I-Metformin ekuqiniseni ukwelashwa kwesifo sikashukela sohlobo 2

I-Metformin yigolide elijwayelekile elidingakalayo kuzo zonke izigaba zokuqinisa ukwelashwa kwesifo sikashukela sohlobo 2. Phezu kwako konke ukufana nokuhlukahluka kweziphakamiso, phakathi namashumi eminyaka ambalwa, washintsha kakhulu izindlela zokwelashwa kwesifo sikashukela sohlobo 2.

Imakethe yanamuhla yezemithi inamakilasi ayi-10 wezidakamizwa enzelwe ukuphatha isifo sikashukela sohlobo 2, kepha iMetformin, njengoba isifundwe kakhulu futhi isetshenziswa kabanzi kuzo zonke izigaba zesifo, ayizange ilahlekelwe yisikhundla sayo esiholayo.

Lesi sidakamizwa kuphela esibonakala siphumelele ku-monotherapy, ukuqinisa okunye futhi ngaphandle kokuzibandakanya kwaso. Kungani kwakufanele athandwe kangaka?

I-Metformin umuthi ongabizi kakhulu futhi onobufakazi obunamandla: uma ucwaninga i-Pubed database kule minyaka eyishumi edlule, ungathola izinkulungwane zezindatshana ezihlola kakhulu amandla weMetformin ekuvinjelweni nasekwelashweni kwesifo sikashukela sohlobo 2, imiphumela yaso ye-antitumor kanye nemiphumela yentliziyo.

Izifundo zemitholampilo zithole ukuthi ukusetshenziswa njalo kweMetformin kunciphisa ukufa komuntu oyedwa kwabathathu, ukufa ngenxa yokufakelwa kwe-myocardial infarction kanye nesifo sikashukela, kuthuthukisa ukusinda kweziguli ezinomdlavuza, futhi kunciphise nengozi yokuthola umdlavuza webele kwabanesifo sikashukela. Ngaphezu kwalokho, umuthi ukhipha umphumela wokunciphisa ukubamba i-caloric, okuyindlela ethembekile kunazo zonke yokwelula impilo.

Izindlela zokuvikela zeMetformin

Yini ebangela imiphumela yayo yokwelashwa?

1. Umuthi uthuthukisa umuzwa we-insulin;
2. Kusiza ukulawula kwe-glycemic;
3. Amanani we-Fibrinolysis ayathuthuka;
4. I-microcirculation kwezicubu ezithambile icushiwe;
5. Ukungasebenzi komzimba kwe-Endothelial kuyancipha;
6. Ngokuphikisana nesizinda se-metformin, i-hyperglycemia iyancipha;
7. Ukwenziwa kwemikhiqizo yokuphela kwe-glycation kuyancishiswa;
8. Ubuningi bezaga zegazi buyancipha;
9. Ukucindezela kwe-Oxidative akuthathiwe;
10. Umphumela omuhle kuma-atherogenesis kanye ne-dyslipidemia.

Umuthi wehlisa ubungozi bemicimbi yezenhliziyo enesifo sikashukela ngohlobo lwesibili lwesifo, futhi umphumela wenkumbulo ye-metabolic ukuvumela ukuthi ugcine umphumela isikhathi eside.

Ukwelashwa nge-Metformin kanye nokuphuma kwayo kuhlinzeka ukunciphisa okukhulu kwe-glycemia.

Uma kuqhathaniswa nama-analogues nezinye izidakamizwa, iMetformin inomphumela ongathathi hlangothi kwesisindo futhi isiza ngisho nasekunciphiseni.

Ucwaningo olwenziwe kabusha lweminyaka emihlanu lwaseChina, olwalubandakanya abantu abanesifo sikashukela abangama-6 800 ngohlobo lwesibili lwesifo ngaphandle komlando wesifo senhliziyo, lwabonisa ukuthi eqenjini lapho ababambe iqhaza kulolu cwaningo bathathe i-metformin ngaphezu kokuguqulwa kwendlela yokuphila, ukufa kwaba ngamacala angama-7.5 umuntu ngamunye Abantu abayi-1000 / iminyaka (izinyanga ezingama-62,5).

