I-Rinsulin R ne-Rinsulin NPH - imiyalo esetshenzisiwe

Ingxenye eyinhloko yokwelashwa kwesifo sikashukela ukulawula izinga likashukela osegazini lesiguli. Ukuguquguquka okubukhali kwalesi sikhombisi kuyizinkinga eziyingozi nezimpawu ezinzima.

Ukuvimbela, izidakamizwa eziqukethe i-insulin zivame ukusetshenziswa. Phakathi kwalokhu kunekhambi leRinsulin R. Iziguli kufanele zazi ukuthi zisebenza kanjani ukuze zilisebenzise ngendlela efanele.

Ukwakheka nefomu lokukhululwa

Umuthi ubhekisela emithini ethengiswa ngumbhalo, ngoba ukusetshenziswa kwayo ngokungalawulwa kungalimaza umzimba.

Kuyisixazululo somjovo, isakhi esiyinhloko saso i-insulin yabantu, eyenziwe yahlangana kusetshenziswa ubuchwepheshe be-DNA esebenza kabusha.

Izithako ezisizayo zomuthi yilezi:

• glycerol;
• metacresol;
• amanzi.

Ukukhishwa kweRinsulin kwenziwa eRussia. Isixazululo sisobala futhi asinawo umbala. Ibekwe emabhodleleni engilazi we-10 ml.

Izici ze-Pharmacological

Umuthi ubonakala ngomphumela we-hypoglycemic. Ukwehla kweglucose yegazi kunikezwa ngumthelela wengxenye eyinhloko. I-insulin, engena emzimbeni wesiguli, yenza kusebenze inqubo yokuthathwa koshukela nokusatshalaliswa kwawo kumaseli. I-Rinsulin futhi yehlisa inani lokukhiqizwa ushukela isibindi.

Leli thuluzi linobude besikhathi sokusebenza. Kuqala ukuthinta umzimba isigamu sehora ngemuva komjovo. Isebenza kakhulu phakathi kwamahora ama-1-3 ngemuva kokusetshenziswa. Ithonya layo liphela ngemuva kwamahora angu-8.

Ukusebenza nobude besikhathi sokuchayeka eRinsulin kuya ngomthamo nendlela yokuphatha. Ukususa le nto emzimbeni yenziwa izinso.

Imiyalo yokusebenzisa

Kunconywa ukusebenzisa ikhambi lohlobo 1 lwesifo sikashukela uma kungeke kwenzeke ngokwejwayelekile izinga leshukela ngemithi yokuqondisa ngomlomo. I-Rinsulin ingumjovo ongenziwa nge-intramuscularly, subcutaneous and intravenous. Indlela efanelekile yesicelo inqunywa ngawodwana.

Umthamo wesidakamizwa ubalwa ngokususelwa ezimfanelweni zesithombe sasemtholampilo. Imvamisa, i-0.5-1 IU / kg yesisindo sesineke kufanele ihanjiswe ngosuku.

Umuthi uvunyelwe ukusetshenziswa ndawonye nezinye izidakamizwa ze-hypoglycemic, uma kunesidingo.

Ezimweni eziningi, i-rinsulin ilawulwa ngokungaziphathi. Imijovo kufanele inikezwe ethangeni, ehlombe, noma odongeni lwesisu sangaphakathi. Kubalulekile ukuthi kuguqulwe amasayithi womjovo, ngaphandle kwalokho kungaqhamuka izindebe zomlomo.

Ukuphathwa kwe-Intramuscular kwenziwa kuphela enconyelweni kadokotela. Ngobumfihlo, lo muthi ungabanjiswa ngumhlinzeki wezempilo kuphela. Lokhu kwenziwa ngezimo eziyinkimbinkimbi.

Isifundo sevidiyo ngokwazisa kwe-insulin sisebenzisa ipeni yesirinji:

Ukuphendula okungafani

Ukuthatha noma yimuphi umuthi kungadala ukusabela okungekuhle. Ukwazi ubunzima obungahle bubangelwe yi-Rinsulin, udinga ukutadisha imiyalo kanye nokubuyekezwa kwizithangami ezivela kwiziguli.

