I-Yanumet ekwehlisa ushukela - imiyalo esetshenzisiwe

Phakathi kwezidakamizwa ezisetshenziswa ekwelapheni isifo sikashukela i-mellitus, singasho ikhambi laseYanumet.

Imvamisa inikezwa abanesifo sikashukela, futhi kubalulekile ukwazi ukuthi lo muthi umangalisa kangakanani nokuthi uwusebenzisa kanjani. Ku-radar, leli thuluzi lihlukaniswa ngokuthi i-hypoglycemic. Ukukhishwa kwayo kusungulwa eNetherlands.

I-Yanumet umuthi onikezwa kadokotela, ngoba ukuqokwa kukadokotela kuyadingeka ukuthatha. Ngaphandle kwalo, akufanele usebenzise leli thuluzi ukuze izinkinga zingaveli. Uma unikezwa incwadi kadokotela, kufanele ulandele imiyalo, ngoba kukhona izingozi ezinkulu zemiphumela emibi.

Ukwakheka, ifomu lokukhulula

Umuthi uthengiswa ezibhebheni ezihlanganisiwe. Kususelwa ezicini ezi-2 ezisebenzayo, ngenxa yalokho umphumela utholakala - iMetformin neSitagliptin

Ukungezelela ukusebenza ngempumelelo kwalo muthi, izinto ezingezekile ezilandelayo zengezwe ekwakhiweni:

• i-talc;
• i-macrogol;
• i-microcrystalline cellulose;
• i-sodium stearyl fumarate;
• i-povidone;
• titanium dioxide;
• i-sodium lauryl sulfate;
• utshwala be-polyvinyl.

Amacwecwe e-Yanumet anezinhlobo ezintathu, ngokuya ngokuqukethwe kweMetformin (500, 850 ne-1000 mg).

I-Sitagliptin kuyo yonke iqukethe inani elifanayo - 50 mg. Umbala wamathebhulethi ungaba opinki okhanyayo, opinki nabomvu.

Umuthi ufakwa emabhulashini ngama-14 ama-pcs. Amaphakethe angaqukatha inombolo ehlukile yamabhuloki.

Ividiyo ephathelene nezakhiwo zeMetformin:

I-Pharmacology ne-pharmacokinetics

Ithuluzi linomphumela obizwa ngokuthi yi-hypoglycemic, otholakala ngenxa yokuxhumana kwezinto ezimbili ezisebenzayo. Ngenxa ye-sitagliptin, isilinganiso sokukhiqizwa kwe-insulin ngamaseli e-beta wamanyikwe. Futhi, le nto inciphisa ukuvela kweglucose esibindini.

Ngenxa yeMetformin, amandla okuthola umzimba we-insulin ayathuthuka futhi inqubo yokufaka ushukela emgodini wokugaya ukudla iba buthaka. Lokhu kunikeza umphumela oyinkimbinkimbi emzimbeni ngenxa yokuthi izinga le-glucose lijwayelekile. Ngasikhathi sinye, iYanumet ayibangeli i-hypoglycemia (ngaphandle kwamacala lapho umuntu onesifo sikashukela esenezifo ezihlangana nazo ezihlanekezela umphumela womuthi).

I-Sitagliptin

Ukufakwa kwe-sitagliptin kwenzeka ngokushesha okukhulu. Inani eliphakeme lale nto (namandla amakhulu) libonwa esikhathini samahora ama-1-4 ngemuva kokuthatha umuthi.

Inani kuphela elingasho lutho elingena ekuxhumaneni namaprotheni e-plasma.

Ingxenye empeleni ayakhi ama-metabolites futhi icishe ikhishwe ezinsweni ngendlela yoqobo lwayo. Konke okunye kuyasuswa ngamalongwe.

Ukufakwa kweMetformin kubuye kuboniswe ngejubane elisheshayo. Umphumela wayo ufinyelela inani lawo eliphezulu ngemuva kwamahora ama-2. Kucishe kungakhethi izibopho ngamaprotheni e-plasma. Ukwembiwa kwale ngxenye kwenziwa izinso.

Izinkomba kanye ne-contraindication

Ukusetshenziswa kwesidakamizwa kuvunyelwe kuphela ngokuxilongwa okufanele. Uma lungekho, ikhambi lizolimaza umuntu kuphela. Ngakho-ke, kubalulekile ukuthi uYanumet aqoke uchwepheshe. Lokhu kwenzelwa isifo sikashukela sohlobo 2.

