I-Trazhenta isidakamizwa se-hypoglycemic sokusetshenziswa kwangaphakathi. Umuthi uyatholakala ngesimo samaphilisi abomvu akhanyayo, ayindilinga. Ithebhulethi ebonakalayo inezinhlangothi zombili futhi idluliselwe emaphethelweni. Uphawu lomakhi luphawulwa ngakolunye uhlangothi, kanti uphawu lwe- "D5" luqoshwe kolunye.
Imiyalo ithi isakhi esiyinhloko sethebhulethi ngayinye yeTrazhenta yi-linagliptin, equkethe ivolumu engu-5 mg. Izinto ezingeziwe yilezi:
- I-2.7 mg magnesium stearate.
- 18 mg isitashi pregelatinized.
- I-130.9 mg ye-mannitol.
- I-5.4 mg ye-Copovidone.
- 18 mg ummbila isitashi.
- Ukwakheka kwegobolondo elihle kufaka phakathi i-pink opadra (02F34337) 5 mg.
Umuthi kaTrazent ufakwa emabhulini e-aluminium, amaphilisi ayi-7 lilinye. Amabhulokhi, wona, asemabhokisini amakhadibhodi ezincezu ezi-2, ezi-4 noma ezi-8. Uma i-blister ibambe amaphilisi ayi-10, khona-ke kwiphakeji elilodwa kuzoba nezingcezu ezi-3.
Isenzo se-Pharmacological somuthi
Isakhi esisebenzayo somuthi i-inhibitor ye-enzyme dipeptidyl peptidase-4 (DPP-4). Le nto inethonya elimazayo kuma-incretin mahormone (i-GLP-1 ne-GUI), okudingekayo ukuze umzimba womuntu ulondoloze izinga elifanele likashukela.
Ngokushesha ngemuva kokudla emzimbeni, ukuqhamuka kwama-hormone womabili kwenzeka. Uma izinga likashukela wegazi livamile noma likhulu ngokweqile, la mahomoni asheshisa ukukhiqizwa kwe-insulin nokugcinwa kwayo yi-parenchyma. I-hormone i-GLP-1, ngaphezu kwalokho, futhi inciphisa ukukhiqizwa koshukela isibindi.
Ngokuqondile umuthi uqobo kanye nezimpawu zalo kwandisa inani lama -retret ngokubakhona kwabo futhi, ngokwenza kubo, kunomthelela emsebenzini wabo wesikhathi eside.
Ekubuyekezweni kweTrazhent, umuntu angathola izitatimende ukuthi umuthi uvusa ukukhiqizwa kwe-insulin kuncike glucose futhi kunciphise ukukhiqizwa kwe-glucagon. Ngenxa yalokhu, izinga likashukela wegazi lijwayelekile.
Izinkomba zokusetshenziswa nemiyalo
I-trazent iyanconywa ukuthi isetshenziswe ezigulini ezitholakala zinesifo sikashukela sohlobo 2, ngaphezu kwalokho:
- Lesi kuphela isidakamizwa esisebenzayo ezigulini ezinokulawulwa okunganele kwe-glycemic, okungenzeka ngenxa yokusebenza komzimba noma ukudla.
- I-trazent ichazwa lapho isiguli sehluleka ngokwezinso, lapho i-metformin inqatshelwe ukuthatha noma kukhona ukungabekezeleleki kwe-metformin ngumzimba.
- I-Trazent ingasetshenziswa ngokuhlanganiswa ne-thiazolidinedione, i-sulfonylurea derivatives, ene-metformin. Noma-ke, lapho ukwelashwa ngalezi zidakamizwa, ezemidlalo, ukubambelela ekudleni akuzange kulethe umphumela ofanele.
Contraindication ekusebenziseni isidakamizwa
Isichasiselo kulo muthi sisho ngokusobala ukuthi iTrazhenta ayinconywa ukusetshenziswa:
- ngesikhathi sokukhulelwa;
- ngesifo sikashukela sohlobo 1;
- ngesikhathi sokuqunjelwa;
- ungabeki umuthi ezinganeni ezingaphansi kweminyaka engu-18;
- labo abanomqondo ophansi ezingxenyeni ezithile zeTrazhenta;
- abantu abane-ketoacidosis ebangelwa isifo sikashukela.
Indlela yokusebenzisa
Umthamo onconyelwe iziguli zabantu abadala yi-5 mg, umuthi kufanele uphuzwe izikhathi ezi-3 ngosuku, imiyalo ikhombisa lokhu ngqo. Uma umuthi uthathwa ngokuhlangana ne-metformin, khona-ke umthamo wokugcina uhlala ungashintshiwe.
Ukudonswa kweziguli okunenkinga yezinso kusebenza akudingi ukulungiswa komthamo.
Izifundo ze-Pharmacokinetic ziphakamisa ukuthi iTrazent ingadinga ukulungiswa komthamo kokungasebenzi kahle kwesibindi. Kodwa-ke, okuhlangenwe nakho kokusetshenziswa kwomuthi yiziguli ezinjalo kusasilela.
Lokhu kulungiswa akudingeki ezigulini esezikhulile. Kepha eqenjini labantu ngemuva kweminyaka engama-80, odokotela abakukhuthazi ukuthatha lo muthi, ngoba akukho okuhlangenwe nakho kokusetshenziswa kwemitholampilo kule minyaka.
Iphephe kangakanani i-Trazenta ezinganeni nasebusheni.
