I-Oktolipen ingumuthi wesizukulwane sokugcina ngendlela yesisombululo sokungenelela. I-Oktolipen yohlobo 2 sikashukela isetshenziselwa ukulawula i-carbohydrate kanye ne-lipid metabolism, ukunciphisa ushukela wegazi nokulahlekelwa amakhilogremu angeziwe.
Umuthi futhi usetshenziswa kabanzi kwezinye izinhlobo zesifo sikashukela njengengxenye yokwelashwa okuyinkimbinkimbi. I-Oktolipen inezibuyekezo ezinhle kakhulu ezivela kubantu abanesifo sikashukela.
I-Oktolipen iyatholakala futhi ngefomethi kanye nethebhulethi.
I-Oktolipen
I-Oktolipen iyi-antioxidant ye-endo native ebopha ama-radicals wamahhala. Le nqubo yenzeka ngesikhathi se-oxidative decarboxylation yama-alpha-keto acid.
Njenge-coenzyme, umuthi ubandakanyeka ku-decarboxylation ye-pyruvic acid ne-alpha-keto acid. Inamandla okwehlisa ushukela wegazi, kanye nokwandisa i-glycogen esibindini futhi inqobe ukumelana ne-insulin. Ngakho-ke, ingasetshenziselwa isifo sikashukela sohlobo 2.
I-Thioctic acid isondele kumavithamini we-B. Le nto inemiphumela elandelayo:
· Ifaka ingxenye kulawulo lwe-lipid ne-carbohydrate metabolism,
· Kuthuthukisa i-cholesterol metabolism,
· Yenza kusebenze isibindi.
Umuthi une:
1. hypocholesterolemic,
2. I-hepatoprotective,
3. ukwehliswa kwe-lipid,
4. umphumela we-hypoglycemic.
Ngosizo lwe-trophism yethuluzi le-neurons ithuthukiswa, kanye nokuqhutshwa kwe-axonal kanye nobunzima be-alcoholne ne-diabetesic polyneuropathy kuyancishiswa.
Umuthi i-Okolipen unqunywe kuphela ngudokotela ohamba yedwa. Kwenqatshelwe ukuzibandakanya nokuzilapha ngalo muthi.
I-Octolipene ku-ampoules iyithuluzi elixhunyiwe elidingekayo ukudala isisombululo se-intravenous. Uketshezi lubonakala, luhlotshiswe luhlaza okotshani.
Ku-1 millilita wesidakamizwa yi-thioctic noma i-lipic acid 30 mg. I-ampoule eyodwa iqukethe ama-mg amathathu wento.
Izingxenye ezisizayo yile:
- i-disodium edetate,
- ethylenediamine
- amanzi agcobhoziwe.
Umuthi uyatholakala kuma-ampoule wengilazi emnyama ngenani lamamililitha ayi-10. Iphakheji yikhadi lamakhadibhodi, kwiphakethe elilodwa - ama-ampoules ayi-5.
Lesi sidakamizwa sithengiswa futhi emaphaketheni angama-Octolipen 300 kanye namaphilisi angu-600 we-Okolipen
Imiyalo yokusebenzisa i-Oktolipen
Ukulungiselela isixazululo sokungenisa, udinga ukufaka i-1 noma 2 ama-ampoules ku-50-250 ml wesisombululo se-0,9% sodium chloride. Isixazululo siphathwa yi-dropper, intravenly. Kusetshenziswa kanye ngosuku okwenzelwe ama-300-600 mg amasonto ama-2-4. Okulandelayo, udinga ukushintshela ekwelashweni ngomlomo.
Ithuluzi linokuzwa kwezithombe, okusho ukuthi ama-ampoules kufanele akhishwe ngokushesha ngaphambi kokuwasebenzisa.
Kungcono ukuvikela isitsha ngesisombululo esivela ekukhanyeni ngesikhathi sokufakwa, ngokwesibonelo, usebenzisa izikhwama ze-foil noma zokuvikela ukukhanya. Isixazululo esenziweyo sigcinwa endaweni emnyama futhi sisetshenziselwa amahora ayisithupha ngemuva kokulungiswa.
Uma udokotela ebeke inkambo yokwelashwa no-Oktolipen, khona-ke kubalulekile ukucubungula amaphuzu alandelayo:
- I-lipoic acid ingadinga ushintsho kumithamo yezinye izidakamizwa nemikhiqizo yokudla,
- uma umuthi ufakiwe ekuvinjelweni ngokuphelele nasekwelapheni isifo sikashukela, kubalulekile ukubheka inani le-glucose egazini kusetshenziswa i-glucometer, ukwenza ushintsho kuthamo labaphatheli be-hypoglycemic,
- into esebenzayo yesidakamizwa iyafana isebenza kumavithamini e-B, kepha akusona isengezo sevithamini. Ukusebenzisa umkhiqizo ngaphandle kokubonana nodokotela kungazenza zibe zimbi kakhulu izinkinga zempilo.