Ukwelashwa nalo kwenziwa ngezindlela eziningi. Kwesinye isikhathi kusetshenziswa lesi sidakamizwa kuphela (kuhlangene nokudla). Kungenzeka futhi ukusebenzisa lezi zibhebhe neminye imithi (ngokwesibonelo, nge-insulin noma i-sulfonylurea derivatives). Ukukhetha kungenxa yesithombe salesi sifo.

Ngaphandle kokuqokwa ngudokotela, lesi sidakamizwa asivunyelwe ukusetshenziswa ngenxa ye-contraindication. Ukuba khona kwabo kungaholela ekwandeni kwezinkinga ezikhona.

Contraindication ifaka:

• ukungabekezeleli izithako;
• isifo sezinso esinzima;
• ukwephulwa okunzima esibindini;
• izifo ezithathelwanayo;
• utshwala noma ubuthi obunobuthi;
• ketoacidosis;
• Uhlobo 1 sikashukela;
• infarction myocardial;
• ukwehluleka kwenhliziyo;
• ukukhulelwa
• ukondla kwemvelo.

Lezi zimo zidinga ukuthi kushiywe ukusetshenziswa kweYanumet, ngaphandle kokuba khona kokuxilongwa okufanele. Udokotela kumele akhethe enye indlela yokwelashwa ukuze angabeki impilo yakhe engozini.

Imiyalo yokusebenzisa

Ukuze umuthi ungalimazi isiguli, ukulandela imiyalo kuyadingeka. Kungcono ukuthola ngemithetho yokwamukelwa nodokotela, ngoba ishedyuli nemithamo ingahluka ngokuya ngezimpawu zesifo.

Uchwepheshe kufanele ahlole isiguli bese ethola isilinganiso somuthi osifanele yena.

Kuyinto efiselekayo ngisho nokuyinciphisa kancane ekuqaleni kwezokwelapha. Ngakho-ke umzimba uzokwazi ukuzivumelanisa nokwamukelwa kwemali. Ngokuzayo, umthamo ungandiswa uma imiphumela yokuhlolwa kwegazi ikhombisa isidingo salokhu.

Kufanele ubheke inani le-sitagliptin. Umthamo ophelele ovunyelwe wale nto ungama-100 mg ngosuku. Umthamo weMetformin ungahluka. Umuthi uphuzwa kabili ngosuku ngokudla. Gaya amaphilisi awadingi.

Iziguli ezikhethekile

Contraindication akusona ukuphela kwesizathu ngoba ngasiphi isidingo sokuqapha lapho uphatha umuthi. Izindlela ezikhethekile zinikezwa iziguli ngazinye, ngoba laba bantu bangabonakala ngokuzwela okwengeziwe emiphumeleni yezakhi.

Lokhu kufaka phakathi:

1. Abesifazane abakhulelwe. Kubo, ukuthatha iYanumet kuyinto engathandeki, ngoba akwaziwa ukuthi leli khambi lizothinta kanjani inkambo yokukhulelwa nokukhula kwengane. Noma kunjalo, uma kunesidingo esiphuthumayo sokwelashwa ngalo muthi, udokotela angawunikeza.
2. Omama abahlengikazi. Umphumela wezinto ezisebenzayo kwikhwalithi yobisi awucwaningwanga. Kulokhu, ngesikhathi sokuqunjelwa, umuntu kufanele anqabe ukusithatha ukuze avikele ukulimala enganeni. Uma ukwelashwa ngeYanumet kusadingeka, phazamisa ukuncelisa ibele.
3. Abantu abadala. Bangathola ukuphazamiseka okuhlukahlukene ekusebenzeni komzimba ngenxa yezinguquko ezihlobene nobudala. Ngaphezu kwalokho, uma iminyaka yobudala isiguli ikhuphuka, amathuba okuphulwa okunjalo kuyanda. Ngenxa yalokhu, kungaba nzima ukuwuqamba futhi uwususe umuthi emzimbeni. Ngakho-ke, ezigulini ezinjalo, kubalulekile ukukhetha ngokucophelela umthamo. Futhi, kufanele bahlolwe isibindi nezinso cishe kanye ezinyangeni eziyisithupha ukuze kukhonjwe izinkinga kule ndawo.
4. Izingane nentsha. Ngenxa yokuntuleka kwe-stamina yomzimba walezi ziguli, uJanumet angazithinta engalindele. Odokotela bagwema ukwelashwa nalesi sidakamizwa okwamanje, bakhetha ezinye izidakamizwa.

