Ukusetshenziswa okuqhubekayo kwezidakamizwa eziqukethe i-insulin kumele izigidi zeziguli ezinesifo sikashukela.
Ngenxa yokuthi ukungena nsuku zonke kwezidakamizwa ezinjalo kwenziwa ngumuntu onesifo sikashukela impilo yakhe yonke, izidingo ezandisiwe kufanele zibekwe kwikhwalithi yezidakamizwa.
Kuyadingeka ukunciphisa umthelela omubi wokudla kwabo emzimbeni, kuyilapho ngasikhathi sinye uqinisekise umphumela omuhle oqondile. Kungenxa yale njongo ukuthi imboni yezemithi yathuthukisa futhi ikhiqize imikhiqizo emisha equkethe i-insulin. Ikakhulu, isidakamizwa esinjalo yiTujeo - enye indlela eLantus evela kumkhiqizi ofanayo.
Zisetshenziselwa ini?
UTujeo noLantus balungiselela i-insulin ngendlela ye-ketshezi lomjovo.
Zombili lezi zidakamizwa zisetshenziselwa isifo sikashukela sohlobo 1 nohlobo 2, lapho ukuguquguquka kwamazinga kashukela kungatholakali ngaphandle kokusebenzisa imijovo ye-insulin.
Uma amaphilisi e-insulin, ukudla okuyisipesheli nokunamathela ngokuqinile kuzo zonke izinqubo ezibekiwe akusizi ukugcina amazinga kashukela egazi ngaphansi kwesilinganiso esivumelekile, ukusetshenziswa kweLantus neTujeo kunqunyelwe. Njengoba izifundo zomtholampilo zikhombisile, le mishanguzo iyindlela ephumelelayo yokuhlola amazinga kashukela egazini.
Ocwaningweni olwenziwe ngumenzi walesi sidakamizwa - inkampani yaseJalimane iSanofi - ucwaningo luhlanganise izisebenzi zokuzithandela ezingama-3 500. Bonke bahlushwa isifo sikashukela esingalawulwa salezi zinhlobo zombili. Ezinyangeni eziyisithupha zocwaningo lomtholampilo, kwenziwa izigaba ezine zokuhlolwa.
Esigabeni sokuqala nesesithathu, kwafundwa ithonya leTujeo esimweni sempilo sohlobo lwesifo sikashukela sesibili.
Isigaba sesine sinikelwe umthelela weTujeo ezigulini ezinesifo sikashukela sohlobo 1. Ngokwemiphumela yocwaningo, kuvezwe ukusebenza kahle kukaTujeo.
Ngakho-ke, ezigulini ezinesifo sikashukela seqembu lesibili, ukwehla okumaphakathi kwezinga le-glucose kwaba -1.02, ngokuchezuka kwe-0-0-0.2%. Iphesenti elamukelekile lemiphumela emibi nephesenti elincane le-pathologies yezicubu ezindaweni zomjovo kwaphawulwa. Inkomba yesibili, yi-0,2% kuphela yezifundo ebinemiphumela engathandeki.
Konke lokhu kwenze ukuthi bakwazi ukufinyelela iziphetho ngokuphepha emtholampilo ngomuthi omusha futhi kuqale ukukhiqizwa kwawo kwezimboni. ITujeo iyatholakala ezweni lethu njengamanje.
ILantus noTujeo: umehluko nokufana
Yini umehluko wayo kuLantus, owaziwa kabanzi futhi wasatshalaliswa ngaphambili? NjengoLantus, umuthi omusha uyatholakala kumashubhu okulula osetshenziswa kuwo.
Ihubhu ngalinye liqukethe umthamo owodwa, futhi ngokuwusebenzisa kwanele ukuvula kanye nokususa i-cap futhi kunciphise ithonsi lokuqukethwe kusuka ngenalithi eyakhelwe ngaphakathi. Ukusetshenziswa kabusha kwe-syringe tube kungenzeka kuphela ngaphambi kokuthi kususwe kumjovo.
ILantus SoloStar
NjengaseLantus, eTujeo, into esebenzayo iyigilogar - i-analogue ye-insulin ekhiqizwa emzimbeni womuntu. I-glargine eyakhiwe yakhiqizwa ngendlela yokuphinda i-DNA yohlobo oluthile lwe-E. coli.
