I-Metformin Teva: intengo nokubuyekezwa, imiyalo nezimpawu

I-Metformin iyisidakamizwa esikhiqizwa ngumenzi ngesimo samathebulethi enenani elihlukile lamamayela wamakhompiyutha wesakhi esisebenzayo esikhulu.

Emakethe yezokwelapha, izidakamizwa zivezwa ezinokuqina okusebenzayo kwe-500, 850 mg ne-1000 mg.

Wonke amaphilisi ane-500, 850 mg ne-1000 mg ahlukile phakathi kwawo hhayi ngenani lesithako esisebenzayo.

Uhlobo ngalunye lwethebhulethi kufanele luhluke phakathi kwabo ngokuqopha ebusweni bomuthi.

Ukwakheka kwalo muthi nencazelo yawo

Ithebhulethi ezinokuqoqwa kwenhlanganisela eyi-500 mg enkulu inombala omhlophe noma ocishe ube mhlophe. Ingaphandle lomuthi limbozwe nge-membrane yefilimu, eqoshwe ngo- "93" kolunye uhlangothi lomuthi kanye "48" ngakolunye uhlangothi.

Amathebhulethi angama-850 mg angama-oval nefilimu efakiwe. Ngaphezulu kwegobolondo, kuqoshwe u- "93" no- "49".

Umuthi, onobunzima obungu-1000 mg, ubumbekile obumbekile futhi umbozwe ngumbala wefilimu ngokusetshenziswa kwezingozi kuzo zombili izinhlaka. Ngaphezu kwalokho, kuhlanganiswe lezi zinto ezilandelayo egobolondweni: “9” ngakwesobunxele kwezingozi bese kuthi u- “3” ngakwesokunxele sezingozi ngapha nangapha u- “72” ngakwesobunxele bezingozi bese kuthi u- “14” ngakwesokunxele sengozi kwenye.

Isakhi esisebenzayo somuthi yi-metformin hydrochloride.

Ngaphezu kwengxenye eyinhloko, ukwakheka kwalesi sidakamizwa kufaka i-asizo, efana:

• i-povidone K-30;
• i-povidone K-90;
• i-silicon dioxide colloidal;
• i-magnesium stearate;
• i-hypromellose;
• titanium dioxide;
• i-macrogol.

Umuthi uhloselwe ukusetshenziswa komlomo futhi ungokweqembu le-Biguanides.

Izwe okuvela kulo u-Israyeli.

I-Pharmacodynamics ne-pharmacokinetics yesidakamizwa

Ukusetshenziswa kweMetformin kusiza ekunciphiseni ukugcwala koshukela wegazi kushukela wohlobo lwesibili. Ukwehla kokuhlushwa kwenzeka ngenxa yokuvinjwa kwama-bioprocesses we-gluconeogeneis kumaseli wesibindi kanye nokuqina kwama-bioprocesses wokusetshenziswa kwawo kumaseli wezicubu ezincike kuma-insulin. Lezi izicubu ziyimisipha e-striated ne-adipose.

Umuthi awunamphumela kuma-bioprocesses alawula ukwakheka kwe-insulin kumaseli we-pancreatic beta. Kusetshenziswa umuthi akubeki ezenzweni zokuvela kwe-hypoglycemic. Ukusetshenziswa kwesidakamizwa kuthinta i-bioprocesses eyenzeka ngesikhathi se-lipid metabolism, ngokunciphisa okuqukethwe kwe-triglycerides, cholesterol kanye ne-low density lipoprotein ku-serum yegazi.

I-Metformin inomphumela ovuselelayo ezinqubweni ze-intracellular glycogeneis. Umphumela we-grcoellis ye-intracellular yi-activation ye-glycogenitase.

Ngemuva kokuthi umuthi ungene emzimbeni, iMetformin icishe ikhangiswe ngokuphelele egazini eliphuma emgudwini wesisu. I-bioavailability yezidakamizwa isukela kumaphesenti angama-50 kuye kwangama-60.

