Inhloso yayo eyinhloko, umuthi uGalvus anayo, ukukhuthaza ama-pancreas.
Ngenxa yalokhu, umzimba wesiguli uqala ukusebenza ngokusekelwe emandleni akhe, ngakho-ke isimo sawo jikelele siyathuthuka.
Kuyaqapheleka ukuthi ukubuyekezwa kweGalvus kumane nje kuhamba phambili, okufakazela ukusebenza kwayo kobuvila kwesifo sikashukela, noma kusimo esibi nesingamahlalakhona.
Incazelo evamile, inhloso
IGalvus inokwakheka kwento esebenzayo njenge vidagliptin.
I-Vidagliptin iyakwazi ukuba nomphumela ovuselelayo kumakhansele wesiguli, okuyi-islet apparatus yayo. Njengomphumela, ukuhlanganiswa kwama-peptides ahlukahlukene akhiqizwe yile gland kuyasebenza.
Kufanele kuqashelwe ngasikhathi sinye ukuthi ukwakheka kweGalvus akusona isidakamizwa esisodwa, ngoba ngaphezu kwento esebenzayo ebalulekile kufaka izinto ezihlukene zamakhemikhali ezisiza ukumunyiswa ngumzimba womuntu.
Umuthi weGalvus usetshenziselwa ukwelapha isifo sikashukela sohlobo 2 kulokhu:
- Kubhekwa njengokuwukuphela kwomuthi ohloselwe ukusetshenziswa njengeyona ndlela esemqoka yokwelashwa usebenzisa ukwelashwa nokuvivinya umzimba. Ngaphezu kwalokho, izibalo zezokwelapha zibonisa ukuthi impumelelo yokusetshenziswa kwayo iphakeme kakhulu, futhi umphumela wokwelapha uphikelela futhi uhlala isikhathi eside.
- Kuvunyelwe ukuyisebenzisa njengengxenye yokwelashwa okuyinkimbinkimbi ekuqaleni kwenkambo yokwelashwa kwesifo sikashukela sohlobo 2 esimweni lapho isiguli singenakho ukubuya okungathi sína kokuvivinya umzimba kanye nokudla.
- Kunokwehluka kwesidakamizwa esichaziwe esibizwa ngeGalvus Met. Ihluka kumuthi oyinhloko onomphumela omnene emzimbeni wesiguli.
- Esimweni lapho lo muthi unganiki umphumela, uvunyelwe ukuwusebenzisa ngokuhambisana nezidakamizwa ezahlukahlukene ezinokutholakala kwe-insulin nezinye izinto ezivusa amanyikwe.
Udokotela we-endocrinologist kuzodingeka anqume inkambo yokwelashwa nokwakheka kwayo kwesiguli esinesifo sikashukela i-mellitus. Njengoba kukhonjisiwe, izidakamizwa zalolu hlobo zingasetshenziselwa i-mono-therapy noma njengengxenye yesifundo esinezidakamizwa ezimbili noma ezintathu. Kulokhu, kumele kudliwe ukudla okuqinile, kanti isiguli kumele senze izivivinyo nsuku zonke ukusuka ekuzivocavoca umzimba.
Ngaphezu kwemiphumela emihle evela ekusebenziseni umuthi ochaziwe, kukhona futhi ingozi yokubonakaliswa kanye nemiphumela emibi. Imiphumela emibi enjalo ingafaka okulandelayo:
- ukuvela kwekhanda elibukhali nesiyezi.
- ukubukeka kokuqhaqhazela.
- kwenzeka komuzwa wokubanda.
- ukuba khona kobuhlungu besisu esibuhlungu, kanye nobuhlungu bokuqaqamba kwezinye izingxenye zomzimba.
- ukuvela komzimba.
- ukwephulwa kwamapheshana emathunjini.
- ukwehlisa isimo sokuzivikela komzimba.
- ukulahleka kokusebenza, ukukhathala kushesha kakhulu.
- imivimbo ehlukahlukene esikhunjeni.
Ngaphezu kwalokho, kungahle kube nokwanda kwenkambo yezifo ezingamahlalakhona, futhi ikakhulukazi kwesibindi namanyikwe.
