ILantus - imiyalo yokusebenzisa kanye nama-analogues

Nge-Type 1 sikashukela mellitus, imithamo ethile ye-insulin idinga ukutholwa nsuku zonke ukunxephezela ukushoda kwe-pancreatic hormone.

Uma umuntu onesifo sikashukela esijwayele ukwenza imijovo usuku lonke, kuncipha ukungaphatheki kahle.

Inkampani yezemithi yaseJalimane uSanofi inikezela isirinji esivumelana nesifo sikashukela nesixazululo seLantus. Imiyalo yokusebenzisa iqukethe imininingwane ebalulekile mayelana nomuthi ngesenzo esisebenza isikhathi eside.

Ukwakheka nefomu lokukhululwa

IGlulin insulin iyisakhi esisebenzayo sesixazululo. Umenzeli we-hypoglycemic osuselwa ku-insulin glargine unqunyelwe uhlobo lwesifo sikashukela esincike ku-insulin.

Ama-cartridge weglasi angabonakali aqukethe ama-3 ml wesisombululo esuselwa ku-insulin glargine.

Isitsha sivaleke ngendlela egcotshwe umphangi, isithibuli esinokwethenjelwa, sihlikihlwe yicaptain eyenziwe nge-aluminium alloy.

Ipeni ngalinye le-syringe elahlekayo ye-SoloStar liqukethe i-1 cartridge. Umenzi unikeza ukupakisha uNo. 5.

Ku-1 ml we-antidiabetesic agent iqukethe ama-PIECES ayi-100 we-analogue ye-insulin yabantu. Isithako esisebenzayo esinethonya le-hypoglycemic sitholakala ngokucutshungulwa okuthile kwe-DNA yamabhaktheriya anethuba i-Escherichia coli.

Izinkomba zokusetshenziswa

Ngesifo sohlobo lwe-1 endocrine, umuthi iLantus uboniswa ezinganeni:

1. Kufinyelele eminyakeni engu-6.
2. Kwabadala.

I-insulin glargine ikhombisa isenzo esijwayelekile ngokumelene nesizinda sokufakwa kancane kancane kokusebenza kwento esebenzayo.

Ngokungafani ne-isulin insulin, isakhi esiyinhloko somuthi uLantus SoloStar asikhuphi iziqongo ekuhlakazweni kwe-hormone yokugcina.

Umphumela wesikhathi eside wokwelapha uhlanganiswa nokuphathwa okukodwa kokuqanjwa usuku lonke kunciphisa ubungozi be-hypoglycemia. Isixazululo esuselwa ku-insulin glargine sinokulinganiselwa okumbalwa, uma kukhonjisiwe, kuvunyelwe ukusetshenziswa ngabesifazane abakhulelwe.

Umthamo kanye ne-overdose

Ngohlobo oluthembele nge-insulin yesifo sikashukela, kubalulekile ukulandela imiyalo, ung yeqi umthamo olandelayo wehormone. Ukudla kakhulu i-insulin nakho akusizi.

Imiphumela yokweqisa ngokweqile:

• Ukwehla okukhulu ushukela wegazi;
• Izimo ezivame kakhulu ze-overdose zingaholela ekhefini elisongela impilo le-hypoglycemic.

Ukuqeda imiphumela emibi ngokuncipha okulinganiselwe kokugxilwa kwe-glucose, umthamo wansuku zonke weLantus uyaguqulwa, kuzwakala izinga lomsebenzi womzimba nemenyu.

Ngokuvela kokuxhamazela, ukuphazamiseka kwemizwa, ukwehla kwengcindezi, ukubanda, isiyezi - udinga ukubiza iqembu labodokotela ukuqinisa isimo.

