I-Colestipol isetshenziswa kabanzi ekwelapheni i-hypercholesterolemia yomndeni.
Umuthi iyi-resin yokushintshana nge-anion, eklanyelwe ukungathathi hlangothi futhi isuse ama-bile acid kusuka ku-lumen yamathumbu.
Ingxenye esebenzayo yomuthi ingaba nomphumela wokuthoba lapho ukulunywa kwenzeka ngenxa yokuthuthuka kwe-hyperbilirubenemia.
Ngaphezu kwalokho, lo muthi udambisa isimo somuntu ogulayo uma kuvela ukubadakwa komzimba kwe-glycosidic.
Umuthi uwukhambi olusebenzayo lohudo olubangelwa ukwephula ukumuncwa kwama-bile acid ngemuva kokuphinda kufakwe i-ileum.
Isimo sokukhishwa kwezidakamizwa nesenzo semithi
I-Colestipol yenziwa ngesimo sempuphu ehlanganiswe kumashekhi ama-gramu ayi-5 lilinye nangesimo sokulungiswa kwethebhulethi enesisindo sethebhulethi esingu-1 gram. Amacwecwe agcwele emabhulashini futhi agcwele emaphaketheni amakhadibhodi.
Intengo yomuthi endaweni yeRussia Federation ingahluka kancane ngokuya ngesifunda sezwe futhi ngokwesilinganiso cishe ama-ruble angama-300.
Umuthi kufanele ugcinwe endaweni evikelwe ukukhanya kwelanga. Indawo yokubeka yama-grlesle weColestipol akufanele ifinyeleleke ezinganeni nasezwaneni ezifuywayo.
Umuthi akufanele ugcinwe kumswakama ophezulu, futhi izinga lokushisa endaweni yokubeka kufanele libe phakathi kuka-15 no-25 degrees Celsius. Ukuthengwa kwemithi kwenziwa emakhemisi kuphela ngokuyalelwa ngudokotela oholayo. Isakhiwo esisebenzayo somuthi yiColestipol hydrochloride.
I-Colestipol yisidakamizwa esinomphumela ophansi we-lipid. Ukwethulwa kwayo emzimbeni kusiza ukwehlisa izinga le-cholesterol ephelele ne-lipoproteins ephansi kwiplasma yegazi. Lapho kuvezwa umzimba, umuthi awubangeli ukwehla kwezinga le-lipoprotein ephezulu kwe-plasma. I-anion-exchange resin eyenza isidakamizwa ikhuthaza ukubopha kwama-bile acid. Lezi zingxenye ezisesimweni esiboshwe zidedelwa emzimbeni kanye namalondolo.
Ukuhlanganiswa kwe-bile acid kunciphisa ukuqina kwezinqubo zokumuncwa kokugcina kusukela ku-lumen yamathumbu. Ngesikhathi esifanayo nale nqubo, ukuhlanganiswa kwama-bile acid aqhamuka ku-cholesterol ngamaseli wesibindi kuyasebenza, okuholela ekunciphiseni kokuqukethwe kwe-cholesterol emzimbeni.
Ngokuyalela imiyalo yokusebenzisa umuthi, inkomba enkulu yokuwusebenzisa njengomuthi wokwelapha ubukhona be-Type 2A hyperlipoproteinemia esigulini. lolu hlobo lwe-pathology alunakulungiswa ngokubheka izindlela ezikhethekile zokudla kanye nokufaka umthwalo ngokomzimba womuntu.
Izifo ezikhona lapho kunconywa ukusetshenziswa komuthi kungukucindezela we-hypertension kanye nokwakha isifo sokuqina kwemithambo yegazi.
Umuthi ungasetshenziswa zombili ngesikhathi se-monotherapy, futhi njengengxenye yokwelashwa okuyinkimbinkimbi, njengenye yezakhi zomphumela womuthi emzimbeni wesiguli.
Imiyalo yokusebenzisa umuthi
Ngaphambi kokuthenga i-Colestipol, kufanele uzijwayeze nemiyalo yokuyisebenzisa, intengo yayo, ukubukezwa mayelana nalesi sidakamizwa, bobabili ochwepheshe bezokwelapha kanye neziguli abazisebenzisele ukwelashwa, kuyanconywa nokuthi ubonane nodokotela wakho futhi uthole ngokutholakala kwezithasiselo zalo muthi.