Ukuqunjelwa okuphezulu kwento esebenza kuyo kutholakala eplasma yegazi amahora angama-2,5 ngemuva kokuthatha umuthi. Amahora angama-7 ngemuva kokuthatha umuthi, ukumuncwa kwekhompiyutha esebenzayo kusuka ku-lumen yendawo yokugaya ku-plasma yegazi kuyaphela, futhi ukugcwala komuthi ose-plasma kuqala ukuncipha kancane. Lapho uthatha umuthi ngokudla, inqubo yokumuncwa ibambezela.

Ngemuva kokungena kwi-plasma, i-metformin ayibandakanyi ukwakheka kwamaprotheni ekugcineni. Futhi isatshalaliswa ngokushesha kuwo wonke izicubu zomzimba.

Ukuhoxiswa komuthi kwenziwa kusetshenziswa izinso. I-Metformin ikhishwe ingashintshiwe emzimbeni. Ukuphila kwesigamu umuthi kungamahora ayi-6.5.

Izinkomba kanye ne-contraindication yokusebenzisa umuthi

Isibonakaliso sokusetshenziswa komuthi iMetformin mv ubukhona besifo sikashukela kumuntu, esingenakunxeshezelwa ngokudla nokudla komzimba.

I-Metformin mv Teva ingasetshenziswa zombili ekwenziweni kwe-monotherapy, futhi njengenye yezingxenye ekusetshenzisweni kokwelashwa okuyinkimbinkimbi.

Lapho wenza ukwelashwa okuyinkimbinkimbi, amanye ama-hypoglycemic agents angasebenza ngokuphathwa ngomlomo noma nge-insulin.

I-contraindication eyinhloko yokuphuza umuthi yile elandelayo:

1. Ukuba khona kwe-hypersensitivity kuforamu enkulu esebenzayo yesidakamizwa noma ezintweni zayo ezisebenzayo.
2. Isiguli sine-ketoacidosis yesifo sikashukela, isifo sikashukela noma ukoma.
3. Umsebenzi wezinso ongasebenzi kahle noma ukuhluleka kwezinso.
4. Ukuthuthukiswa kwezimo ezibucayi, lapho ukuvela kwephulwa ekusebenzeni kwezinso kungenzeka. Izimo ezinjalo zingahlanganisa ukomisa kanye ne-hypoxia.
5. Ukuba khona emzimbeni wokubonakaliswa kwezifo ezingamahlalakhona ezingavusa ukubukeka kwezicubu hypoxia.
6. Kwenziwa ukungenelela okubanzi kokuhlinzwa.
7. Isiguli sinokuhluleka kwesibindi.
8. Ukuba khona kotshwala obungamahlalakhona esigulini.
9. Isimo se-lactic acidosis.
10. Akunconyelwe ukusebenzisa lesi sidakamizwa amahora angama-48 ngaphambili namahora angama-48 ngemuva kokuhlolwa okwenziwe ngekhompiyutha equkethe iodine.
11. Akusizi ukusebenzisa lesi sidakamizwa amahora angama-48 ngaphambili namahora angama-48 ngemuva kokuhlinzwa, okuhambisana nokusetshenziswa kwe-anesthesia jikelele.

Ngaphezu kwalezi zimo, umuthi awusetshenziswa ngokudla kokudla okuphansi kwe-carb futhi uma isiguli esinesifo sikashukela singaphansi kweminyaka engu-18.

Umuthi uvunyelwe ngokuphelele ukusetshenziswa lapho uzala ingane noma uncelisa ibele.

Lapho uhlela ukukhulelwa, iMetformin MV Teva ithathelwa indawo yi-insulin kanti isifo sikashukela siselapha se-insulin. Ngesikhathi sokukhulelwa nesikhathi sokuncelisa, isiguli singaphansi kokuqashwa ngudokotela.

Uma kunesidingo sokuthatha umuthi ngesikhathi sokuncelisa, kubalulekile ukuyeka ukuncelisa ibele.

Imiyalo yokusebenzisa umuthi

Ekufakweni kwesidakamizwa iMetformin Teva, ukufundiswa kuphelele futhi kuchaza ngokuningiliziwe imithetho yokwamukelwa kanye nomthamo, onconywa ukwamukelwa.

