UGlidiab waziwa cishe sonke isifo sikashukela. Ine-gliclazide - isithako esivame kakhulu esisebenzayo esivela ku-sulfonylurea derivatives. Ngenxa yokusebenza kwawo nokutholakala kwawo, izidakamizwa ezivela kuleli qembu zichazwa emhlabeni wonke ngobuningi beziguli ezinesifo sikashukela.
Amacwecwe akhiqizwa i-Akrikhin, ongomunye wabakhiqizi abayisihlanu abahola amakhambi eRussia. IGlidiab inekhono eliphakeme le-hypoglycemic, ukwelashwa kuyabavumela ukuthi banciphise i-glycated hemoglobin iye ku-2%. Uhlangothi lwe-flip lwalokhu kusebenza luyingozi enkulu ye-hypoglycemia.
Wenza kanjani uGlidiab MV
Ukulawula okuqinile kwe-glycemic kuyadingeka ukuvikela izinkinga zesifo sikashukela sekwephuzile. Njengomthetho, irejimeni yokwelashwa ifaka ukulungiswa komsoco nomsebenzi. Ngesifo sohlobo 2, lezi zindlela ngokuvamile azanele, ngakho-ke kuphakama umbuzo wokuqokwa kwezidakamizwa ezinciphisa ushukela. Isigaba sokuqala salesi sifo sibonisa ngokumelana ne-insulin nokukhiqizwa okukhuphukile kwe-glucose esibindini, ngakho-ke ngalesi sikhathi umuthi ophumelela kakhulu yi-metformin (ngokwesibonelo, i-Glucofage).
I-hyperglycemia engapheli ngesikhathi esifushane iholela ekungasebenzi kahle kwe-pancreatic cell kanye ne-insulin synthesis. Lapho ushintsho olunjalo luqala, kungakuhle ukuthi ungeze amaphilisi ekwelashweni elibekiwe ngaphambili okungavusa ukukhiqizwa kwe-insulin. Ezidakamizwa ezitholakala njengamanje, ama-DPP4 inhibitors, ama-incretin mimetics, nama-sulfonylureas ayakwazi lokhu.
Amaqembu amabili okuqala asetshenziswa muva nje, yize izidakamizwa zisebenza, kodwa zibiza kakhulu. Ezifundeni eziningi zaseRussia, ukuzitholela mahhala kuyinkinga. Kepha okutholakala kushibhile kwe-sulfonylureas kuqinisekisiwe ukuthi kuchazwe kuyo yonke imitholampilo. Izidakamizwa eziphephe nezindlula zonke zalezi izidakamizwa i-glimepiride (Amaryl) nefomu elishintshiwe le-glyclazide (Diabeteson MV kanye ne-analogues yayo, kufaka phakathi uGlidiab MV)
Isifo sikashukela nokucindezela kuzoba yinto yesikhathi esedlule
- Ukwehlela ushukela -95%
- Ukuqedwa kwe-vein thrombosis - 70%
- Ukuqedwa kokushaya kwenhliziyo okuqinile -90%
- Ukuqeda umfutho wegazi ophakeme - 92%
- Ukwanda kwamandla ngesikhathi sosuku, ngcono ukulala ebusuku -97%
I-Diabeteson umuthi wokuqala, uGlidiab uluhlobo olujwayelekile lwasekhaya lwekhwalithi enhle. Ucwaningo luqinisekisile imiphumela efanayo yale mithi ku-glycemia.
Imiyalo esetshenziswayo ichaza izenzo eziningana eziwusizo zeGlidiab:
- Ukutholwa kwesigaba sokuqala sokukhiqizwa kwe-insulin, ngenxa yokuthi ushukela uqala ukuphuma emikhunjini ngokushesha ngemuva kokuthola.
- Isigaba 2 sokukhulisa.
- Ukunciphisa ukunamathela kwe-platelet, ukuthuthukisa amandla we-epithelium yemithambo yokuhlanza i-thrombi. Lo mphumela wehlisa amathuba okuba nezinkinga zemithambo yegazi.
- Ukungathathi hlangothi kwama-radicals kwamahhala, inani lazo likhuphuka ngesifo sikashukela.
