Izibhebhe ze-Gluconorm zingumuthi ohlanganisa izinto ezi-2 ze-hypoglycemic ezingamalungu ahlukene amaqembu wama-pharmacological: metformin kanye ne-glibenclamide.
I-Metformin yinto yokwelapha engokwesigaba sama-Biguanides, futhi isiza ukunciphisa ukugcwala kwe-glucose emzimbeni, ngenxa yokuthi ikhulisa ukubekeka kwezicubu zomzimba emiphumeleni ye-hormone.
I-Glibenclamide ithathwe isizukulwane sesibili sulfonylurea. Inikeza ukukhuthaza ukukhiqizwa kwama-hormone ngokwehlisa umkhawulo wokucasulwa kashukela we-pancreatic beta-cell. Ngenxa yalokhu, i-insulin susceptibility iyanda, kanye nokuhlangana kwayo namaseli kwelitshe.
I-Gluconorm iyanconywa ekwelapheni uhlobo 2 lwesifo sikashukela, kuyilapho ichazwa kuphela ngemuva kweminyaka eyi-18.
Udinga ukucubungula izinkomba kanye ne-contraindication yokusetshenziswa komuthi, ukukhomba imiphumela emibi ekuyisebenziseni? Futhi cabanga ukuthi uwuphuza kanjani umuthi ngendlela efanele, futhi yiziphi izibuyekezo iziguli ezishiya?
Izinkomba kanye ne-contraindication
Njengoba kushiwo ngenhla, umuthi iGluconorm uyanconywa ekwelapheni isifo sikashukela ezigulini ezingaphezu kweminyaka engu-18. Ngaso leso sikhathi, kunqunywa ezimweni lapho bekungenakwenzeka khona ukufeza umphumela oyifunayo wokudla okunempilo kanye nokuzivocavoca umzimba.
I-Gluconorm nayo ibekiwe lapho ukwelashwa nge-metformin ne-glibenclamide kungazange kunikeze umphumela oyifunayo wokwelapha. Futhi esimweni lapho ukufaka esikhundleni ukwelashwa ngezidakamizwa ezimbili kudingeka ezigulini ezinokuqukethwe ushukela okulawulwayo emzimbeni.
Naphezu kokusebenza kahle kwalo muthi, unohlu olukhulu lwe-contraindication. Odokotela abalunqamuleli isidakamizwa iGluconorm kulezi zimo ezilandelayo:
- Thayipha isifo sikashukela sokuqala.
- Isifo sikashukela ketoacidosis, ukoma.
- Isimo se-precomatose.
- Ukuphazamiseka Kwezinso.
- Isifo esikhulu sesibindi.
- Ngesikhathi sokuzala kanye nokuncelisa.
- Ukudla okuphansi kwekhalori.
Awukwazi ukunikeza isidakamizwa sokuncika ngokungagodli, ubuthi obunobuthi, ukulimala, ukushiswa. Ngesikhathi sezimo ezinzima ezingavela ngenxa yokungasebenzi kahle kwezinso.
Awukwazi ukuphuza umuthi ezinsukwini ezimbili ngaphambi kwezifundo ezidinga ukwethulwa kwephawundi eliphakathi nendawo. Kuvunyelwe ukuphuza umuthi ngemuva kwezinsuku ezimbili, ngemuva kocwaningo olunjalo.
Kubantu abaneminyaka engaphezu kwengu-60 ubudala, kanye nomlando we-febrile syndrome, i-pituitary pituitary gland, izidakamizwa ze-gluconorm zinconywa ngokuqapha ngokweqile, futhi kuphela ngaphansi kokuqondisa kukadokotela owelaphayo.
Okunye ukwephula umthetho i-hypersensitivity kwenye yalezi zinto ezimbili ezisebenzayo, noma ezingxenyeni ezisizayo zomuthi, eziyingxenye yomuthi.