Uma isiguli esihlala sithatha lesi sidakamizwa nganoma yisiphi isizathu siphuthelwe umthamo, khona-ke ithebhulethi kufanele ithathwe ngokushesha ngokushesha. Kepha ungaphindi umthamo ophindwe kabili. Ungasiphuza umuthi noma kunini, kungakhathalekile ukuthi udla ini.
Ngabe ukugcoba ngokweqile komuthi kungaholela kuphi?
Ngokusho kocwaningo oluningi lwezokwelapha (okwamenyelwa kulo iziguli zokuzithandela), kuyacaca ukuthi i-drug overdose eyodwa enenani lamaphilisi ayi-120 (600 mg) ayilimazanga impilo yalaba bantu.
Namuhla, awekho amacala okusebenzisa ngokweqile lesi sidakamizwa aqoshwe ngokuphelele. Vele, uma umuntu athathe umthamo omkhulu weTrazhenta, kufanele asuse ngokushesha okuqukethwe esiswini sakhe, abangele ukugabha nokuqaqamba. Ngemuva kwalokho, akulimalanga ukubonana nodokotela.
Kungenzeka ukuthi uchwepheshe aqaphele noma yikuphi ukwephulwa futhi anikeze ukwelashwa okufanele.
Ukusetshenziswa kwesidakamizwa ngesikhathi sokukhulelwa nokuqunjelwa
Ukusetshenziswa kweTrazenti ngabesifazane ngesikhathi sokubeletha akukafundwa. Kodwa-ke, izifundo zezilwane ngomuthi azibonisanga zimpawu zobungozi bokuzala. Ngaphandle kwalokhu, ngesikhathi sokukhulelwa, odokotela batusa ukugwema ukusetshenziswa komuthi.
Imininingwane etholwe njengomphumela wokuhlaziywa kwe-pharmacodynamic ezilwaneni zibonisa ukuthathwa kwe-linagliptin noma izakhi zalo kubisi lwebele lowesifazane oncelisayo.
Ngakho-ke, umphumela wezidakamizwa ezinganeni ezisanda kuzalwa abancelwanga ngaphandle.
Kwezinye izimo, odokotela bangaphikelela ekuyekeni ukuncelisa ibele uma isimo sikamama sidinga ukuthatha i-Trazenti. Ucwaningo lwethonya lomuthi emandleni omuntu wokukhulelwa alwenziwe. Ukuhlolwa kwezilwane kule ndawo akuvezi imiphumela emibi; ukubuyekezwa kososayensi nakho akuqinisekisile ubungozi bomuthi.
Imiphumela emibi
Inani lemiphumela emibi ngemuva kokuthatha i-Trazhenta iyafana nenani lemiphumela emibi ngemuva kokuthatha i-placebo.
Nakhu ukusabela okungenzeka ngemuva kokuthatha i-Trazhenty:
- i-pancreatitis
- ukukhwehlela
- i-nasopharyngitis (isifo esithathelwanayo);
- i-hypertriglyceridemia;
- ukuzwela kwezinye izingxenye zomuthi.
Kubalulekile! Izakhi Trazenti zingadala isiyezi. Ngakho-ke, ngemuva kokuthatha lesi sidakamizwa, ukushayela akunconywa kakhulu!
Imiphumela emibi engenhla yenzeka ikakhulu ngokuhlanganiswa kokusetshenziswa kweTrazhenta kanye nama-analogues ayo nge-metformin ne-sulfonylurea.
Ukuphathwa kanyekanye kwe-pioglitazone ne-linagliptin empeleni kunomthelela ekwandeni kwesisindo somzimba, ukuvela kwe-pancreatitis, hyperlipidemia, nasopharyngitis, ukukhwehlela, nakwezinye iziguli hypersensitivity kusuka kumasosha omzimba.
Ngokusebenzisa kanyekanye umuthi nge-metformin ne-sulfonylurea derivatives, hypoglycemia ngesikhathi sokukhulelwa, ukukhwehlela, i-pancreatitis, i-nasopharyngitis kanye ne-hypersensitivity ezingxenyeni zomuthi kungenzeka.
Impilo yeshelf nezincomo
Imiyalo ehambisana nalesi sidakamizwa ithi udinga ukugcina lesi sidakamizwa endaweni yokushisa engeqi ngama-25 degrees futhi endaweni emnyama engafinyeleleki ezinganeni. Usuku lokuphelelwa isikhathi kweTrazenti yiminyaka engu-2,5.
Odokotela abayinikezi i-Trazent kubantu abanesifo sikashukela se-ketoacidosis. Umuthi awuvunyelwe nhlobo lwesifo sikashukela sohlobo 1. Amathuba okukhula kwe-hypoglycemia lapho uthatha iTrazhenta ilingana nalokho okungenzeka uma usebenzisa i-placebo.
Ama-Derivatives we-sulfonylureas angavusa i-hypoglycemia, ngakho-ke, lezi zinto zokwelapha kufanele zihlanganiswe ne-linagliptin ngokucophelela okukhulu. Uma kunesidingo, i-endocrinologist inganciphisa umthamo wokuphuma kwe-sulfonylurea.
Kuze kube manje, ayisekho idatha ethembekile ocwaningweni lwezokwelapha engatshela ngokuxhumana kweTrazhenta ne-hormone-insulin. Kubantu abahlushwa ukungaphatheki kahle kwezinso, umuthi unqunyelwe kanye nezinye izidakamizwa ze-hypoglycemic, futhi izibuyekezo zihlala zinempilo.
Ukuhlangene noshukela egazini kuncishiswa kangcono lapho isiguli sithatha iTrazhenta noma izidakamizwa ezifanayo ngaphambi kokudla.