Kukhona izifundo ezifakazela ukuthi amalungiselelo e-sulfonylurea aletha ukubhujiswa kwamangqamuzana e-beta, kuholele ekushoneni kwe-insulin futhi aphoqelele abanesifo sikashukela ukuba beshintshe ekwelashweni kwe-insulin. UGlidiab eqenjini lakhe ungomunye wezidakamizwa eziphephe kakhulu kulokhu. Umthamo ojwayelekile wesidakamizwa unyusa ukuhlanganiswa kwama-hormone ngama-30%, emva kwalokho ukukhiqizwa kwawo kwehle ngo-5% njalo ngonyaka. Ekhambweni yemvelo yesifo, ukuntuleka kwe-insulin kukhuphuka minyaka yonke nge-4%. Lokho wukuthi, akunakwenzeka ukuthi ushayele i-pancreas ephephile ngokuphelele, kodwa futhi akunakwenzeka ukuyilinganisa nezidakamizwa ezinzima ezivela eqenjini elifanayo, ngokwesibonelo, iManinil.
Izinkomba zokuqokwa komuthi
Ngokusho kwemiyalo, uGlidiab unqunyelwa kuphela kwabanesifo sikashukela abanezinhlobo ezi-2 zokuphazamiseka kwe-carbohydrate. Isenzo somuthi siqondiswe ngqo kumaseli we-beta, angekho ngohlobo 1 sikashukela. Ukwelashwa kumele kuhlanganiswe nokudla nokuzivocavoca, kanye nokukhuluphala kanye / noma ukumelana ne-insulin, i-metformin iyanezelwa.
UGlidiab unqunyelwe kuphela njengesengezo se-metformin futhi kuphela lapho isiguli sigcwalisa yonke imiyalo, kodwa singakwazi ukufinyelela i-glycemia eqondisiwe. Njengomthetho, lokhu kukhombisa ukulahleka okuyingxenye komsebenzi we-pancreatic. Ukuqinisekisa ukushoda kwe-insulin kanye nesidingo seGlidiab, kungakuhle ukuthatha ukuhlolwa kwe-C-peptide.
Ekuqaleni kwalesi sifo, umuthi ubekelwa kuphela uma ushukela wegazi uphezulu kakhulu, futhi kukhona izinsolo zokuthi isifo sikashukela satholakala eminyakeni eminingana kamuva kunokuba saqala.
Ifomu lomthamo kanye nomthamo
Umenzi ukhiqiza uGlidiab ngezindlela ezimbili:
- Isikali sika-Glidiab sama-80 mg. Lawa ngamathebulethi endabuko ane-gliclazide, into esebenzayo evela kuwo igxiliselwa masinyane egazini futhi ifinyelela ekuphakameni okukhulu kakhulu ngemuva kwamahora ama-4. Kwakungalesi sikhathi lapho ingozi enkulu kakhulu ye-hypoglycemia. Umthamo ongaphezulu kwe-160 mg uhlukaniswe ngemithamo emi-2, ushukela ungaphonsa kaningi phakathi nosuku.
- IGlidiab MV ingeyasesimanjemanje, amaphilisi enziwe ngendlela yokuthi i-gliclazide evela kuwo ingene egazini ngokunensa nangokulinganayo. Lokhu kubizwa ngokuthi ukuguqulwa, noma ukuqhubeka isikhathi eside. Ngiyabonga ngakho, umphumela weGlidiab ukhuphuka kahle futhi isikhathi eside ugcinwa ezingeni elifanayo, elonyusa ukusebenza kwomuthi, wehlise umthamo odingekayo, futhi uvikele i-hypoglycemia.
Umehluko wentengo phakathi kwalezi zidakamizwa mncane - UGlidiab MV ubiza kakhulu ngama-ruble angama-20, futhi umehluko wokuphepha ubalulekile, ngakho-ke, umenzi utusa ukuthi abantu abanesifo sikashukela baphendukele emthini omusha. Ngokusebenza kahle kwayo, ithebhulethi engu-1 yeGlidiab 80 ilingana nethebhulethi eyi-1 yeGlidiab MV 30.
