I-Starlix isidakamizwa se-hypoglycemic esuselwa ku-phenylalanine amino acid. Umuthi lo unesandla ekukhiqizweni kwe-insulin emenyezelwe emizuzwini eyi-15 umuntu eseyidlile, ngenkathi kushibilika ukuguquguquka kushukela wegazi.
Ngenxa yalomsebenzi, i-Starlix ayikuvumeli ukuthuthukiswa kwe-hypoglycemia uma, ngokwesibonelo, umuntu ephuthelwe isidlo. Umuthi uthengiswa ngohlobo lwamaphilisi aphekwe ngefilimu; ngalinye lazo liqukethe ama-60 noma angama-120 mg wezinto ezisebenzayo nateglinide.
Kuhlanganiswe ne-magnesium stearate, titanium dioksidi, i-lactose monohydrate, i-macrogol, i-iron ironideide, i-croscarmellose sodium, i-talc, i-povidone, i-microcrystalline cellulose, i-colloidal anhydrous silicon dioxide, i-hypromellose. Ungathenga umuthi ekhemisi noma esitolo esikhethekile, kwiphakethe lika-1, 2 noma ku-7 amabhulokhi, i-blister eyodwa iqukethe amaphilisi ayi-12.
Incazelo yesidakamizwa
Umuthi unezibuyekezo ezinhle. Kuyasiza ukubuyisa ukuvela kokuqala kwe-insulin, kanye nokunciphisa ukuqina koshukela egazini kanye ne-glycated hemoglobin.
Indlela enjalo yokwenza isenzo ibalulekile kwabanesifo sikashukela, ngenxa yokuthi amazinga kashukela egazi asetshenziswa ngokwejwayelekile. Ku-mellitus yesifo sikashukela, lesi sigaba se-insulin secretion siyaphazamiseka, kuyilapho i-nateglinide, okuyingxenye yesidakamizwa, isiza ukubuyisela isigaba sokuqala sokukhiqizwa kwama-hormone.
Ngokungafani nezidakamizwa ezifanayo, i-Starlix iqala ukukhiqiza ngokunamandla i-insulin kungakapheli imizuzu eyi-15 ngemuva kokudla, okuthuthukisa isimo sesifo sikashukela futhi iguqule ukugcwala kweglucose egazini.
- Emahoreni amane alandelayo, amazinga we-insulin abuyela kwinani lawo lasekuqaleni, lokhu kusiza ukuvimbela ukwenzeka kwe-postprandial hyperinsulinemia, okuzothi esikhathini esizayo kubangele ukukhula kwesifo se-hypoglycemic.
- Lapho ukuhlushwa ushukela kuncipha, ukukhiqizwa kwe-insulin kuyancipha. Umuthi, nawo, ulawula le nqubo, futhi ngamanani aphansi weglucose, unomphumela obuthakathaka kokukhululwa kwehomoni. Lesi ngesinye isici esihle esingavumeli ukuthuthukiswa kwe-hypoglycemia.
- Uma i-Starlix isetshenziswa ngaphambi kokudla, amaphilisi adonswa ngokushesha emgudwini we-gastrointestinal. Umphumela omkhulu wesidakamizwa wenzeka ngaphakathi kwehora elilandelayo.
Izindleko zalo muthi zincike endaweni ekhemisi, ngakho eMoscow naseForos intengo yephakethe elilodwa lama-60 mg ngama-ruble angama-2300, iphakheji enesisindo esingu-120 mg izobiza ama-ruble ayi-3000-4000.
I-Starlix yezidakamizwa: imiyalelo yokusetshenziswa
Ngaphandle kokuthi umuthi unezibuyekezo ezinhle, kubalulekile ukubonisana nodokotela wakho ngaphambi kokusebenzisa umuthi. Amacwecwe kufanele athathwe imizuzu engama-30 ngaphambi kokudla. Ukuze uthole ukwelashwa okuqhubekayo ngalo muthi kuphela, umthamo ungama-120 mg kathathu ngosuku ngaphambi kokudla. Uma kungekho mphumela obonakalayo obonakalayo, umthamo ungandiswa ube ngu-180 mg.
Ngesikhathi sesifundo sokwelashwa, isiguli sidinga ukulawula izinga likashukela wegazi futhi, ngokubheka imininingwane etholakele, lungisa umthamo. Ukuhlola ukuthi umuthi usebenza kangakanani, ukuhlolwa kwegazi kwezinkomba ze-glucose kwenziwa ngehora elilodwa noma amabili ngemuva kokudla.
Kwesinye isikhathi i-ejenti eyengeziwe ye-hypoglycemic ingezwa kulo muthi, imvamisa iMetformin. Kubandakanya i-Starlix kungasebenza njengethuluzi elingeziwe ekwelapheni iMetformin. Kulokhu, ngokwehla kanye nokulinganiselwa kwe-HbA1c oyifunayo, umthamo we-Starlix wehliselwa ku-60 mg kathathu ngosuku.
Kubalulekile ukucabanga ukuthi amaphilisi ane-contraindication ethile. Ikakhulu, awukwazi ukuthatha lesi sidakamizwa nge-:
- I-Hypersensitivity;
- I-mellitus yesifo sikashukela esincike ku-insulin;
- Ukulimala kwesibindi okunamandla;
- I-ketoacidosis.
- Futhi, ukwelashwa ku-contraindicated ebuntwaneni, ngesikhathi sokukhulelwa nokukhulelwa.
Umthamo awudingi ukulungiswa uma isiguli sithatha i-Warfarin, iTroglitazone, i-Diclofenac, ne-Digoxin. Futhi, akukho ukusebenzisana okusobala okuvela kwezinye izidakamizwa ze-antidiabetes kutholakele.