Ngokuvamile ngokusetshenziswa kwaso, ukwephulwa okulandelayo kwenzeka:

• isimo se-hypoglycemic (ihambisana nezimpawu eziningi ezimbi, ezibandakanya isiyezi, ubuthakathaka, isicanucanu, i-tachycardia, ukudideka, njll.);
• i-allergy (ukuqubuka kwesikhumba, ukushaqeka kwe-anaphylactic, i-edema kaQuincke);
• ukungaboni kahle
• ubomvu besikhumba;
• ukulunywa

Imvamisa, imiphumela emibi yenzeka lapho usebenzisa umuthi yize kungabekezeleleki ukwakheka kwawo. Ukuqeda i-phenomena engemihle, udinga ukuxhumana nochwepheshe. Eminye imiphumela emibi ihamba ngemuva kokuyeka ukuyithatha; eminye idinga ukwelashwa okubonakalayo.

Kwesinye isikhathi ukubonakaliswa kwe-pathological kubangela ukonakala okukhulu enhlalakahleni yesiguli, bese idinga ukwelashwa okukhulu esibhedlela.

Ukusebenzelana kwezidakamizwa

I-Rinsulin kwesinye isikhathi isetshenziswa ekwelapheni okuyinkimbinkimbi, kepha kufanele ihlelwe kahle. Kunamaqembu ezidakamizwa ngenxa yokuthi ukuzwela komzimba ku-insulin kuthuthukiswa noma buthakathaka. Kulezi zimo, kuyadingeka ukulungisa umthamo wemithi.

Kufanele ukunciphisa ingxenye yeRinsulin ngenkathi uyisebenzisa ngezindlela ezilandelayo:

• izidakamizwa ze-hypoglycemic;
• ama-salicylates;
• ama-beta-blockers;
• I-MAO ne-ACE inhibitors;
• ama-tetracyclines;
• ama-antifungal agents.

Ukusebenza kweRinsulin kwehla uma kusetshenziswa kanye nezidakamizwa ezinjengokuthi:

• okokugcobisa;
• antidepressants;
• izidakamizwa ze-hormonal.

Uma kunesidingo sokusetshenziswa kanyekanye kweRinsulin nale mishanguzo, imithamo kufanele inyuswe.

Musa ukulungisa ngokunganqikazi i-schedule yokwelashwa. Uma ingxenye enkulu kakhulu ye-insulin ingena emzimbeni, kungavela i-overdose, isibonakaliso esiyinhloko saso yi-hypoglycemia. Uma usebenzisa isilinganiso esincane kakhulu somuthi, ukwelashwa kuzoba kungasebenzi.

Imiyalo ekhethekile

Izindlela ezikhethekile zokuphuza imithi zivame ukuhlinzekelwa izingane, abesifazane abakhulelwe nabadala.

Ukwelashwa ngeRinsulin kusho ukuthobela imithetho elandelayo:

1. Abesifazane abakhulelwe. Asikho isidingo sokushintsha umthamo womuthi, ngoba isakhi sawo esisebenzayo asithinti inkambo yokukhulelwa. Kepha ngasikhathi sinye, kuyadingeka ukulawula izinga likashukela wegazi lowesifazane, ngoba le nkomba ingashintsha lapho ingane izalwa.
2. Omama abahlengikazi. I-insulin ayidluleli kubisi lwebele futhi, ngenxa yalokho, ayithinti ingane. Ngakho-ke, awudingi ukushintsha umthamo. Kepha owesifazana kumele aqaphele indlela adla ngayo, alandele izincomo.
3. Abantu abadala. Ngenxa yezinguquko ezihlobene nobudala, umzimba wazo ungahle uthinteke kakhulu emiphumeleni yomuthi. Lokhu kudinga ukuhlolwa ngokuphelele kwesiguli nokubalwa kwemithamo ngaphambi kokuqokwa kweRinsulin.
4. Izingane. Baphinde bavunyelwe ukwelashwa ngalesi sidakamizwa, kepha ngaphansi kokuqashwa kukachwepheshe. Umthamo unqunywe ngokuhlukile.

Kuhlinzekwa nemiyalo ekhethekile yeziguli ezihlushwa i-pathologies yesibindi nezinso. Umuthi uthinta isibindi, futhi izinso ziyabandakanyeka ekususeni umuthi emzimbeni. Uma kunezinkinga ngalezi zitho zomzimba, umthamo we-Rinsulin kufanele uncishiswe ukuze ungavuseleli i-hypoglycemia.

Ama-Analog

Uma kukhona ukungabekezeleli le ejenti esigulini, kuyadingeka ukuyibuyisela kwenye. Udokotela uzokusiza ukuyikhetha.

