IFommetin ngesinye sezidakamizwa ezifuywayo eziqukethe i-metformin - ithuluzi elithandwayo, elisebenzayo neliphephile lokunciphisa ushukela kuma-diabetes. Ezigulini ezingaphezu kwe-90%, umuthi unganciphisa ushukela ngama-25%. Lo mphumela uhambelana nokwehla okuphakathi kwe-hemoglobin ye-glycated ngu-1.5%.
Umuthi uvame ukubekwa njengomugqa wokuqala ngokuhlanekezela kokuqala kwe-carbohydrate metabolism, kuhlangene nokudla nokuzivocavoca, kungenzeka ukugwema isifo sikashukela i-mellitus (kuze kufike ku-75%). Imiphumela emibi iyingozi empilweni ngesikhathi sokwelashwa ngeFomuetin ayivelakancane, akukho bungozi be-hypoglycemia. Umuthi awuthathi hlangothi ngokwesisindo, futhi ezigulini eziningi ezinesifo sikashukela kuya nomthelela ekwehliseni isisindo.
Yini i-formetin enqunyelwe?
IFommetin iyi-analogue yesidakamizwa saseJalimane i-Glucophage: iqukethe into efanayo esebenzayo, inezinketho zemithamo efanayo, nokwakhiwa okufanayo kwamacwecwe. Ucwaningo nokubuyekezwa kweziguli eziningi kuqinisekisile umphumela ofanayo wazo zombili lezi zidakamizwa zesifo sikashukela. Umkhiqizi weFomumetin yiqembu laseRussia lezinkampani zasePhemessard, manje elisesikhundleni esiphambili emakethe yezokwelapha.
NjengoGlucophage, iFormetin itholakala ezinguqulweni ezi-2:
| Ukwehluka kwezidakamizwa | IFethethine | Ifomu elide |
| Khipha ifomu | Ubungozi bethebhulethi yecylindrical | Amathebulethi efakwe kumafilimu anikezela ngokukhishwa okuqinile kwe-metformin. |
| Umnikazi wekhadi le-ID | I-Pharmstandard-Leksredstva | I-Pharmstandard-Tomskkhimfarm |
| Imithamo (i-metformin ngethebhulethi), g | 1; 0.85; 0.5 | 1; 0.75; 0.5 |
| Imodi yokwamukela, kanye ngosuku | kufinyelela ku-3 | 1 |
| Umthamo omkhulu, g | 3 | 2,25 |
| Imiphumela emibi | Ihambelana ne-metformin ejwayelekile. | 50% sehlisiwe |
Njengamanje, i-metformin ayisetshenziselwa kuphela ukwelashwa kwesifo sikashukela, kodwa futhi nokunye ukuphazamiseka kwe-pathological okuhambisana nokungahambisani ne-insulin.
Isifo sikashukela nokucindezela kuzoba yinto yesikhathi esedlule
- Ukwehlela ushukela -95%
- Ukuqedwa kwe-vein thrombosis - 70%
- Ukuqedwa kokushaya kwenhliziyo okuqinile -90%
- Ukuqeda umfutho wegazi ophakeme - 92%
- Ukwanda kwamandla ngesikhathi sosuku, ngcono ukulala ebusuku -97%
Izindawo ezingeziwe zokusebenzisa umuthi iFomuetin:
- Ukuvimbela Ushukela E-Russia, ukusetshenziswa kwe-metformin kuvunyelwe engcupheni - kubantu abanamathuba aphezulu okuthola isifo sikashukela.
- IFommetin ikuvumela ukuthi uvuselele i-ovulation, ngakho-ke, iyasetshenziswa lapho uhlela ukukhulelwa. Isidakamizwa sinconywa yi-American Association of Endocrinologists njengomuthi wokuqala olusebenzisa i-polycystic ovary. E-Russia, le nkomba yokusebenzisa ibingakabhaliswa, ngakho-ke, ayifakiwe kwimiyalo.
- IFomuethine ingathuthukisa isimo sesibindi nge-steatosis, esivame ukuhambisana nesifo sikashukela futhi singenye yezingxenye ze-metabolic syndrome.
- Ukwehla kwesisindo ngokuqina kwe-insulin. Ngokusho kodokotela, amaphilisi weFormin akhulisa ukusebenza kokudla okunama-kilojoule amancane futhi angahambisa inqubo yokunciphisa isisindo ezigulini ezinokukhuluphala.