Uma isifo sikashukela sitholakala kubamele lawa maqembu, ochwepheshe kufanele bathathe izinyathelo zokuqapha bese belandela imiyalo.

Imiyalo ekhethekile

Ukuba khona kwezifo ezikhona futhi kuyisikhathi sokuhlolwa ngokuphelele ngaphambi kokuqokwa kweYanumet.

Lokhu kuyiqiniso ikakhulukazi kulezi zimo ezilandelayo:

1. Isifo sezinso. Ngokuphulwa okuncane emsebenzini walo mzimba, ukwelashwa kuvunyelwe. Isimo esilinganiselwe noma esinzima sisho ukulahlwa kokusetshenziswa kwaso, ngoba ngenxa yazo, ukuqedwa kwezinto ezisebenzayo emzimbeni kuzokwehla, okungabangela i-hypoglycemia.
2. Ukuphambuka ekusebenzeni kwesibindi. Lesi sidakamizwa sinomphumela esibindini. Uma kunezinkinga ngalesi sitho, lokhu kungakhuphuka, okuzoholela ezinkingeni. Ngakho-ke, kwenqatshelwe ukuthatha iYanumet kuleli cala.

Ithuluzi alinawo amandla okuthonya ijubane lokuphendula nokunaka, ngakho-ke ukushayela nomsebenzi odinga ukugxilwa akunqatshelwe. Kepha uma usebenzisa umuthi uhlangana namanye ama-ejenti, kungaqhamuka isimo se-hypoglycemic, ngenxa yokuthi yiziphi izinkinga ezingavela kule ndawo.

Imiphumela emibi kanye ne-overdose

Ukusetshenziswa kwalo muthi kungaholela ekwakhiweni kwemiphumela emibi.

Phakathi kwazo kukhona:

• ukukhwehlela
• ikhanda
• Ubuhlungu besisu
• isicanucanu
• ukozela
• ukuphazamiseka kwamapheshana emathunjini;
• i-pancreatitis

Lokhu akwenzeki njalo, futhi ukwenzeka kwabo kaningi akubonwa njengeyingozi. Imvamisa lezi zibonakaliso ziqedwa ngokwazo ngemuva kwesikhathi esithile. Lokhu kungenxa yokuvumelana nomzimba nokwelashwa. Kepha ngamandla amakhulu wezinto ezifakiwe, kunconywa ukuthi ungene esikhundleni seYanumet ngenye indlela.

Uma kwenzeka kweqisa ngokweqile, izehlakalo ezifanayo zenzeka ezihlobene nemiphumela emibi, kuphela eziphinyiselwe ngokwengeziwe. Zingaqedwa ngokususa izinsalela zomuthi emzimbeni kanye ne-hemodialysis. Ukwelashwa okusekelayo nakho kungadingeka.

Ukusebenzisana kwezidakamizwa kanye nama-analog

Izifo ezihlangana zidinga ukulungiswa kwecebo lokwelashwa elikhethiwe. Uma zitholakala, kuyadingeka ukubhekana nama-pathologies amaningana ngasikhathi sinye, ngokulandelana, kunesidingo sokuhlanganiswa kwemithi ehlukile.

Ucwaningo olunemininingwane ngemiphumela yeYanumet kwezinye izidakamizwa alukenziwa. Kepha kuyaziwa ukuthi kungashintsha umphumela wezidakamizwa ezithile uma zisetshenziswa ndawonye.

Phakathi kwazo kukhona:

• Furosemide;
• INifedipine;
• I-Digoxin;
• I-cyclosporin;
• UJanuvius.

Uma kunesidingo sokusetshenziswa kwenhlanganisela enjalo, udinga ukukhetha ngokucophelela imithamo futhi ubheke inkambo yokwelashwa.

Lesi sidakamizwa sithathwa njengesebenzayo ekwelapheni isifo sikashukela, kodwa asifanelekile kuzo zonke iziguli. Ngenxa yalokhu, kuba nesidingo sokukhetha imali enesenzo esifanayo.