Imvamisa, kubekwa okunye esikhundleni:

1. I-Actrapid. Isisekelo somuthi insulin yomuntu. Kutholakala ngesimo sesixazululo somjovo, owenziwa ngaphakathi nangokuziqhenya.
2. IGensulin. Umuthi ungaba wezinhlobo ezimbili: I-Gensulin N (isixazululo somjovo osebenza isikhathi eside) neGensulin M30 (ukumiswa kwezigaba ezimbili). Yikhiphe emabhodleleni engilazi emabhokisini.
3. I-Protafan. Isisekelo saleli thuluzi yi-insulin isophan. I-Protafan itholakala ngesimo sokumiswa, esibonakaliswa yisikhathi sobude besenzo.
4. Sizokwenza. Lo muthi unesenzo esifushane. IVozulim ikhona ngendlela yesisombululo somjovo, isakhi esiyinhloko saso i-insulin yabantu.
5. Biosulin. Ikhona ngendlela yokumiswa nesixazululo. Umuthi uhlinzeka ukufakwa kweglucose okusebenzayo emzimbeni, okusiza ukunciphisa inani layo egazini.
6. IGansulin. Kwenziwa njengokumiswa lapho into esebenzayo i-insulin isophan. Uma uyisebenzisa, kufanele ulandele imiyalo futhi unake ukuphikiswa okungenzeka kube khona.
7. Humulin. Umuthi lo usesekelwa ku-insulin yomuntu futhi ubukeka sengathi umisiwe. Imijovo nalesi sidakamizwa isiza ukuguquguqula amazinga kashukela. Kwenqatshelwe ukuyisebenzisa nge-hypoglycemia nokungabekezeleli izingxenye.
8. Rosinsulin. Leli thuluzi lithengiswa njengesisombululo somjovo. Ibekwe kuma-cartridge we-3 ml. Isithako sayo esiyinhloko i-insulin yabantu.
9. I-Insuran. Umuthi ukumiswa osetshenziselwa ukusetshenziswa subcutaneous. Ihluka ngokwesilinganiso sesikhathi sesenzo. Idalwe ngu-Insuran ngokususelwa ku-isophan insulin.

Le mishanguzo iboniswa ngomphumela ofanayo, kepha ibe nokuhluka okuthile okufanele kucatshangwe. Udinga nokwazi ukuthi ungashintsha kanjani ngokunembile kusuka kwesinye isidakamizwa usiya kwesinye.

I-Rinsulin NPH

Lesi sidakamizwa sifana kakhulu neRinsulin R. Ine-isofan insulin. Umuthi unesikhathi esiphakathi sokusebenza futhi umisiwe wokujovwa.

Kusetshenziswa kuphela ngokunqenqemana, okusiza ukwenza ipeni lesirinji leRinsulin NPH.

Kuyadingeka ukwethula umuthi odongeni lwesisu, ethangeni noma ehlombe. Ukuze izinto zokwelapha zithakwe ngokushesha, imijovo kufanele yenziwe ezingxenyeni ezihlukene zomzimba ngaphakathi kwendawo echaziwe.

Izingxenye ezilandelayo ezisizayo nazo ziyingxenye yeRinsulin NPH:

• phenol;
• glycerin;
• protamine sulfate;
• sodium hydrogen phosphate;
• metacresol;
• amanzi.

Lesi sidakamizwa sikhishwa emabhodleleni engilazi ayi-10 ml. Ukumiswa kumhlophe; phezu kokudlubulundela, kuyindlela efinyelela kuyo.

Lesi sidakamizwa sisebenza cishe ngendlela efanayo neRinsulin R. Sigqugquzela ukusetshenziswa okusheshayo kweshukela ngama-cell futhi sinciphise ukukhiqizwa kwawo yisibindi. Umehluko ulele esikhathini eside sethonya - ungafinyelela amahora angama-24.

Intengo yeRinsulin NPH iguquguquka cishe kuma-ruble ayi-1100.

Ungathola ukuthi umuthi usebenza kangakanani ngokuhlola ukubuyekezwa kweziguli ngeRinsulin P ne-NPH. Zihlukahlukene kakhulu. Iningi leziguli lisabela kahle kule mishanguzo, kepha kukhona labo obekuphathwa ngale ndlela kungafanele. Ukwaneliseka kubangelwa imiphumela emibi engavusa izidakamizwa eziqukethe i-insulin.

Imvamisa, ubunzima beba khona kubantu abanesifo sikashukela abangazange balandele imiyalo noma kulabo abanomzimba ozwela izakhi. Lokhu kusho ukuthi ukusebenza komuthi kuncike ezimeni eziningi kakhulu.