Imithetho Yezicelo:

• Isixazululo somjovo weLantus sinomphumela wesikhathi eside: asikho isidingo sokuphathwa okuphindaphindiwe kwe-insulin glargine. Ukuze ulondoloze izinga elifanele le-hormone emzimbeni, ukuvimbela ukugxuma ekugxiliseni ushukela wegazi, kwanele ukujova kanye ngosuku. Umthamo ofanele ukhethwa yi-endocrinologist ngamunye ngamunye.
• Iphuzu elibalulekile ukwethulwa kwekhambi le-insulin glargine ngesikhathi esithile. Isikhathi phakathi kwemijovo amahora angama-24. Kuyinto engathandeki ukuthola i-hormone kungekudala noma isikhathi esithe xaxa: ukugcwala kwe-insulin ngosuku olulodwa kuyaphazamiseka.
• Isixazululo sikulungele ukusebenzisa, akudingekile ukuthambisa uketshezi ngaphambi kokujova.
• Ungahlanganisi umenzeli we-hypoglycemic namanye amalungiselelo e-insulin.
• Amaviki okuqala ngemuva kokuqala kokwelashwa, udinga ukukala ushukela wegazi kaningana ngosuku. Ngenqubo, udinga idivaysi ephathekayo yendabuko noma idivaysi yesimanje (yocwaningo, awudingi uthango lwezinto eziphilayo). Imitha ye-glucose engahlaseli kancane ngaphandle kokukhohlisa umunwe inciphisa ubungozi bokutheleleka, futhi yenza sikwazi ukukala amanani kashukela kashukela ngokushesha.
• I-Lantus yezidakamizwa iphathwa endaweni enamafutha athuthukisiwe angaphansi: isisu, okhalweni, amahlombe. Isikhathi ngasinye, indawo yomjovo iyaguqulwa. Ukuphathwa kwe-Intravenous akuvunyelwe: ubungozi be-hypoglycemia bukhuphuka kakhulu.
• Ukulungiswa kwesimo sansuku zonke sehomoni noma i-dosing regimen senziwa ngesikhathi soguquko kusuka kwamanye ukwakheka kwe-antidiabetes kuya ku-Lantus yezidakamizwa.

Ngemuva kwenqubo, ipeni lesirinji alikwazi ukuphinde lisetyenziswe noma lidluliselwe kwelinye, uma kungeyona yonke insulin efakiwe. Ngaphambi kwenqubo, udinga ukubheka ikhambi lesisombululo: uketshezi kufanele lube sobala futhi lungabi namibala, ngaphandle kokungcola okuqinile, kufane namanzi.

Imiphumela emibi

Ngokwazisa kwe-insulin glargine kwezinye izimo, ukusabela okungekuhle kwesistimu nokwendawo kungenzeka. Imvamisa yokubonakaliswa okungefani iyahlukahluka ngokuya ngokuzwela komuntu ngamunye.

Kukhula kaningi:

• i-hypoglycemia;
• lipodystrophy;
• ukungahambi kahle komzimba endaweni yomjovo.

Ezinye izinhlobo zemiphumela emibi azivamile ukwenzeka:

• ushintsho lokunambitha;
• Ubuhlungu bemisipha
• I-edema kaQuincke;
• ukulahleka kombono;
• i-lipoatrophy;
• ukuvuvukala kwezicubu ngokumelene nesizinda sokulibaziseka kwama-ion sodium.

Uma kwenzeka kunenkinga yesifo sikashukela esincike ku-insulin, labo abathola imijovo yeLantus kufanele bazi ukuthi ngasiphi isikhathi ukwanda kwe-hypoglycemic coma kuyanda. Udokotela we-endocrinologist uyadingeka ukuxwayisa onesifo sikashukela ngoshintsho olunokwenzeka lwezimpawu, okubonisa ukwehla okukhulu kwamazinga kashukela ngemijovo ye-insulin glargine.

Izimpawu ezingezinhle ezihambisana nokwakhiwa kwe-hypoglycemia zibuthakathaka ezigulini ezimweni ezilandelayo:

• ukuthuthukiswa kwe-neuropathy;
• ukuthola izidakamizwa zamaqembu ahlukahlukene;
• ubudala
• ukukhula kancane kwe-hypoglycemia;
• ukuzinza okuphambili kwezinkomba zeglucose yegazi;
• ukugula kwengqondo;
• isifo sikashukela satholakala eminyakeni engaphezu kweshumi eyedlule;
• Uhlobo lokwelashwa lubandakanya ukushintshwa kwe-insulin yomuntu.