Ngokuyalela imiyalo yokusebenzisa, umuthi unconywa ukuthi usetshenziswe ngesikhathi sokwelashwa umthamo wama-gramu ayi-5 ngosuku. Imithamo yokuqala, uma kunesidingo, ingandiswa ngudokotela ohambelayo. Khuphula umthamo kufanele ube ngama-gramu ayi-5 njalo ezinyangeni ezi-1-2.
Uma umuthi usetshenziswa ngemithamo emincane naphakathi nendawo, kufanele uphuzwe kabili ngosuku. Ngokukhuphuka komthamo ongaphezu kwama-20 amagremu ngosuku, umthamo uhlukaniswe ngemithamo emithathu phakathi nosuku.
Imvamisa, umphumela okhulunywa kakhulu ngokuthatha i-Colestipol ubonwa ngemuva kwenyanga yokusebenzisa umuthi njalo.
Isilinganiso esivumelekile esiphezulu ngama-30 amagremu ngosuku.
I-Colestipol, njengayo yonke eminye imishanguzo, inezinombolo eziningi zemibandela yokusetshenziswa, icatshangwe lapho uyithatha.
Ukusetshenziswa kwesidakamizwa akunconyelwe:
- ukuba khona kokungabekezeleli komuntu ngamunye ezingxenyeni zomuthi;
- i-steatorrhea;
- nobudala besiguli buze bufike eminyakeni eyi-6.
Ngesikhathi sokulashwa ngomuthi, imiphumela elandelayo elandelayo ingavela esigulini:
- Isicanucanu
- Izingcingo zokuhlanza.
- Ukubonakala kwama-hiccups.
- Ukuqunjelwa.
- I-Flatulence.
- Isifo sohudo.
Ngaphezu kwalokho, ezimweni ezingavamile, ukuvela kwe-urticaria kanye nesikhumba.
Ukusebenzelana kwezidakamizwa, imiyalo ekhethekile kanye nezifanekiso zomuthi
Uma kukhona ama-contraindication esigulini, kungenzeka ukusebenzisa i-analogues yayo njenge-ejenti yokwelapha.
Ukufana kwezidakamizwa yimithi efana neLipantil, Lipantil 200 M, Tribestan, Roxer, Vitrium Cardio Omega-3 ye-cholesterol.
Ngokuhambisana nezincomo ezichazwe emiyalweni yokusetshenziswa, lapho usebenzisa i-Colestipol, leyo mishanguzo ephethwe nayo kufanele icatshangwe.
Inani elikhulu lemithi lingathinta umsebenzi weColestipola.
Le mithi elandelayo ithinta umsebenzi weColestipola:
- I-Atorvastatin - inciphisa ukugxila futhi ithuthukise umphumela wokunciphisa we-lipid;
- IVancomycin - ibopha into esebenzayo;
- I-Gemfirozil - inciphisa i-adsorption yesakhi esisebenzayo;
- I-Hydrocortisone - lowers adsorption.
Ngaphezu kwalokho, ukusetshenziswa okuhlangene kweTetracycline, Furosemide, Pravastatin, Carbamazepine, Diclofenac nabanye abaningana kunethonya elibonakalayo ekusebenzeni kwezinto.
Ngaphambi kokubeka umuthi, qiniseka ukuthi isiguli asinakho:
- I-Hypothyroidism
- Thayipha isifo sikashukela sokuqala.
- I-Dysproteinemia syndrome.
- Izimo ezonakalisayo zepheshana elisetshenziswayo.
Phambi kwalezi zifo, umuthi ungavunyelwa, kepha ukusetshenziswa kwawo kufanele kwenziwe ngaphansi kokuqashwa ngokuqinile kodokotela ohambelayo.
Kuyo yonke inqubo yokwelashwa nalesi sidakamizwa, kumele kuqashelwe ngokuqinile i-cholesterol, lipoprotein, kanye namazinga e-TG.
Akufanele iphathwe neColestipol ngesikhathi sokukhulelwa. Lokhu kungenxa yokuthi akukho datha yenhloso ngemiphumela yengxenye esebenzayo yomuthi esibelethweni esikhulayo nesimo sesimo sikamama ngalesi sikhathi. Ngaphezu kwalokho, lesi sidakamizwa akufanele sisetshenziselwe ukwelashwa ngesikhathi sokuncelisa, ngoba akukho datha ethembekile kumthelela wengxenye esebenzayo ekwakhiweni kobisi lwebele.
Mayelana nezidakamizwa ze-cholesterol ephezulu ezichazwe kuvidiyo kule ndatshana.
