Izicubu ezinamafutha zinamaseli omzimba angadambisa ukuvela kokuvela kokuvuvukala, ushukela nezinye izifo. Kepha qala kuqala
Umbuthano onobubi
Njengoba wazi, uhlobo 2 sikashukela luvame ukuhambisana nokukhuluphala. Nalu uhlobo lombuthano onesihluku. Ngenxa yokuthi izicubu ziyeka ukuphendula ngokujwayelekile kuyi-insulin futhi zimunca ushukela, i-metabolism iyalahleka, okubandakanya ukubonakala kwamakhilogremu angeziwe.
Kubantu abakhuluphele ngokweqile, amaseli wamafutha ahlala ebhujiswa, futhi esikhundleni sawo kubekwa amasha, ngamanani amakhulu kakhulu. Ngenxa yalokhu, i-DNA yamahhala yamangqamuzana afile ivela egazini futhi likhuphuka ushukela. Kusukela egazini, i-DNA yamahhala ingena ikakhulu kumaseli omzimba, ama-macrophages azulazula ezicutshini ze-adipose. Ososayensi baseTokushima University kanye naseNyuvesi yaseTokyo bathole ukuthi ekuphenduleni amasosha omzimba, inqubo yokuvuvukala iyabangelwa, okuvame ukuthi kube yisikhali sokulwa nezifo namagciwane ahlukahlukene, futhi ngezinga elikhulu kubangela izinkinga ze-metabolic futhi, ikakhulukazi, kungadala isifo sikashukela.
Izindaba ezimbi
Abaphenyi baseNyuvesi yaseCalifornia, iSan Diego bathole ukuthi izibalo zemikhakha esezivele zishiwo - ama-microscopic vesicles akhonza ukushintshanisa imininingwane phakathi kwamaseli. Ama-Exosomes aqukethe i-microRNA - ama-molekyuli alawulayo athinta ukwakheka kwamaprotheni. Ngokuya ngokuthi iyiphi i-microRNA ezotholwa "kumlayezo" yisitokisi esiqondisiwe, izinqubo zokulawula zizoshintsha kuwo ngokusho kolwazi olutholakele. Okunye ukukhipha - ukuvuvukala - kuthinta umzimba ngendlela yokuthi amaseli angakwazi ukumelana ne-insulin.
Ngesikhathi sokuhlolwa, kwafakwa izimbotshana zokuvuvukala ezivela kumagundane agqamile ezilwaneni ezinempilo, futhi umuzwa wazo wezicubu we-insulin wawungasebenzi. Ngokuphambene nalokho, izinto “ezinempilo” ezihanjiswa ezilwaneni ezigulayo zibuyisele engcupheni ye-insulin.
Umlilo oqondisiwe
Uma kungenzeka ukuthola ukuthi yimaphi ama-microRNA avela ngaphandle okubangela isifo sikashukela, odokotela bazothola "okuhlosiwe" ekwakhiweni kwemithi emisha. Ngokusho kokuhlolwa kwegazi, okulula ukubahlukanisa i-miRNAs, kuzokwazi ukucacisa ubungozi bokuthola isifo sikashukela esigulini esithile, kanye nokukhetha umuthi ofanele yena. Ukuhlaziywa okunjalo kungabuye kuthathe indawo ye-biopsy ebuhlungu esetshenziselwa ukuthola isimo sezicubu.
Ososayensi bakholelwa ukuthi ucwaningo olwengeziwe lwama-miRNAs luzosiza hhayi ekwelapheni isifo sikashukela kuphela, kepha futhi nasekukhululeni ezinye izinkinga zokukhuluphala.