Kuneziphakamiso zokuthi lo muthi ungasetshenziswa njenge-ejenti ye-antitumor, kanye nokunciphisa inqubo yokuguga. Lezi zinkomba bezingakabhaliswa, ngoba imiphumela yezifundo ingeyokuqala futhi idinga ukuthi kuphinde kubhekwe kabusha.
Isenzo se-Pharmacological
Kunezici eziningana ezingaphansi komphumela wokwehlisa ushukela weFomuetin, okungekho kuwo othinta ngqo ama-pancreas. Imiyalo esetshenziswayo ibonakalisa indlela yokusebenza yesithasiselo:
- Iqinisa ukuzwela kwe-insulin (isebenza kakhulu ezingeni lesibindi, ngezinga elincane lemisipha kanye namafutha), okubangela ukuba ushukela wehle ngokushesha ngemuva kokudla. Lo mphumela utholakala ngokwandisa umsebenzi wama-enzyme atholakala kuma-insulin receptors, kanye nangokuqinisa umsebenzi we-GLUT-1 ne-GLUT-4, okuyizithwali zeglucose.
- Yehlisa ukukhiqizwa kwe-glucose esibindini, lapho isifo sikashukela sikhuphuka kuze kube kathathu. Ngenxa yaleli khono, amaphilisi we-formin anciphisa ushukela wokuzila kahle.
- Kuphazamisa ukumuncwa kwe-glucose ephuma emgodini wesisu, okukuvumela ukuthi wehlise ukukhula kwe-postprandial glycemia.
- Inomphumela omncane we-anorexigenic. Ukuxhumana kwe-metformin ne-mucosa esiswini kunciphisa isifiso sokudla, okuholela ekunciphiseni isisindo. Kanye nokwehla kwe-insulin kanye nokwehla kokukhiqizwa kwe-insulin, izinqubo zokuhlukaniswa kwamaseli wamafutha ziyaholwa.
- Umphumela onenzuzo emithanjeni yegazi, uvimbela izingozi ze-cerebrovascular, izifo zenhliziyo. Kusungulwe ukuthi ngesikhathi sokwelashwa ngeFomuthi, isimo sezindonga zemikhumbi siyathuthuka, i-fibrinolysis iyakhuthazeka, futhi ukwakheka kwezigaxa zegazi kuyancipha.
Imithamo nezimo zesitoreji
Umyalo uncoma ukukhulisa umthamo weFomuetin kancane kancane ukuthola isinxephezelo sikashukela kanye nokunciphisa amathuba emiphumela engathandeki. Ukwenza lula le nqubo, amaphilisi atholakala kuzindlela ezintathu zomthamo. IFommetin ingaqukatha u-0.5, 0,85, noma 1 g we-metformin. IFetetin Long, umthamo uhlukile kancane, kuthebhulethi engu-0.5, 0,75 noma 1 g ye-metformin. Lokhu kwehluka kubangelwa ukusetshenziswa kalula, ngoba iFometin ibhekwa njengethamo elikhulu le-3 g (amaphilisi ama-3 we-1 g ngalinye), neFomuetin Long - 2.25 g (amaphilisi ama-3 we-0.75 g lilinye).
IFomu ligcinwa iminyaka emi-2 kusukela ngesikhathi sokukhiqizwa, esikhonjisiwe epakethini kanye nesiqhumane ngasinye somuthi, emazingeni okushisa afinyelela kuma-25 degrees. Umphumela wamathebulethi ungenziwa buthaka ngokuchayeka isikhathi eside kwimisebe ye-ultraviolet, ngakho-ke imiyalo yokusebenzisa itusa ukugcina ama-blisters ebhokisini lekhadibhodi.
Ungayithatha kanjani i-FORMETINE
Isizathu esiyinhloko sokuthi abanesifo sikashukela benqabe ukwelashwa ngeFormetin kanye nokufana kwayo yimizwa engathandeki ehambisana nokuphazamiseka kokugaya ukudla. Yehlisa kakhulu imvamisa yabo namandla uma ulandela ngokuqinile izincomo ezivela emiyalweni yokuqalisa i-metformin.