Imiyalo yokusebenzisa umuthi
E-Gluconorm, imiyalo ikhombisa ukuthi amaphilisi kufanele aphuzwe ngomlomo ngesikhathi sokudla. Umthamo wesidakamizwa uhlala unqunywa ngawodwana esigulini ngasinye, kuyilapho kuncike ekuhlatshweni koshukela emzimbeni.
Imvamisa, umthamo wokuqala wokuqala uyithebulethi eyodwa. Ngemuva kwamaviki ambalwa, kwenziwa umthamo wokulungiswa, futhi lokhu kuncike kokuqukethwe ushukela emzimbeni.
Lapho uthatha indawo yokwelapha yangaphambilini, kungabekwa ithebhulethi elilodwa noma amabili. Imithamo iyahlukahluka ngokuya ngokuthi iyiphi imithamo eyedlule. Umthamo omkhulu ngosuku akufanele wedlule amaphilisi amahlanu.
Kumele kuqashelwe ukuthi umthamo omkhulu ubekwa kuphela ngaphansi kokuqondisa udokotela ohambelayo. Imvamisa lokhu kwenzeka ezimeni zokuma, futhi hhayi kuphela izinga likashukela emzimbeni wesiguli elilawulwa, kepha futhi nenhlala-kahle yakhe.
Ukuqina kweziguli kukhombisa ukuthi umuthi usebenza ngempela ngempumelelo, usiza ukuguqula ushukela emzimbeni ngokwezinga elidingekayo. Kanye nokusebenza kahle kwezidakamizwa iGluconorm, kuyadingeka ukugqamisa imiphumela emibi engahle ivele ezinhlakeni eziningi zomzimba:
- Ukusabela komzimba kwenzeka kakhulu kuyaqabukela, njengomthetho, kususelwa ekungabekezelelekeni komuthi ngamunye. Lokhu kusabela komzimba kuziveza njengokulunywa kwesikhumba, i-urticaria, ubomvu besikhumba, ukwanda kwezinga lokushisa lomzimba.
- Ukusuka ohlangothini lwe-carbohydrate metabolism, ukuthuthukiswa kwesimo se-hypoglycemic akuhlanganisiwe.
- Kwezinye izimo, i-leukopenia ibonwa engxenyeni yesistimu yegazi.
- Isistimu yezinzwa ephakathi nendawo ingaphendula emithini ngemithi elandelayo: ukuqaqamba ekhanda, isiyezi, ubuthakathaka obungapheli, ukunganaki kanye nokubabaza, ukukhathala okungamahlalakhona, ukuthambekeka kwengqondo.
- Ukuphazamiseka komgudu wesisu nokugaya ukudla, izinhlungu esiswini, ukuntuleka kokudla, ukunambitheka kwensimbi emgodini womlomo.
Kufanele kushiwo ukuthi lapho ubheka imiphumela emibi kakhulu, kunconywa ukuthi uthintane nodokotela wakho ngokushesha. Kungenzeka ukuthi umthamo ukhethwe ngokungalungile, noma izinkinga zihambisana ne-hypersensitivity kuzakhi zomuthi.
Kwa-Gluconorm, inani lentengo emakhemisi e-Russian Federation (Russia) lihluke kancane, futhi ngokwesilinganiso kuyehluka kusuka kuma-ruble angama-221 kuya kwangama-390 ngephakeji lomuthi ngamunye.
Analogs ngokwakhiwa
Ungathenga izidakamizwa ezifanayo ezisondelene ne-Gluconorm - lezi ngamaGlucovans kanye neBagomet Plus.
IGlucovans iyisidakamizwa esihlanganisiwe se-hypoglycemic equkethe izithako ezisebenzayo ezifanayo njenge-Gluconorm. Izinkomba eziphambili ezisetshenziselwa isifo sikashukela sohlobo lwesibili ukungasebenzi kokudla, ukusebenza komzimba, futhi ngenhloso yokufaka esikhundleni sokwelashwa ezigulini ezisezingeni elilawulwa ushukela emzimbeni.