Imiyalo yokusebenzisa umuthi
Uma isiguli esinesifo sikashukela simiselwe uGalvus, imiyalo yokusebenzisa kufanele ifundwe kuqala yena. Iqiniso ngukuthi leli thuluzi likhethwe ngokuqinile ngakwelinye, kuye ngokuthi yiluphi ugxila olusungulwe esigulini, futhi futhi libheka ukungabekezeleleki kwalo muthi. Kulesi simo, imvamisa ngokuya ngokuya kadokotela we-endocrinologist, isidakamizwa esichaziwe siphuzwa ngomlomo, kungakhathalekile ukuthi ukudla kwesiguli kuthathwa kanjani.
Esimweni lapho uGalvus, futhi leli igama lakhe lesiLatini, eqokwa yi-endocrinologist njengengxenye ye-Metformin, thiazolidinedione noma i-insulin, kanye ne-monotherapy. Isiguli sivame ukunikezwa ukuthatha imithamo yomuthi kusuka ku-50 iye ku-100 mg ngosuku. Esimweni esifanayo, lapho isiguli sisesimweni esibucayi, ukusetshenziswa kwalo muthi ukuze kuzinze isimo sakhe, isilinganiso sansuku zonke sikhuphuka sibe ngamamiligremu ayi-100. Ngaphezu kwalokho, umthamo ofanayo ungakhonjiswa esigulini noma ngabe umuthi onjalo ubekelwe kuye njengengxenye yokwelashwa okuyinkimbinkimbi.
Esimweni lapho kunconyelwa umthamo omncane, uthathwa kanye, ekuseni ngaphambi noma ngemuva kokudla. Uma kuthathwa idosi elingathi sína kakhulu, khona-ke ukwamukela kuhlukaniswe ngemithamo emibili, kuyilapho kuthathwa umthamo wokuqala ngenani lama-50 mg ekuseni, kuthi owesibili kusihlwa. Uma isiguli, ngenxa yezizathu ezingaphezu kwamandla akhe, sephuthele umthamo owodwa walo muthi, kuyodingeka ngesikhathi sokuqala ukwenza leso sidingo, ngaphandle kokweqa umthamo obekwe udokotela.
Kunoma ikuphi, umthamo omkhulu wansuku zonke walesi sidakamizwa akufanele udlule i-100 mg. Uma ulidlula, lapho-ke ungadala ingozi enkulu esibindini nasezinsweni kweziguli. Kulokhu, eRussia ukuze kuthengwe izidakamizwa zesifo sikashukela salolu hlobo kungenzeka kuphela lapho kuvezwa incwadi kadokotela. Ngokuqondene nentengo, khona-ke ithebhu engama-28. imithi Galvus 50mg. kubiza cishe ama-ruble ayi-1300. Emakhemisi online, intengo yalo muthi ingabiza kakhulu.
Ngokuqondene nezichasiso nezinhlobonhlobo zomuthi ochaziwe, enconyweni ye-endocrinologist ezimweni ezibucayi, futhi lapho isiguli sineminyaka engama-60 noma singabekezeleli izingxenye ezithile zalo muthi, uzodinga ukuthatha umuthi onjengeGalvus Met. Inomphumela ofanayo neGalvus 50 mg, kepha ayinamphumela oqinile esibindini nasezinso zesiguli.
Ngokuqondene nezichazi eziqondile, khona-ke uGalvus ngekhwalithi yazo unezidakamizwa ezinjenge-Onglisa neJanuvius. Izindleko zabo zingaphansi kunezoqobo, kepha ngasikhathi sinye ekusetshenzisweni nasekwenzeni kahle bayakwazi ukubuyisa amaphilisi weGalvus ngokuphelele.
Kunoma ikuphi, ukuqokwa kwama-analogues alo muthi kuzodingeka kuhlanganiswe nodokotela ohamba nge-endocrinologist.
I-contraindication esemqoka ekusetshenzisweni kweGalvus
Njenganoma yimuphi umuthi, i-Galvus ine-contraindication yayo.
Imiyalo yokusebenzisa umuthi ikhombisa ubukhona benkimbinkimbi yonke yezimpawu eziphikisayo kulo muthi.
Ukuhambisana nokuphikisana okukhonjiswe kwimiyalo kuphoqelekile lapho usebenzisa umuthi.
