I-Insulin Lizpro - indlela yokulawula amazinga kashukela wegazi kwiziguli ezinesifo sikashukela sohlobo lwe-1-2

Abantu abanesifo sikashukela kufanele balawule njalo ukudla kwabo, futhi basebenzise nemithi eyenza amazinga abo kashukela abhalwe ngokwejwayelekile.

Ezigabeni zokuqala, asikho isidingo sokusebenzisa imishanguzo njalo, kepha kwezinye izimo yiso esingakwazi ukwenza isimo sibe ngcono, kepha futhi sisindise nempilo yomuntu. Umuthi owodwa onjalo yi-Insulin Lizpro, esisatshalaliswa ngaphansi kwegama lomkhiqizo elithi Humalog.

Incazelo yesidakamizwa

I-Insulin Lizpro (Humalog) isidakamizwa esisetshenziswa kakhulu esingasetshenziswa ukukhipha amazinga kashukela ezigulini zamaqembu ahlukahlukene yobudala. Leli thuluzi liyi-analogue ye-insulin yabantu, kepha ngezinguquko ezincane esakhiweni, ezikuvumela ukuba ufinyelele ukumunyiswa okusheshayo komzimba.

Ithuluzi yisixazululo esakhiwa ngezigaba ezimbili, esingeniswa emzimbeni ngokuthinteka, ngaphakathi noma ngaphakathi.

Umuthi, ngokuya ngomkhiqizi, uqukethe lezi zinto ezilandelayo:

• I-Sodium heptahydrate hydrogen phosphate;
• IGlycerol;
• IHydrochloric acid;
• IGlycerol;
• Metacresol;
• I-zinc oxide

Ngomgomo wesenzo sawo, i-Insulin Lizpro ifana nezinye izidakamizwa eziqukethe i-insulin. Izakhi ezisebenzayo zingena emzimbeni womuntu bese ziqala ukwenza izinto njengama cell membranes, athuthukisa ukuthathwa koshukela.

Umphumela womuthi uqala kungakapheli imizuzu eyi-15-20 ngemuva kokuphathwa kwawo, okuvumela ukuthi uwusebenzise ngqo ngesikhathi sokudla. Le nkomba ingahluka ngokuya ngendawo nendlela yokusebenzisa umuthi.

Ngenxa yokugxila okukhulu, ochwepheshe batusa ukuthi kungeniswe uHumalog ngokungazenzisi. Iqoqo eliphezulu lomuthi osegazini ngale ndlela lizotholwa ngemuva kwemizuzu engama-30-70.

Izinkomba nemiyalo esetshenzisiwe

I-Insulin Lizpro isetshenziswa ekwelapheni iziguli ezinesifo sikashukela, kungakhathalekile ubulili nobudala. Ithuluzi lihlinzeka ngezinkomba zokusebenza okuphezulu ezimweni lapho isiguli sihola khona ngendlela engajwayelekile, evame kakhulu ezinganeni.

I-Humalog inqunywe kuphela ngudokotela ohamba no:

1. Thayipha 1 bese uthayipha i-2 mellitus yesifo sikashukela - esimweni sokugcina uma kuphela omunye umuthi ungalethi imiphumela emihle;
2. I-Hyperglycemia, engakhishwa ezinye izidakamizwa;
3. Ukulungiselela isiguli ukuhlinzwa;
4. Ukungabekezeleleki kwezinye izidakamizwa eziqukethe i-insulin;
5. Ukuvela kwezimo ze-pathological eziyinkimbinkimbi yenkambo yesifo.

Ukuthola umphumela omuhle kakhulu, inani nendlela yokuphatha umuthi kufanele inqunywe ngokuya ngezimpawu zomuntu ngamunye. Okuqukethwe umuthi osegazini kufanele kusondelane nemvelo - 0.26-0.36 l / kg.

Indlela yokulawulwa kwezidakamizwa enconywe ngumenzi ingasashintshashintshi, kepha ngokuya ngesimo sesiguli, i-ejenti ingalawulwa zombili intramuscularly and intravenously. Ngendlela esetshenziswayo, izindawo ezifanele kunazo zonke kukhona okhalweni, ihlombe, amabhuzu kanye nesisu sesisu.

