Izinkomba zokusetshenziswa nemiyalo yokusebenzisa umuthi iFomuetin

Isifo sikashukela asisona isifo esingajwayelekile. Minyaka yonke isibalo sabantu abahlushwa yilezi zifo siyakhula.

Ukubuyisa i-glycemia kokujwayelekile, ezinye iziguli kufanele zisebenzise imishanguzo eyehlisa ushukela impilo noma i-insulin.

Phakathi kwezinhlobonhlobo zamalungiselelo ekhemisi, iziguli eziningi zithanda umuthi onjenge- "Fommetin".

Imininingwane ejwayelekile, ukwakheka kanye nendlela yokukhululwa

IFomin (bona isithombe) isidakamizwa i-hypoglycemic. Umuthi uyingxenye yeqembu le-Biguanide, ngakho-ke isetshenziswa ekwelapheni isifo sikashukela sohlobo 2.

Njengawo wonke amalungiselelo eqembu le-Biguanide, "iFommetin" inesakhi esisebenzayo - Metformin hydrochloride. Inani layo lingaba ngu-0.5, 0,85 noma 1 g.

Izingxenye ezisizayo:

• i-croscarmellose sodium;
• i-magnesium stearate esetshenziswe embonini yezemithi;
• isisindo somzimba wamaphakathi povidone (polyvinylpyrrolidone).

Umuthi uyatholakala ezibhebheni, uhlobo lwazo oluncike kumthamo:

• nxazonke i-0.5 g;
• i-oval biconvex (0.85 ne-1 g).

Amathebulethi athengiswa emaphepheni amakhadibhodi, ngalinye lawo lingaba izingcezu ezingama-30, 60 noma eziyi-100.

I-Pharmacology ne-pharmacokinetics

Umuthi "iFomu" uthinta umzimba ngale ndlela elandelayo:

• kubambezela inqubo ye-gluconeogenesis esibindini;
• kwehlisa inani loshukela oludonswe amathumbu;
• kusiza ukuthuthukisa ukusetshenziswa kwe-glucose egazini;
• kuholela ekwandeni kokuzwela kwezicubu kwe-insulin;
• akuholeli ekwakhiweni kwe-hypoglycemia;
• lowers triglycerides ne-LDL;
• Kwejwayelekile noma kunciphisa isisindo;
• isiza ukuncibilikisa ukuchitheka kwegazi.

Isenzo se-pharmacological sibonakaliswa yizici zokufaka, ukusatshalaliswa kanye nokuphuma kwezimpawu eziphambili.

1. Ukuhlelwa. Ingxenye esebenzayo yesidakamizwa idonswa izindonga zephephisi lesisu ngemuva kokuthatha iphilisi. Ukuqalwa kwe-bioavailability yomthamo ojwayelekile kusuka ku-50% kuya ku-60%. Iqoqo eliphezulu lomuthi lisethwe amahora angama-2,5 ngemuva kokuphathwa.
2. Ukusatshalaliswa. Izakhi zomuthi empeleni azenzi ukuxhumana ngamaprotheni e-plasma.
3. Ukuzala. Ukuchithwa kwezingxenye zesidakamizwa kwenziwa ngokungashintshiwe. Izakhi zifakwe kumchamo. Isikhathi esidingekayo sehafu yempilo yesidakamizwa sisuka emahoreni ayi-1.5 siye kwayi-4,5.

Esimweni lapho izingxenye zomuthi ziqongelela emzimbeni, udinga ukwazi ukuthi zingavela kuphi. Imvamisa, isizathu silele ekusebenzeni kokulimala kwezinso.

Izinkomba kanye ne-contraindication

Ukwelashwa kwezidakamizwa kuyadingeka ezimweni ezilandelayo:

• ngesisindo ngokweqile noma ukukhuluphala, lapho ukudlela ukudla kungaphumelelanga;
• ngohlobo lwesibili sikashukela.

"IFomula" akufanele isetshenziselwe kuphela ukunciphisa isisindo, yize iqiniso lokuthi umuthi unomthelela ekulahlekelweni kwalo. Ukuphuza amaphilisi kusebenza ngokuhambisana nokwelashwa kwe-insulin ezigulini ezinokukhuluphala obukhulu, okuhambisana nokungahambisani nokuqina kwe-hormone.