Contraindication

Isixazululo seLantus sokwenza kube nzima ukuhlushwa kwe-insulin

• ngokungabekezeleli komuntu ngamunye ku-mahormone noma okutholile;
• izingane ezingaphansi kweminyaka eyisithupha.

Izindleko

Umuthi osezingeni eliphezulu waseJalimane uLantus ovela eSanofi osuselwa ku-insulin glargine ungowesigaba samanani aphezulu.

Ukupakisha inombolo ye-5 kubiza kusuka kuma-ruble angama-2900 kuya kwangama-4000.

Izindleko zezichazi:

• izidakamizwa zesenzo eside isikhathi iTujeo SoloStar 300 UNITS - ama-ruble angama-3100;
• Isixazululo somjovo weLevemir Flexpen - sisuka kuma-ruble ayi-2000 kuye kwangama-3000.

Izimo zokugcina nokuphila eshalofini

Amapeni wesirinji weSoloStar kufanele abekwe emnyango wesiqandisi. Umbuso wokushisa olungile uvela ku- + 2 kuya ku- + degrees. Kuyenqatshelwa ukuthi kufrize ikhambi kususelwa ku-insulin glargine: umuthi iLantus ulahlekelwe izakhiwo zayo zokupholisa.

Gcina iziqukathi zemithi ebhokisini lekhadibhodi ukuvikela ekuvezweni ukukhanya. Impilo yeshelufu lamaphenti wesirinji ngenkathi kugcinwa ukupakishwa okuvaliwe kuyizinyanga ezingama-36.

Ama-Analog

I-insulin esebenza isikhathi eside iqukethe le mithi elandelayo:

1. I-Tujeo SoloStar. Isixazululo somjovo simiselwe iziguli ezindala.
2. I-Aylar. Kusetshenziswe ukwelashwa kwe-insulin kubantu abadala nasezinganeni kusukela eminyakeni emi-2.
3. I-Levemire FlexPen. Umuthi osuselwa ku-Detemir insulin usebenza kuhlobo lweshukela likashukela. Isisombululo sivunyelwe kusukela eminyakeni emibili nokwelashwa kwe-insulin kubantu abadala.

Ukubuyekezwa

Mayelana nomuthi iLantus SoloStar kunemibono eminingi emihle yeziguli ephoqelelwa ukuthola insulin nsuku zonke njengomjovo. Izinqubo ezijwayelekile, udinga ipeni lesirinji eliseduze nomuthi wezenzo ezinde. Kubalulekile ukuqinisekisa ukukhishwa okubushelelezi kwe-insulin ukuze kugcinwe amazinga aphezulu (ngaphandle kokuxhuma ngokungazelelwe) amazinga e-hormone kanye nokufakwa isikhathi eside kwengxenye ephathisiwe.

Umuthi uLantus uhlangabezana nalezi zidingo. Ukusebenza kwezokwelapha, isikhathi eside, esigcwele se-insulin kuqinisekiswa ukubuyekezwa kweziguli nodokotela. Inzuzo ebalulekile ukuthi kungenzeka ukusebenzisa i-insulin glargine ezinganeni ezingaphezu kweminyaka eyi-6 nabesifazane abakhulelwe (ngokuqapha).

I-ejenti yokulwa ne-antidiabetesic Lantus ikhombisa ukusebenza isikhathi eside, igcina ngempumelelo amazinga kashukela egazini elisezingeni elifanele imini nobusuku, ekuseni. Umuthi unemikhawulo embalwa, kulandela imiyalo, ukukhethwa komthamo ophelele we-hypoglycemia kukhula ngokungajwayelekile. Kubalulekile ukubheka ushukela wakho wegazi nsuku zonke ukuze ugweme amanani aphansi abucayi.