USolwazi E. Malysheva ukhuluma ngamakhono weMetformin kule vidiyo:

Izidakamizwa ezifanayo namagama okuhweba

Ibhizinisi lezidakamizwa lingenye yezinzuzo kakhulu, futhi yinkampani evilaphayo kuphela engakhiqizi imithi ene-metformin esebenzayo yezithako. Namuhla, kunezidakamizwa ezifanayo ezinemikhiqizo ehlukahlukene - kusuka ngegama lomkhiqizo kuya kwisabelomali kakhulu.

Umuthi wokuqala unegama lomhlaba jikelele - metformin hydrochloride. Umuthi ovela eqenjini lama-biagunides, kuleli banga lezidakamizwa usalokhu uwunye. Zonke ezinye izindlela esizithola kunethiwekhi yamakhemisi ngamagama okuhweba ezinkampani akhipha i-metformin efanayo.

Lapho owelaphi noma we-endocrinologist enikeza lowo onikezwe isifo sikashukela, uzokhonjiswa lapho.

Yikuphi inkampani okuzoba yiyo umuthi kuncike ekuqinisekisweni kokuphuma kanye nezinhlaka ezilawulayo ezisayina izimvume zokusebenzisa uhlobo oluthile lomuthi.

Isibonelo, izinhlangano ezilawulayo zingene esivumelwaneni ne-Akrikhin. Ngakho-ke, ekhemisi uzonikezwa uGlyformin (genericin Met Metin), hhayi uGlyukofazh (owangempela). Ngakho-ke ukusola udokotela ngokuchaza ukuthi amaphilisi “angalungile” akusizi ngalutho - lokhu akuyona ikhono lakhe. Ifomu libonisa igama okungelona okuphathelene nalo.

Ngaphambi kokuthi umuthi omusha ungene kwinethiwekhi yokusabalalisa, kuthatha iminyaka eyi-10. Sonke lesi sikhathi, iMetformin icwaningwe yinkampani eyodwa yokwenziwa kwemithi ekhiqiza okwangempela. Ngokuzayo, njengomthetho, uthengisa ilungelo lobunikazi lokwakha umuthi kuwo wonke umuntu. Imithi ekhishwe yilezi zinkampani ibizwa ngama-generics.

Okwehlukile kwehluka kubo ngekhwalithi nangentengo, ngoba iMetformin ifundwe ngendlela eyiyo ekwakhiweni lapho kuqhubeka kuthengiswa khona, kufaka phakathi ukwakheka kwegobolondo nezinye izihlungi. IGenerikhi idedelwa nezinye izithako ezingeziwe ezingakaze zidlule iminyaka eminingi yocwaningo, okusho ukuthi amandla ayo azobe ephansi.

Umuthi wokuqala ubizwa ngeGlucophage, futhi ukhiqizwa eFrance. I-Metformin inezimpawu eziningi, kepha iningi labathengi likhetha:

• IsiJalimane uSiofor;
• I-Argentine Bagomet;
• IsiCroatia formin pliva;
• I-Domestic Gliformin;
• Metfogamme yaseJalimane;
• I-Russian Formethine;
• Patriotic Novoformin;
• I-Serform Metformin;
• I-Russian Metformin Richter;
• I-Israeli Metformin Teva.

Kunemithi eminingi kunenethiwekhi yokusabalalisa enezimpande zaseChinese noma zaseNdiya, futhi izothengwa kakhulu kunaleyo ebhalwe phansi, kodwa ukusebenza kwayo kuhambelana nentengo. KuMetformin, inani entweni ekhemisi lisuka ku-94 liye kuma-ruble angama-287 futhi kuya ngomthamo, inkampani, nenombolo yamathebulethi.

Izinhlobo ezahlukahlukene zohlobo lwe-Metformin olukhishwa isikhathi eside ezifana neGlucofage-eside zakhiwe. Imvamisa, i-metformin esetshenziswayo esetshenziselwa amafomula emithi yokuhlanganisa - iGluconorm, iGlucovans, Glibomet, Galvus Mete, Yanumet, Amarile M nezinye. Labo abathola imishanguzo mahhala abanakho ukukhetha, kepha uma impilo ibiza kakhulu kunemali futhi kukhona ukukhetha, gxila esilinganisweni.

