I-Metformin kushukela - umphumela wokwelapha kanye nezici zokusetshenziswa

I-Metformin hydrochloride iyinto esebenzayo enomphumela ophonsa ushukela. Umuthi uvame ukubekwa njengengxenye yokwelashwa okuyinkimbinkimbi kwesifo sikashukela sohlobo 2.

Ukubuyekezwa okuhle ngokusetshenziswa kwamathebulethi ehlobo lwe-endocrine uhlobo 1 njengesengezo sokulimala kwe-insulin.

Umthamo ofanele kanye nokuvama kweMetformin yesifo sikashukela esigulini esithile kunqunywa yi-endocrinologist, kucatshangelwa izici eziningana.

Iqembu lezemithi

I-Metformin iyisidakamizwa esenziwe nge-hypoglycemic effect. I-ejenti yomlomo ye-antidiabetesic isetshenziswa ngenkuthalo ekwelapheni uhlobo lwe-endocrine pathology, okuvame kakhulu - ngaphezu kokuphathwa kwe-insulin. Uhlobo oluphambili lokudalulwa kokwehla kushukela wegazi.

Imiphumela yokwelapha yeMetformin

Umphumela oyinkimbinkimbi emzimbeni ngohlobo lwesifo sikashukela olungathembisi i-insulin ungenye yezinzuzo zesidakamizwa esisebenzayo. Umuthi osebenzayo awugcini ngokuqinisa ushukela wegazi, kodwa futhi uvamisa nokuqina kwe-lipid. Umuthi ubuthaka kalula ukusebenza kwe-pancreas (ikhombisa umphumela we-perogheral hypoglycemic), ukwehla okubukhali kokuxineka kweglucose kungabandakanywa.

Ngemuva kokuthatha iMetformin, umzimba uhlangana kahle nezakhi zomenzeli wesifo sikashukela:

• izinga lokwakheka koshukela kusuka kuma-lipids namaprotheni kuncishisiwe;
• ukuzwela kwezicubu ekwandeni kwe-insulin;
• i-glycogen evela kumaseli wesibindi ikhishwa kancane, amazinga kashukela egazi abuyele kwesejwayelekile;
• imicu yemisipha idla ushukela okhuthele ngokwengeziwe;
• ukumbiwa kwe-cholesterol emibi kuyathuthukiswa, i-metabolism yamafutha ivamile;
• ukumuncwa kwe-glucose esiswini kungasebenzi kancane;
• emgodini wokugaya kukhona ukuguqulwa okuthuthukisiwe kweshukela.

Izinkomba zokuqokwa

I-Metformin yezidakamizwa yinto ebalulekile ekwelapheni isifo sikashukela esingaxhomekeki ku-insulin (uhlobo lwe-2 pathology).

Isidakamizwa esuselwa kuMetformin hydrochloride sisetshenziselwa uhlobo lwe-1 endocrine yesifo ukulawula ukugcwala kwe-glucose, ngaphezu kwemijovo ye-insulin.

Ezinye izinkomba:

• ukwelashwa okuyinkimbinkimbi kokukhuluphala ngemuva kwesisekelo sokumelana ne-insulin;
• i-polycystic ovary syndrome;
• noshukela omkhulu wegazi esiswini esingenalutho;
• kwezokwelapha;
• nokwehla kokubekezelela ushukela.

Umthamo

Izinkampani ezenza imithi zinikeza izinhlobo ezimbili zeMetformin:

1. isikhathi eside;
2. ezejwayelekile.

Amathebulethi anomthamo ohlukile - kusuka ku-500 kuye ku-1000 mg. Izinhlobo eziningi ezihlanganisiwe ze-antidiabetic nazo ziqukethe isithako esisebenzayo, kepha ngamanani amancane.

Udokotela we-endocrinologist ukhetha umthamo ofanele obheka amazinga kashukela egazini kanye nohlobo lwesifo sikashukela. Isidingo esiphansi sansuku zonke sokufeza umphumela wokwehlisa ushukela ngu-500 mg. Ngobungozi obukhulu be-hyperglycemia, njengoba kuyalelwe ngudokotela, ungangezelela ukungena kwe-metformin hydrochloride iye ku-2 g.

Thayipha isifo sikashukela sesi-2

I-Metformin iyi-hypoglycemic enkulu. Umthamo omaphakathi nsuku zonke ngu-0.5 noma 0,85 g, inani liyithebhulethi eyi-1.

Ngokukhula kwesifo sohudo noma isicanucanu, sebenzisa lesi sidakamizwa ngokudla, ngemuva kokudla, uphuze ngamanzi.

Ngomthelela obuthakathaka, ngokwesivumelwano nodokotela, ungangeza umthamo wansuku zonke ukuya ku-2 g.

I-carbohydrate metabolism ibuyela kokujwayelekile ngemuva kwamasonto amabili kuya kwamathathu. Ngokuncipha kwezinga le-hyperglycemia, umthamo wehliswa kancane kancane. Ukulungiswa kwenani lamathebhulethi kanye nemvume yansuku zonke kuvunyelwe njengoba kuyalelwe yi-endocrinologist.

Ama-nuances abalulekile:

• nge-metabolic syndrome emelana nesifo sikashukela, ungathola amaphilisi asuselwa ku-metformin hydrochloride ukuze wenze kube yi-metabolism ngokweqile, anciphise ama-triglycerides, anciphise i-hyperglycemia ephezulu kakhulu ngemuva kokudla;
• ukuhlanganiswa kwamalungiselelo we-sulfonylurea kuthuthukisa imetabolism kuma-60% eziguli. Izinga le-glycemia liyancipha - amanani kashukela awela ngo-20-40%. Ngokuhamba kwesikhathi, umzimba ujwayela esenzweni sezidakamizwa nge-sulfonylurea. Ukuphuza i-Metformin kugcina ukuqina kwe-lipid metabolism noshukela wegazi ofanele.