Ama-Glucovans kumele athathwe ngomlomo. Kulokhu, umthamo wesidakamizwa unqunywa ngokuhlukile, futhi ukwahluka kwawo kuncike ekuhlushwa ushukela emzimbeni wesiguli esithile.
Njengomthetho, ukwelashwa kuvame ukunconywa ngethebhulethi eyodwa, ethathwa kanye ngosuku. Ukuze ubeke eceleni ukuthuthukiswa okungenzeka kwesimo se-hypoglycemic, kuyadingeka ukubala umthamo ukuze umthamo wansuku zonke ungeqi umthamo wokwelashwa okwedlule ngalezi zinto ezisebenzayo.
Ama-Glucovans awanconywa kulezi zimo ezilandelayo:
- Hypersensitivity kulo muthi.
- Ukuphazamiseka kokusebenza kwezinso.
- Ukuba khona kokwehluleka kwezinso.
- Thayipha isifo sikashukela sokuqala.
- Uhlobo lwesifo sikashukela se-ketoacidosis.
- Ama-pathologies ashubile futhi angamahlalakhona ahambisana ne-izicubu ezithambile zezicubu.
- Iminyaka yezingane.
- Uhlobo olungapheli lotshwala.
Ngesikhathi sokwelashwa kweGlucovans, kuvela imizwa ehlukahlukene engathinta zonke izitho nezinhlelo zangaphakathi.
I-Bagomet Plus iyanconywa ekwelashweni okuyinkimbinkimbi kohlobo 2 lwesifo sikashukela ngokumelene nesizinda sokungasebenzi ngempumelelo kwendlela yokudla eyenziwe ngcono impilo. Umthamo uncike ekuhlolweni kokuqala ushukela emzimbeni.
Ama-capsule athathwe wonke, ahlanzwa phansi ngenani lewuketshezi oluningi. Musa ukuhlafuna noma ukugaya nganoma iyiphi enye indlela. Umthamo omkhulu ngosuku ngu-3000 mg.
Imvamisa, umthamo wokuqala uqala ngokuhluka kusuka ku-500 kuye ku-1000 mg ngosuku. Ngokuya kobunzima be-glycemia, umthamo ungakhuphuka ngemuva kwamasonto ambalwa. Ukunciphisa amathuba okuba nemiphumela emibi, umthamo kunconywa ukuthi uhlukaniswe ngemithamo eminingana ngosuku.
Lapho uthatha iBagomet Plus, imiphumela emibi elandelayo ingenzeka:
- Ukuphelelwa isifiso sokudla, ukugcwala kwenhliziyo.
- Ukunambitha kwensimbi emgodini womlomo.
- Ubuhlungu esiswini.
- Ukwenyuka kokwenza igesi.
- Ukwephulwa komgudu wokugaya ukudla.
- Ukuvela komzimba wesimo sendawo.
Intengo yeBagomet Plus iyahlukahluka kusuka kuma-ruble angama-350 kuya kwangama-500, kanye nezindleko zamaGlucovans kusuka kuma-ruble angama-360 kuya kwangama-350.
Zingathengwa kunoma iyiphi ikhemisi, zithengiswe ngaphandle kokuyalelwa ngudokotela.
Ama-analoggs ane-metformin
Kunemithi futhi ene-metformin ekwakhiweni kwayo - i-Glibomet ne-Glyukofazh.
Ngaphambi kokungcwelisa izidakamizwa ezifanayo ngemininingwane eminingi, kufanele kwaziwe ukuthi kunconywa kakhulu ukuthi ungazifaki wena ngokwakho imali. Ngaphezu kwalokho, ukuze amalungiselelo angenhla ahambisane ngokuphelele ne-Gluconorm, kuyanconywa futhi ukuthi kuthengwe iGlibenclamide.