Izindlela zokuvezwa kwezidakamizwa

I-antidiabetesic Metformin inezindawo ezinokwehlisa ushukela, okusho ukuthi ngeke ikhuthaze ukukhiqizwa kwe-insulin endulin futhi kulayishe ama-pancreas, osevele esebenza emkhawulweni wamandla ayo.

Imiphumela eyinhloko ye-peripheral yesidakamizwa:

1. Yehlisa ukukhula kwe-basal glycemic ngokulawula ukukhishwa kwe-glycogen;
2. Inqanda ukuvela kwe-glucose kusisekelo samaprotheni;
3. Yehlisa ukufakwa koshukela yizindonga zamathumbu;
4. Yehlisa ukumelana ne-insulin ngokwenza ngcono ukuzwela kwe-receptor;
5. Kusheshisa ukuguqulwa kwama-molecule eglucose abe yi-lactate emgodini wokugaya ukudla;
6. Kuthuthukisa ukwakheka kwegazi: kwandisa ukugcwala kwe-HDL ("enhle" cholesterol), kunciphisa inani le-cholesterol ephelele, yehlisa i-triglycerol ne-LDL ("embi" cholesterol);
7. Kusheshisa ukuthutha kweglucose kwezicubu zomzimba, ngaleyo ndlela kwandise ukusetshenziswa kwayo yimisipha.

I-Metforminum: izinkomba zokusetshenziswa

Umnyombo wokuguga ukwanda kwezinga le-glycemia. Amaprotheni ayanukelwa, amafomu avele esikhunjeni, kuqhume imifantu emikhunjini, lapho amafutha akha izingqwembe; kwakhiwa amangqamuzana omzimba amabili aqhamuka emolekyulu eyodwa yeglucose engafakwanga.

Kodwa okususelwa ku-metformin akuyona nje kuphela imithi yokwehlisa ushukela. Umuthi ubalulekile lapho kunezinkinga zokubekezelelwa kwe-glucose kanye ne-glycemia esheshayo.

Ngokwengeziwe kulokhu:

• I-Metformin ikhonjelwa ukukhuluphala kuma-diabetes, uma kuyinto yesibili, icasulwa ukumelana ne-insulin;
• Isetshenziselwa ukukhululeka kwe-metabolic syndrome;
• Sebenzisa i-metformin ye-ovary ye-polycystic;
• Sebenzisa ukuvimbela ukuguga;
• Yemukelwa ukwakheka komzimba ekwakheni umzimba.

Kanye nokujwayelekile kwe-glycemia, izinqubo eziningi zokuguga zehla - ukuthuthukiswa kwe-atherosulinosis, umfutho wegazi ngokwejwayelekile, namaprotheni angaqhamuki ahlala isikhathi eside. Umthamo we-metformin wokwelula isikhathi sokuphila ufinyelela kuma-250 mg / ngosuku.
I-Metformin namuhla akuyona nje indinganiso egolide yesifo sikashukela: ayisetshenziswa kuphela ama-endocrinologists, kepha futhi ngabasebenza ngezokwelapha, abezenhliziyo, oncologists, nodokotela be-gynecologists.

ICanadian Diabetes Association incoma ukusetshenziswa kweMetformin ekwelapheni iziguli ezinokwehluleka kwenhliziyo.

Contraindication ngokusebenzisa umuthi

Phakathi kwezidakamizwa zokwenziwa ezibulala izinzwa, iMetformin yiyona ephephe kunazo zonke, yezingxabano ezibucayi, ngaphandle kokwehluleka kakhulu kwe-renal.