Thayipha isifo sikashukela sokuqala

Umuthi uvame ukubekelwa uhlobo 2 lwe-pathology, kepha odokotela abaningi bengeza umjovo we-insulin nge-Metformin.

Umphumela oyinkimbinkimbi uqinisa isimo sesiguli.

Ukwanda kwamazinga we-insulin ngemuva kokujova, kuhlanganiswe nokwehla kokuxineka koshukela, kunciphisa ubungozi bezinkinga zohlobo lwesifo esincike ku-insulin.

Ukwelashwa okusebenzayo kwe-antidiabetesic (imijovo ye-insulin ne-metformin hydrochloride) kunciphisa isidingo sokugcina ama-hormone ngo-20% noma ngaphezulu. Uvivinyo luvame ukukhombisa ukuthuthuka kwe-carbohydrate metabolism.

Ngabe iMetformin ingasetshenziswa ukuvikela isifo sikashukela?

Odokotela baseMelika ngasekupheleni kwekhulu lama-20 benza ucwaningo oluningi lokufunda umphumela womenzeli we-hypoglycemic ngemiphumela ebekiwe yokuphazamiseka.

Iziguli ezisengozini zazimenyiwe: ngokubekezelela i-glucose engasebenzi kahle futhi kwaqinisekiswa i-prediabetes.

Abaningi bahlushwa ukukhuluphala, bakhala kakhulu ngomfutho wegazi ophakeme, izinkinga zenhliziyo, ukuhlolwa kwabonisa izinga elibucayi le-triglycerides ne-cholesterol "embi".

Izilinganiso nezivivinyo ezithile zenziwa ezikhungweni ezingama-27. Iziguli zithole iMetformin kabili ngosuku ku-850 g iminyaka emithathu. Ucwaningo luye lwabonisa: ukwelashwa kwezidakamizwa, kuhlanganiswe nokulungiswa kwendlela yokuphila nokudla, kunciphisa ukufa kwabantu okuvela kuma-pathologies ezinhliziyo.

Umuthi olwa nesifo sikashukela ukhombise ukusebenza kahle kakhulu futhi wamemezela ukuqina kwamanani kashukela wegazi ngenhloso yokuthola isifo sikashukela kubantu abanokukhuluphala ngokweqile. Noma ngiphila ngendlela ejwayelekile, amathuba okukhulisa uhlobo oluzimele lwesifo sikashukela kwehle ngo-30%. Imiphumela yokwelashwa ngenkathi udla, ukwanda komsebenzi wezimoto, kanye nokwehla kwezinga lokucindezelwa laliphezulu kakhulu: kuma-58% abantu abasengozini, amazinga e-glucose azinza.

Contraindication

Ngokungafani nezinye izinhlobo zemithi ye-antidiabetic, iMetformin namagama afanayo anemikhawulo embalwa:

• iminyaka yengane ifinyelela eminyakeni eyi-10;
• walimala kabi kakhulu nokuhlinzwa okuyinkimbinkimbi;
• umlando we-lactic acidosis;
• inkathi yokuhlanza;
• Ukudla ikhalori ngaphansi kwe-1000 kcal ngosuku: ingozi enkulu ye-metabolic acidosis;
• ukwehluleka kwezinso;
• ukulimala kwesibindi okunzima;
• izindlela zenhliziyo;
• ukukhulelwa
• izimo lapho ukuthuthukiswa kwe-lactic acidosis kungenzeka.

Imiyalo ekhethekile

Lapho welapha ngeMetformin, kubalulekile ukwazi: ukuqoqwa okuphezulu kwengxenye esebenzayo akuholeli ku-hypoglycemia, kepha nge-overdose, kungenzeka ukuthuthukisa isimo esiyingozi - lactic acidosis. Izihlobo zesifo sikashukela nezihlobo zesiguli kufanele zizazi izimpawu zokushintshwa kwe-pathological ukuze zibize ngokushesha i-ambulensi ukuthi ilaliswe esibhedlela.

• ukuphefumula ngokushesha;
• isifo sohudo
• i-hypothermia;
• isicanucanu
• Ubuhlungu besisu esibuhlungu;
• ukuhlanza
• ukuqina kwemisipha;
• ukulahlekelwa ukwazi.

Ama-Analog

I-Metformin hydrochloride iyingxenye yezidakamizwa eziningi. Izinkampani ezenza imithi zinikeza izidakamizwa ngezithako ezisebenzayo ngaphansi kwamagama ahlukene kumakhemisi. Umehluko ezingxenyeni ezisizayo empeleni azithinti izinqubo emzimbeni.

Amagama aphumelelayo asuselwa ku-metformin hydrochloride:

1. IFomu.
2. I-Glucophage.
3. I-Metospanin.
4. I-Glycomet.
5. Siofor.
6. Glyminfor.
7. I-Novoformin.
8. I-Vero-Metformin.
9. I-Bagomet.
10. UDianormet nabanye.

Ukubuyekezwa kweMetformin nezimpawu zayo kuqinisekisa umphumela ozinzile we-hypoglycemic kuhlobo 2 sikashukela.

Umphumela omuhle wokwelapha ngefomu lokuncika kwe-insulin nawo uyaboniswa. Ngokuya ngokujwayelekile kwansuku zonke, imiphumela emibi yenzeka ngamaphesenti amancane eziguli. Izindleko ezamukelekayo (kusuka kuma-ruble ayi-110 kuye kwangama-190, ukupakishwa uNo. 30 no-No 60) kuyinzuzo engathandabuzekwayo ngenkambo ende yokwelashwa.

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