Isibonakaliso esiyinhloko sokusetshenziswa kweKrestor ukuqina kwe-cholesterol uma kwenzeka kuba ne-hypercholesterolemia, isifo sokuqina kwemithambo yegazi nezinye izifo zentliziyo.
Amathebulethi abekezelelwa kalula yiziguli, imiphumela emibi ivela kakhulu kakhulu. Uma kunesidingo, uchwepheshe ubeka izifanekisombhalo (i-Rosuvastatin, i-Rosart, i-Mertinil) noma i-analogues (Atoris, Vasilip, Zokor). Imininingwane eminingi enemininingwane ingatholwa kulokhu okuqukethwe.
Imininingwane ejwayelekile yezidakamizwa
Umenzi walesi sidakamizwa inkampani yezokwelapha i-AstraZeneca UK Limited, ese-UK.
UCrestor (igama lesiLatini - uCrestor) ukhishwa kwifomu lethebhulethi ukusetshenziswa kwangaphakathi. Umthamo ungahluka - 5, 10, 20 noma 40 mg wento esebenzayo. Ukufakwa kwamakhadibhodi, okungabonakala ezithombeni ezikwi-Intanethi, kuqukethe izigaxa ezimbili zamathebulethi ayi-14.
Ithebhulethi elilodwa lifaka isithako sokudla se-rosuvastatin calcium (rosuvastatin) nababekhona. Amacwecwe enziwa ayindilinga noma ama-oval, umbala wabo uncike kumthamo - ophuzi (5 mg) no-pink (10, 20, 40 mg).
Isiphambano sinomphumela ophansi we-lipid. I-Rosuvastatin, ekhulisa inani lama-receptors wesibindi, yehlisa okuqukethwe kwe-cholesterol "embi" (LDL ne-VLDL) egazini. Njengomphumela, ukucwaswa (i-catabolism) kanye nenqubo yokuthathwa kwe-LDL kuyasheshiswa, futhi ukwenziwa kwe-cholesterol "embi" nakho kuncishisiwe.
Ngakho-ke, isonto elilodwa ngemuva kokwelashwa, ukwehla kwe-cholesterol ephelele, i-LDL, i-VLDL, ama-triglycerides, njll. Umphumela omkhulu wokusebenzisa umuthi ubonwa ngemuva kwezinsuku eziyi-14.
Ngemuva kokuthatha amaphilisi, ukuqoqwa okuphezulu kakhulu kwengxenye esebenzayo kufinyelelwa ngemuva kwamahora ama-5. Ngaphezu kwalokho, i-rosuvastatin ibopha kahle amaprotheni e-plasma.
Ukuphuma kwengxenye eyinhloko kwenzeka, njengomthetho, ngokugcwala indle futhi ngezinga elincane ngomchamo. Ukusetshenziswa kwesidakamizwa isikhathi eside kwezifo zesibindi kungathinta nemingcele ye-pharmacokinetic.
Izinkomba kanye ne-contraindication ukuze zisetshenziswe
Udokotela unquma umuthi we-hypolipidemic wokuvimbela kanye nokwelashwa kwe-homozygous hypercholesterolemia, atherossteosis.
Ngaphezu kwalokho, umuthi usetshenziselwa ukwelapha i-pathologies ye-inhliziyo, kanye nengxenye yokwelapha okuyinkimbinkimbi kwe-hypercholesterolemia exubile.
Imiyalo esetshenzisiwe inayo uhlu olubonakalayo lwe-contraindication. Zincike kumthamo wesidakamizwa.
Kwenqatshelwe ukusebenzisa i-Krestor 5.10.20 milligrams kubantu:
- abe nokuzwela okwengeziwe kwezinto ezakha ukwakheka;
- uhlushwa yizifo ezinkulu zesibindi, kanye nokwanda komsebenzi we-hepatic transaminases;
- ngasikhathi sinye ekwelashwa i-cyclosporin;
- uhlushwa ukungasebenzi kwezinso;
- ukungabekezelelani kwe-lactose noma ukuntuleka kwe-lactase;
- abafikanga eminyakeni engu-18;
- uhlushwa i-myopathy (i-pathology ye-neuromuscular eqhubekayo);
- ukhulelwe noma uncelisa ibele.