I-Metformin ayinqunyelwe:

• Ngesikhathi sokukhulelwa nokuncelisa (kuyanconywa ukwelashwa kwe-insulin);
• Ngesikhathi sokuhlinzwa kakhulu, izifundo ze-radiopaque, ukulimala okungathi sína noma ukushiswa, isiguli sidluliselwa ku-insulin izinsuku ezimbili;
• Uma umlando wokungasebenzi kahle kwesibindi;
• Izingane ezingaphansi kweminyaka engu-10 ubudala - ayikho idatha ethembekile ekusebenzeni nasekuphepheni;
• Ngomuntu olambile (kuze kufike ku-1000 Kcal / ngosuku.) Ukudla - i-acidization yomzimba kuholela ku-ketoacidosis ye-metabolic;
• Kwi-pathologies ye-renal, lapho amanani we-creatinine angaphezulu kwe-0.132 kanye ne-0.123 mmol / l kwiziguli zowesilisa nabesifazane, ngokulandelana;
• Uma onesifo sikashukela esesimweni esisongela impilo futhi kuvusa i-lactic acidosis.

I-contraindication yokugcina kwakuyi-biagunids yesizukulwane sokuqala nesesibili.

Lezi zimo ezilandelayo zinomthelela ekuqongeleleni kwezinqolobane ze-lactic acid ezivuselela i-lactic acidosis:

• Ukungasebenzi kwezinso, okungavumeli ukukhipha i-acid ngesikhathi futhi kugcwele ngendlela yemvelo;
• Ukuphuza ngokweqile utshwala kanye ne-acan ethanol ukudakwa;
• Izifo ezibangela ubunzima bokuphefumula kwezicubu (ukuhluleka kwenhliziyo, ukutheleleka kwezifo zokuphefumula,
• I-acute myocardial infarction, i-pathological pulmonary pathology)
• I-Ketoacidosis (ifomu lesifo sikashukela);
• Izifo ezithathelanayo ezenzeka ngamandla, ezihambisana nokuphelelwa ngamanzi emzimbeni ngenxa yokuhlanza, isifo sohudo, umkhuhlane.

Kuzo zonke izimo, umuthi uyakhanselwa, kwesinye isikhathi kuba yisikhashana, kuze kube yilapho i-homeostasis yomzimba ibuyiselwa.

Imiphumela engathandeki

Yonke imishanguzo yokwenziwa ayinayo kuphela inzuzo, kepha futhi nokubi, futhi i-metformin ayifani kulokhu. Umphumela wecala ovame kakhulu ukucasuka kwesisu.

Ngaphezulu kwe-20% yabanesifo sikashukela abathatha iMetformin banezikhalazo:

1. Ngokuphazamiseka kwe-dyspeptic;
2. Ukuphazamiseka kwesigqi sokuhamba kwamathumbu;
3. Ukwehla kwesifiso sokudla;
4. Shintsha ekunambithekeni (ngokuthinta ngensimbi).

Ukwahlulela nge-metformin ngokubuyekezwa kwesifo sikashukela, imvamisa yezimo ezinjengalezi zivela ngesikhathi sokwelashwa kokuqala bese inyamalala ngokuzikhandla. Lokhu kungachazwa ngokuvimba ukumuncwa kwe-glucose ezindongeni zamathumbu amancane; ngenxa yalokho, ukuvutshelwa ngokuvela kwegesi kuyabonakala. Ngenxa yokusabela okunjalo, isifo sohudo siyakhula ngemuva kokuthatha umuthi, futhi isisu siqhume. Ngemuva kwamasonto ambalwa, amathumbu azojwayela futhi aphendule ngokuthula.

Uma ukuphazamiseka kwesisu ngemuva kokudla umuthi kudala ukungakhululeki, umuthi ukhanselwa okwesikhashana noma umthamo uncishiswe. Uma lezo zinyathelo zinganele futhi ukwephulwa kungakaze kudlule, umuthi kufanele ushintshwe. Okokuqala - i-analogue yomunye umenzi.

Ngokusho kokubuyekezwa kwesifo sikashukela, i-metformin, isidakamizwa sokuqala esinegama lokuhweba iGlucofage, sinemiphumela emibi emincane.

Imiphumela yokungezwani komzimba (i-erythema, ukuqubuka, ukulunywa kwesikhumba) akuvamile, kepha kudinga ukufaka umuthi esikhundleni esiphuthumayo. Yebo, kunjalo, kufanele ukhumbule njalo nge-lactic acidosis, ngoba ezimweni ezingama-50% lesi simo siholela ekufeni.