Amacala lapho uthatha umuthi u-contraindified:

• ketoacidosis;
• i-coma noma i-precoma ngenxa yesifo sikashukela;
• ushintsho lwe-pathological ezinso nasezibindini;
• izimo eziholela ekuthuthukisweni kwe-lactic acidosis, kufaka phakathi ukwehluleka kwenhliziyo, ushintsho ekugelezeni kwegazi lokubeletha, isigaba esibuhlungu sokuqunjelwa kwe-myocardial, ukudakwa okungapheli, ukuphuma komzimba;
• ubuthi obunobungozi obukhulu;
• inkambo enzima yezifo ezithathelwanayo;
• ukungenelela kokuhlinzwa;
• ukulimala
• I-x-ray, efaka ukwethulwa kwama-ejenti akhethekile wokuhlukanisa (izinsuku ezi-2 ngaphambi nangemva kwalokho);
• ukunamathela ekudleni okuvumela ukuba khona ekudleni kwansuku zonke kwama-kilojoule ayi-1000;
• ukuncelisa ibele, kanye nokuqala kokukhulelwa;
• hypersensitivity kuzakhi zomuthi.

Imiyalo yokusebenzisa

Ukukhetha umthamo kufanele kwenziwe kuphela ngudokotela onaka zonke izici zesiguli kanye nesifo sikashukela. Imiyalo ikhombisa umthamo onconyiwe ekuqaleni kokusebenzisa. Kungaba kusuka ku-500 kuye ku-1000 mg ngosuku.

Ukulungiswa komthamo ojwayelekile akufanele kwenziwe kungakapheli izinsuku eziyi-15 ngemuva kwephilisi yokuqala. Ngaphezu kwalokho, kufanele kukhethwe ngokuya ngokulawulwa kwe-glycemic. Umthamo wansuku zonke awunakuba ngaphezulu kuka-3000 mg. Ezimweni eziningi, ukwelashwa kokulungiswa kudinga ukuthatha i-1500-2000 mg / ngosuku. Iziguli esezikhulile akufanele zidle ngaphezu kwe-1 g yesithako esisebenzayo.

Amathebulethi kufanele adakwe ngemuva kokudla. Umthamo obekwe udokotela unconywa ukuthi uhlukaniswe ngokulinganayo, uphuze umuthi kabili ngosuku. Lokhu kuzovikela ukwenzeka kwemiphumela emibi maqondana nokugaya.

Ividiyo evela kuDkt Malysheva mayelana neMetformin nemithi esekelwe kuyo:

Iziguli ezikhethekile

Isidakamizwa sinconyelwe ukuthi sisetshenziswe hhayi kuzo zonke iziguli.

Imikhakha elandelayo yeziguli ifakiwe eqenjini elikhethekile:

1. Omama abakhulelwe futhi ababelethayo. Uvivinyo luye lwabonisa ukuthi izingxenye zomuthi ziyakwazi ukuba nomthelela ongemuhle ezinganeni zombili esibelethweni nangemva kokuzalwa.
2. Iziguli ezinesifo sesibindi. Bahlanganiswe ne-contraindicated ekwelashweni kwezidakamizwa.
3. Iziguli ezinenkinga yezinso umsebenzi. Ngokushintshwa okukhulu kwe-pathological, ukusetshenziswa kwe-ejenti yemithi akuvunyelwe. Kwezinye izimo, ukwelashwa ngalesi sidakamizwa kungenzeka, kodwa ngaphansi kokuqashwa okujwayelekile kokusebenza kwesitho.
4. Iziguli esezikhulile. Kukhona ubungozi be-lactic acidosis kubantu abangaphezu kweminyaka engama-60 abahlala bezisebenza kanzima.

Imiyalo ekhethekile

Ukwelapha ngomuthi kunezici ezithile:

1. Iziguli nakanjani kufanele ziqaphe umsebenzi wezinso. Imvamisa yokuqapha okunjalo yenzeka izikhathi ezi-2 ngonyaka. Lokhu kungenxa yokuthi izingxenye ze- "Formethine" zinganqwabelana ngaphakathi emzimbeni uma kwenzeka zephulwa ekusebenzeni kwalesi sitho.
2. Uma i-myalgia yenzeka, kunconywa ukuhlola izinga le-plasma lactate.
3. Ukusetshenziswa kwe- "Fomula" kuhlangene ne-sulfonylurea derivatives kudinga ukulawulwa kwe-glycemic.
4. Ingozi ye-hypoglycemia iyanda lapho la macwecwe esetshenziswa neminye imithi enganciphisa amazinga kashukela. Lesi simo siyingozi kakhulu ngenkathi ushayela noma uhlanganyela kunoma yimuphi umsebenzi ohilela ijubane lokuphendula.
5. Ukuvimbela i-lactic acidosis ezigulini ezinokuphazamiseka kwe-metabolic, ukwelashwa kufanele kuqalwe ngemithamo encishisiwe.