Umthamo wamamayela ama-milligram angama-40 uhlukaniswe ngabantu abasebenza:
- Phuza utshwala.
- Hlukana nokuqothuka kwe-hepatic noma kwe-renal.
- Banobungozi obukhulu be-myopathy.
- Thatha imicu eyinkimbinkimbi.
- Uhlinzwe kabanzi muva nje.
- Unenkinga yokufelwa, isithuthwane.
- Iba ne-hypothyroidism.
- Banokungalingani kwama-electrolyte egazini.
- Sisanda kuthola ukulimala okungathi sína.
- Ihlushwa i-hypotension ye-arterial.
- Itheleleka ngegciwane le-septic.
- Ihlushwa ukuphazamiseka kwe-metabolic.
- Ungowomjaho wamaMongoloid.
Ipheshana lemiyalo libuye lithi kubantu abadala (iminyaka engama-60 nangaphezulu), umuthi ubekwa ngokuqapha ngokweqile.
Imiyalo yokusebenzisa umuthi
Abantu abadala baphuza lo muthi noma ngabe udla ini - ekuseni noma kusihlwa. Amacwecwe awakwazi ukuhlafunwa futhi aphulwe, ayagezwa ngenani elincane lamanzi.
Umthamo nesikhathi sokulashwa kunqunywa ngudokotela, kucatshangelwa izici ezinjengobunzima besifo kanye nezimpawu zomuntu ngamunye.
Ngokwemiyalo, umthamo wokuqala ungama-milligram angama-5- 10. Inkambo yokwelashwa izinsuku ezingama-21, ikhefu akudingekile. Uma kunesidingo, udokotela unelungelo lokunyusa umthamo womuthi.
Kunconywe ngokuqinile ukuthi uqaphe impilo yesiguli ezinsukwini ezimbalwa zokuqala, osanda kushintshela ku-Krestor milligrams. Ngenxa yokulutha komzimba engxenyeni esebenzayo, ukuthuthukiswa kokuboniswa okungalungile kungenzeka.
Kubantu abanesilinganiso esiphakathi sokwehluleka kwezinso, udokotela ubeka umthamo wokuqala we-5 mg ngosuku, kancane kancane ukhuphukela ku-40 mg.
Ngenxa yokuthi abantu bohlanga lwamaMongoloid banezici ezithile zokusebenza kwesibindi, ukuthatha i-Krestor 20 no-40 mg kuyenqatshelwe. Umthamo wokuqala ngu-5 mg, khona-ke uyandiswa ube ngu-10 mg.
Kuphikisiwe ukuthi kunikezwe ngaphezulu kwe-20 mg ngosuku kwiziguli ezithambekele ku-myopathy.
Umsebenzeli ongehlisa i-lipid kufanele agcinwe endaweni epholile. Ungavumeli ukuthi okuhlanganisiwe kuwele ezandleni zezingane.
Impilo yeshelf iyiminyaka emithathu, ngemuva kwalesi sikhathi, ukuphuza umuthi akuvunyelwe ngokuphelele.
Imiphumela emibi kanye ne-overdose
Ezimweni ezingavamile, lapho usebenzisa iKrestor, kungavela umphumela ongemuhle.
Njengomthetho, umuthi ubekezelelwa kahle, futhi ngesikhathi sokusebenzisa imithamo emikhulu, ukusabela okungekuhle kungasingathwa ngokuzimela ngaphandle kokufuna usizo lodokotela.