Phakathi kokufana kweYanumet etholakala endaweni yaseRussia yilezi:

• IVelmetia;
• I-Tripride;
• I-Glibomet;
• Avandamet;
• I-Douglimax, njll.

Ukukhethwa kwama-analogues kufanele kunikezwe kudokotela, ngoba ukuguqulwa kusuka kwesinye umuthi kuye kwesinye kufanele kwenziwe ngokwemithetho. Ngaphezu kwalokho, izidakamizwa ezifakwe kuhlu zinokuphikisana, ukubhaliswa kokuphoqelekile.

Umbono wodokotela neziguli

Imibono yezazi ngeYanumet yehlukile kakhulu - akubona bonke odokotela ababeka umuthi ngenxa yemiphumela yayo emisha, iziguli nazo ziphenduka ngendlela eyehlukile - othile wasiza umuthi, futhi othile wahlushwa imiphumela emibi. Intengo ephezulu yomuthi nayo iyabonakala.

Nginikeza umuthi uJanumet ezigulini kaningi. Inomphumela omuhle ezimweni ezingavamile zemiphumela emibi. Kepha ngaphambi kokunquma umuthi, kuyadingeka ukuthi uhlole isiguli ukuze uqiniseke ukuthi akukho okuphikiswa, uma kungenjalo isiguli siba sibi.

UMaxim Leonidovich, udokotela wobuchopho

Kumkhuba wami, iYanumet akulona ikhambi elidumile. Ukusebenza kwayo kuncike ekutheni isilungele kanjani isiguli. Uma kukhona ama-contraindication, kuyingozi ukuwunikeza. Ngaphezu kwalokho, ayifanele wonke amacala. Ngakho-ke, kufanele ngiyincome njalo - imvamisa iziguli zidinga eminye imithi. Kwesinye isikhathi iziguli ziyenqaba ngenxa yezindleko eziphakeme. Yize iningi labalingani bami lisabela kahle kulesi sidakamizwa.

UTamara Alexandrovna, udokotela wobuchopho

Ubaba uthatha iYanumet, futhi lokhu akwenza unyaka nonyaka. Akanazikhalazo, izinga likashukela lihlala lijwayelekile, izinkinga zivela kuphela ngokuphulwa kokudla.

UMarina, oneminyaka engama-32

Umuthi ubiza kakhulu, kodwa ufanelekile. Kwatholakala ukuthi nginesifo sikashukela eminyakeni engu-5 eyedlule, ngakho ngazama izidakamizwa eziningi. Abanye kuphela abasizanga, kanti abanye baholele emiphumeleni emisha engapheli. I-Yanumet yisidakamizwa sokuqala esingadalanga ukusabela okungesihle noshukela olujwayelekile.

UPavel, oneminyaka engama-49 ubudala

Angikwazi ukubiza uYanumet ikhambi elilungile - akazange angisize. Ekuqaleni ushukela awuzange unciphe, khona-ke ngokuzumayo wehla kakhulu - udokotela waze wacabanga ukuthi senginyuse umthamo. Kwaphela amasonto ambalwa ngiyithatha, futhi izinkomba zazijwayelekile, kepha ngangihlushwa ikhanda, ngaqala ukulala kabi, futhi ngihlala ngomile. Bese futhi, ukwehla okubukhali ngaphandle kwezinguquko zemthamo. Izinkinga ezithile, ngakho ngacela udokotela ukuthi akushintshele kokunye futhi kushibhile.

U-Elena, oneminyaka engama-42

Izindleko zomuthi ziyinto ebaluleke kakhulu ethinta ukukhetha kwendlela yokwelashwa. I-Yanumet iphakathi kwezidakamizwa ezinezindleko eziphakeme - akuzona zonke iziguli ezingakwazi ukuzisebenzisa. Intengo yomuthi ingahluka ngokuya ngomthamo nenani lamathebulethi amaphakethe.

Kumathebhulethi angama-56 anokuqukethwe kweMetformin 1000 mg, udinga ukusebenzisa ama-ruble angama-2800-3000. Inani elifanayo lezingcezu kumthamo wama-500 noma ama-850 mg abiza ama-ruble angama-2700-2900.