Imiphumela emibi kanye ne-overdose

Ubufakazi besifo sikashukela sibonisa ukuthi ukwelashwa nomuntu osebenza “ngeFommetin” kungahle kuhambisane nokuvela kokunye okungahambi kahle:

1. Ngokuphathelene nokugaya - ukuphefumula kwenhliziyo, ukunambitheka kwensimbi emlonyeni, ukugabha, ukulahlekelwa isifiso sokudla, izinhlungu esiswini, isihlalo sokucasuka.
2. I-lactic acidosis iyavela. Lesi simo sidinga ukuyekiswa kokwelashwa ngenxa yengozi yokufa.
3. I-Hypovitaminosis iyakhula.
4. I-Megaoblastic anemia ivela.
5. I-Hypoglycemia iyakhula.
6. Kuqhume isikhumba.

Ngokweqile komuthi, i-lactic acidosis iyakhula. Ezimweni ezinjalo, kuyaphuthuma ukuyeka ukwelashwa, futhi isiguli kufanele silaliswe esibhedlela. Esimweni sesibhedlela, i-lactate ibalwa kakhulu ukuze kuqinisekiswe noma kuphikiswe ukuthi lesi sifo sitholile. Ukusetshenziswa kwe-hemodialysis kuyasebenza ezimweni eziningi zokuphuma kwe-lactate ne-metformin.

Ukusebenzisana kwezidakamizwa kanye nama-analog

Umphumela we-hypoglycemic uthuthukiswa ngabenzeli abalandelayo:

• umjovo insulin;
• Ama-inhibitors e-ACE, i-MAO;
• I-Acarbose;
• I-Oxetetracycline;
• beta blockers
• derivatives sulfonylurea.

Ukusebenza kahle kunciphisa kusuka kuzidakamizwa ezilandelayo:

• I-GCS;
• izindlela zokuvimbela inzalo;
• adrenaline
• i-glucagon;
• izidakamizwa ze-hormonal ezisetshenziswa kuma-pathologies we-yegilo yegilo;
• i-sympathomimetics;
• okuphuma ku-phenothiazine, kanye ne-nicotinic acid.

Amathuba we-lactic acidosis akhuphuka ngokuthatha umuthi "Cimetidine", ethanol.

Imakethe yemithi imelelwa ngamanxusa ahlukahlukene anciphisa ushukela. Ezinye zazo zingasetshenziswa njengezindawo zokulungiselela i- "Fomula", ngenxa yobukhona be-metformin hydrochloride ekwakhiweni kwabo.

Ama-analogues adumile:

• IVero-Metformin;
• Metformin Richter;
• IGlucophage;
• ILangerine;
• IGlucophage Long;
• I-Metfogamma.

Umbono wesineke

Ukusuka ekubuyekezweni kwabanesifo sikashukela mayelana nesidakamizwa IFormetin, singaphetha ngokuthi umuthi awulungele wonke umuntu, ngakho-ke, ngaphambi kokuwusebenzisa, ukubonisana nodokotela kuyimpoqo.

Bengineminyaka engama-66 lapho kutholakala ushukela omningi. Udokotela watusa masinyane ukuthatha iFomumetin. Imiphumela yajabulisa. Ngaphezu kweminyaka emi-2 yokwelashwa, ushukela ugcinwa ngaphakathi kwe-7.5 mmol / L. Kuyajabulisa kakhulu ukuthi sikwazile ukuqeda amanye amakhilogremu ayi-11, futhi nomlomo owomile wanyamalala.

UKonstantin, oneminyaka engama-72

Ezinyangeni eziningana kwakudingeka ngikhethe umuthi ukuze ngilinganise ushukela. Isifo sikashukela satholakala ezinyangeni ezi-5 ezedlule, kepha ngenxa yokubonga kuphela amaphilisi we-formin akwazi ukusondela kumanani ashukela ajwayelekile. Ngiyabemukela noSiofor. Ngokungafani nezinye izindlela zokwelapha ngalo muthi, anginazinkinga ngokugaya. Kuwo wonke umuntu ongakasitholi isidakamizwa, ngincoma ukusizama.

U-Elena, oneminyaka engama-44

Ngifunda ezinye izibuyekezo futhi ngiyamangala impumelelo yabanye. Mina ngokwami ​​ngithathe lesi sidakamizwa ngokugcizelelwa udokotela. Ngaphambi kokuthi aphuze iMetformin Teva, bekungekho zinkinga. Futhi ngokushintshela kuFometin ngezinsuku ezi-3, ngathola yonke imiphumela emibi ekhona. Nganginesiyezi, nganginamahlwili, ngangizizwa ngibuthakathaka kakhulu, futhi angithulanga ngokunye. Lesi sidakamizwa akufanele sithathwe ngemuva kweminyaka engama-60, kepha akekho owangixwayisa. Finyelela iziphetho.

U-Arina, oneminyaka engama-64

Intengo yamathebhulethi angama-60 e-formin incike kumthamo. Cishe ama-ruble angama-200.