Umthamo onconyiwe:
| Dose mg | UGlidiab | UGlidiab MV |
| ukuqala | 80 | 30 |
| isilinganiso | 160 | 60 |
| ubukhulu | 320 | 120 |
Umthetho wokukhulisa umthamo ngokwemiyalo yokusetshenziswa: uma umthamo wokuqala unganele, ungangezelelwa ngo-30 mg (80 weGlidiab ojwayelekile) ngemuva kwenyanga yokuphatha. Ungangezelela umthamo ngaphambili kulabo abanesifo sikashukela abangashintshwa ushukela wegazi. Ukwanda okusheshayo komthamo kuyingozi nge-hypoglycemic coma.
Ungayisebenzisa kanjani iGlidiab
| I-oda lokwamukelwa kusuka kumiyalo | UGlidiab | UGlidiab MV |
| Isikhathi sokwamukela | Dose 80 mg - kwasekuseni. Ukudla kumele kube nama-carbohydrate ahamba kancane. Umthamo we-160 mg uhlukaniswe ngemithamo emi-2 - ibhulakufesi nesidlo sakusihlwa. | Noma imuphi umthamo uthathwa ekuseni ngesikhathi sasekuseni. Izidingo zokuhlanganiswa azihambelani njengezikaGlidiab ojwayelekile. |
| Imithetho Yokwamukela | Ithebhulethi ingachotshozwa, izindawo zayo ezinciphisa ushukela ngeke zishintshe. | Ithebhulethi ligwinyiwe lonke ukuze kulondolozwe ukukhishwa okuqinile kwe-glycazide. |
Ngokusho kodokotela, iziguli ezinezifo ezingamahlalakhona aziphuzi yonke imishanguzo ebekiwe. Ngokwesifo sikashukela sohlobo 2, ukuphazamiseka akugcini ku-glucose ephezulu yegazi, ngakho-ke iziguli ziphoqelelwa ukuthatha ama-statins, i-aspirin, kanye nemithi yengcindezi yegazi ngaphezu kwemithi enciphisa ushukela. Kumenyezelwa amaphilisi amaningi futhi kuyinkimbinkimbi kakhulu irejista yemithamo, kwehlisa amathuba wokuthi azodakwa ngendlela eqondisiwe. I-Glidiab MV ithathwa kanye ngosuku, kungakhathalekile ukuthi ithathwa kanjani, ngakho-ke, mancane amathuba okuthi ungaphuthelwa umthamo.
Yimiphi imiphumela emibi
Uhlu lwemiphumela engathandeki okungenzeka lapho uthatha i-Glidiab MV 30 mg kanye nama-analogues ayo:
- I-Hypoglycemia yenzeka ne-drug overdose, yeqa ukudla noma ukuntuleka kwama-carbohydrate kuyo. Amaconsi avamile kushukela adinga ukulungiswa kokudla okunempilo kanye nokwehliswa komthamo weGlidiab.
- Ukuphazamiseka kokugaya ukudla. Ukunciphisa ubungozi bomphumela wecala, imiyalo incoma ukuthatha uGlidiab ngasikhathi sinye nokudla.
- Izikhumba zomzimba. Ngokusho kokubuyekezwa, ukusabela okubi kakhulu kwe-allergic empeleni akwenzeki.
- Shintsha kokuqukethwe kwezingxenye ezisegazini. Imvamisa kuyaphindeka, okusho ukuthi, inyamalala ngokwayo ngemuva kokuqedwa kokwamukelwa.
Ingozi ye-hypoglycemia ilinganiselwa cishe ku-5%, ephansi kakhulu kunama-sulfonylureas amadala. Abantu abanesifo sikashukela i-mellitus ngokuhambisana nezifo ezinzima zenhliziyo ne-endocrine, kanye nokuthatha isikhathi eside ama-hormone, bathambekele ekwehlekeni kwe-glucose. Kubo, umthamo omkhulu ovunyelwe weGlidiab ukhawulelwe ku-30 mg. Isifo sikashukela nge-neuropathy, asebekhulile, abaguli abane-hypoglycemia ejwayelekile noma yesikhathi eside, bayeka ukuzwa izimpawu zoshukela ophansi, ngakho-ke ukuthatha uGlidiab kungaba yingozi kubo. Kulokhu, kuyanconywa amaphilisi wesifo sikashukela angenawo umthelela omubi onjalo.
