeka okukhulu kokusebenza kwezinso.
- Ubukhona be-myopathy esigulini.
- Ukusetshenziswa kokwelashwa nge-cyclosporine.
- Isikhathi sokukhulelwa kanye nesikhathi sokukhulelwa.
- Ukubikezela kwangaphambili ekuqhubekeni kwezinkinga ze-myotoxic.
- Iminyaka engaphansi kweminyaka engu-18.
- Hypersensitivity kuzakhi zomuthi.
Uma usebenzisa amaphilisi ane-rosuvastatin 40 mg, contraindication ukusetshenziselwa yilena:
- ukwehluleka kwezinso kanye nesibindi;
- ukuthwala ingane nokuncelisa;
- ukusetshenziswa kwe-cyclosporine;
- ukuba khona kwesifo sesibindi esigabeni esibuhlungu sokuthuthuka;
- ukuba khona komzimba wokungabekezeleleki ezingxenyeni zomuthi.
I-drug overdose yesiguli yenzeka ngenkathi kuthathwa imithamo eminingana yansuku zonke.
Uma kwenzeka kweqa ngokweqile, kunqunywa ukwelashwa okubonakalayo futhi imisebenzi yesibindi, kanye nomsebenzi we-CPK, kubhekwe.
Ayikho i -ididote ethile esetshenziswayo lapho kwenzeka i-overdose. Inqubo ye-hemodialysis ayisebenzi.
Imiyalo yokusebenzisa umuthi
Umuthi uphathwa ngomlomo, nganoma yisiphi isikhathi sosuku, ngaphandle kokudla.
Ithebhulethi kufanele igwazwe lonke ngaphandle kokuchotshozwa, kuyilapho ukuthatha umkhiqizo kufanele kuhambisane nokuphuza amanzi amaningi.
Endabeni yokuqokwa komuthi kumthamo we-5 mg, ithebhulethi enesisindo sengxenye esebenzayo engu-10 mg ingahlukaniswa ngesigamu.
Ngaphambi kokwenza i-Rosuvastatin, i-Canon idinga ukuthi isiguli sinamathele ekudleni okuqinile kwe-hypocholesterol isikhathi esithile. Ukuhambisana nokudla okunjalo kuyadingeka futhi ngemuva kokuqala kwemithi.
Umthamo wamathebulethi e-cholesterol ukhethwa udokotela obhekele imiphumela yokuhlaziya kanye nezifundo zomzimba wesiguli ngemuva kokusebenzisa ukudla kokudla kanye nezimpawu zayo.
Ngaphezu kwalokho, umthamo wezidakamizwa ezisetshenziswayo ungahle uthintwe inhloso yenkambo yokwelapha kanye nemvelo yokusabela komzimba ekusetshenzisweni kweCanon ekwelapheni iRosuvastatin.
Ngokuyalela imiyalo esetshenzisiwe, umthamo wokuqala ophakanyisiwe wesidakamizwa ngu-5 noma 10 mg kanye ngosuku.
Ngokusebenzisa kanyekanye i-rosuvastatin enama-fibrate noma i-nicotinic acid emthamo ongekho ngaphezu kwegramu 1 ngosuku, umthamo wokuqala ungama-5 mg kanye ngosuku.
Lapho ukhetha umthamo, udokotela kufanele aqondiswe yimiphumela yokulinganiswa kwenani le-cholesterol emzimbeni wesiguli futhi anake ingozi engaba khona yokuthola ubunzima bezinkinga zenhliziyo. Ngaphezu kwalokho, uchwepheshe kufanele acabangele ubungozi obungahle bube nemiphumela emibi kusukela ekusetshenzisweni kwalo muthi phakathi nokwelashwa.
Uma kunesidingo, umthamo wezidakamizwa ezisetshenziswayo uguqulwa njalo emavikini ama-4.
Ukusetshenziswa komthamo ka-40 mg kwenziwa kuphela ezigulini ezinesilinganiso esibuhlungu sokuthuthuka kwe-hypercholesterolemia futhi lapho kunengozi enkulu yezinkinga emsebenzini wezinhlelo zemithambo yegazi nenhliziyo, kanye nasekutholweni komfutho wegazi ophezulu esigulini. Endabeni yokusebenzisa umthamo ophelele ovunyelwe enkambweni yokwelashwa, isiguli kufanele siqashwe njalo ngudokotela ohambelayo.
Ukusetshenziswa kwesidakamizwa umthamo ophelele kufakwa ku-iziguli ezinokwehluleka kwezinso nokukhubazeka ngokulinganiselwe kwe-renal.
Kulesi sigaba seziguli, umthamo onconywayo ngu-5 mg ngosuku ngethamo elilodwa.
Imiphumela emibi nokufana kweRosuvastatin Canon
Ngesikhathi sokusebenzisa umuthi, imiphumela emibi ingakhula emzimbeni wesiguli.
Imvamisa yemiphumela emibi incike kumthamo osetshenzisiwe kanye nezimpawu zomzimba ngamunye zesiguli.
Kusukela ohlangothini lwesistimu yezinzwa ephakathi, ikhanda, isiyezi, futhi ezimweni ezingatheni, ukulahleka kwememori kungenzeka.
Engxenyeni yendlela yokugaya ukudla, imiphumela emibi ibonakaliswa ukubonakala kokuqunjelwa, isicanucanu, isisu esibuhlungu, ezimweni ezingandile, ukuthuthukiswa kwe-pancreatitis kanye ne-jaundice.
Uhlelo lokuphefumula lungaphendula kulo muthi ngokubonakaliswa okunjengokukhwehlela kanye nokuphefumula.
Kusukela ohlelweni lwe-musculoskeletal, ukubonakala kwe-myalgia kungenzeka. I-Myopathies futhi, ezimweni ezingavamile, i-arthralgia.
Engxenyeni yesistimu yokuchama, ukusabela okuvela eceleni kungaziveza ngesimo se-proteinuria, ukuvuvukala kwecala futhi, ezimweni ezingandile, i-hematuria.
Ngenxa yokuphuza umuthi, isiguli singase sibe nezimpawu zesifo sikashukela sohlobo 2.
Uma kutholakala imiphumela emibi emzimbeni ekuphuzeni umuthi, ingafakwa endaweni yokunconyelwa kukadokotela ohambelayo ngama-analogues akhona.
Kuze kube manje, abakhiqizi bezemithi banikela ngemishanguzo ehlukahlukene engaphezu kwe-10 eyi-analogue yeRosuvastatin Canon.
Lawa mathuluzi:
- I-Akorta,
- I-Mertenil.
- URosart.
- Rosistark.
- I-Rosuvastatin Sotex.
- Rosuvastatin SZ.
- URosulip.
- I-Rosucard.
- Roxer.
- I-Rustor.
- I-Tevastor
Yonke le mishanguzo inomphumela ofanayo emzimbeni, kodwa ibe nokwehluka okukhulu kwezindleko, okuvumela isiguli ukuthi sikhethe ikhambi elilungele kakhulu, kokubili ezindlekweni nasemiphumeleni yokwelapha enikezwe emzimbeni.
Mayelana nomuthi iRosuvastatin uchazwe kuvidiyo kule ngxenye.