Umphumela we-hypoglycemic ubonakala ngokufana kanye nobude besikhathi, obutholakala ngenxa yendlela yokwenza ethile emzimbeni womuntu. Umuthi osebenzayo wesidakamizwa ungeniswa emathanjeni wamafutha abantu, ngaphansi kwesikhumba.
Ngenxa yalokhu, umjovo cishe awubuhlungu futhi kulula kakhulu ukuwenza.
Isixazululo se-acidic asifakwanga uhlangothi, kuholele ekwakhekeni kwama-micro-reagents akwazi ukukhipha kancane kancane into esebenzayo.
Ngenxa yalokhu, ukuhlushwa kwe-insulin kukhuphuka kahle, ngaphandle kweziqongo namaconsi abukhali, futhi isikhathi eside. Ukuqala kwesenzo kubonwa ngehora eli-1 ngemuva komjovo wamafutha angaphansi. Isenzo sihlala okungenani amahora angama-24 kusukela esikhathini sokuphatha.
Kwezinye izimo, kukhona ukunwetshwa kweTujeo kuya kuma-29 - 30 amahora. Ngaso leso sikhathi, ukwehla okungaguquki kwe-glucose kutholakala ngemuva kwemijovo emi-3-4, okungukuthi, kungakapheli izinsuku ezintathu kuqalile umuthi.
Tujo SoloStar
NjengokukaLantus, ingxenye ye-insulin iphulwe ngisho nangaphambi kokuba ingene egazini, izicubu ezinamafutha, ngaphansi kwethonya le-asidi eliqukethwe kulo. Ngenxa yalokhu, ngesikhathi sokuhlaziywa, idatha ingatholakala ekuqokeleleni okwenyuka kwemikhiqizo yokuqhekeka kwe-insulin egazini.
Umehluko omkhulu kusuka kuLantus ukugcotshwa kwe-insulin eyenziwe ngohlobo olulodwa lweTujeo. Ekulungiseleleni okusha, kuphakama kathathu futhi kufinyelela kuma-300 IU / ml. Ngenxa yalokhu, ukwehla okukhulu kwenombolo yansuku zonke yemijovo kutholakala.
Ngaphezu kwalokho, ngokusho kukaSanofi, ukwanda komthamo kwaba nomthelela omuhle "ekubusheni" kwesidakamizwa.
Ngenxa yokwanda kwesikhathi phakathi kwezokuphatha, ukwehla okukhulu kweziqongo zokukhishwa kwe-glargine kutholakale.
Lapho isetshenziswa kahle, i-hypoglycemia elinganiselayo ivame ukubonwa kuphela lapho isuka kwezinye izidakamizwa eziqukethe i-insulin iye kuTujo. Izinsuku ezingama-7-10 ngemuva kokuqala kokuthatha i-hypoglycemia iba yinto engandile kakhulu futhi eyethypical futhi kungakhombisa ukukhethwa okungalungile kwezikhathi zokusebenzisa umuthi.
Kuliqiniso, ukwanda okuphindwe kathathu kokuhlushwa kwenze umuthi wangakwazi ukusebenza ngezindlela eziningi. Uma uLantus engasetshenziselwa isifo sikashukela ezinganeni nasentsheni, khona-ke ukusetshenziswa kweTujeo kunqunyelwe. Umenzi utusa ukusebenzisa lesi sidakamizwa kuphela kusukela eminyakeni eyi-18.
Umthamo
Umkhiqizi uhlinzeke ngokunokwenzeka kwesinyathelo ngesinyathelo sokushintsha umthamo womuthi. I-pen-syringe ikuvumela ukuthi ushintshe inani le-inj injone kuma-unit of unit eyodwa. Umthamo uwumuntu ngamunye, futhi okulungile ungakhethwa kuphela ngokunamandla.
Ukushintsha umthamo esibayeni se-Lantus syringe
Okokuqala udinga ukusetha umthamo ofanayo owasetshenziswa ngenkathi kusetshenziswa umuthi wangaphambilini. Ngokwesifo sikashukela sohlobo 2, kuvame ukusuka kumayunithi ayishumi kuya kwayi-15. Kulokhu, kuyadingeka ukukala ushukela njalo ngedivayisi efakazelwe.