I-Glibomet umuthi oyinkimbinkimbi osiza ukunciphisa ushukela emzimbeni womuntu. Amaphilisi, amungene emgudwini wesisu, asiza ukwenza kusebenze amanyikwe, andise ukutholakala kwezicubu ukungena kwe-insulin, futhi kuthuthukise ukwenziwa kwawo.
Izinkomba eziphambili zokusebenzisa zimi ngokulandelayo:
- Uhlobo olungesilo i-insulin lokuncika kwisifo sikashukela.
- Ukuphikiswa komzimba ezidakamizweni ezitholakala ku-sulfonylurea.
- Ukunciphisa ukuthambekela kwesiguli izidakamizwa ze-sulfonylurea, okuqubuke ngenxa yokusetshenziswa kwazo isikhathi eside.
Isikhathi sokwelashwa kanye nerejimeni yemithamo kunqunywa ngokuya ngokuqhathaniswa noshukela emzimbeni, futhi i-carbohydrate metabolism yesiguli nayo iyabhekwa. Imvamisa, kubekwa amathebhulethi amaningana ngosuku, kanti isiguli sibhekwa njalo ukuthola umthamo ofanele.
I-Glibomet ingavusa imiphumela elandelayo elandelayo:
- Ukwehlisa izinga lamaseli amhlophe egazi.
- Ukulahlekelwa isifiso sokudla, ukugcwala kwenhliziyo kanye nokuhlanza, ukunambitheka kwensimbi emlonyeni. Akuvamile - umsebenzi owandisiwe wezinto zesibindi, ukuthuthukiswa kwesibindi.
- Ukukhathala okungapheli, ubuthakathaka bemisipha. Akuvamile, ukuphazamiseka kwemizwa.
- Ukwelwelana nokubonakala kwesikhumba (ukulunywa, ubomvu kwesikhumba).
Kumele kuqashelwe ukuthi ngesikhathi sokulashwa kwezidakamizwa kunconywa ukwenqaba ukushayela imoto, kanye nokuphuza utshwala.
I-Glucophage ingumuthi we-hypoglycemic womlomo osetshenziselwa ukwelapha isifo sikashukela sohlobo lwe-2, uma nje isiguli singazuzi ngokudla kokudla kanye nezindlela zokudla zokudla kwabaneshukela. Isithako esikhulu esisebenzayo ezibhebheni yi-metformin.
Imiyalo esetshenzisiwe funda imininingwane elandelayo:
- Amaphilisi athathwa ngesikhathi sokudla, noma ngokushesha ngemuva kwawo.
- Awukwazi ukugaya noma ukuhlafuna umuthi, udinga ukugwinya ithebhulethi yonke ngoketshezi olujwayelekile.
- Umthamo kanye nesikhathi sokwelashwa kukhethwa ngokwahluka, kuye ngezimpawu zesiguli esithile.
- Njengomthetho, 500-800 mg kanye ngosuku kunconywa; umthamo ungahlukaniswa ngemithamo eminingana.
- Ngemuva kwezinsuku eziyi-14, umthamo uyanda. Kulokhu, udinga ukuthembela kokuqukethwe ushukela emzimbeni wesiguli.
- Umthamo omkhulu kumahora angama-24 ngu-1000 mg.
Ngokuqapha ngokweqile, umuthi ubekelwe iziguli eziwohlokile umsebenzi wezinso. Njengomthetho, ukwelashwa kuqala ngethamo elincane, futhi ngokunyuka komthamo, izinga likashukela liyabhekelelwa futhi ukusebenza kwezinso kuyahlolwa.
I-Gluconorm kanye nama-analogues ayo kuyanconywa ekwelapheni isifo sikashukela sohlobo 2. Le mishanguzo iyasebenza, kepha inemiphumela emibi eminingi kanye ne-contraindication, ngakho-ke kunconywa kuphela ngudokotela ohambelayo. Ividiyo ekulesi sihloko izachaza ukuthi uhlobo 2 lwesifo sikashukela luselashwa kanjani.
