Ukwakheka emithanjeni yegazi yesistimu yokujikeleza kwegazi okuvimbela ukuhamba kwegazi okujwayelekile kuyisifo esiyingozi futhi esivame kakhulu.
Ukuze ulwe nokwakheka ngokweqile kweziqeshana zegazi, kusetshenziswa izidakamizwa ezahlukahlukene ezisebenza ku-plasma protein factor antithrombin.
Enye yezidakamizwa ezivame kakhulu yi-Fraxiparin, kanye nezinye izikhala zayo eziningi. Yimaphi ama-analogues weFraxiparin asetshenziswa kwezokwelapha?
Igama Lezwe elingafanele
Igama elejwayelekile i-Fraxiparin, elibonisa ukwakheka kwezidakamizwa, yi-Nadroparin calcium, igama lesiLatin lamazwe omhlaba yiNadroparinum calcium.
Isidakamizwa uFraksiparin 0,3 ml
Onke amagama okuhweba amaningi ale mishanguzo, ahlanganiswe ngegama elilodwa elijwayelekile, anomphumela ofanayo emzimbeni womuntu ngokuya ngezimpawu namandla.
Ngaphezu kwegama, umehluko phakathi kwezidakamizwa ezihlukile ngumkhiqizi ezilinganisweni, kanye nasendleleni yokwakheka kwababekhona kanye nokutholakala kwemithi nomuthi ongathathi hlangothi ngamakhemikhali okhona kulo muthi.
Umkhiqizi
Umuthi obizwa ngeFraxiparin ukhiqizwa eFrance ezikhungweni zezimboni zeqembu lesibili ngobukhulu bezokwelapha eYurophu, iGlaxoSmithKline, ikhanda eLondon.
Kodwa-ke, lesi sidakamizwa sibiza kakhulu, ngakho-ke imboni yezemithi ikhiqiza ama-analogues ayo amaningi.
Ozakwethu abajwayelekile kakhulu abashibhile bafaka:
- AmaNadroparin-Farmeks akhiqizwa yiFarmeks-Group (Ukraine);
- I-Novoparin eyenziwe yiGenofarm Ltd (UK / China);
- I-Flenox ekhishwe yi-PAO Farmak (Ukraine);
Imikhiqizo efanayo nayo ikhiqizwa yizinkampani eziningi zemithi yaseNdiya nezaseYurophu. Ngokusho kwemiphumela emzimbeni, zingama-analogue aphelele.
Ifomu lomthamo
Umuthi uyatholakala ngendlela yesisombululo somjovo. Ngokuya ngomkhiqizi nezinhlobonhlobo, izinketho zemithamo eminingana zingatholakala.
Okuvame kakhulu imithamo yemililitha engu-0,2, 0,3, 0,6 no-0.8. Indawo yokukhiqiza yenkampani yaseJalimane i-Aspen Pharma inganikezwa kumthamo wamamililitha ayi-0,4.
Ngaphandle, ikhambi liwuketshezi olungenawoyela, olungenawo umbala noma ophuzi. Umuthi ubuye unephunga lesimilo. Isici se-Fraxiparin ukuthi ikhambi alinikezwa kuma-ampoules angajwayelekile kubathengi bethu, okudinga ukuthi kuthengwe isirinji esilahlayo somthamo ofanele nokukhohlisa okuthile ngaphambi komjovo.
Isidakamizwa sithengiswa kuma-injection akhethekile alahlekayo wesirinji, alungele ukusetshenziswa ngokuphelele. Ukuze ujove, vele ususe cap yokuvikela enalwaneni bese ucindezela piston.
Into esemqoka esebenzayo
Akunandaba negama lomkhiqizo lapho umuthi wenziwa khona abakhiqizi, into esebenzayo isisindo se-heparin ephansi.Le polysaccharide ehlukaniswe ngaphandle kwesibindi iyi-anticoagulant esebenzayo.
Lapho esegazini, i-heparin iqala ukubopha kumasayithi we-cationic we-tri-antithrombin.
Njengomphumela, ama-molecule we-antithrombin aguqula izakhiwo zawo futhi enze kuma-enzyme namaprotheni abhekene nokuqunjelwa kwegazi, ikakhulukazi, ku-thrombin, kallikrein, kanye nama-serine proteinases.
Ukuze into isebenze ngokwengeziwe nangokushesha, ekuqaleni i-molecule yayo "ende" ihlukaniswe yaba yifushane ngokususwa phansi ngaphansi kwezimo ezikhethekile kumishini eyinkimbinkimbi.
I-analogues yokukhulelwa
Umuthi i-Fraxiparin uvame ukusetshenziswa ngesikhathi sokukhulelwa.
Ngempela, phakathi nalesi sikhathi, ngenxa yezinguquko ngemuva kwesizinda se-hormonal, izakhiwo ezihlanganayo zokwanda kwegazi, okungaholela emithwalweni ye-thrombotic. Yikuphi ukufana komuthi okungathathwa lapho uzalela ingane?
Kaningi, i-Angioflux iyasetshenziswa - ingxube yezingcezu ezinjenge-heparin, ekhishwa ku-mucosa wephethini elincane lamathumbu lezingulube ezifuywayo. Amakhompiyutha wokulawulwa ngomlomo, kanye nezisombululo ezisebenzayo zokujova ziyatholakala.
Enye i-analog esetshenziswa kabanzi ekukhulelweni yi-hepatrombin. Ngokwakheka kwento esebenzayo, iyi-analogue ephelele yeFraxiparin, noma kunjalo, iyahluka ngendlela yesilinganiso. Ngokungafani nalokhu okugcina, i-hepatrombin iyatholakala ngohlobo lwamafutha okusetshenziswa kwangaphandle.