Uma umncane umthamo wokuqala uqala, kuzoba lula ngomzimba ukuzivumelanisa nomuthi. Ukwemukelwa kuqala ngo-0.5 g, okuvame kakhulu nge-0.75 noma i-0.85 g.Amathebulethi athathwa ngemuva kokudla okunzima, mhlawumbe kusihlwa. Uma ukugula kwasekuseni kukhathaza ekuqaleni kokwelashwa, ungadambisa lesi simo ngesiphuzo esine-asidi esenziwe kancane esinezithelo noma umhluzi we-rose yasendle.
Uma kungekho imiphumela emibi, umthamo ungandiswa ngeviki. Uma umuthi ungabekezelelwa kahle, umyalo ululeka ukuthi kuhlehliswe ukukhuphuka komthamo kuze kube sekupheleni kwezimpawu ezingemnandi. Ngokusho kwesifo sikashukela, lokhu kuthatha amasonto amathathu.
Umthamo wesifo sikashukela wanda kancane kancane kuze kube yilapho i-glycemia isizinza. Ukungezelela umthamo ku-2 g kuhambisana nokwehla okusebenzayo koshukela, khona-ke inqubo incipha kakhulu, ngakho-ke akuhlali kunengqondo ukunquma umthamo ophelele. Umyalo wenqabela ukuthatha amaphilisi we-formmetin ngethamo eliphezulu labashukela asebekhulile (ngaphezulu kweminyaka engama-60) kanye neziguli ezisengozini enkulu ye-lactic acidosis. Okuphezulu okuvunyelwe kubo yi-1 g.
Odokotela bakholelwa ukuthi uma umthamo ophelele we-2 g unganikeli amanani egalofu we-glucose, kunengqondo ngokwengeziwe ukufaka esinye isidakamizwa kuhlobo lokwelashwa. Imvamisa, iba ngomunye we-sulfonylurea derivatives - glibenclamide, glyclazide noma glimepiride. Le nhlanganisela ikuvumela ukuthi uphindze kabili ukusebenza kahle kokwelashwa.
Imiphumela emibi
Lapho uthatha i-Formetin, okulandelayo kungenzeka:
- izinkinga zokugaya. Ngokusho kokubuyekezwa, imvamisa kukhonjiswa ekucasheni kwenhliziyo noma kuhudo. Okungajwayelekile, abanesifo sikashukela bakhala ngobuhlungu besisu, ukwanda kwegesi, ukunambitheka kwensimbi esiswini esingenalutho;
- i-malabsorption ye-B12, ibonwa kuphela ngokusebenzisa isikhathi eside kwe-formin;
- I-lactic acidosis iyinkinga enqabile kepha eyingozi kakhulu yesifo sikashukela. Kungenzeka noma nge-overdose ye-metformin, noma ngokwephulwa kokuphuma kwayo okuvela egazini;
- ukungezwani komzimba ngendlela yokuqhuma kwesikhumba.
I-Metformin ithathwa njengesidakamizwa sokuphepha esiphakeme. Imiphumela emibi ejwayelekile (ngaphezu kwe-10%) ingukuphazamiseka kokugaya ukudla, okukhona endalweni futhi akuholeli ezifweni. Ingozi yeminye imiphumela engafuneki ayikho ngaphezu kwe-0.01%.
Contraindication
Uhlu lwe-contraindication ekwelashweni ngeFommetin:
- izinkinga ezinzima zesifo sikashukela, ukulimala okungathi sína, ukusebenza, izifo ezithathelwanayo ezidinga ukwelashwa kwe-insulin;
- ukwehluleka okunzima kwezinso;
- ukwehluleka kwesibindi;
- icala le-lactic acidosis esikhathini esidlule noma ingozi enkulu yalomphumela wecala ngenxa yokuphefumula nokuhluleka kwenhliziyo, ukuphelelwa amandla emzimbeni, ukondleka okuhlala isikhathi eside kwama-kilojoule angama-1000 noma ambalwa, uphuzo oludakayo, ukudakwa ngokweqile, ukwethulwa kwezinto ezine-radiopaque, kubantu abanesifo sikashukela asebekhulile abanomfutho omkhulu womzimba;
- ukukhulelwa, ukukhulelwa;
- izingane ezingaphansi kweminyaka eyi-10.