I-contraindication esemqoka yilena elandelayo:
- Ukuba khona kokungabekezeleli komuntu noma ukusabela komzimba kumakhemikhali akhona kulo muthi.
- Ukuba khona kokwehluleka kwezinso, isifo sezinso noma umsebenzi okhubazekile.
- Ukuba khona komkhuhlane ophakeme, isifo sohudo kanye nokuhlanza, okungahle kube wuphawu lokwanda kwesifo sezinso esingapheli kanye nokubonakaliswa kwesiguli esinezifo ezithathelwanayo.
- Allergy
- Ukwehluleka kwezinso okungamahlalakhona, kanye nezinye izifo ezihambisana nakho kungaba ukwephula imisebenzi yazo.
- I-infyoction ye-Myocardial, ukungakwazi kwenhliziyo nezinye izifo zesistimu yenhliziyo.
- Izifo eziphefumulayo.
Ngaphezu kwalokho, i-contraindication ekusetshenzisweni ukuba khona kwe-ketoacidosis yesifo sikashukela ne-lactic acidosis, ngokumelene nesizinda sesimo se-coma noma i-precommata.
Ngaphezu kwalokho, i-Glavus ayinconywa ukuthi isetshenziswe phambi kokukhulelwa, kanye nangesikhathi sonke sokudla kwengane. Kubantu abahlukumeza kakhulu utshwala, lo muthi nawo ubekelwe uphawu. Iziguli ezingaphezulu kweminyaka engama-60 ezivezwa ukuthi ziphuza lo muthi ngaphansi kweso elibukhali dokotela nazo kufanele zifakwe kulesi sigaba seziguli. Ngaphezu kwalokho, ukwamukelwa kwakhe kwenqatshelwe abantu abangaphansi kweminyaka engu-18 ubudala, lokhu kungenxa yokuthi iziguli kulezi zigaba zobudala zithinta kakhulu ingxenye enjalo yalesi sidakamizwa njenge-metformin.
Futhi, zonke iziguli ezinesifo sikashukela sohlobo lwe-2 mellitus, ngokuhambisana nokudla lesi sidakamizwa, zinconywa ukulandela ukudla okuqinile kakhulu, lapho ukudla ikhalori kuzobe kungasekho ngaphezu kwe-1000 ngosuku. Kuyajabulisa futhi ukuthi iqiniso lokuthi amalungiselelo weGalvus noma kaGalvus Meta ane-contraindication efana nokuba khona kwe-lactic acidosis. Lo mkhuba ubonakala njengohlobo lwe-1 mellitus yesifo sikashukela, ngakho-ke kunqatshelwe ngokuphelele ukuthi uzisebenzisele ukuzelapha.
Kuyafuneka ukuthi uqaphele ngokwehlukile iqiniso lokuthi esikhundleni somuthi oyinhloko lapho kukhona okuchaziwe, ama-endocrinologists ngokuvamile anquma okuhlukahlukene - isidakamizwa uGalvus Met. Zithambile futhi zithinta izinso nesibindi njengoba nje noGalvus uqobo.
Esikhundleni kuvame ukuthathwa ngomlomo, kugezwe ngamanzi amaningi, kanti umthamo wesidakamizwa onjalo akufanele udlule i-100 mg.
Izici zokwelashwa kwabesifazane abakhulelwe
Ngaphandle kokuthi umuthi ochaziwe kudala wasetshenziswa kwezokwelapha, umthelela wawo emzimbeni wabesifazane abakhulelwe nabafaka lactating awukafundwa. Mayelana nalesi simo, ukuthatha lo muthi akunconywa kuze kube ngemuva kokukhulelwa. Esimweni esifanayo, lapho kudingeka ukwelashwa ngeMetformin, udokotela obambelayo angakwazi ukukhetha omunye umuthi omphumela wawo emzimbeni wabesifazane abakhulelwe kade wafundwa.
Kulokhu, abesifazane abakhulelwe badinga ukukala ushukela wegazi nge-glucometer sonke isikhathi sokwelashwa. Uma lokhu kungenziwa, kungahle kube nengozi yokungalingani kokuzalwa kwengane engakazalwa. Esimweni esibi kakhulu, ukufa kwe-fetus kungenzeka. Noma yini le yenzeka, iziguli ziyalulekwa ukuthi zisebenzise imijovo ye-insulin ukwenza lesi sikhombisi sijwayelekile.
