Isibalo seziguli ezinesifo sikashukela eRussia sedlule ezigidini eziyisithupha, uhhafu wazo unalesi sifo ezigabeni ezibolile nezinqunyelwe. Ukuthuthukisa ikhwalithi yempilo yesifo sikashukela, ukuthuthukiswa kwama-insulin athuthukisiwe kuyaqhubeka.
Omunye wemithi emisha ebhaliswe eminyakeni yamuva iToujeo. Lesi yi-insulin insulin entsha ye-Sanofi, enikezwa kanye ngosuku futhi ikuvumela ukuthi uthuthukise ukulawulwa kwe-glycemic ngokuqhathaniswa nokwandulelayo, iLantus. Ngokusho kocwaningo, iTujeo iphephe kakhulu ezigulini, ngoba ubungozi be-hypoglycemia ngokusetshenziswa kwayo buphansi.
Umyalo omfishane
I-Tujeo SoloStar ingumkhiqizo wabaholi bomhlaba wonke ekukhiqizeni i-insulin, ukukhathazeka kwaseYurophu uSanofi. E-Russia, imikhiqizo yenkampani imelwe iminyaka engaphezu kwengu-4. UTujeo uthole isitifiketi sokubhalisa saseRussia muva nje, ngonyaka we-2016. Ngo-2018, le insulin yaqala ukukhiqizwa egatsheni leSanofi-Aventis Vostok, esifundeni sase-Oryol.
Umenzi utusa ukushintshela kuTujeo insulin uma kungenzeki ukunxephezela ngokwanele isifo sikashukela noma ukuqeda i-hypoglycemia ejwayelekile. Iningi labanesifo sikashukela kuzodingeka basebenzise iTujeo kungakhathalekile ukuthi bayifisa kanjani, njengengxenye yezifunda zaseRussia ezithenga le insulin esikhundleni seLantus.
| Khipha ifomu | I-Toujeo inezikhathi ezi-3 zokuhlushwa okuphakeme kunamalungiselelo e-insulin ejwayelekile - i-U300. Isixazululo sisobala ngokuphelele, asidingi ukuxutshwa ngaphambi kokuphathwa. I-insulin ifakwa kuma-cartridge angu-1.5 ml engilazi, nayo ivalwe emapeni weSroloStar nge-dosage isinyathelo esingu-1 ml. Ukufakwa esikhundleni kwama-cartridges akunikezwanga kuwo, ngemuva kokukusebenzisa. Ku-package 3 noma ama-5 syringe pens. |
| Imiyalo ekhethekile | Abanye abantu abanesifo sikashukela bagqashula emgqonyeni wamapeni wesirinji ukuze bawafake ekuphathweni ngomthamo onembe kakhudlwana. Lapho usebenzisa iTujeo kuba kwenqatshelwe ngokuphelele, ngoba wonke amapeni wesirinji, ngaphandle kweSoloStar yasekuqaleni, enzelwe i-insulin U100. Ukufaka esikhundleni ithuluzi lokuphatha kungahle kuholele Ukweqiwa kathathu komuthi. |
| Ukwakheka | NjengaseLantus, into esebenzayo glargine, ngakho-ke umgomo wokusebenza walawa ma-insulin amabili uyefana. Uhlu lwezakhi ezisizayo luhlangana ngokuphelele: i-m-cresol, i-glycerin, i-chloride ye-zinc, amanzi, izinto zokulungiswa kwe-acidity. Ngenxa yokwakheka okufanayo, ingozi yokuphendula komzimba phakathi kokushintsha isuka kwelinye i-insulin iye kwelinye iyehliselwa ku-zero. Ukuba khona kwezivikelo ezimbili kusixazululo kuvumela umuthi ukuthi ugcinwe isikhathi eside, ulawulwe ngaphandle kokungezelela ukwelashwa kwe-antiseptic kwesikhumba, futhi kunciphisa ubungozi bokulimala endaweni yomjovo. |
