Imithi yokwelapha isifo sikashukela ihlukahlukene kakhulu. Ziyahlukahluka kumgomo wethonya, uhlobo lokukhululwa, ukwakheka nezinye izici.
Ukuze ukusetshenziswa kwabo kukhiqize, udinga ukwazi izici zemithi. Enye yazo iCombogliz Prolong. Njengazo ezinye izidakamizwa, unezici ezithile okufanele azijwayeze nazo.
Imininingwane ejwayelekile, ukwakheka kanye nendlela yokukhululwa
Umuthi lo uthengiswa ngaphansi kwegama elithi Combogliz Prolong. Inomphumela we-hypoglycemic.
Ukhona ngesimo samathebulethi ekuhlanganiseni kwefilimu. Umbala wazo ungahluka ngokuya ngokuqukethwe kwezinto ezisebenzayo.
Izakhi ezisemqoka zalawa mathebhulethi yizinto ezimbili - iMetformin neSaxagliptin. Kungaphansi kwethonya labo ukuthi izinhloso ezibekelwe umuthi ziyafezeka.
Ngaphezu kwabo, ukwakheka kwalo muthi kufaka phakathi:
- i-magnesium stereate;
- i-hypromellose;
- i-carmellose;
- titanium dioxide;
- i-talc;
- i-hydrochloric acid;
- i-butanol;
- propylene glycol;
- amadayi.
Ngokuthengisiwe ungathola iCombogliz ngomthamo we-1000 + 2,5 mg (Metformin noSaksagliptin, ngokulandelana), 500 + 5 mg no-1000 + 5 mg. Ahlanganiswe emabhulini angama-7 ama-pcs. Ibhokisi lingaqukatha ama-4 noma ama-8. Umbala wezibhebhe ungaba ophuzi, onsundu, noma opinki. Iyunithi ngalinye liqoshwe ngokuqukethwe kwezinto ezisebenzayo.
Isenzo se-Pharmacological ne-pharmacokinetics
Izici zalawa mathebhulethi zibangelwa ukwakheka kwawo, lapho kunezinto ezimbili ezisebenzayo ezinomphumela ohambelana nawo.
Ngenxa kaSaksagliptin, isenzo samahomoni, ama-incretin, ashukumisa ukukhiqizwa kwe-insulin yi-pancreas, kuyagcinwa.
I-insulin inomthelela ekutholeni ngokushesha i-glucose ngamangqamuzana, okuqinisekisa ukwehla kokuxineka kwayo kuyi-plasma yegazi. Futhi, ama-insretin anciphisa ukuhlangana kwe-glucose ngesibindi.
Ngaphansi kwethonya lesakhi sesibili, iMetformin, umsebenzi wokukhiqiza ushukela esibindini nawo uyancipha. Futhi, le nto ikhulisa ukuzwela komzimba ku-insulin, eqinisekisa ukutholwa okusheshayo nokusatshalaliswa koshukela ngezicubu nezitho zomzimba. I-Metformin ayithinti ukukhiqizwa kwe-insulin.
Lapho ingena emzimbeni, i-saxagliptin icishe ifakwe ngokuphelele. Le nto cishe ayingene ekuxhumaneni namaprotheni egazi. I-metabolism yayo yenzeka ngaphansi kwethonya le-cytochrome isoenzymes, ngenxa yalokho kwakhiwa i-metabolite eyinhloko. Ukusetshenziswa kwengxenye kwenziwa ngamathumbu nezinso. Ingxenye yento isuswe ingashintshiwe, inani elisele lishiya umzimba ngesimo se-metabolite.
Isenzo esisebenza kahle kunazo zonke seMetformin sibonakaliswa cishe amahora angama-7 ngemuva kokwethulwa emzimbeni. Akukho mininingwane eqondile ekusatshalalisweni kwale nto, kepha imiphumela yocwaningo oluthile ikhombisa ukuthambekela kwayo okuncane kokungena ekuxhumaneni namaprotheni egazi. I-Excretion yenziwa izinso, kuyilapho isakhi sasesimweni saso sokuqala.
Izinkomba kanye ne-contraindication
Sebenzisa imithi ngokuqapha. Lokhu kuyiqiniso ikakhulukazi ngezimali eziqinisekisa ukulondolozwa kwezinkomba ezibalulekile. Njengoba umuntu angafa nokufa ngenxa yokwanda noma ukwehla okubukhali koshukela wegazi, izidakamizwa ezinomphumela we-hypoglycemic kufanele zithathwe kuphela njengoba kuyalelwe uchwepheshe nangomuthi.
Inkomba enkulu yokuqokwa kwe-Combogliz Prolong uhlobo lwesifo sikashukela sohlobo 2. Kepha ngaphambi kokuncoma lo muthi, udokotela kufanele aqinisekise ukuthi akukho okuphikisana. Kumele futhi abale isilinganiso, acabangele zonke izimo ezibalulekile.
Lawa mathebhulethi anokuphikisana, ngenxa yokuthi i-Combogliz akufanele isetshenziswe, yize kukhona i-mellitus engavikelekile nge-insulin.