Ucwaningo olwenziwe kuze kube manje lukhombisa ukuthi owesifazane okhulelwe angakwazi, ngaphandle kokulimaza impilo yakhe, athathe umthamo weGalvus odlula umthamo ophakeme cishe izikhathi ezingamakhulu amabili. Ama-anomalies ekukhuleni kwesibeletho noma ukwephulwa kwawo nawo awazange aqoshwe. Ngeshwa, yonke le mininingwane ingeyokuqala, kanye nedatha emiphumeleni yalo muthi ekwakhiweni kobisi lwebele ngesikhathi sokudla.
Lokhu kuholela ekutheni udokotela ayelulekwa ukuthi ayise komama abancelayo.
Ama-analogues ajwayelekile kakhulu
Ngaphezu kweGalvus, ezinye izidakamizwa ezingabhekwa njengezimpawu zayo nazo zinomphumela ochaziwe.
Izidakamizwa ezinjengeBaeta, Januvia, Onglisa zidluliselwa ezidakamizweni ze-analogue.
Zonke zinomphumela ocasulayo emzimbeni wesiguli, inqobo nje uma zithathwa ngemuva kokudla.
Imiphumela elandelayo yemiphumela yale mishanguzo yaqoshwa yimiphumela elandelayo emzimbeni wesiguli esinohlobo 2 lwesifo sikashukela:
- Ukwanda kokukhiqizwa kwe-insulin. Lokhu kwenzeka ngesikhathi sokudla, futhi nalapho izinga likashukela wegazi lingaphezulu kuka-5-5,5 mmol / L. Ngenxa yalokhu, ukwehla okukhulu kwamazinga kashukela egazini ngokuthuthukiswa kwezimpawu ze-hypoglycemia akwenzeki.
- Yehlisela phansi ukwakheka kwe-glucogon insulin antagonist egazini. Ngakho-ke, umphumela wokuvimbela ukukhishwa kwe-glucose esibindini ngamanani amakhulu uyatholakala.
- Yehlise isifiso sokudla ngenxa yengcindezi ezikhungweni zokugcwalisa ezisebuchosheni besiguli.
- Ukwanda ngobude besikhathi sokudla esiswini sesiguli. Ngenxa yalokhu, ukugaya ukudla emathunjini amancane kwenzeka ngezingxenye ezincane. Ngakho-ke, ushukela udonswa kancane kancane futhi kungenzeka ukugwema ukuthuthukiswa kwesimo esinjenge-hyperglycemia ngemuva kokudla.
- Ukwanda kwesisindo samaseli e-islet kuma-pancreas, akuvikela ekunciphiseni.
- Ukuvuselelwa kohlelo lwenhliziyo nolwezinzwa. Ngasikhathi sinye, izifundo zalo mphumela azenziwanga ngokuhlelekile futhi kunemininingwane engayodwa yokuthi le mishanguzo ingabakhuthaza kanjani.
Ngaphandle kwemiphumela efanayo, yonke imishanguzo echaziwe inemishini yayo yokusebenza, ngokwesibonelo, iBaeta neViktoza lilingisa imiphumela ye-insulin. Ngokuqondene noJanuvius, uGalvus, no-Onglise, basebenza kuma-peptides anjenge-glucagon. Ngokuqondene nalesi simo, udokotela onolwazi we-endocrinologist onolwazi kuphela ongakhetha umuthi owodwa noma omunye wokwelashwa.
Ngakho-ke, akufanele uthenge leyo mishanguzo efana nekaGalvus ekwakhiweni ngaphandle kokubonisana naye, uma kungenjalo esikhundleni sokuthola umphumela omuhle wokwelapha, isimo sesiguli singase sibe sibi kakhulu. Ngesikhathi sokwelashwa ngezidakamizwa, kufanele unamathele ekudleni okuphansi kwe-carb kanye nokuzivocavoca ushukela waluphi uhlobo.
Ividiyo ekulesi sihloko ikhuluma ngesifo sikashukela nezimbangela zayo.