Ukuphathwa okuqhubekayo kwe-Insulin Lizpro ngasikhathi sinye kuyaphulwa, ngoba lokhu kungaholela ekulimaleni kwesakhiwo sesikhumba ngendlela ye-lipodystrophy.

Ingxenye efanayo ngeke isetshenziselwe ukuphatha umuthi ngaphezu kwesikhathi esingu-1 ngenyanga. Ngokuphathwa kwe-subcutaneous, umuthi ungasetjenziswa ngaphandle kobukhona besazi sezokwelapha, kepha kuphela uma umthamo ubukhethiwe ngaphambili uchwepheshe.

Isikhathi sokuphatha umuthi sinqunywa nodokotela oholayo, futhi kufanele siqashelwe ngokuqinile - lokhu kuzovumela umzimba ukuzivumelanisa nombuso, futhi kubuye kunikeze umphumela wesikhathi eside womuthi.

Ukulungiswa kwedosi kungadingeka ngenkathi:

• Ukushintsha ukudla futhi ushintshele ekudleni okune-carbohydrate okuphansi noma okuphezulu;
• Ukucindezelwa okungokomzwelo;
• Izifo ezithathelwanayo;
• Ukusetshenziswa okufanayo kwezinye izidakamizwa;
• Ukushintsha kusuka kwezinye izidakamizwa ezinesivinini esikhulu ezithinta amazinga kashukela;
• Ukuboniswa kokwehluleka kwezinso;
• Ukukhulelwa - ngokuya nge-trimester, isidingo somzimba sokushintsha kwe-insulin, ngakho-ke kuyadingeka
• Vakashela umhlinzeki wakho wezokunakekelwa kwezempilo njalo ukukala izinga lakho loshukela

Ukwenza ushintsho maqondana nomthamo nakho kungadingeka lapho ushintsha umenzi we-Insulin Lizpro futhi ushintsha phakathi kwezinkampani ezahlukahlukene, ngoba ngayinye yazo yenza izinguquko zayo ekwakhiweni, ezingathinta ukusebenza kahle kokwelashwa.

Imiphumela emibi nokuphikisana

Lapho unquma umuthi, udokotela oholayo kufanele acabangele zonke izici zomzimba wesiguli.

I-Insulin Lizpro icutshwe kubantu:

1. Ngokuzwela okukhulayo kwengxenye eyengeziwe noma eyengeziwe esebenzayo;
2. Ngokuqina okuphezulu kwe-hypoglycemia;
3. Kuyo kukhona i-insulinoma.

Ngesikhathi sokusebenzisa umuthi kuma-diabetes, imiphumela emibi elandelayo ingaba khona:

1. I-Hypoglycemia - iyingozi enkulu kunazo zonke, yenzeka ngenxa yedosi elikhethwe ngendlela engeyilo, kanye nangomuthi wokuzelapha, kungaholela ekufeni noma ekulimazeni okukhulu kobuchopho;
2. I-Lipodystrophy - kwenzeka ngenxa yemijovo endaweni efanayo, ukuvimbela, kuyadingeka ukushintshanisa izindawo ezinconyelwe isikhumba;
3. I-Allergy - iyazibonakalisa ngokuya ngezici ngazinye zomzimba wesiguli, ukusuka ekubusheni obumnene besayithi lomjovo, iphetha ngokushaqeka kwe-anaphylactic;
4. Ukuphazamiseka kwemishini yokubonakalayo - ngethamo elingalungile noma ukungabekezelelani ngakunye kwezakhi, i-retinopathy (ukulimala kokwehla kwesilengesi samehlo ngenxa yokuphazamiseka kwemithambo yemithambo yegazi) noma ukwehla okubonakalayo kuyancipha, kuvame ukuziveza ebuntwaneni noma ngomonakalo ohlelweni lwenhliziyo;
5. Ukuphendula kwendawo - endaweni yomjovo, ubomvu, ukulunywa, ubomvu nokuvuvukala kungenzeka, okudlula ngemuva kokuba umzimba usetshenziselwe.

Ezinye izinkomba zingaqala ukubonakala ngemuva kwesikhathi eside. Uma kwenzeka imiphumela emibi, kubalulekile ukuyeka ukuthatha i-insulin bese uthintana nodokotela wakho. Izinkinga eziningi zivame ukuxazululwa ngokulungiswa kwamthamo.

