I-Trypsin iyi-enzyme ye-proteinolytic (i-enzyme) efikelwa yingxenye ye-pancreas engaphandle kwe-pancreas. Kuqala kukhiqizwa okwandulelayo ezweni elingasebenzi, i-trypsinogen.
Ingena ku-duodenum 12, futhi lapho icushiwe ngenxa yesenzo sesinye i-enzyme kuyo - Enterokinase.
Isakhiwo samakhemikhali se-trypsin sihlukaniswa ngamaphrotheni. Ekusebenzeni, kutholakala ezinkomeni.
Umsebenzi obaluleke kakhulu we-trypsin yi-proteinolysis, i.e. ukuhlukaniswa kwamaprotheni nama-polypeptides abe izingxenye ezincane - ama-amino acid. I-enzyme ekhuthazayo.
Ngamanye amagama, i-trypsin idiliza amaprotheni. Amanye ama-enzymes e-pancreatic ayaziwa futhi - i-lipase, ebandakanyeka ekugayweni kwamafutha, kanye ne-alpha-amylase, echitha carbohydrate. I-Amylase ayiyona nje i-enzyme ye-pancreatic, ibuye ihlanganiswe emithanjeni ye-salivary, kodwa ngamanani amancane.
I-Trypsin, i-amylase ne-lipase yizinto ezibaluleke kakhulu endaweni yokugaya ukudla. Uma kungekho okungenani esisodwa sazo, ukugaya ukudla kuphazamiseka kakhulu.
Ngaphezu kokubamba iqhaza kokugaya, i-enzyme ye-trypsin isebenza kakhulu ekwelapheni izifo ezahlukahlukene:
- isiza ukunciphisa ukuvuvukala emzimbeni;
- kusheshisa ukuphulukiswa kokusha, amanxeba anzima;
- ukwazi ukwahlukanisa izicubu ezifile ukuze imikhiqizo ye-necrosis ingangeni egazini futhi ibangele ukudakwa;
- kwenza umakhutshana amancanyana, amasende akhiphe uketshezi oluningi;
- kusiza i-liquefaction yezicucu zegazi;
- isiza ekwelapheni izifo ngokuvuvukala kwe-fibrinous;
- kuthuthukisa ukususwa kwezixuku ze-purulent;
- iphatha ukhubazeka okubucayi besilonda somlomo wesibeletho;
Esimweni esingasebenzi, le khompiyutha iphephe ngokuphelele.
Njengoba i-trypsin inezakhiwo ezinjalo eziphilisiwe, isetshenziselwa ukwenziwa kwemithi.
Njenganoma iyiphi enye into esebenzayo yanoma yisiphi isidakamizwa, ukusetshenziswa kwe-trypsin kunezinkomba zazo kanye ne-contraindication ukuze isetshenziswe.
Lapho usebenzisa izidakamizwa ezibandakanya i-trypsin, izincomo zikadokotela nemiyalo yokusebenzisa umuthi kufanele iqashelwe.
Ukuhlukaniswa Kwe-Trypsin:
- I-Amorphous - ingasetjenziswa kuphela (endaweni ethize yesikhumba).
- ICrystalline - iza ngesimo se-powder emhlophe-ephuzi, ngokungabikho kwephunga elikhona. Kusetshenziswa zombili ngokulandelana nangokuphatha kwe-intramuscular.
I-Trypsin itholakala ngaphansi kwamagama ahlukene: "Pax-trypsin", "Terridekaza", "Ribonuclease", "Asperase", "Lizoamidase", "Dalcex", "Profezim", "Irukson". Wonke amalungiselelo kufanele agcinwe endaweni eyomile, emnyama endaweni yokushisa engeqi ama-degree ayishumi.
Izinkomba ezisetshenziswayo yilezi:
- izifo ezithathelwanayo zamaphaphu kanye nemizila yomoya (i-bronchitis, pneumonia, pleurisy exudative);
- isifo se-bronchiectatic (ukuba khona kwezandiso ezinamandla ku-bronchi);
- ukutheleleka okuthelelekile kanye namanxeba ngokulimala kwe-purulent;
- ukuvuvukala okungapheli kwendlebe ephakathi (abezindaba ze-otitis);
- ukuvuvukala kokuhlanjululwa kwezono zangaphambi kanye nama-maxillary;
- ukuvuvukala kwamathambo (osteomyelitis);
- isifo se-periodontal;
- ukuvaleka komsele we-lacrimal;
- ukuvuvukala kwe-iris;
- izilonda zokucindezela;
- izinkinga ngemuva kokuhlinzwa iso.
Ukuxhumana kokusetshenziswa kwe-trypsin yile:
- Ukusabela komzimba nge-trypsin.
- Ukwanda komoya wamaphaphu, noma i-emphysema.
- Ukuntuleka kokusebenza kwenhliziyo.
- Izinguquko ze-Dystrophic nokuvuvukala esibindini.
- Isifo sofuba
- Isifo sezinso.
- I-pancreatitis iyasebenza.
- Ukwephulwa kohlelo lokubumbana kanye ne-anticoagulation.
- Izinqubo zokuvuvukala ezinso (i-jade).
- I-hemorrhagic diathesis.
Kungaba yini imiphumela emibi ngemuva kokusebenzisa i-trypsin?
- komzimba
- ukuzindla kwenhliziyo;
- ubomvu nobuhlungu ngemuva komjovo we-intramuscular;
- i-hyperthermia
Ngaphezu kwalokho, ukuqina kokuqina kungavela kuzwi lesiguli.
Lapho kufakwa kakhulu ekwelapheni amanxeba owomile noma amanxeba ngezicubu ezifile, kusetshenziswa ama-trypsin impregnated compress.