| Isenzo se-Pharmacological | Iyabonakala esenzweni se-insulin eyenziwe kumuntu onempilo. Naphezu komehluko omncane ekwakhiweni kwe-molecule ye-glargine ne-insulin yomshuwalense, iTujeo iyakwazi nokubopha kuma-insulin cell receptors, ngenxa yalokho okushukela okuvela egazini kuya ngaphakathi kwezicubu. Ngasikhathi sinye, ivuselela ukugcinwa kwe-glycogen emisipheni kanye nesibindi (glycogenogeneis), kuvimbela ukwakheka koshukela ngesibindi (gluconeogenesis), kuvimbela ukweqiwa kwamafutha, futhi kusekele ukwakheka kwamaprotheni. |
| Izinkomba | Ukubuyiselwa kokusilela kwe-insulin kubantu abadala abanesifo sikashukela. I-insulin kaTujeo ivunywa iziguli ezinesifo sikashukela, ukwehluleka kwezinso, nezifo zesibindi. Njengomthetho, umthamo wayo kulezi zimo uphansi. |
| Umthamo | Imiyalo esetshenziswayo ayinayo imithamo yokunconywa yeTujeo, ngoba inani elifanele le-insulin kufanele likhethwe ngokulandelana kwemiphumela kashukela wegazi. Lapho kubalwa i-insulin, ziqondiswa ikakhulu yidatha ye-glycemia yangemuva kosuku. Umenzi utusa ukujova iTujeo kanye ngosuku. Uma umjovo owodwa ungavumeli ukufezekisa ushukela obushelelezi esiswini esingenalutho, umthamo wansuku zonke ungahlukaniswa amahlandla ama-2. Umjovo wokuqala unikezwa ngaphambi kokulala, owesibili - ekuseni kakhulu. |
| Ukweqisa | Uma inani leTujeo elilawulwa lingaphezu kwezidingo ze-insulin zesiguli, i-hypoglycemia izokwenzeka nakanjani. Esigabeni sokuqala, kuvame ukuhambisana nezimpawu ezicacile - indlala, ukuthuthumela, ukuzizwa kwenhliziyo. Bobabili oshukela kanye nezihlobo zakhe kufanele bayazi imithetho ye-ambulensi ye-hypoglycemia, bahlala bephethe ama-carbohydrate asheshayo kanye nesethi yosizo lokuqala nge-glucagon. |
| Ithonya lezinto ezingaphandle | I-insulin yi-hormone esenzo sayo singenziwa buthaka ngamanye ama-hormone enzeke emzimbeni womuntu, laba okuthiwa ngabaphikisi. Ukuzwela kwezicubu zomuthi kungancipha okwesikhashana. Izinguquko ezinjalo ziyisimo sezimo ezihambisana nokuphazamiseka kwe-endocrine, umkhuhlane, ukugabha, isifo sohudo, ukuvuvukala okubanzi, nokucindezela. Ebantwini abaphilile, ngezikhathi ezinjalo, ukukhiqizwa kwe-insulin, abanesifo sikashukela badinga ukwandisa umthamo weTujeo. |
| Contraindication | Ukushintshwa kabusha komuthi kuyadingeka uma kwenzeka kuba nokuvela okungahambi kahle okwenziwa yizakhi zomzimba ze-glargine noma izingxenye ezisizayo. ITujeo, njenganoma iyiphi i-insulin ende, ayikwazi ukusetshenziselwa ukulungiswa koshukela okuphuthumayo. Umsebenzi wawo ukugcina i-glycemia isezingeni elifanayo. Lapho kungekho khona izifundo eziqinisekisa ukuphepha kwezingane, i-insulin Tujeo kuvunyelwe kuphela kwabanesifo sikashukela esidala. |
| Ukuxhumana neminye imithi | I-Hormonal, hypotensive, psychotropic, ezinye izidakamizwa ezilwa ne-antibacterial zingathinta umphumela we-hypoglycemic. Yonke imishanguzo esetshenziselwa ushukela kufanele ivumelane nodokotela wakho. |
| Umphumela wecala | Ngokusho kwemiyalo, abanesifo sikashukela bangathola:
Ukwehla okubukhali ushukela ngemuva kokuqala kokusebenza kwe-insulin kungaholela ku-neuropathy yesikhashana, i-myalgia, umbono ofiphele, ukuvuvukala. Le miphumela emibi izonyamalala lapho ukuzivumelanisa nomzimba sekuphelele. Ukuze uzigweme, iziguli ezinesifo sikashukela esincibilikisiwe zandisa umthamo weTujo SoloStar kahle, uzuza ukwehla kancane kancane kwe-glycemia. |
