Izici zokusetshenziswa kwamaqembu eRosinsulin C no-P

Umuthi iRosinsulin wenziwa kusetshenziswa ubuchwepheshe be-DNA esebenza kabusha. Umuthi ubonakala ngokuvezwa okujwayelekile kwesikhathi eside. Ngokuphikisana nesizinda sokuthatha iRosinsulin, i-glucose egazini iyancipha, ehambisana nokukhuphuka kokuhamba kwayo kwangaphakathi. Ukwelashwa kwenziwa phambi kwezinkomba eziqinile futhi njengoba kuyalelwe udokotela.

Khipha ifomu

Rosinsulin etholakala ngesimo semijovo ka-3 no-5 ml. Umkhiqizo we-3 ml ufakwa kwipeni yesirinji ye-Autopen Classic 1-Unit. Ikhishwa yi-United Kingdom. Inkampani yaseRussia LLC I-Plant Medsintez ibuye futhi ibambe iqhaza ekwenziweni kwemithi. I-Rosinsulin 5 ml itholakala emaqenjini C no-R.

Umuthi ubekelwe ukwamukelwa onesifo sikashukela. Ifakwe ohlotsheni lokuhlanganiswa olukumelana ngokwengxenye nemithi ye-hypoglycemic yomlomo. Imiyalo yokusebenzisa iRosinsulin C ikhombisa ukuthi nayo ifakiwe kwi-monotherapy ngesikhathi sokuhlinzwa.

Umuthi weqembu P unqunyelwe i-ketoacidosis yesifo sikashukela, i-hyperosmolar coma, metabolism ephazamisekile. Lawa magama amabili ngaphansi kokucutshungulwa afakwa kwiziguli ezine-hypoglycemia kanye ne-hypersensitivity ezingxenyeni zawo eziyinhloko.

Isakhi esisebenzayo samaqembu P no-C

I-Rosinsulin P iyabhekwa i-insulin esebenza kancane e-soluble. Isebenzisana kalula ne-receptor ekhethekile elangeni olungaphandle lamaseli, yakha i-insulin receptor complex. Ngesikhathi sokwelashwa, ukwakheka kwe-cAMP esibindini kanye namaseli wamafutha kuyanda. Izakhi zomuthi nazo zingena kumaseli emisipha, zivuselela umsebenzi we-hexokinase kanye nezinye izinqubo ezenzeka ngaphakathi.

Ngenxa yokwanda kwamaprotheni, ukugcwala kwe-glucose egazini nokuqhekeka kwe-glycogen kuyancipha. Ngemuva komjovo, ukuvezwa kuyabonakala imizuzu engama-30. Isikhathi sokusebenza esivela kumthamo owodwa sifinyelela emahoreni angama-8. Inani lalesi sikhombisi lincike kumthamo, indlela kanye nendawo yokuphatha.

I-Rosinsulin C ivezwa njenge-insulin-isophan enomphumela omuhle ophakathi. Umuthi unciphisa ukugcwala kweglucose egazini, ukhulisa ukumuncwa kwawo ngezicubu, kuthuthukisa i-lipogenesis. Lokhu kwehlisa izinga lokukhiqizwa koshukela isibindi.

Ngemuva komjovo, ukwakheka kuqala ukusebenza ngemuva kwamahora ama-2. Ukusebenza ngobukhulu kutholakala ngemuva kwamahora ayi-12. Umphumela wokwelapha uqhubeka ufike ngosuku. Inani lalesi sikhombisi lithinteka ngqo umthamo nokwakheka kwalo muthi.

Ukwelapha

Umuthi weqembu C uhanjiswa izikhathi eziyi-1-2 ngosuku. Umenzi weluleka njalo ngokuzayo ukuthi ashintshe indawo yomjovo. Umuthi uthathwa imizuzu engama-30 ngaphambi kokudla kwasekuseni. Kuyaqabukela, isiguli sinqunywe umjovo wezinzwa we-Rosinsulin C. Ukuphathwa kwe-Intravenous akuvunyelwe.

Umthamo ukhethiwe ngamunye. Kuya kokuqukethwe koshukela emchameni nasegazini, izici zenkambo yesifo. Ezimweni ezijwayelekile, kwanele ukungena ku-8-24 IU kanye ngosuku. Uma isiguli sinokuzwela okuphezulu kwe-insulin, umuthi unqunywa kumthamo omncane, nangomuzwa oncishisiwe - kumthamo ongaphezu kwe-24 IU ngosuku. Uma ntambama umthamo wedlula u-0,6, imijovo emibili iyalawulwa ezindaweni ezihlukile. Iziguli ezithole ngaphezu kwe-100 IU ngosuku zilaliswa esibhedlela ngokufakwa esikhundleni se-insulin.