IHepatrombin Ointment
Ekugcineni, ukulungiswa kweWessel Duet F, equkethe ingxube yama-polysaccharides - glycosaminoglycans, nayo inomphumela ofanayo neFraxiparin. Ukuphathwa kwabo kubuye kucindezele i-factor X yokuhlangana kwegazi ngokusebenza kanyekanye kwama-prostaglandins kanye nokwehla kwenani le-fibrinogen egazini.
Ama-analogues ashibhile
Ngeshwa, njengemikhiqizo eminingi yaseYurophu, i-Fraxiparin iyabiza impela. Noma kunjalo, kukhona ama-analogues ashibhile avumela ukuvimbela okusebenzayo kanye nokwelashwa kwezibonakaliso ze-thrombotic futhi konga imali. I-analogues engabizi kakhulu yalo muthi izidakamizwa ezenziwe e China, India nase CIS.
I-Enoxaparin-Pharmex injekishini
Ukuphakama kokutholakala kubanjwa ngomuthi ngaphansi kwegama lokuhweba i-Eneksaparin-Farmeks lemvelaphi yase-Ukraine. Lapho kulungiswa inkampani "Pharmex-Group", isithako esiyisisekelo esisebenzayo futhi sisebenza ngokubambisana, okusho ukuthi, i-heparin engahlangani.
Akubizi kakhulu kune-Enoxarin ekhiqizwa yiBiovita Laboratories - iqembu elikhulu lemithi laseNdiya. Kuhlinzekwa futhi kwisirinji ekhethekile yokulahlwa futhi iqukethe into efanayo esebenzayo - i-calcium complication ye- "short" heparin.
Isilungu esijwayelekile kakhulu seFraxiparin umuthi obizwa ngokuthi uClexane. Izithako zemithi yaseFrance zenziwa ekukhiqizweni, okuqinisekisa ikhwalithi ephezulu yemithi nokuphepha kokuphathwa kwayo.
Umehluko weFraksiparin kusuka kuKleksan
UClexane uhlukaniswa ngentengo ephakeme, noma kunjalo, kubhekwa odokotela abaningi abasebenzayo ukuthi kubhekwa njenge-anticoagulant elula kakhulu futhi ephumelelayo ngesikhathi sokukhulelwa.
Ukusebenziseka kalula kweClexane kungukuhlala isikhathi eside, okuhlobene neFraxiparin, nomphumela emzimbeni.
Clexane Injection
Ngokwendlela ejwayelekile, i-Fraxiparin kufanele iphathwe kabili ngosuku. Ngasikhathi sinye, uClexane unomphumela kungakapheli amahora angama-24, anciphisa inani lemijovo ngesigamu.
Ngokunikwa ukuthi lesi sidakamizwa sithathwa isikhathi eside, ukwehla kwenani lansuku zonke lemijovo kukhethwa ngokuya ngenduduzo yeziguli nenhlala-kahle.
Ngaphandle kwalokho, le mithi ifana ngokuphelele futhi ayifani ngendlela yokukhululwa, noma into esebenzayo, noma ekuthini umzimba uphathwe kanjani.
Yini engcono?
I-Fraxiparin noma iHeparin
Enye yezidakamizwa zokuqala ezisetshenziselwa ukweqisa kwegazi ngokweqile kwakunguHeparin, umuthi oqukethe i-sodium heparin njengento esebenzayo.Kodwa-ke, okwamanje iya ngokuya ifakwa i-Fraxiparin nama-analogues ayo.
Umbono wokuthi uHeparin weqa isithiyo se-placental futhi angaba nomthelela ongemuhle ku-fetus awunangqondo.
Ngokusho kocwaningo, bobabili abakwaFraxiparin noHeparin abakhombisi ikhono lokungena kwi-placenta futhi bangaba nomthelela ongemuhle ku-fetus kuphela uma dosage evumelekile idluliwe.
Ukwanda kwe-Fraxiparin kwezokwelapha zesimanje kuchazwe kuphela ukusetshenziswa kwayo - ngaphandle kwalokho izidakamizwa zinomphumela olingana ngokuphelele.
I-Fraxiparin noma i-Fragmin
IFragmin, njengezinye izidakamizwa eqenjini, iqukethe i-heparin eqhekekile. Kodwa-ke, i-Fragmin isetshenziswa njenge-coagulant ejwayelekile, ngokungafani neFraxiparin, eyenzelwe ukusetshenziswa ngesikhathi sokukhulelwa.
Fragmin umjovo
Uma lokhu okugcina kuqukethe i-calcium compact yento esebenzayo, khona-ke uFragmin uqukethe usawoti we-sodium of heparin. Kunobufakazi bokuthi kulokhu, i-Fragmin inethonya elibi emzimbeni.
Esezinhlelweni zokuthatha lo muthi, ukopha okuvela emithanjeni yegazi emincane kuvame kakhulu. Ikakhulu, ukusetshenziswa kweFragmin kungadala i-nosebleeds ngezikhathi ezithile, kanye nezinsini zokuphuma kwegazi kweziguli.
Amavidiyo ahlobene
Ungawenza kanjani umjovo ocashile waseClexane:
Ngokuvamile, kukhona cishe izifanekiso eziyishumi nambili eziphelele zeFraxiparin, ezahlukahluka kunoma yizindleko ezinhle noma isenzo esijwayelekile, futhi sikuvumela ukuthi wonge imali ngokumelana ngempumelelo nokuqina kwegazi okuqashelwa ngesikhathi sokukhulelwa noma uma ngabe kuphazamiseka i-enzymatic.