Imithi efana neCaptopril, Furosemide, Pravastatin, Nicardipine. IPhenytoin, Warfarin, Propranolol, Metformin, Acetylsalicylic acid, Glibenclamide ayikuthinti ukusebenzisana kwe-nateglinide ngamaprotheni.
Kubalulekile ukuqonda ukuthi ezinye izidakamizwa zandisa i-glucose metabolism, ngakho-ke, ngenkathi bezithatha ngomuthi we-hypoglycemic, ushintsho lokuhlushwa kwe-glucose.
Ikakhulu, i-hypoglycemia ku-mellitus yesifo sikashukela yathuthukiswa ngama-salicylates, ama-blocka-blocker angakhethi, ama-NSAIDs nama-inhibitors we-MAO. Izidakamizwa ze-Glucocorticoid, i-thiazide diuretics, ama-sympathomimetics nama-hormone e-thyroid anegalelo ekwenzeni buthaka kwe-hypoglycemia.
- Kuhlobo 2 sikashukela mellitus, ukunakekelwa okukhethekile kumele kuthathwe, ngoba ubungozi bokuba ne-hypoglycemia kuphezulu impela. Ikakhulu, kubalulekile ukubheka amazinga kashukela wegazi kubantu abasebenza ngemishini eyinkimbinkimbi noma izimoto zokushayela.
- Iziguli ezinobungozi obuphansi, asebekhulile, iziguli ezitholakala zine-pituitary noma i-adrenal insuffence zisengozini. Ushukela wegazi ungancipha uma umuntu ephuza utshwala, ehlangabezana nokuzivocavoca okuphezulu komzimba, futhi futhi ephuza nezinye izidakamizwa ze-hypoglycemic.
- Ngesikhathi sokulashwa, isiguli singathola imiphumela emibi ngesimo sokujuluka okuthe xaxa, ukwethuka, isiyezi, isifiso sokudla, ukukhuphuka kwenhliziyo, isicanucanu, ubuthakathaka, kanye ne-malaise.
- I-ushukela egazini kungenzeka ibe ngaphansi kuka-3.3 mmol / litre. Ezimweni ezingavamile kakhulu, umsebenzi wama-enzyme wesibindi egazini uyanda, ukusabela komzimba, okuhambisana nokuqhuma, ukulunywa kanye ne-urticaria. Ubuhlungu bekhanda, uhudo, i-dyspepsia, nobuhlungu besisu nakho kuyenzeka.
Gcina umuthi emazingeni okushisa asekamelweni, kude nelanga ngqo nezingane. Impilo yeshelufu yiminyaka emithathu, uma kungenzeka kuphele isikhathi sokulondolozwa, umuthi uyalahlwa futhi awusetshenziselwa injongo yawo okuhlosiwe.
Ukufana kwezidakamizwa
Ngomkhiqizo osebenzayo, ukufana okuphelele komuthi akukho. Kodwa-ke, namuhla kungenzeka ukuthenga izidakamizwa ezinemiphumela efanayo elawula ushukela wegazi nokuvimbela i-hypoglycemia.
Amathebhulethi eNovonorm athathwe ngohlobo lwe-2 yesifo sikashukela, uma ukudla okwelaphayo, ukuncipha kwesisindo kanye nokuzivocavoca komzimba kungasizi ukwenze kube ngcono isimo sesiguli. Kodwa-ke, umuthi onjalo uphikisana nohlobo 2 lwesifo sikashukela, i-ketoacidosis yesifo sikashukela, i-diabetes kanye ne-coma kanye nokwehluleka kwesibindi okunzima. Izindleko zamaphilisi okupakisha ama-ruble ayi-130.
Umuthi i-Diagnlinide usetshenziselwa uhlobo 2 lwesifo sikashukela, kanye ne-Metformin, uma kungenakwenzeka ukwenza amanani egciwane likashukela abejwayelekile ngezindlela ezijwayelekile. Umuthi uphambaniswe nohlobo lwesifo sikashukela sohlobo 1 sikashukela, i-ketoacidosis yesifo sikashukela, isifo esibangelwa isifo sikashukela kanye nesibindi, izifo ezithathelwanayo, ukungenelela kokuhlinzwa nezinye izimo ezidinga ukwelashwa kwe-insulin. Intengo yalo muthi ishiya ama-ruble angama-250.
Amathebulethi eGlibomet athathelwa isifo sikashukela sohlobo 2. Umthamo ukhethiwe ngamunye, kuya ngezinga le-metabolism. Umuthi ubhebhethekiswa ku-ketoacidosis yesifo sikashukela kanye nohlobo 1 lwesifo sikashukela, i-lactic acidosis, i-diabetes kanye ne-coma, hypoglycemia, hypoglycemic coma, isibindi noma izinso. Ungathenga ithuluzi elinjalo ngama-ruble angama-300.
Umuthi iGlucobai usebenza kahle kuhlobo 1 nesifo sikashukela sohlobo 2. Umthamo omkhulu wansuku zonke ungama-600 mg ngosuku. Umuthi uthathwa ngaphandle kokuhlafuna, ngenani elincane lamanzi, ngaphambi kokudla noma ihora ngemuva kokudla. Intengo yepakethe elilodwa lamacwecwe angama-ruble angama-350.
Kwividiyo ekulesi sihloko, udokotela uzonikeza izincomo zokuthi wehlisa kanjani ushukela wegazi futhi ubuyisele ukugcinwa kwe-insulin.