Umuthi kufanele uphuzwe ngesikhathi sokudla noma ngokushesha emva kwawo.

Umthamo wokuqala onconyiwe womuthi ungahluka, kuye ngesidingo, ungahluka kusuka kuma-milligram angama-500 kuya kwangama-1000 kanye ngosuku. Kunconywa ukuthatha umuthi kusihlwa. Uma ukungatholakali kwemiphumela emibi kusuka ekuphuzeni umuthi ngemuva kwezinsuku ezingama-7-15, umthamo, uma kunesidingo, unganyuswa ube ngama-milligram angama-500-1000 kabili ngosuku. Ngokuphathwa kwezidakamizwa kwezikhathi ezimbili, umuthi kufanele uphuzwe ekuseni nakusihlwa.

Uma kunesidingo, ngokuzayo. Ngokuya ngezinga le-glucose emzimbeni wesiguli, umthamo womuthi ungangezelelwa futhi.

Lapho usebenzisa umthamo wokulungisa weMetformin MV Teva, kunconywa ukuthatha kusuka ngo-1500 kuye ku-2000 mg / ngosuku. Ukuze umthamo othathwe weMetformin MV Teva ungacasuli isiguli ukuthi ube nemiphumela emibi evela emgudwini we-gastrointestinal, umthamo wansuku zonke kunconywa ukuba uhlukaniswe ngemithamo emi-2 kuye kwemi-3.

Umthamo omkhulu ovunyelwe we-Metformin MV Teva ungama-3000 mg ngosuku. Lomthamo wansuku zonke kufanele uhlukaniswe ngemithamo emithathu.

Ukuqaliswa kokukhuphuka kancane kancane komthamo wansuku zonke kusiza ukwenza ngcono ukubekezelela esiswini somuthi.

Uma ushintsha usuka kwesinye isidakamizwa esinezakhiwo ze-hypoglycemic uye kwiMetformin MV Teva, kufanele uqale uyeke ukuthatha esinye isidakamizwa bese uqala ukuthatha uMetformin.

I-drug Metformin MV Teva ingasetshenziswa ngasikhathi sinye ne-insulin njengengxenye yokwelashwa okuhlanganisiwe. Uma usebenzisa umuthi kanye nawo, kunconywa ukusebenzisa ama-insulin asebenza isikhathi eside. Ukusetshenziswa kwama-insulin asebenza isikhathi eside ngokuhlangana ne-Metformin kukuvumela ukuthi uzuze umphumela omuhle we-hypoglycemic emzimbeni womuntu.

Ngaphambi kokusebenzisa umuthi, ukuhlolwa kwegazi kokuqukethwe ushukela kuyadingeka, umthamo womuthi esimweni ngasinye ukhethwa ngamunye.

Lapho usebenzisa umuthi ukwelapha iziguli esezikhulile, umthamo wezidakamizwa ngosuku akufanele udlule ku-1000 mg ngosuku.

Imiphumela emibi nemiphumela yokudakwa ngokweqile

Lapho usebenzisa umuthi, eminye imiphumela emibi ingavela emzimbeni wesiguli.

Ngokuya ngemvamisa yokwenzeka, imiphumela emibi ihlukaniswe ngamaqembu amathathu: kaningi kakhulu - isilinganiso sezehlakalo sidlula i-10% noma ngaphezulu, imvamisa - izehlakalo zivela ku-1 kuye ku-10%, hhayi kaningi - izehlakalo zemiphumela emibi zisuka ku-0.1 ziye ku-1%, kuyaqabukela - izehlakalo zemiphumela emibi zisuka ku-0,01 ziye ku-0,1% futhi kuyaqabukela kakhulu ukuthi izehlakalo zemiphumela emibi zingaphansi kuka-0,01%.

Imiphumela emibi lapho uphuza umuthi ungavela cishe kunoma yiluphi uhlelo lomzimba.