I-Metformin: imiyalo esetshenzisiwe

Umuthi ubekelwa esigabeni se-prediabetes, kanye nokuvinjezelwa kwawo ngemuva kweminyaka engama-45. Lesi kuphela isidakamizwa esilungele abanesifo sikashukela esinohlobo lwesibili lwesifo sokuqala i-monotherapy. Ukwelashwa okuqala ngesikhathi kuyisiqinisekiso sempumelelo.

KuMetformin, indlela yokukhishwa yizinhlobo ezimbili zamathebulethi: uhlobo olude nolwejwayelekile. Ziyahluka ngesikhathi sokuvezwa kanye nomthamo.

1. Ukulungiswa okujwayelekile kungathengwa ezibhebheni ze-500 mg, 850 mg kanye ne-1000 mg.
2. Ngamandla anwetshiwe - 500 mg no-750 mg.

Ekuqaleni kwesifundo, kuthathwa umthamo omncane - 500 mg / ngosuku. Udinga ukusebenzisa ithebhulethi kuphela ngokudla noma ngokushesha emva kwayo. Ngemuva kwamasonto angu-1-2, umthamo uyalungiswa uma ukuguqulwa kwendlela yokuphila nedosi yokuqalisa ingakhombisi imiphumela oyifunayo. KwiMetformin, umthamo omkhulu wansuku zonke ngu-2000 mg / usuku. Uma uphuza iphilisi ngaphambi kokudla, amandla alo ancishiswa kakhulu.

Kubalulekile ukuqonda ukuthi ngaphandle kokulandela imigomo yokudla okuphansi kwe-carb kanye nokuzivocavoca okwanele komzimba, ukusebenza kweMetformin kuncishiswa kakhulu.

I-Metformin ihlanganiswe kahle nawo wonke amaqembu ezidakamizwa ze-antidiabetic, kufaka phakathi i-insulin, futhi isetshenziswa kaningi ekwelapheni okuyinkimbinkimbi ne-DPP-4 inhibitors, sulfonylureas, thiazolidinediones, b-glucoosidase inhibitors. Amathuba umuthi awaveli ngokushesha: kuyadingeka ukuhlola amandla we-glycemia kungakapheli amasonto ama-2 ngemuva komthamo wokuqala weMetformin.

Kuyinto elula ukubheka ushukela wakho nge-glucometer ephathekayo ekuseni (ngaphambi kwesidlo sasekuseni), amahora amabili ngemuva kokudla naphambi kokulala. Kubalulekile ukulawula ukuthi ukuvumelana okuphakathi kokudla okulula kungadluli amahora angama-4-5. Uma izinkomba ze-glycemic ezihlosiwe zingafinyelelwa esikhathini esibekiwe, okujwayelekile kungalungiswa ngaphakathi komthamo ovumelekile.

Isikhathi sokwelashwa

Isifo sikashukela yisimo sempilo yonke, futhi akunakwenzeka ukuthola ngokungenakuphikiswa isikhathi sesifundo. Konke kuya ngobufakazi kanye nenhloso oyifunayo. Uma inhloso ingeyesikhashana esifushane, ngokwesibonelo, ukunciphisa isisindo, khona-ke isidakamizwa sikhanselwa ngokushesha ngemuva kokuthola umphumela oyifunayo.

Esithombeni - isibonelo somtholampilo sokubalwa komthamo wokwelashwa nge-metformin (iresiphi ngesiLatin - Rp Tab. Metformini).

Siza ngokweqile

Imithamo ye-hypoglycemia eyenzeka ngengozi noma ngamabomu ayesongelwa, futhi i-lactic acidosis kungenzeka ngokuphelele. Ingqinamba eyingozi ingabulala noma ngabe ukunakekelwa kwezokwelapha okufika ngesikhathi. Lesi simo singakhula ngenxa yezizathu eziyinkimbinkimbi ezibangela i-hypoglycemia.