Isenzo se-Pharmacological
I-Lipoic acid yakhiwa ngaphakathi emzimbeni ngesikhathi senqubo ye-oxidative yama-keto acid. Amandla ayo okuqeda impendulo ye-metabolic metabolic ku-insulin ifakazelwe. I-Lipoic acid ithinta ngqo isibindi, okubalulekile kusifo sikashukela sohlobo 2.
Umuthi manje uvame ukusetshenziselwa ukukhuluphala uma kutholakala ukuthi kunesifo sikashukela sohlobo 2 noma ngaphandle kokuxilongwa okunjalo.
I-Lipoic acid ithinta ngempumelelo ukugcinwa kwamasu kwamafutha omzimba. Ngaphansi kwethonya le-asidi, izindawo ezinamafutha zidilizwa phansi bese kukhishwa inani elikhulu lamandla. Ukuze ulahlekelwe isisindo, kubalulekile futhi ukwandisa ukusebenza komzimba futhi unamathele ekudleni okwelaphayo.
I-Lipoic acid ithumba ama-carbohydrate, kepha ayidlulisele hhayi ku-adipose izicubu, kepha izicubu zomsipha, lapho zichithwa khona noma zisetshenziselwa umsebenzi wethambo. Ngakho-ke, umuthi usetshenziselwa ukunciphisa isisindo kuphela ngokuhambisana nokudla nemidlalo.
Ucwaningo oluningi lubonisa ukuthi i-thioctic acid ayinamphumela oqondile we-anabolic.
I-Oktolipen inciphisa ngempumelelo inani le-lactic acid ezicutshini zemisipha eyakha ngesikhathi sokuzivocavoca. Umuntu uthola ithuba lokumelana nokuxineka okusebenzayo futhi okuhlala isikhathi eside, okuthinta kahle inhlala-kahle yomuntu nokubukeka kwakhe.
I-Lipoic acid ikhulisa ukuthathwa koshukela ngamaseli emisipha. Ngakho-ke, ngisho nokuqeqeshwa okuncane kuzokwenza sikwazi ukuguqula isimo ngemuva kokuphuza itiye. Kufanele kukhunjulwe ukuthi lapho wenza izivivinyo, umetabolism emangqamuzaneni ukhuphuka ngokushesha, bese kuvela inani elikhulu lama-radicals wamahhala, elingathathi hlangothi kalula nge-lipoic acid.
Ukuxhumana nezinkomba
I-Oktolipen ibekelwe abantu abane-polyneuropathy esungulwe yemvelaphi yeshukela kanye notshwala.
Kuboniswa futhi i-cirrhosis ne-neuralgia, ukudakwa ngosawoti wezinsimbi ezisindayo. Abantu abanokuzwela okuphezulu kufanele basebenzise lesi sidakamizwa ngokuqapha.
Lapho usebenzisa lo muthi, imiphumela emibi elandelayo kungenzeka:
- ukushaya kwenhliziyo, isicanucanu, ukuhlanza,
- Ukuvela kokuvela komzimba,
- hypoglycemia
Izimpawu zokweqisa yilezi:
- ukuhlanza
- isicanucanu
- ikhanda.
Uma uthatha i-thioctic acid ngenani lama-10 kuye kwangama-40 g, amaphilisi angaphezu kweshumi wama-600 mg, noma ngethamo elingaphezu kwama-50 mg ngekhilogremu ngayinye yesisindo somzimba ezinganeni, khona-ke ukuvela kwe:
- ukuphazamiseka kwengqondo noma ukusizakala kwengqondo,
- ukubanjwa okujwayelekile,
- ukuphazamiseka okukhulu kwe-acid-base esele nge-lactic acidosis,
- I-hypoglycemia (kuze kufike ekwakhekeni komkhovu),
- i-acute skeletal kwemisipha necrosis,
- hemolysis
- I-DIC syndrome
- amathambo ukucindezelwa
- ukwehluleka kwezitho eziningi.
Uma kusetshenziswa enye yezidakamizwa bese kwenziwa i-overdose, ukulaliswa esibhedlela ngokushesha kanye nokusetshenziswa kwezinyathelo ezisuselwa ezimisweni ezijwayelekile uma kwenzeka kunobuthi ngengozi kubalulekile. Unga:
- hlanza
- hlambulula isisu
- thatha amalahle ocushiwe.
Ukwelashwa kokuhlaselwa okujwayelekile, i-lactic acidosis kanye neminye imiphumela esongela impilo kufanele kwenziwe ngokuhambisana nemithetho yokunakekelwa kakhulu futhi kube nezimpawu. Ngeke ulethe umphumela:
- hemoperfusion,
- hemodialysis
- izindlela zokuhlunga lapho i-thioctic acid ikhishwa.
Ukusebenzelana kwezidakamizwa
Umphumela we-hypoglycemic wesidakamizwa uyanda uma uthathwa nge-insulin namathebulethi onomphumela ofanayo. Lokhu kungaholela ekwehleni ngokweqile koshukela wegazi.
Uma ukusetshenziswa okuhlangene kudingekile, khona-ke kuvame ukuhambisana nokuqapha njalo kwenani le-glucose egazini. Lapho kutholakala ukuphambuka okungamukeleki, umthamo we-insulin noma amanye ama-hypoglycemic agents kufanele ulungiswe ngokushesha.