Ukwelashwa ngeRosinsulin P kungumuntu ngamunye. Umthamo nendlela yokufaka incike ekubaleni kwegazi ngaphambi nangemva kokudla, izinga le-glycosuria. Izindlela Zokuphatha:

• subcutaneous
• intramuscular
• intravenous.

Kaningi iRosinsulin P ilawulwa ngokungaziphathi. Uma ukuqina kukashukela kuqinisekisiwe noma kukhonjiswa ukuhlinzwa, ukwakheka kwalapha kuqhutshwa nge-intramuscularly noma ngokuhlinzwa. Nge-monotherapy, umuthi usetshenziswa kathathu ngosuku. Ezimweni ezingavamile, imvamisa yabaphathi ifinyelela izikhathi ezi-6 ngosuku. Ukugwema i-atrophy, lipodystrophy, isayithi lomjovo lishintsha njalo ngokuzayo.

Umthamo wansuku zonke ngokwesilinganiso akufanele wedlule amayunithi angama-40. Izingane zinqunywe kumthamo wamayunithi ayi-8. Uma ngaphezu kwama-0.6 amayunithi nge-1 kg yesisindo sinqunyelwe, i-insulin iphathwa kabili futhi ezingxenyeni ezahlukene zomzimba. Uma kunesidingo, iRosinsulin C ihlanganiswa ne-insulin esebenza isikhathi eside.

Ukuphendula okungafani

Umuthi wanoma yiliphi iqembu okukhulunywa ngalo ungavusa ukungezwani ngesimo se-urticaria. IDyspnea ibonakala kaningi, ingcindezi iyancipha. Ezinye izimpawu ezingezinhle zeRosinsulin P no-C:

• ukuqwasha
• i-migraine
• isifiso sokudla;
• Izinkinga zokuqwashisa;
• ukukhuphuka kwe-titer yama-anti-insulin antibodies.

Esigabeni sokuqala sokwelashwa, iziguli zivame ukukhononda nge-edema kanye nokuphazamiseka okungahambi kahle. Izimpawu ziyanyamalala ngokushesha okukhulu. Ukunakwa okukhethekile kubhekelwa esimweni sebhodlela. Ngaphambi kokuphatha, isixazululo sihlolwa ukuze singabonakali. Uma kunemizimba yangaphandle kulolu ketshezi, iRosinsulin ayisetshenziswa.

Umthamo wesidakamizwa ulungiswa ukutheleleka, ukungasebenzi kahle kwe-yegilo, i-Addison syndrome. I-Hypoglycemia ivame ukukhula njengophawu lwe-overdose. Isibonakaliso esifanayo sizibonakalisa lapho sithatha isikhundla seRosinsulin C no-P ngesinye i-ejenti. Ezinye izimpawu ze-overdose:

• ukuhlanza
• isifo sohudo
• ukwehla emsebenzini wabasebenzi.

Uma kuvela lo mtholampilo ongenhla, kunconywa ukwazisa udokotela oholayo. Kaningi isiguli sitshelwa ukuba siye esibhedlela. Isikimu esilandelayo sikhethwe ngemuva kokuhlolwa kweziguli ngokuphelele.

Uma isiguli sinesifo sesibindi nezinso, isidingo somuthi siyancishiswa. Ukuhlushwa kweglucose kungashintsha lapho isiguli sidluliswa sisuka esilwaneni sesiya e-insulin yomuntu. Ukudluliselwa okunjalo kumele kube nesizathu sezokwelapha. Kwenziwa ngaphansi kokuqashwa kodokotela.

Iseluleko sezokwelashwa

Isifo sikashukela simisa umuzwa we-hypoglycemia emnene ngokudla ushukela. Lapho isimo siba sibi, ukwelashwa kuyalungiswa. Uma isiguli sikhulelwe, okulandelayo kuyabhekwa:

• Kwi-trimester eyi-1, umthamo uyancishiswa.
• Kuma-trimesters e-2 ne-3, isidingo se-Rosinsulin siyanda.

Ngesikhathi sokubeletha nangemva kokubeletha, isidingo somuthi sehliswa kakhulu. Ngokukhishwa kwesibeletho, owesifazane ungaphansi kokuhlolwa odokotela nsuku zonke.

Ngokombono wokubukwa kwemithi, iRosinsulin R ne-C ayihambelani nezixazululo zezinye izidakamizwa. Umphumela we-Hypoglycemic uthuthukiswa ngokudla kwe-sulfonamides, i-monoamine oxidase inhibitors ne-angiotensin-converting enzyme. Umphumela wezokwelapha wenziwa buthaka yi-glucagon, glucocorticoids, inzalo yomlomo wokubeletha, uDanazole. AmaBeta-blockers akhulisa futhi enze buthaka umphumela weRosinsulin.

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