I-Lactic acidosis ingaqashelwa yizimpawu ezilandelayo zomtholampilo:

• Ubuhlungu be-epigastric;
• I-Myalgia;
• Ukuphazamiseka kwe-dyspeptic;
• Ukuphefumula;
• Ukuxhumana okungahambi kahle;
• Isifo sohudo
• Ukwehla kwezinga lokushisa lomzimba;
• Iyahluleka.

Uma usizo lunganikezwa ngesikhathi, isisulu siwela ekhefeni elinamathuba amaningi okufa okuzalwa.

Ungasisiza kanjani isisulu nge-lactic acidosis? Ukuhoxiswa kwezidakamizwa ngokushesha nokwelashwa esibhedlela. Esikhathini esedlule esedlule, bazamile ukumisa lesi sifo ngokungenisa i-sodium bicarbonate, kepha kube nezinkinga kusuka kushukela. Manje ukwelashwa okunjalo akuvamile ukusetshenziswa.

Kungenzeka yini ukuthi ungene esikhundleni somuthi

Uma isiguli sine-contraindication noma umuthi ungafanele kwezinye izizathu, kubalulekile ukukhetha okunye.Lapho ukungabekezeleli akunzima, ungasiphuza nomuthi ngesisekelo se-metformin, kepha kusuka kumenzi ohlukile (ngokufanele, okwangempela). Ngemuva kwakho konke, ukungezwani komzimba konke kungadala hhayi kuphela isithako esiyinhloko, kodwa futhi nabenzi bokuhlunga. Futhi umkhiqizi ngamunye unokwakhe.

Uma i-metformin iphikiswe ngokuqinile, ukuphindisela okunjalo ngeke kuxazulule inkinga, ngoba uhlu lokuphikisana nalokhu alushintshi.

Izidakamizwa ze-antidiabetic zinendlela efanayo yokwenza kuMetformin:

1. I-DPP-4 inhibitors yohlobo lweJanuvia, Onglisa, Galvus, Trazhenty;
2. Ama-Analoggs ohlobo lwe-GPP-4 Bajeta neViktoza
3. Ama-Thiazolidinediones ohlobo lwe-Avandia ne-Aktos.

Imininingwane inikezwe ireferensi ejwayelekile kuphela, udokotela kufanele akhethe i-algorithm entsha yokwelashwa.

Lapho i-Metformin Ingasizi

Ezithangamini ezibabazisayo, abanye abanesifo sikashukela bakhala ngokungasebenzi komuthi. Kungani umuthi onzima kangaka ungewona wonke umuntu ongakwazi ukuthola i-glycemia 100%?

• Uma umuthi ungabelwe ngokuya izinkomba, awukwazi ukubala ukusebenza kwawo;
• Umthamo obaliwe ngokungalungile;
• Ukwephula uhlelo lokuthatha umuthi;
• Ukwehluleka ukulandela imigomo yokudla okuphansi kwe-carb;
• Ukuntuleka kokuzivocavoca umzimba;
• Ukuzindla komuntu ngamunye;
• Ama-generator asezingeni eliphansi.

Uma uhlaziya lesi simo futhi ulungisa amaphutha, umphumela uzovela ngokushesha.

I-Metformin ekwakheni umzimba

Kubantu abane-diabetes, umuthi ubalulekile, ubuyisela umzimba we-lipid owonakele ngalesi sifo. Uma isetshenziswa ngokuqhubekayo, ivikela nemithambo yegazi ekubeni noshukela, kusuka ku-cholesterol eyeqile nokuwohloka kwamafutha. Kepha umzimba womsubathile unemizwa ehlukene ngokuphelele yokuphendula, futhi ukomisa umuthi usetshenziselwa izifundo ezinomkhawulo ngokuqinile.

Uma ufuna umuthi ngaphandle kokuthola umuthi othize, kunzima ukuhamba nge-assortment: esikhundleni seMetformin, uzonikezwa iMetfogamma, iBagomet, iSiofor, iNovoformin, iGlyukofazh, iDiaformin, i-Orabet, ... Yonke le mishanguzo inesakhi esisebenzayo - i-metformin. Imithamo, njengesikhathi somsebenzi, yehlukile. Yikuphi ukukhetha? Into esemqoka ukuyeka entweni eyodwa bese uyisebenzisa kuze kube sekupheleni kwesifundo.