Imiyalo yokusebenzisa iqukethe uhlu olulandelayo lwemiphumela emibi:
- ukungezwani komzimba - i-urticaria, ukuqubuka esikhunjeni, i-edema kaQuincke;
- ukuphazamiseka kwengqondo okukhona emzimbeni - isihlalo sokulimala, isicanucanu, ukugabha, ukuqhakaza;
- ukwephulwa kohlelo lwezinzwa - isiyezi nobuhlungu ekhanda;
- ukuba khona kwamaprotheni kumchamo, kwesinye isikhathi ukwenzeka kokuhluleka kwezinso;
- Ubuhlungu bemisipha, ezimweni ezingavamile, ukuvela kwe-myopathy;
- ukuthuthukiswa kokungaxhomekeki kwe-insulin (uhlobo 2) isifo sikashukela;
- ukungasebenzi kahle kwe-hepatic, umsebenzi owengeziwe wama-hepatic transaminases.
Nge-overdose yesidakamizwa, umphumela ongemuhle uyanda. Kuboniswa kungqubuzana nomsebenzi wesistimu yenhliziyo nokwenqatshelwa kwezinso nesibindi.
Ayikho i-antidote ethize, kulokhu i-hemodialysis ayisebenzi. Ukuqeda i-overdose, ukwelashwa okubonakalayo kuyenziwa.
Ngaphezu kwalokho, ukuqapha okufanele ama-enzyme wesibindi kuyadingeka.
Okunye ukusebenzisana kwezidakamizwa
Ukusebenzisana kweKrestor namaqembu athile wezidakamizwa kungaholela emiphumeleni engathandeki. Ngakho-ke, isiguli kufanele sazise udokotela ohambayo ngazo zonke izifo ezihlangene ukuze sigweme ukungaphatheki kahle emzimbeni.
Imiyalo isho ngokuhlanganiswa okungathandeki kweKrestor neCyclosporin. Ukusetshenziswa kwamanye ama-ejidini okwehlisa i-lipid, isibonelo, i-Hemifibrozil, kuguqula ukugcwala kwe-plasma kwento esebenzayo ye-rosuvastatin.
I-Krestor ayihambelani kahle nabaphikisi beWarfarin ne-Vitamin K, ngoba ithinta inkomba ye-prothrombotic.
Akunconyelwe ukuthatha i-Krestor ne-Ezetimibe ngasikhathi sinye, ngoba lokhu kungandisa imvamisa nobunzima bemiphumela emibi.
Iziguli ezithambekele ekuqaleni kwe-myopathy akufanele zisebenzise i-hemofibrate, i-fibrate, i-nicotinic acid, kanye ne-gemfibrozil ene-rosuvastatin.
Futhi, okufakwayo kuqukethe imininingwane mayelana nokuphathwa okungathandeki ngasikhathi sinye kwama-antacid, izindlela zokuvimbela inzalo ngomlomo, ama-proteinase inhibitors. Kwenzeka okufanayo nasemithini efana ne-Erythromycin, Lopinavir neRitonavir.
Ekwelapheni i-lipid ephezulu, ukusetshenziswa kotshwala akuvunyelwe ngokuphelele.
Izindleko nombono wabathengi
Ungathenga umuthi kaKrestor kuphela ngomuthi kadokotela. Ngaphezu kwalokho, kushibhile uku-oda ku-inthanethi kuwebhusayithi yommeli osemthethweni.
Izindleko zincike kwinani lamatshwele kanye nomthamo. Uhla lwamanani luhanjiswa ngezansi:
- Intengo engu-5mg (No. 28) - ama-ruble ayi-1835.
- Intengo yeKrestor 10mg - ama-ruble angama-2170.
- 20 mg - 4290 rub.
- 40 mg - 6550 rub.
Ngakho-ke, umuthi ongenisiwe weKrestor uyabiza, ngakho-ke, awubizi kwiziguli ezinemali ephansi. Lokhu ukukhipha okukhulu kwesidakamizwa.
Kusukela uKrestor avele emakethe yamakhemikhali yasekhaya esikhathini esedlule kakhulu, akukho kuzibuyekezo eziningi kakhulu ngaye. It is ngokukhethekile inikezwe abantu ukwelashwa kwe-hyperlipidemia, ikakhulukazi ngemuva kokushaywa unhlangothi noma ukushaya kwenhliziyo.