| Ukukhulelwa | I-insulin kaTujeo ayibangeli ukuphazamiseka kokukhula kwengane; uma kunesidingo, ingabuye isetshenziswe ngesikhathi sokukhulelwa. Empeleni alungeni ubisi, ngakho-ke abesifazane bavunyelwe ukuncelisa ibele le-insulin. |
| Sebenzisa ezinganeni | Kuze kube manje, imiyalo yeTujeo yenqabela ukusetshenziswa kwalesi insulin ezinganeni ezinesifo sikashukela. Kulindelwe ukuthi njengoba imiphumela yocwaningo itholakala, lo mkhawulo uzosuswa. |
| Isikhathi sokuphelelwa yisikhathi | Iminyaka engu-2,5 kusukela ngosuku lokukhishwa, emasontweni ama-4 ngemuva kokuvula ibhokisi lomngcwabo, uma izimo zokugcina zihlangatshezwa. |
| Izici zesitoreji nokuhamba | Ukupakisha iTujeo SoloStar kugcinwa ku-2-8 ° C esiqandisini, ipeni lesirinji elisetshenzisiwe lingaphakathi ezindlini uma izinga lokushisa kulo lingadluli kuma-30 ° C. I-insulin ilahlekelwa yizakhiwo zayo lapho ivezelwa yimisebe ye-ultraviolet, iqhwa, ukushisa ngokweqile, ngakho-ke ivikelwa yizembozo ezikhethekile ezishisayo ngesikhathi sokuhamba. |
| Intengo | Iphakethe elinamapeni ama-syringe ama-3 (iyunithi engama-1350) libiza cishe ama-ruble angama-3200. Intengo yebhokisi eliphethe izibambo ezi-5 (amayunithi angama-2250) ngama-ruble angama-5200. |
Imininingwane ewusizo ngeTujeo
IToujeo yi-insulin ende kunazo zonke eqenjini layo. Okwamanje, ingaphezulu kuphela kwesidakamizwa iTresib, esihlobene nama-insulin angeziwe. I-Tujeo kancane kancane ingena emikhunjini ivela ezicutshini ezingaphansi komhlaba futhi kungakapheli amahora angama-24 ihlinzeka ngokuqina kwe-glycemia, emva kwalokho umphumela wayo iba buthaka kancane. Isikhathi sokusebenza esimaphakathi singamahora angama-36.
Isifo sikashukela nokucindezela kuzoba yinto yesikhathi esedlule
- Ukwehlela ushukela -95%
- Ukuqedwa kwe-vein thrombosis - 70%
- Ukuqedwa kokushaya kwenhliziyo okuqinile -90%
- Ukuqeda umfutho wegazi ophakeme - 92%
- Ukwanda kwamandla ngesikhathi sosuku, ngcono ukulala ebusuku -97%
Njengamanye ama-insulin, iTujeo ayikwazi ukuthatha indawo ngokuphelele ukukhiqizwa kwe-hormone okungokwemvelo. Noma kunjalo, ukusebenza kwawo kusondele ngangokunokwenzeka ezidingweni zomzimba. Umuthi unephrofayili ecishe ibe yisicaba yesenzo phakathi nosuku, esisiza ukukhethwa komthamo, sinciphise inani kanye nobunzima be-hypoglycemia, futhi sinanela ngempumelelo isifo sikashukela esikhulile.
I-Tujeo insulin inconyelwa ikakhulukazi iziguli ezinomthamo omkhulu womuthi. Umthamo wesisombululo owethulwe ipeni yesirinji uncishiswa cishe izikhathi ezi-3, ngakho-ke, ukulimala kwezicubu ezingaphansi kuncishisiwe, imijovo ibekezelelwa kalula.
Umehluko kusuka kuLantus
Umkhiqizi wembula izinzuzo eziningi zeTujeo SoloStar ngaphezulu kukaLantus, ngakho-ke, ngokunxeshezelwa okunganele kwesifo sikashukela, utusa ukushintshela kulo muthi omusha.