Ama-analogues adumile
Njengolwazi lwereferensi, sethula uhlu lwemithi ebhaliswe e-Russian Federation, okuyizifaniso zeFometin neFometin Long:
| Ama-analoggs eRussia | Izwe lokukhiqizwa kwamathebhulethi | Umsuka wento yemithi (metformin) | Umnikazi wekhadi le-ID |
| Imithi Equkethe Metformin Ejwayelekile, i-Formetin Analogs | |||
| I-Glucophage | IFrance, Spain | EFrance | Merk |
| I-Metfogamma | IGermany, iRussia | India | I-Worwag Pharma |
| Glyformin | IRussia | I-Akrikhin | |
| IFomu Pliva | ECroatia | Pliva | |
| Metformin Zentiva | ISlovak | I-Zentiva | |
| ISofamet | Bulgaria | I-Sofarma | |
| Metformin teva | Israyeli | Teva | |
| I-Nova Met (Metformin Novartis) | EPoland | I-Novartis Pharma | |
| Siofor | EJalimane | Berlin Chemie | |
| Metformin Canon | IRussia | I-Canonpharma | |
| I-Diaspora | India | Iqembu le-Actavis | |
| I-Metformin | Belarus | BZMP | |
| Merifatin | IRussia | China | I-Pharmasynthesis |
| I-Metformin | IRussia | ENorway | Usokhemisi |
| I-Metformin | ISerbia | EJalimane | I-Hemofarm |
| Izidakamizwa ezisebenza isikhathi eside, ama-analogues kaFetetin Long | |||
| I-Glucophage Long | EFrance | EFrance | Merk |
| Methadiene | India | India | I-Wokhard Limited |
| I-Bagomet | I-Argentina, iRussia | I-Valeant | |
| I-Diaformin OD | India | San Pharmaceutical | |
| Metformin Prolong-Akrikhin | IRussia | I-Akrikhin | |
| I-Metformin MV | IRussia | India, China | Izvarino Pharma |
| Metformin MV-Teva | Israyeli | ISpain | Teva |
Ngaphansi kwegama lomkhiqizo iMetformin, lesi sidakamizwa sibuye sikhiqizwe ngu-Atoll, Rafarma, Biosynthesis, Vertex, Promomed, Izvarino Pharma, Medi-Sorb, uGideon-Richter; I-Metformin Long - iCanonpharma, i-Biosynthesis. Njengoba kubonakala etafuleni, iningi le-metformin emakethe yaseRussia livela eNdiya. Akumangazi ukuthi i-Glucophage yasekuqaleni, ekhiqizwa ngokuphelele eFrance, ithandwa kakhulu phakathi kweziguli ezinesifo sikashukela.
Abakhiqizi abakufaki ukubaluleka okuthile ezweni lemvelaphi ye-metformin. Into ethengiwe eNdiya idlula ngempumelelo ngisho nokulawulwa kwekhwalithi okuqinile futhi empeleni ayihlukile kulokho okwenziwa eFrance. Ngisho nezinkampani ezinkulu kakhulu eBerlin-Chemie neNovartis-Pharma zikubheka njengekhwalithi ephezulu kakhulu futhi ziyasebenza futhi ziyisebenzisela ukwenza amaphilisi azo.
IFomu noma iMetformin - okungcono (izeluleko zikadokotela)
Kuma-generator we-Glucophage atholakala eRussia, akekho ohlukile ekuphatheni kwayo isifo sikashukela. Zombili iFometin nezincazelo eziningi zezinkampani ezahlukahlukene ezibizwa ngokuthi iMetformin zinokwakheka okufanayo futhi imvamisa efanayo yemiphumela emibi.
Iningi labanesifo sikashukela bathenga i-metformin yaseRussia ekhemisi, benganaki umenzi othile. Emgqonyeni wamahhala, igama lezinto ezisebenzayo kuphela eliveziwe, ngakho-ke, ekhemisi ungathola noma yiziphi izichasiselo ezibalwe ngenhla.
Intengo
IMetformin umuthi odumile futhi ongabizi kakhulu. Ngisho ne-Glucofage yasekuqaleni inentengo ephansi (kusuka kuma-ruble ayi-140), abalingani basekhaya bashibhile. Intengo yephakheji yeFometin iqala kuma-ruble angama-58 wamathebulethi angama-30 ngomthamo omncane futhi iphelela kuma-ruble angama-450. zamathebhulethi angama-60 eForin Long 1 g.
