Cishe wonke umuntu ohlushwa isifo "esimnandi" sohlobo lwe-II uyazi ukuthi le ndlela yesifo ingeyohlobo lwesifo se-metabolic.
Ihlukaniswa ukukhula kwe-hyperglycemia engapheli, eyakheka ngenxa yokwephulwa kokusebenzisana kwe-insulin nezicubu zeseli.
Kulesi sigaba seziguli okufanele sinake umuthi onjengeGlurenorm, odume kakhulu namuhla.
Kepha izimpawu ezinjengokoma ongagculiseki, umlomo owomile, ukuchama kaningi, ukulunywa isikhumba, ukuphulukiswa okwanele kwamanxeba, kanye nesisindo somzimba ngokweqile kungakhombisa ukutholakala kwesifo sikashukela sohlobo 2.
Kungokuthuthuka kwesimo esinjalo ukuthi kusetshenziswe umuthi ochaziwe. Ngezansi kuzokwethulwa imiyalo yokusetshenziswa kwayo, ama-analogues atholakalayo, izici nefomu lokukhishwa.
Ukwakheka nezenzo zamakhemikhali
Ithebhulethi elilodwa lesidakamizwa liqukethe:
- into esebenzayo ye-glycidone kumthamo we-30 mg;
- ama-excipients, amelelwa yilokhu: isitashi sommbila, i-lactose, isitashi sommbila 06598, i-magnesium stearate.
Uma sikhuluma ngesenzo se-pharmacological somuthi, khona-ke akunikeli nje ukukhuthaza ukucashunwa kwe-hormone yi-beta-cell ye pancreas, kodwa futhi kwandisa umsebenzi we-insulin-secretory we-glucose.
Ithuluzi liqala ukusebenza ngemuva kwamahora angu-1-1,5 ngemuva kokufaka isicelo, ngenkathi ukusebenza okuphezulu kwenzeka emahoreni angama-2-3 futhi kuthatha amahora angama-9 kuya kwayi-10.
Kuyavela ukuthi umuthi ungasebenza njenge-sulfonylurea yesikhashana futhi ungasetjenziselwa ukwelapha abanesifo sikashukela ngohlobo lwe-II yesifo sikashukela kanye neziguli ezihlulwa wukulimala kwezintso.
Izibhebhe ze-Glurenorm
Ngoba inqubo yokususa i-glycidone yizinso ayibalulekanga kangako, ikhambi linqunyelwe kwabanesifo sikashukela abane-nephropathy yesifo sikashukela. Kufakazelwe ngokwesayensi ukuthi ukuthatha i-Glyurenorm kusebenza impela futhi kuphephile.
Kuliqiniso, kwezinye izimo, bekuyehla kancane ekumbeni kwama-metabolites angasebenzi. Ukuthatha umuthi iminyaka engu-1.5-2 akuholeli ekwenyukeni kwesisindo somzimba, kepha, kunalokho, ekwehleni kwawo ngo-2-3 kg.
Izinkomba zokusetshenziswa kwomuthi
Njengoba sekuphawuliwe ngenhla nje, umuthi unqunywa ngudokotela lapho kutholakala isifo soshukela sofuzo "esizimele" sohlobo II. Ngaphezu kwalokho, lokhu kusebenza ezigulini zesigaba esiphakathi noma esidala sokukhula lapho ukwelashwa kokudla kungalethi imiphumela emihle.
Imiyalo yokusebenzisa amaphilisi i-Glenrenorm
Umuthi wenzelwe ukuphathwa ngomlomo. Umthamo odingekayo unqunywa udokotela ngemuva kokuhlola isimo esivamile sesifo sikashukela, ethola noma yikuphi ukugula okufana nakho, kanye nenqubo esebenzayo yokuvuvukala.
Inqubo yokuphuza iphilisi ihlinzeka ngokuhambisana nokudla okunqunyelwe uchwepheshe kanye nohlu olunqunyelwe.
Inkambo yokwelashwa "iqala" ngesilinganiso esincane esilingana ne-½ ingxenye yepilisi. Ukubamba kokuqala kweGlyurenorm kwenziwa kusukela ekuseni kuze kube sekudleni.
Uma umphumela omuhle ungabonakali, khona-ke kufanele ufune izeluleko se-endocrinologist, ngoba, kungenzeka kakhulu, ukwanda komthamo kuyadingeka.
Ngosuku olulodwa, kuvunyelwe ukungathathi ama-pcs ayi-2. Ezigulini lapho ungekho umphumela we-hypoglycemic, umthamo obekiwe uvame ukungakhushulwa, futhi iMetformin nayo ibekiwe njengesengezo.
Contraindication
Njenganoma yisiphi esinye isidakamizwa, umuthi ochaziwe ubonakala ngokuba khona kwe-contraindication ukuze isetshenziswe, okubandakanya:
- Thayipha isifo sikashukela;
- isikhathi sokululama ngemuva kokuhlinzwa ukuze kuqale kabusha ama-pancreas;
- ukwehluleka kwezinso;
- ukungasebenzi kahle kwesibindi;
- i-acidosis ebangelwa isifo "esimnandi";
- ketoacidosis;
- ukukhohlisa okubangelwa isifo sikashukela;
- ukungabekezelelani kwe-lactose;
- inqubo ye-pathological yesimo esithathelwanayo;
- ukungenelela kokuhlinzwa kwenziwa;
- isikhathi sokuzala ingane;
- izingane ezingaphansi kweminyaka engu-18;
- ukungabekezelelani ngakunye kwezakhi zomuthi;
- isikhathi sokuncelisa;
- ukugula kwegilo;
- ukuncika otshwaleni;
- i-porphyria eyingozi.