I-Ethanol nama-metabolites akhulisa amathuba emiphumela emibi. I-Oktolipen ayihambelani nezixazululo ze-dextrose ne-Ringer, kanye nezithako nezixazululo eziphendula nge-disulfide namaqembu we-SH ne-ethanol.
Kufanele futhi ugcine ikhefu lemizuzu engama-30 phakathi kokudla okolipen nokuthatha imikhiqizo yobisi. Ngaphezu kwalokho, ikhefu elinjalo livumelekile nezidakamizwa ezine:
- insimbi
- calcium
Ukuqapha kuyadingeka futhi ukuhlanganisa i-Oktolipen nezidakamizwa ezenzelwe i-magnesium zabanesifo sikashukela.
Kulokhu, kungcono ukusebenzisa i-Oktolipen ekuseni, namalungiselelo nge-magnesium, iron ne-calcium kusihlwa.
Ngaphezu kwalokho, umuthi onjalo unciphisa ubulukhuni besenzo se-cisplatin, uma izindlela zisetshenziswa ngasikhathi sinye.
Izindleko nama-analogues
Intengo yesidakamizwa i-Okolipen ayiyona ephezulu kakhulu. Amaphilisi aqukethe ama-300 mg wento esemqoka azobiza ama-ruble angama-310.
Amaphilisi we-Octolipen 600 mg azobiza cishe ama-ruble ayi-640. Kumakhemisi, ungathola ne-alpha lipoic acid uqobo. Kubiza okuncane - ama-ruble angama-80 kuphela. Intengo yeTiolept icishe ibe ngama-ruble angama-600, iTiogamma ibiza ama-ruble angama-200, i-Espa-lipon - cishe ama-ruble angama-800.
Izindlela azifani ekusebenzeni futhi zingathathelwa indawo ngomunye:
- I-Tiolepta
- I-Berlition,
- I-Lipothioxone;
- I-Alpha lipoic acid,
- I-Tiogamm
- I-Thioctacid
- Lipamide
- Neuro lipone
- Espa lipon
- I-Thiolipone.
Okuvame kakhulu, manje isidakamizwa i-Neyrolipon, siyindlela enhle ye-Oktolipen.
I-Thioctacid
I-Thioctic acid ikhona kusisombululo se-Thioctacid, kanti ne-thioctate trometamol isetshenziswa enguqulweni yethebhulethi yamathebulethi.
I-Thioctacid iyisidakamizwa se-metabolic esisiza ukunciphisa ukubonakaliswa kwe-nephropathy yesifo sikashukela ne-alcohol.
Ithuluzi line:
- antioxidant
- hypoglycemic,
- umphumela we-hepatoprotective.
I-Thioctacid ijwayele izinqubo ze-metabolic emzimbeni, okubalulekile kusifo sikashukela sohlobo 2.
Kunezindlela zama-dosage:
- amaphilisi
- Isixazululo somjovo.
Isakhi esiyinhloko salo muthi yi-antioxidant endo native. Ukuba khona kwento emzimbeni kunikela:
- ukususwa ushukela okusebenzayo,
- ukulungiswa kwama-neuroph trophic,
- Ukuvikelwa kwamaseli esenzweni sobuthi,
- ukubonakaliswa okuncishisiwe kwalesi sifo.
Le antioxidant imvamisa isemzimbeni ngesilinganiso esifanele, futhi isekela ukusebenza kwayo okujwayelekile.
Umuthi osebenzayo oqukethwe umuthi i-Thioctacid usheshe futhi umunca ngokuphelele, futhi ucashunwe okuvela emzimbeni cishe kwesigamu sehora. Kepha ukusetshenziswa kwalesi sidakamizwa ngokudla kuthinta ukumuncwa kwento esemqoka. I-Bioavailability ingama-20%.
Ngokuyisisekelo, imetabolism yenziwa nge-oxidation kanye ne-conjugation. Ukuhoxiswa kwesamba esikhulu somuthi kwenziwa izinso. I-Thioctacid ivame ukubekelwa i-neuropathies yesifo sikashukela.
Isidakamizwa esinjalo sinqunyelwe ne-pathologies yesibindi. Isibonelo, ikhambi linqunyelwe kusuka ku:
- isifo sokuqina kwesibindi
- isifo sokusha kwesibindi
- ukonakala kwamafutha,
- i-fibrosis.
I-Thioctacid yenza sikwazi ukuqeda umphumela onobuthi ophenduka insimbi.
Intengo yomuthi ngesimo se-ampoules icishe ibe ngama-ruble ayi-1,500, amaphilisi abiza kusuka kuma-ruble ayi-1,700 kuya kwayi-3,200.
Thola ukuthi yikuphi okungcono: I-Thioctacid noma i-Oktolipen, udokotela ohambelayo uzosiza. Izinzuzo ze-lipoic acid zabanesifo sikashukela zizohlanganiswa ngevidiyo kuleli vidiyo.