Ukwenza lokhu, udinga ukuncibilikisa i-50 mg yokulungiswa kwe-enzyme ku-50 mg we-saline yezomzimba (i-sodium chloride, noma i-0.9% saline).
Imvamisa sebenzisa ama-wipes amathathu angenhla enzelwe.
Ngemuva kokufaka i-compress, ihlelwe ngebhandeshi futhi ishiywe amahora angamashumi amabili nane.
Ukuphathwa kwemisipha I-5 mg ye-trypsin ihlanjululwe ku-1-2 ml ye-saline, i-lidocaine noma i-novocaine. Kubantu abadala, imijovo yenziwa kabili ngosuku, ezinganeni - kanye kuphela.
Ukusetshenziswa kwangaphakathi. Ngemuva kokwethulwa kwalo muthi, awukwazi ukuba sesimweni esifanayo isikhathi eside, ngoba lokhu kwenza ukuthi kube nzima ukucindezela imfihlo. Imvamisa, ngemuva kwezinsuku ezimbili, le mfihlo iphuma edamini.
Uhlelo lokusebenza lokuphefumula. I-Trypsin inhalations yenziwa kusetshenziswa i-inhaler noma i-bronchoscope. Ngemuva kwenqubo, kungcono ukuhlanza ikhala noma umlomo wakho ngamanzi afudumele (kuya ngokuthi inqubo yenziwa kanjani).
Ngendlela yamaconsi eso. Zidinga ukudonswa njalo amahora angama-6-8 izinsuku ezintathu.
Izici zokusebenzisa i-trypsin:
- I-Trypsin ayenqatshelwe ukufaka amanxeba okopha.
- Ayikwazi ukusetshenziselwa ukwelapha umdlavuza, ikakhulukazi ngokulimala kwezicubu.
- Ayiphathwanga ngokuhlinzwa.
- Lapho welapha izingane ezincane, kusungulwa uhlelo oluthile.
- Abesifazane abakhulelwe noma abancelile kufanele baphuze lo muthi kuphela uma ingozi yokufa kwakhe noma yokushona kwengane ibaluleke kakhulu.
I-Pharmacokinetics, i.e. ukusatshalaliswa kwalesi sidakamizwa emzimbeni akukafundwa. Kuyaziwa ukuthi lapho inja ingena emzimbeni, i-trypsin ibopha ama-alpha macroglobulins kanye ne-alpha-1 antitrypsin (inhibitor yayo).
Njengamanje, kunenamba enkulu yokubuyekezwa okuhle ngezidakamizwa eziqukethe i-trypsin. Uhla ikakhulukazi ukusetshenziswa kwalo ku ophthalmology. Ngalo, kuphakama, ukunamathela, izinqubo zokuvuvukala kanye ne-dystrophic ze-iris kuyelashwa, ngoba lezi zinqubo lapho kungekho makhambi owanele zingaholela ekungaboni kahle. Inhlanganisela ekwelashweni kwamalungiselelo we-enzyme ngezidambisigciwane ezindala, ama-anti -gic, ama-hormone, imishanguzo ye-glaucoma isebenza kahle, ekhulisa kakhulu isilinganiso sokuvuselelwa kwezicubu.
I-Trypsin yasiza ekudambiseni inkambo yezifo ezihlangene, ezinjenge-arthritis, i-polyarthritis, i-arthrosis nesifo se-rheumatic. Ikhulula izinhlungu, icindezela ukuvuvukala, ibuyise uhla oluphelele lokunyakaza.
Ngokulimala okukhulu, ukusikeka okujulile, ukusha, i-enzyme ivumela, okungenani, ukunciphisa inhlala-kahle yohlukumezekile, futhi kusheshise ukwelashwa.
Intengo ephakathi yamalungiselelo we-trypsin eRussia isuka kuma-ruble angama-500.
Egazini, okuthiwa i- "immunoreactive" trypsin kunqunywa ndawonye ngento evimbela umsebenzi wayo - i-alpha-1-antitrypsin. Izinga le-trypsin ngu-1-4 μmol / ml.min. Ukukhuphuka kwayo kungabonakala ekulimazeni okukhulu kwama-pancreas, izinqubo ze-oncological kuwo, nge-cystic fibrosis, ukwehluleka kwezinso okungamahlalakhona, futhi futhi kungahambisana nenkambo yezifo ezibangelwa amagciwane. Ukwehla kwenani le-enzyme kungakhombisa uhlobo lwe-1 mellitus yesifo sikashukela, noma izifo ezingenhla, kodwa ngezindlela ezingapheli futhi ezigabeni zakamuva.
Ngaphezu kokuhlolwa kwegazi, iziguli zivame ukunikezwa i-coprogram. Ngaphambi kwalolu cwaningo, ama-antibiotic ayi-3 awanconywa izinsuku ezintathu. Lapho i-trypsin eqondayo emafutheni kungenzeka ingatholakali. Ngokuvamile lokhu kuwuphawu lwezinqubo ze-cystic fibrous in the pancreas. Ukwehla okubukhali kuyo kuyabonakala nge-cystic fibrosis, kodwa lokhu akusho ukuthi ukuxilongwa kuyaqinisekiswa, futhi izifundo ezengeziwe ziyadingeka ukucacisa. Okwamanje, kukholelwa ukuthi ukuzimisela komsebenzi we-trypsin ezindlini zokugcoba kubonisa ukuthi akukho lutho.
Imininingwane emfushane nge-trypsin namanye ama-enzyme anikezwe kuvidiyo ekulesi sihloko.