Ukuxhumana nezinye izidakamizwa

Lapho unquma umuthi weHumalog, udokotela oholayo kufanele abhekele ukuthi imiphi imishanguzo osuvele uyithatha. Ezinye zazo zingathuthukisa futhi zinciphise isenzo se-insulin.

Umphumela we-Insulin Lizpro uyathuthuka uma isiguli sithatha izidakamizwa namaqembu alandelayo:

• Mao inhibitors;
• Ama-Sulfonamides;
• I-Ketoconazole;
• Ama-Sulfonamides.

Ngokuthatha ngokulinganayo kwale mishanguzo, kuyadingeka ukwehlisa umthamo we-insulin, futhi isiguli kufanele, uma kungenzeka, senqabe ukuyithatha.

Izinto ezilandelayo zinganciphisa ukusebenza kwe-Insulin Lizpro:

• Izindlela zokuvimbela inzalo zeHormonal;
• Ama-estrogens;
• I-Glucagon
• UNicotine.

Umthamo we-insulin ekulesi simo kufanele ukhuphuke, kepha uma isiguli senqaba ukusebenzisa lezi zinto, kuzodingeka senze ushintsho lwesibili.

Kuyafaneleka futhi ukubheka ezinye izici ngesikhathi sokwelashwa nge-Insulin Lizpro:

1. Lapho ubala umthamo, udokotela kufanele acabangele ukuthi kungakanani futhi kudla hlobo luni lokudla okudla umguli;
2. Kwezifo ezingamahlalakhona zesibindi nezinso, umthamo uzodinga ukuncishiswa;
3. I-Humalog inganciphisa umsebenzi wokuhamba kokuhamba kwezinzwa, okuthinta inani lokuphendula, futhi lokhu kubeka ingozi ethile, ngokwesibonelo, kubanikazi bezimoto.

Analogs of the izidakamizwa Insulin Lizpro

I-Insulin Lizpro (Humalog) inezindleko eziphakeme impela, ngenxa yokuthi iziguli zivame ukuhamba ziyofuna ama-analogue.

Izidakamizwa ezilandelayo zingatholakala emakethe ezinomgomo ofanayo wokusebenza:

• IMonotard;
• I-Protafan;
• I-Rinsulin;
• I-Intral;
• I-Actrapid.

Kuyenqatshelwe ngokuphelele ukubuyisela isidakamizwa ngokuzimela. Okokuqala udinga ukuthola izeluleko kudokotela wakho, ngoba ukuzelapha kungaholela ekufeni.

Uma ungabaza amandla akho ezibonakalayo, xwayisa uchwepheshe ngalokhu. Ukwakheka kwomuthi ngamunye kungahluka ngokuya ngomkhiqizi, ngenxa yalokho amandla womphumela womuthi emzimbeni wesiguli uzoshintsha.

Leli khambi livame ukusetshenziswa kakhulu ezinhlotsheni zesifo sikashukela ezingatheni insulin (1 no-2), kanye nokwelashwa kwezingane nabesifazane abakhulelwe. Ngokubalwa kwethamo elifanele, i-Humalog ayibangeli imiphumela emibi futhi ithinte umzimba ngobumnene.

Umuthi ungalawulwa ngezindlela eziningi, kepha okuvame kakhulu ukwenze, futhi abanye abakhiqizi bahlinzeka ngethuluzi ngomjovo okhethekile umuntu angawusebenzisa ngisho esimeni esingazinzile.

Uma kunesidingo, isiguli esinesifo sikashukela singathola i-analogues kumakhemisi, kodwa ngaphandle kokubonisana kwangaphambili nodokotela, ukusetshenziswa kwabo kwenqatshelwe ngokuphelele. I-Insulin Lizpro iyahambisana neminye imithi, kepha kwezinye izimo kudingeka ukulungiswa kwamthamo.

Ukusetshenziswa njalo kwesidakamizwa akuyona umlutha, kepha isiguli kufanele silandele irejimenti ekhethekile ezosiza umzimba ukuzivumelanisa nezimo ezintsha.