Imvamisa, ukubukeka kwephula umthetho uma uthatha umuthi kuyabonakala:

• kusuka ohlelweni lwezinzwa;
• emgodini wokugaya ukudla;
• ngesimo sokuphendula komzimba;
• ukwephulwa kwezinqubo ze-metabolic.

Kusukela ohlangothini lwesistimu yezinzwa ephakathi, imiphumela emibi ibonakaliswa ukunambitheka okungahambi kahle.

Lapho uthatha umuthi kusuka epheshaneni emathunjini, kungabonakala ukuphazamiseka nokuphazamiseka okulandelayo:

1. Isicanucanu
2. Izifiso zokuhlanza.
3. Ubuhlungu esiswini.
4. Ukulahlekelwa isifiso sokudla.
5. Ukuphazamiseka kwesibindi.

Ukungezwani komzimba kwenzeka kakhulu ngesimo se-erythema, ukulunywa kwesikhumba nokuqhuma ebusweni besikhumba.

Udokotela kufanele achazele abanesifo sikashukela ukuthi baphuze kanjani iMetformin ukuze bagweme imiphumela emibi. Kuyaqabukela, iziguli ezisebenzisa umuthi isikhathi eside zingakha i-B12 hypovitaminosis.

Ngokusetshenziswa kweMetformin ngethamo lika-850 mg, ukuthuthukiswa kwezimpawu ze-hypoglycemic akubonwa ezigulini, kepha kwezinye izimo i-lactic acidosis ingahle ivele. Ngokwakhiwa kwalesi sibonakaliso esibi, umuntu unezimpawu ezinjengokuthi:

• umuzwa wokucanuzelelwa kwenhliziyo;
• isifiso sokuhlanza;
• isifo sohudo
• kwehla ekushiseni komzimba;
• Ubuhlungu esiswini;
• ubuhlungu bemisipha;
• ukuphefumula ngokushesha;
• isiyezi nokuqwasha.

Ukuze uqede ukuphuza ngokweqile, kufanele uyeke ukuthatha umuthi futhi uphathe ukwelashwa okubonakalayo.

Ukufana kwezidakamizwa, izindleko zayo nokubuyekezwa ngakho

Iithebhulethi emakhemisi zithengiswa emaphepheni amakhadibhodi, ngalinye liqukethe amanxeba amaningi lapho kubekwa khona amaphilisi esidakamizwa. Ibhola ngalinye lithwala amaphilisi ayi-10. Ukufakwa kwamakhadibhodi, kuye ngokuthi kufakwa kanjani, kungaqukatha kusuka ku-3 kuya ku -ithusi ayisithupha.

Gcina umuthi endaweni yokushisa engeqi ama-25 degrees endaweni emnyama. Impilo yeshalofu yesidakamizwa yiminyaka emi-3.

Akunakwenzeka ukuthenga lesi sidakamizwa wedwa emakhemisi, ngoba ukukhishwa komuthi kwenziwa kuphela ngomuthi odingekayo.

Ukubuyekezwa kweziguli ezisebenzise lo muthi ukwelashwa kukhombisa ukusebenza kwawo okuphezulu. Iningi leziguli lishiya izibuyekezo ezinhle mayelana nomuthi. Ukubuyekezwa okungekuhle kuvame ukuhlotshaniswa nokuvela kwemiphumela emibi eyenzeka lapho kwephulwa imithetho yokuvuma kanye ne-overdose yomuthi.

Kunenombolo enkulu yama-analogues alo muthi. Okuvame kakhulu yilezi:

1. I-Bagomet.
2. I-Glycon.
3. Glyminfor.
4. UGlatiniin.
5. I-Glucophage.
6. Langerine.
7. I-Metospanin.
8. Metfogma 1000.
9. Metfogamm 500.

I-Taccena Metformin 850 ml incike esikhungweni samakhemikhali kanye nesifunda esithengiswa eRussia Federation. Izindleko ezijwayelekile zesidakamizwa ekufakweni okuncane zivela kuma-ruble ayi-113 kuye kwangama-256.

Ividiyo ekulesi sihloko ikhuluma ngesenzo seMetformin.