Contraindication
Lapho uGlidiab angaba yingozi:
- Umuthi uhlolwe kuphela kwisifo sikashukela esikhulile, umphumela wawo emzimbeni wezingane awuzange ufundwe, ngakho-ke awuchaziwe kuze kube iminyaka engu-18, noma ngabe ingane isiqinisekisile uhlobo 2 lwalesi sifo.
- E-coma yesifo sikashukela kanye nemibandela eyandulelayo, kusetshenziswa kuphela ukwelashwa kwe-insulin. Noma imaphi amaphilisi anciphisa ushukela, kufaka phakathi i-Glidiab kanye nama-analogues ayo, akhanselwe okwesikhashana.
- I-Glyclazide iphulwe isibindi, ngemuva kwalokho ama-metabolites ayo athiwa emchameni. Kulokhu, ukuthatha i-Glidiab kuyenqatshelwe kwabanesifo sikashukela esinokuqina kwesihlungu nokulimala kwe-hepatic.
- I-antifungal miconazole ithuthukisa kakhulu imiphumela ye-Glidiab futhi ingavusa ikomidi le-hypoglycemic, ngakho-ke ukuphatha kwabo okuhlangene akuvunyelwe ngemiyalo.
- Ngesikhathi sokukhulelwa nokuqunjelwa, i-gliclazide iyakwazi ukungena egazini lengane, ngakho-ke ayikwazi ukuthathwa ngalesi sikhathi.
Ama-analogues adumile
Phakathi kwamathebulethi antidiabetesic ekwelapheni isifo sohlobo 2, ngamalungiselelo we-glyclazide asatshalaliswa kabanzi. I-Metformin kuphela engancintisana nabo ngenani lamagama okuhweba abhalisiwe. Iningi lama-analogia kaGlidiab lenziwa eRussia, intengo yazo emakhemisi ihluka phakathi kwama-ruble ayi-120-150, okubiza kakhulu kwasekuqaleni French Diabeteson kubiza cishe ama-ruble angama-350.
Ama-analog namagidi we-Glidiab:
| Iqembu | Izimpawu Zentengiso | |
| Amalungiselelo we-Gliclazide | Ukukhishwa Okujwayelekile, Glidiab Analogs 80 | UDiabefarm, uDikinax, uGliclazide Akos, uDiatika. |
| Ukukhishwa okulungisiwe, njengase-Glidiab MV 30 | Glyclazide-SZ, Golda MV, Glyclazide MV, Glyclada, Diabefarm MV. | |
| Amanye ama-sulfonylureas | Maninil, Amaryl, Glimepiride, Glemaz, Glibenclamide, Diamerid. | |
UGlidiab noma iGliclazide - okungcono?
Izinga lezidakamizwa linqunywa ngezinga lokuhlanzwa kanye nokunemba komthamo wento esebenzayo, ukuphepha kwezakhi ezisizayo. IGlidiab neGlyclazide (ukukhiqizwa kwe-Ozone) kufana ngokuphelele kule mikhakha. Bobabili ama-Akrikhin ne-Ozone banemishini yesimanje, zombili lezi zinkampani azakhiqizi izinto zokwelapha ngokwazo, kodwa ziyithenga, ngaphezu kwalokho, ezivela kubakhiqizi baseChina abafanayo. Futhi ngisho nasendleleni okwakhiwa ngayo, uGlidiab noGliclazide bacishe baphindane. Ukubuyekezwa kwabantu abebephuze le mishanguzo isikhathi esingaphezu konyaka nako kuqinisekisa ukusebenza kwabo okulinganayo kushukela.
I-Glyclazide inezinketho ezimbili zemithamo - 30/60 mg, Glidiab - 30 mg kuphela; IGlidiab ingashintshwa futhi ikhishwe ngokujwayelekile, iGliclazide khiqiza kuphela enwetshiwe - yikho konke ukungafani phakathi kwalezi zibhebhe.