Abanye abathengi baxwayisa ukuthi izinkinga zekhanda nezinkinga zokulala zivela ngesikhathi sokwelashwa. Ochwepheshe baqapha ngokucophelela ukwakheka kwegazi leziguli, kanye nenombolo yama-enzyme esibindi.
Ngokuvamile, odokotela neziguli bathanda umphumela wokwelapha weCrestor.
Ngokuvamile, izibuyekezo ezinhle zitholakala mayelana nomuthi.
Izithonjana nezifanekiswane zomuthi
Uma i-Krestor igxunyekwe isiguli, noma iba nemiphumela emibi, udokotela unquma obambele esikhundleni.
Lokhu kungaba ukufana, ekwakhekeni lapho kukhona into eyodwa esebenzayo, noma i-analogue enomphumela ofanayo wokwelapha, kepha iqukethe izinto ezihlukile ezisebenzayo.
Phakathi kwamagama wokuvumelanisa, osebenzayo kakhulu futhi athandwayo yile:
- IMertenil ing umuthi oshibhile (ama-ruble angama-450 ngephakethe ngalinye No. 30 nge-5 mg), ehlisa i-cholesterol ekuhlolweni okwamukelekayo. Inezinkomba ezifanayo kanye ne-contraindication. Ukuqapha kuthathwa ezigulini ezisengozini enkulu yokuthola i-myopathy / rhabdomyolysis, hypothyroidism, kanye nokwehluleka kwezinso.
- URosart ungomunye umuthi ongabizi kakhulu weziguli ezihola kancane naphakathi. Ngokwesilinganiso, izindleko zokupakisha (Cha. 30 ze-5 mg) ngama-ruble angama-430.
- I-Rosuvastatin, enegama elifanayo nesithako esisebenzayo. Okudumile phakathi kweziguli, ngoba izindleko zokupakisha (Cha. 30 ze-5 mg) ngama-ruble angama-340 kuphela.
Ukufana okusebenzayo kufaka:
- I-Vasilip inomphumela wokunciphisa okwe-lipid, into yayo esebenzayo yi-simvastatin. Umenzi ukhiqiza amaphilisi ngomthamo wamamitha ayi-10,20 nama-milligram angama-40. Intengo yokufaka (amaphilisi angama-28 nge-10 mg) ngama-ruble angama-250.
- I-Atoris ifaka isakhi esisebenzayo i-atorvastatin, esandisa umsebenzi we-LDL receptors esibindini nakwizicubu ezengeziwe. Kunokuphikisana okumbalwa: i-hypersensitivity yomuntu ngamunye, ukungasebenzi kwesibindi, ama-transaminases akhuphukile, ukuphuma kwe-lactation nokukhulelwa. Izindleko ze-Atoris (amaphilisi angama-30 nge-30 mg) ngama-ruble angama-330.
- I-Zokor iqukethe i-simvastatin, evumela ukunciphisa i-HMG-CoA reductase. Abakhiqizi yi-USA neNetherlands. Inezinkomba ezifanayo kanye ne-contraindication njengemithi yangaphambilini, kufaka phakathi ingane. Izindleko zokufaka (amaphilisi angama-28 nge-10 mg) ngama-ruble angama-385.
Ngakho-ke, ungaqhathanisa umphumela wokwelashwa nezindleko zemithi, ukhetha okukhethiwe kakhulu. Akumele sikhohlwe ukuthi ekuvinjelweni nasekwelapheni i-atherossteosis ne-hypercholesterolemia, udinga ukwenza izivivinyo zomzimba futhi ulandele indlela odla ngayo.
Ukudla okuyisipesheli akufaki ukusetshenziswa kwamafutha, okuthosiwe, okufakwe emanzini anosawoti, kanye nezitsha ezinokuqukethwe kwe-cholesterol ephezulu. Ngaphandle kwalezi zinto ezimbili, ukwelashwa ngezidakamizwa kungasebenzi.
Izimo zichazwe ngokuningiliziwe kuvidiyo kule ndatshana.