>> Funda kabanzi ngeLantus insulin - funda lapha
Izinzuzo ze-insulin Tujeo:
- Umthamo wesisombululo ungaphansi kakhulu, ngakho-ke, indawo yokuxhumana nomuthi ngemithambo yegazi incishisiwe, i-hormone ingena egazini kancane kancane.
- Isikhathi sokusebenza singaphezu kwamahora angama-24, okuvumela ukuthi ushintshe kancane isikhathi somjovo ngaphandle kokulimaza impilo.
- Lapho ushintshela eToujeo usuka kwamanye ama-insulin we-basal, imvamisa ye-hypoglycemia iyancipha. Imiphumela emihle ibonwa ezigulini esezikhulile ezinesifo sikashukela sohlobo 2, amaconsi kashukela asephelele ngama-33%.
- Ukushintshashintsha kweshukela kushukela kuyancishiswa.
- Intengo ye-insulin kaTujeo ngokuya ngeyunithi eli-1 incane kancane kuneLantus.
Ukubuyekezwa okuningi kwabanesifo sikashukela kulungile, ukukhethwa komthamo lapho uguqula i-insulin kulula, kuthatha isikhathi esingaphezu kwesonto. Lezo ziguli ezisebenzisa iTujeo ngokuqinile ngokwemiyalo zikhuluma ngaye njengomuthi osezingeni eliphakeme, osetshenziswa kalula. UTujeo akajabuli nabanesifo sikashukela abajwayele ukusebenzisa inaliti yepeni kaninginingi. Ngenxa yokuqina okunyukayo, kuthambekele ekukhetheni, ngakho-ke, kungavimba umgodi ngenaliti.
Ukuphendula komzimba kuToujeo kungokomuntu ngamunye, njenganoma iyiphi i-insulin. Ezinye iziguli zibhekene nokungakwazi ukuthatha isilinganiso somuthi, ukweqa ushukela, ukwanda kwesidingo se-insulin esifushane, kanye nokwenyuka kwesisindo somzimba, ngakho-ke zibuyela ekusebenziseni iLantus.
Ukushintshwa kusuka kuLantus kuya eTujeo
Naphezu kwezakhi ezifanayo, i-insulin kaTujeo ayilingani neLantus. Imiyalo esetshenzisiwe ikhombisa ukuthi awukwazi nje ukufaka esikhundleni somuthi owodwa kwesinye. Kuyadingeka ukukhetha umthamo omusha nokulawula njalo kwe-glycemic ngalesi sikhathi.
Ungashintsha kanjani usuka eLantus uye eTujeo enoshukela:
- Sishiya umthamo wokuqala ungashintshiwe, inqobo nje uma kukhona amayunithi amaningi eTujeo njengoba kukhona amaLantus. Umthamo wesisombululo uzoba izikhathi eziphindwe kathathu.
- Ungashintshi isikhathi somjovo.
- Sigada i-glycemia izinsuku ezintathu, phakathi nesikhathi i-insulin iqala ukusebenza ngokugcwele.
- Silinganisa ushukela hhayi kuphela esiswini esingenalutho, kodwa futhi nangemva kokudla. ILantus ingalungisa amaphutha kancane ekubaleni ama-carbohydrate ekudleni. I-Tujeo SoloStar ayixoleli amaphutha anjalo, ngakho-ke, kungenzeka ukwandisa umthamo we-insulin emfushane.
- Ngokuya ngemininingwane etholakele, siguqula umthamo. Imvamisa idinga ukukhushulwa kancane (kuze kufike ku-20%).
- Ukulungiswa ngakunye okulandelayo kufanele kwenzeke okungenani ezinsukwini ezi-3 ngemuva kweyedlule.
- Umthamo uthathwa njengowulungile lapho ushukela egunjini lokulala, ekuseni nasesiswini esingenalutho, kugcinwa kuleveli efanayo phakathi kokudla.
Ukuze uqiniseke ngethamo elikhokhelwayo, kufanele ulandele ngqo inqubo yokujova. Ngaphambi komjovo, udinga ukukhipha iyunithi ye-insulin ukubheka ukusebenza kwepeni yesirinji kanye nokuqina kwenaliti.