Ukweqisa komzimba nemiphumela emibi
Imvamisa, umuthi ubekezelelwa kahle ngumuntu onesifo sikashukela, kepha kwezinye izimo, isiguli sinokuhlangana:
- isicanucanu
- ukuqunjelwa
- ukuhlanza
- isifo sohudo
- ukwehla kwesifiso sokudla;
- ukungezwani komzimba (ukulunywa, i-eczema);
- ikhanda, indawo yokulimala, isiyezi;
- thrombocytopenia.
Ezinye iziguli zithole i-choleraasis ye-intrahepatic cholestasis, i-urticaria, i-Stevens-Johnson syndrome, i-agranulocytosis kanye ne-leukopenia. Uma kwenzeka kusetshenziswa izidakamizwa ngokweqile, kungaba khona uhlobo olunamandla lwe-hypoglycemia.
Ngaso leso sikhathi nge-overdose, isiguli sizizwa:
- ukuzindla kwenhliziyo;
- ukukhuphuka kokujuluka
- umuzwa onamandla wendlala;
- ukuzamazama kwemilenze;
- ikhanda
- ukulahleka kwengqondo;
- umsebenzi wokukhubazeka ongafanele.
Uma kuvela ezinye zezimpawu ezingenhla, kunconywa ukuthi ngokushesha ufuna usizo lochwepheshe ofanelekayo.
Ukusebenzelana kwezidakamizwa
Umphumela we-hypoglycemic womuthi ungakhuphuka lapho usetshenziswa ngasikhathi sinye ngezinto ezinjengokuthi:
- i-salicylate;
- i-sulfanilamide;
- i-phenylbutazone derivatives;
- izidakamizwa ezilwa nesifo sofuba;
- i-tetracycline;
- I-ACE inhibitor;
- I-MAO inhibitor;
- guanethidine.
Umphumela we-hypoglycemic uyancipha lapho usebenzisa i-ejenti ene-GCS, phenothiazines, diazoxides, izindlela zokuvimbela inzalo ngomlomo nemithi ene-nicotinic acid.
Intengo yamathebulethi eGlurenorm emakhemisi
Iphakethe elilodwa lemithi liqukethe ama-60 ama-pcs. amaphilisi anesisindo esingu-30 mg. Izindleko zephakethe lokuqala elinjalo ezitolo zezidakamizwa ezifuywayo zingama-ruble angama-415-550.
Kulokhu singaphetha ngokuthi kuyinto eyamukelekayo kuhlu ngalunye lwezenhlalo.
Ngaphezu kwalokho, ungathenga umuthi ekhemisi eliku-inthanethi, elizokonga ezinye zezimali.
Analogs kanye esikhundleni somuthi
Namuhla ungathola ama-analogues alandelayo we-Glurenorm:
- I-Glibenclamide;
- UGlidiab;
- IGlllada;
- I-Diamerid;
- I-Glimepiride;
- Maninil;
- I-Bisogma;
- Amaril.
Kumele kuqashelwe ukuthi okufana nomuthi okungenhla komuthi ochaziwe kuboniswa ukuba khona kwesenzo esifanayo sokhemisi, kodwa ngentengo ebiza kakhulu.
Ukubuyekezwa kodokotela kanye nabanesifo sikashukela
Odokotela, kanye neziguli ezinesifo sikashukela i-mellitus, ingxenye enkulu, zishiya ukubuyekezwa okugculisayo nge-Glyurenorm.Kodwa-ke, umuntu kufanele azi ukuthi lesi sidakamizwa akuyona into etholakala ngokujwayelekile "zokuzijabulisa".
Kutholwa ikakhulu ngokuya ngokuya kadokotela futhi kuhloselwe ukwelashwa okungathi sína kwezifo ezinamandla.
Ngakho-ke, ngokutadisha kanyekanye kokubuyekezwa kweziguli kunethiwekhi, kubalulekile ukubonana nochwepheshe. Ngempela, kwabanye abanesifo sikashukela lo muthi uyikhambi elifanele, kanti kwabanye mubi kakhulu.
Amavidiyo ahlobene
Mayelana nama-nuances wokusebenzisa amaphilisi we-Glurenorm kuvidiyo:
Ekuphetheni, kufanele kuqashelwe ukuthi ukwelashwa kwezifo ezinzima njengokuthi isifo sikashukela kudinga ukusetshenziswa kwezokwelapha okufika ngesikhathi, futhi okubaluleke kakhulu, kukhethwe uchwepheshe onguchwepheshe okwenziwe ngokufanele.
Impela, manje ezitolo zezidakamizwa ezifuywayo ungathola okunezinhlobonhlobo zemithi, enye nenye inomphumela wayo, kanye nezindleko. Udokotela ofanelekayo kuphela ozokusiza wenze isinqumo esifanele ngemuva kokwenza izifundo ezidingekayo.