IMetformin isekela isilinganiso sikashukela ngokuvimbela ama-carbohydrate emgodini wokugaya ukudla futhi ivimbele ukukhiqizwa kwe-glycogen esibindini. Umzimba awunawo amandla futhi kufanele uchithe owawo amanoni. Ngokufana, umuthi awulethi umzimba ku-hypoglycemia, ngakho-ke, ngisho nasekudla, umsubathi akahlushwa isifiso sokudla esingalawulwa.

Umuthi uqobo ngokwawo awusiwona owokushisa amafutha, kepha amanoni amaningi ngokweqile ayahamba. Lokhu kungenxa yamandla omuthi wokunciphisa ukumelana ne-insulin - umlawuli oyinhloko wezinqubo ze-metabolic, isilawuli sendlala kanye nenqubo yokwakhiwa kwamafutha. Futhi amafutha amancane afakwa, okuvame ukuba nesifiso sokuhlala phansi futhi ungqimba lwamafutha luncibilika ngokwengeziwe.

Noma ngubani osebenzisa iMetformin yokunciphisa umzimba, kufanele ulandele imithetho ukugwema izinkinga eziyingozi. Umthamo owodwa (500 - 850 mg) udliwa ngokudla noma ngemuva kwawo amahlandla amabili noma amathathu ngosuku, inkambo - ukuya ezinyangeni ezi-3. Kubalulekile ukunciphisa umkhawulo wokudla kokudla okunoshukela kanye nama-carbohydrate asheshayo ukugwema imiphumela emibi ngendlela yokucasuka kwesisu. Umthamo woketshezi oludakayo kufanele ube ngu-30 ml nge-1 kg yesisindo. Kufanele kuqashelwe ukuthi

Ekuqaleni kwesifundo, abasubathi bathola izimpawu ezifana ne-toxicosis yabesifazane abakhulelwe: isicanucanu, ukulahlekelwa yinhliziyo, ukuguqulwa kokunambitheka okuvela ekushoneni kwama-carbohydrate. Ukungajabuli kudlula ngokwawo noma ngemuva kokulungiswa kwamthamo. Kubalulekile ukuthi ungabulawa yindlala! Ngama-pathologies wesibindi nezinso, kungcono ukungazami ukwehliswa kwesisindo okunjalo.

Uhlu oluphelele lwe-contraindication lweMetformin likumiyalo esemthethweni yokusetshenziswa. Awukwazi ukuphuza izithasiselo ngomphumela we-diuretic noma laxative ngokuhambisana nalo - ubungozi bokulimaza okukhulu ezinsweni buyanda.

Funda kabanzi ngokusetshenziswa kweMetformin kwezemidlalo - esiteshini semidlalo nakwezokwazisa ISIMEMO SESAYENSI

Ingabe kufanelekile ukulahlekelwa isisindo nge-metformin

Ukulandela isibalo esifanele, esingasisebenzisi, noma ngabe indlela isolisayo, futhi amaphilisi ngokuvamile ayalimaza impilo. Kuhle ukukhumbula ukuthi iMetformin ekuqaleni yayenzelwe ukulawula isifo sikashukela sohlobo 2. Ngesikhathi ufunda amakhono ayo, kwavela ukuthi kunomthelela omuhle ekukhuluphweni ngokweqile - esinye sezizathu ezibalulekile zokuqalwa kwalesi sifo esikhohlisayo.

Ngabe usebenza kanjani lo muthi futhi ukukhuluphala kuhlale kuhlotshaniswa nokudla ngokweqile? Odokotela baqinisekisa ukuthi kuma-99% wamacala, abantu abanamafutha bathuthukisa ukumelana ne-insulin. Umsebenzi we-insulin ukuhambisa i-glucose kumaseli. Ekhotheni elinamafutha esitokisini, ukuzwela kwalo kuyancipha, futhi amangqamuzana “amnandi” awangeni kuwo. Ngenxa yalokhu, ama-pancreas athola isibonakaliso esivela kuma-b-cell ukusheshisa ukwakheka kwe-insulin, kanye nezindlela zayo ezeqile egazini. Leli qiniso linomphumela omubi kuma-metabolism we-lipid, ngoba manje sekulula ukuqoqa amafutha.

