I-Aries isidakamizwa esibekwe njengomuthi owelapha ukutholwa kwe-hypercholesterolemia kanye nesifo senhliziyo esigulini. Isakhi esisebenzayo somuthi yi-simvastatin. Lesi sakhiwo sithe izakhiwo zokwehlisa i-lipid.
Umuthi lowo usesimweni sezibhebhe. Umenzi wesidakamizwa yinkampani yezokwelapha yaseRussia i-OZON LLC. Umumo wamatafula uyindilinga yendabuko. Ukuqanjwa kwamacwecwe njengeyakhi enkulu esebenzayo kufaka phakathi i-simvastatin ngevolumu ye-10 noma 20 mg.
Ngaphezu kwento esemqoka ekwakhiweni kwamathebhulethi, kukhona uhla lonke lwamakhompiyutha angeziwe:
- ascorbic acid;
- i-citric acid;
- isitashi se-gelatinized;
- i-lactose;
- titanium dioxide;
- i-magnesium stearate;
- i-talc;
- propylene glycol;
- uwoyela we-castor;
- isitashi sommbila.
Isidakamizwa sithengiswa emakhemisi ngesimo samaphilisi apakwe emaphaketheni ama-contour, ngalinye lazo liqukethe izingcezu eziyi-10, ezingama-20 noma ezingama-50. Ukufakwa kwe-Contour kufakwa emaphepheni amakhadibhodi enziwe amakhadibhodi.
Ukusetshenziswa komuthi kwenziwa kuphela uma kunefomu lokuyalelwa kadokotela oluzayo.
Impilo yeshelf umuthi iminyaka emi-3. Ukugcinwa komuthi kufanele kwenziwe endaweni evikelwe elangeni. Ukushisa kwesitoreji akufanele kube ngaphezulu kune-+25 degrees Celsius. Indawo yokubeka kufanele ivikelwe umswakama futhi ingatholakali ezinganeni.
Ngemuva kosuku lokuphelelwa yisikhathi, umuthi ulahlwa.
I-Pharmacodynamics ne-pharmacokinetics yesidakamizwa
Umuthi i-Ovenkor usho izidakamizwa ezithoba i-lipid ezenziwe ngendlela yokwenziwa. Ukulungiswa kwalesi sidakamizwa kwenziwa ngokubiliswa komkhiqizo otholakala kwisikhunta se-Aspergillusterreus saprophyte se-pathogenic.
I-lactone engasebenzi iyakhiwa, ilandelwa ukuvela kokuphuma kwe-hydroxy acid.
I-metabolite esebenzayo ye-simvastatin inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase.
I-enzyme ecacisiwe ifaka ukusabela kokuqala kokuvela okuvela ku-HMG-CoA mevalonate.
Ukuguqulwa kwe-HMG-CoA ku-mevalonate kumelela isigaba sokuqala sokuhlanganiswa kwe-cholesterol. Ukusetshenziswa kwe-simvastatin akubeki phansi intuthuko emzimbeni wenqubo yokuqongelelwa kwama-sterols anobuthi. I-HMG-CoA iguqulwa kalula ibe yi-acetyl-CoA. Le khompiyutha ibandakanyeka emzimbeni ngenani elikhulu lezinqubo ze-metabolic.
Kwi-simvastatin, izakhiwo eziyisisekelo ezilandelayo zimpawu:
- Ukwehlisa amazinga e-plasma we-triglycerides, LDL ne-VLDL, kanye ne-cholesterol ephelele.
- Ukwanda kokuxineka kwe-HDL kanye nokwehla kwesilinganiso phakathi kwe-lipoproteins ephansi kwabantu ne-lipoproteins ephezulu.
- Ukunciphisa isilinganiso phakathi kwe-cholesterol ephelele ne-HDL.
Umphumela wokusetshenziswa kwomuthi ubonakala ezinsukwini eziyi-14 ngemuva kokuqala kokusetshenziswa okuhleliwe kwe-Ovenkor.
Ukufeza umphumela wokwelapha ophakeme kakhulu, kuyadingeka ukuthi ubhekane nenkambo yokwelashwa, isikhathi sayo kusuka kumaviki amane kuya kwayisithupha.
Uma kunesidingo, udokotela ohambela isikhathi eside uyandisa inkambo yokwelashwa, esiza ukugcina umphumela womuthi. Ukusetshenziswa isikhathi eside kwesidakamizwa kuholela ekujezisweni kancane kancane kwe-cholesterol emzimbeni wesiguli.
ISimvastatin inamazinga aphezulu okufakwa emzimbeni. Ukuqunjelwa okuphezulu kwesidakamizwa kutholakala emzimbeni ngemuva kwamahora we-1,3-2,5. Ngemuva kwamahora ayi-12 ngemuva kokusetshenziswa kwomuthi, kuyehla ukwehla kokuxineka kwakhe egazini lesiguli ngama-90%.
Into esebenzayo ye-Ovenkor iyakwazi ukubopha amaprotheni e-plasma. Izinga lokubopha amaprotheni lifinyelela ku-95%.
Isikhathi sokuphila sengxenye esebenzayo yesidakamizwa amahora angama-1.9.
I-Excretion yama-metabolites yenziwa yisibilini njengengxenye yamalondolo. Uhlobo olungasebenzi lwama-metabolites luchithwa yizinso ezinomchamo.
Cishe i-60% yesitofu ikhishwa emzimbeni, futhi cishe u-10-15% wezidakamizwa ukhishwa emchameni.