Okungenani izilinganiso ezine kufanele zenziwe ngosuku, ezimbili zazo ihora ngaphambi komjovo kanye nehora elilodwa ngemuva. Ezinsukwini ezintathu zokuqala noma ezinhlanu, ukwanda kancane kancane komthamo wezidakamizwa ngo-10-15% kungenzeka. Ngokuzayo, lapho umphumela wokuqongelela weTujeo uqala, umthamo wehla kancane kancane.
Kungcono ukungayinciphisi kakhulu, kepha ukuyinciphisa ngeyunithi elilodwa ngasikhathi - lokhu kuzonciphisa ubungozi begxuma kushukela. Ukusebenza kahle kakhulu kutholakala futhi ngenxa yokuntuleka komphumela wokulutha.
Ukusebenza kahle okuphezulu nokuphepha komuthi kuncike ekusetshenzisweni okufanele. Okokuqala, udinga ukukhetha isikhathi esifanele somjovo.
Umuthi kufanele unikezwe imizuzu engama-30 ngaphambi kokulala.
Ngakho-ke, umphumela ongabili uzotholakala. Ngakolunye uhlangothi, ukusebenza komzimba okuphansi ngesikhathi sokulala kusiza ukunciphisa amathuba okuncipha okubukhali kwe-glucose yegazi.
Ngakolunye uhlangothi, umphumela wesikhathi eside wezidakamizwa uzosiza ukunqoba lokho okubizwa ngokuthi "umphumela wokusa wokusa", lapho izinga le-glucose egazini landa kakhulu ngezikhathi zokusa, ekuseni kakhulu.
Uma usebenzisa iTujeo, kufanele ulandele izincomo eziphathelene nokudla. Kumele zenziwe ukuze isidlo sokugcina siqedwe amahora amahlanu ngaphambi kokuba isiguli silale.
Ngakho-ke, kungcono kakhulu ukuthi udle isidlo sasebusuku ngo-18-00, futhi ungadli ukudla ebusuku. Ucwaningo lukhombisa ukuthi ukukhethwa okuqondile kohlobo losuku nesikhathi somjovo kukuvumela ukuthi wenze umjovo owodwa kuphela womuthi ngamahora angamashumi amathathu nesithupha.
Yini engcono?
Ngokusho kweziguli ezishintshe imijovo kaTujeo namanye amalungiselelo e-insulin, kulula futhi kuphephile ukuyisebenzisa.
Umphumela omnene we-hormone, ukuthuthuka kwenhlala-kahle, kanye nokusebenziseka kalula kwe-injektha yokuphatha kuyaphawulwa.
Uma kuqhathaniswa neLantus, iTujeo inokuhluka okungatheni, kanye nokungatholakali kwemiphumela yokuncipha okukhulu kwamazinga kashukela. Ngasikhathi sinye, ezinye iziguli zaphawula isimo esande kakhulu ngemuva kokushintsha umuthi omusha.
Kunezizathu eziningana zokuwohloka:
- isikhathi sokulimala okungalungile;
- Ukukhetha imithamo engalungile;
- ukuphathwa okungalungile kwesidakamizwa.
Ngendlela efanele yokukhethwa komthamo, imiphumela emibi yokusebenzisa iTujeo empeleni ayenzeki.
Ngasikhathi sinye, kaningi ngenxa yedosi elikhethwe ngendlela engafanele, ushukela wesiguli uncishiswa ngokungadingekile.
Amavidiyo ahlobene
Yonke imininingwane odinga ukuyazi ngeLantus insulin kuvidiyo:
Ngakho-ke, ithuluzi linganconyelwa kubantu abanesifo sikashukela sohlobo 2, ikakhulukazi labo abadinga umphumela wokunxephezela obonakalayo ovela ku-hormone ephethwe. Ngokusho kocwaningo, ukungasebenzi kahle kwe-renal ne-hepatic akukhona ukwephulwa kokusetshenziswa kwalesi sidakamizwa.
Kuphephile ukuyisebenzisa lapho uguga. Ngaso leso sikhathi, ukusebenzisa iTujeo ebuntwaneni akunconywa - kulokhu, uLantus uzoba inketho enengqondo.