Kunezizathu eziningi zokuthi kungani ukuzwela kwamangqamuzana ukuya ku-insulin kunciphe, kepha eyinhloko wukudla ngokweqile ama-carbohydrate emzimbeni. Amaseli afakwe ushukela asuke evaliwe kuwo futhi evela ku-insulin. Futhi lapho i-hormone iqongelela ngokushesha emzimbeni, iba nenjabulo engaphansi kuye. Umphumela womjikelezo omubi onjalo uzoba ukukhuluphala, ukumelana ne-insulin kanye ne-hyperinsulinism.

Umuthi ubuyisela umuzwa weseli futhi ubuyisele i-hormone. IGlucose imvamisa, i-insulin ikhiqizwa ngendlela ejwayelekile, ayifakeli ekwakhiweni kwamafutha.

Umuthi ubuye ube nomphumela we-uncencitant umphumela - i-anorexigenic. Yilokho wonke umuntu akubala ngakho lapho ethenga umuthi ngenhloso yokunciphisa isisindo. Kepha umuthi unciphisa isifiso sokudla futhi akusizi wonke umuntu.

Imiyalo yokulahlekelwa isisindo kuMetformin

Alikho iphilisi eliwumlingo elishisa ngamafutha ngenkathi wenza enye i-bun ku-TV.

Ngokomqondo, ungalahlekelwa isisindo ngaphandle kweMetformin, ngoba ukugcizelelwa okuyinhloko kusendleleni yokuphila enempilo. Lezi zixwayiso azisebenzi kwabanesifo sikashukela esinokukhuluphala kwesibili. Kepha uma amantombazane ephilile ekhululeka ngokwengeziwe ngokulahlekelwa isisindo ngamaphilisi, udinga ukukwenza kahle.

Ungathenga noma iyiphi i-analog yeMetformin, inkampani ngayinye ekhiqiza amakhambi iyikhiqiza ngaphansi kwegama layo noma ungeza isiqalo kokuqala: iTeva, iCanon, iRichter. Amakhemikhali ahlukile ekwakhiweni kwegobolondo kanye nama-fillers. Imvamisa zibangela ukungahambi kahle komzimba, yize umuthi unezimpikiswano zazo nemiphumela engathandeki, okumele ijwayelane nokwehlisa isisindo.

Qala isifundo ngomthamo omncane ka-500 mg, uthathe iphilisi kanye. Umuthi ukhiqizwa ngemithamo ehlukene, uma uqala ngeminye imithamo, ungazizwa kusukela ezinsukwini zokuqala yonke injabulo yemiphumela engathandeki, ikakhulukazi ukucasuka kwesisu. Umthamo omkhulu yi-3000 mg / ngosuku, kodwa odokotela abaningi bancoma ukukukhawulela kumkhawulo we-2000 mg / ngosuku.

Umuthi udliwa ngokudla noma ngemuva kokudla. Ungayithatha ebusuku, uhlelo olunjalo nalo luyalulekwa.
Uma kusukela ezinsukwini zokuqala imiphumela engathandeki ibonakaliswa futhi umzimba ungakavumelanisi izinsuku eziyi-14 zokudla okujwayelekile, umuthi udinga ukuthi ungene esikhundleni.

Imibono yokulahlekelwa isisindo

Mayelana neMetformin, ukubuyekezwa kokuncipha kwesisindo, ikakhulukazi, kube kubi. Labo abathola imiphumela efiselekayo abasebenzisanga lesi sidakamizwa kuphela, kodwa nezinye izindlela, ngakho-ke kunzima ukunikeza ukuhlolwa kwenhloso komuthi ngamunye.

I-Metformin: ukubuyekezwa kodokotela

Ngokusobala, iMetformin akuyona into yokuphakanyiswa okusha noma yokushiswa kwamafutha, kepha umuthi onzima onobufakazi obunamandla besisekelo sokusebenza, uma uthathwe ngenhloso eyayihloselwe. Mayelana nemiphumela yokwelashwa

Ungafunda i-metformin kuvidiyo