Imiyalo yokusebenzisa umuthi
Ngaphambi kokufaka i-Ovenkor, kuyadingeka ukuthi utadishe imiyalo yokuyisebenzisa ngokuningiliziwe, ngaphezu kwalokhu, kufanele uzijwayeze ngentengo yomuthi ngokubukezwa kweziguli nodokotela, futhi kufanele ufunde izifaniso zomuthi uma kungenzeka ungene esikhundleni sokunye.
Ngaphambi kokuthatha umuthi, isiguli sinqunywe indlela yokudla ejwayelekile ye-hypocholesterol.
Lapho unquma umuthi, umthamo wansuku zonke ungahluka kusuka ku-1- kuya ku-80 mg.
Umthamo wokuqala onconywayo ngu-10 mg; umthamo omkhulu ngu-80 mg. Ukulungiswa komthamo kwenziwa ngokuhamba kwamaviki ama-4. Imvamisa, umthamo ophelele ngu-20 mg ngosuku.
Imithamo ephumelelayo ye-Ovenkor lapho kunesifo senhliziyo noma esimweni esikhulu sokukhubazeka okunjalo sisuka kuma-20 kuye kwangama-40 mg ngosuku. Esigabeni sokuqala sokwelashwa, kusetshenziswa umuthi kumthamo we-20 mg bese kuthi ngemuva kwamasonto amane umthamo uguqulwe ube ngu-40 mg.
Uma kutholakala umthamo we-cholesterol ongaphansi kwe-140 mg / dl emzimbeni, umthamo womuthi uyancishiswa.
Umthamo omncane usetshenziswa ezimweni lapho isiguli sinokuhluleka okungapheli kwe-renal noma lapho senza ukwelashwa okuhlanganisa inhlanganisela neCyclosporine, i-Danazole, iGemfibrozil noma amanye ama-fibrate.
Izinkomba zokusetshenziswa ngokuya ngemiyalo yile
- ukuba khona kwe-hypercholesterolemia;
- ubukhona emzimbeni we-IHD noma izimfuneko zokuqalwa kwalokhu kwephulwa.
Ukuxhumana kokusebenzisa umuthi yilezi:
- Isifo sesibindi ngesimo esisebenzayo.
- Porphyria.
- I-Myopathy
- Iminyaka yesiguli ifinyelela eminyakeni eyi-18.
- Ukukhulelwa nokukhulelwa.
- Ukuba khona kokungabekezeleleki komuntu ngamunye.
Ukuqapha lapho uphuza umuthi kufanele kuboniswe ngokuphuza ngokweqile, ubukhona be-hypertension ye-arterial esigulini, ngesikhathi sokwelashwa kwe-immunosuppression. Ngaphezu kwalokho, ukuqapha kuyadingeka uma isiguli sinesifo sokuwa kanye ne-pathology ethoni yemisipha yamathambo ye-genesis engacacile.
Lapho usebenzisa umuthi, ukubonakala kwemiphumela emibi yesidakamizwa kuboniswa ngale ndlela elandelayo:
- Ubuhlungu esiswini;
- ukuqunjelwa, ukubhuqa, isicanucanu, i-pancreatitis eyingozi, i-hepatitis, isifiso sokuhlanza;
- ikhanda
- i-peripheral neuropathy;
- Isiyezi
- ukuqwasha
- umkhuhlane
- ukulunywa
- i-urticaria;
- ukukhuphuka kwenhliziyo, i-anemia, kunciphe i-potency.
Uma kutholakala izimpawu zokuqala zemiphumela emibi, i-Ovenor kufanele ichithwe.
Izindleko zomuthi, ukufana kwawo kanye nokubuyekezwa mayelana nomuthi
Ngokuhambisana nokubuyekezwa okutholakalayo kweziguli nokwelapha odokotela, i-Ovencor iyindlela ephumelela kakhulu yokulwa ne-cholesterol ephezulu emzimbeni. Enye yezimo zokufeza izinguquko ezinhle ekuziphatheni zokwelapha idinga ukunamathela ngokuqinile ekudleni. Ububi bomuthi ukuthuthuka okungenzeka esigulini semiphumela emibi ehlukahlukene ehlukahlukene engaholela ekuqedweni kokwelashwa.
Intengo ye-Ovenkor okwamanje kumakhemisi e-Russian Federation isuka kuma-ruble angama-300 kuye kwangama-600 iphakethe ngalinye, kuya ngesifunda.
Izidakamizwa ezilandelayo ziyizifanekiso zomuthi:
- Simvastatin.
- I-Vero-simvastatin.
- I-Zokor.
- I-Atherostat.
- I-Zovatin.
- I-Avestitin.
- Simvastol.
- Simvakard.
- Simlo.
- I-Holvasim.
- I-Zorstat.
Izindleko zama-analogues zomuthi oyinhloko zingashintshashintsha ebangeni elibalulekile. Ngakho-ke, ngokwesibonelo, iSimvastatin inezindleko ezingama-ruble angama-41 kwithebhulethi engama-30, ngalinye linama-10 mg wezithako ezisebenzayo, kanti iVasilip inezindleko ezingama-ruble ayi-124 kwiphakeji elinezibhebhe eziyi-14, ngalinye liqukethe u-10 mg wesithako esisebenzayo.
Ngaphambi kokukhetha i-analogue efanelekile yokufaka umuthi oyinhloko, kufanele uthintane nodokotela wakho.
Ingabe kukufanele ukuthatha izazi ze-statins ezizokutshela kuvidiyo ekulesi sihloko.