Lokhu kufaka phakathi:
- ukuzwela kwesineke kokwakheka;
- Uhlobo 1 sikashukela;
- ukuphazamiseka enqubweni ye-galactose metabolism;
- isifo sezinso;
- izifo ezinzima zenhliziyo;
- i-lactic acidosis;
- ukwehluleka kwesibindi;
- i-metabolic acidosis;
- I-hypoxia kanye nengozi yokukhula kwayo;
- iminyaka efinyelela eminyakeni eyi-18;
- ukukhulelwa
- ukuncelisa.
Ezimweni ezinjalo, kuyanconywa ukuthi lezi zibhebhe zithathelwe indawo nesinye isidakamizwa. Ngaphandle kwalokho, umzimba wesiguli uzolimala.
Imiyalo yokusebenzisa
Noma yimuphi umuthi kufanele usetshenziswe ngokuya ngemiyalo. Kepha izincomo zikadokotela zivame ukubonakala zibaluleke kakhulu, ngoba imiyalo iqukethe imininingwane ejwayelekile kuphela, futhi uchwepheshe angakwazi ukuhlaziya izici ngazinye zecala ngalinye. Ngakho-ke, ungasebenzisi i-Comboglize ngaphandle kokuqokwa.
Lezi zibhebhe zenzelwe ukuphathwa komlomo, okuvame ukwenziwa kanye ngosuku. Lokhu kwenziwa kangcono kusihlwa. Ithebhulethi ayidingi kuchotshozwa futhi ihlafunwe - igwinywa ngamanzi.
Umthamo ukhethiwe ngamunye. Imvamisa aqondiswa ngenani leSaksagliptin, ingxenye yansuku zonke yazo okungafanele idlule ku-5 mg. Umthamo ophakanyisiwe weMetformin esigabeni sokuqala sokwelashwa ngu-500 mg. Uma kunesidingo, ingakhushulelwa ku-2000 mg (lapho-ke kufanelekile ukusebenzisa i-Combogliz 1000 + 2,5). Kulokhu, umthamo womuthi uhlukaniswe ngemithamo emi-2 - ekuseni nakusihlwa.
Ukungezelela umthamo kufanele kwenziwe kancane kancane, ngoba uma kungenjalo kungenzeka kuvuse ukuthuthukiswa kwe-pathologies emgodini wokugaya ukudla.
Iziguli Ezikhethekile Nezinkomba
Lapho usebenzisa lezi zibhebhe, kufanelekile ukubheka ukuthi ukuqapha kuyadingeka kwezinye iziguli.
Lokhu kufaka phakathi:
- Abantu abadala. Abantu abanesifo sikashukela abaneminyaka engaphezu kwengu-60 ubudala, okuphila kwabo kubandakanya ukusebenza kanzima, basengozini enkulu yokuba ne-lactic acidosis.
- Abesifazane abakhulelwe. Umphumela walesi sidakamizwa ngesikhathi sokukhulelwa awuphenwanga, ngakho-ke ukusetshenziswa kwawo kumele kugwenywe.
- Omama abahlengikazi. Akunamininingwane yokuthi izinto ezisebenzayo zingena kubisi lwebele yini. Ukuze ugweme ubungozi obukhona, ukwelashwa kwesifo sikashukela nge-Combogliz akwenziwa ngalesi sikhathi.
- Izingane. Umuthi awuhloliswanga ukusebenza kahle nokuphepha maqondana nabantu abaneminyaka engaphansi kweminyaka eyi-18.
Lezi zigaba zeziguli zidinga ukwelashwa nezinye izidakamizwa.
Kubalulekile ukuthola ama-comorbidities akhona kwisifo sikashukela. Ezinye zazo ziyisizathu sokwenqaba ukusebenzisa lesi sidakamizwa okukhulunywa ngaso.
Lokhu kufaka phakathi:
- I-pancreatitis. Isenzo sezinto ezisebenzayo kuma-pancreas kuleli cala singalindela.
- Ukwehluleka kwenhliziyo. Ngalesi sifo, ukusetshenziswa kweCombogliz kungalimaza.
- Isifo sesibindi. Ngenxa yokuba khona kwabo, umuthi ungadala ukukhula ngokushesha kwe-lactic acidosis.
- Umsebenzi wokuphazamiseka kwezinso. Le nkinga ingadala ukubambezeleka kwezinto ezisebenzayo emzimbeni, eziyingozi ngokuhambisana nezinkinga.
Ezinye izifo azikho phakathi kokuphikisana, kepha uma zikhona, udokotela kufanele ahlole ubungozi.
Imiphumela emibi kanye ne-overdose
Lapho usebenzisa lo muthi ngeseluleko sikadokotela, amathuba emiphumela emibi aphansi kakhulu.
Imvamisa, izehlakalo ezimbi ezinjengalezi kuthiwa:
- ikhanda
- isicanucanu
- ukuvuvukala kwe-nasopharynx;
- isimo se-hypoglycemic.
Uma uthola lezi zimpawu, kuzodingeka ukhulume nodokotela wakho. Kwesinye isikhathi bayashintsha umuthi.
Ukweqisa izidakamizwa ngesikhathi sokwelashwa ngalawa maphilisi akunakwenzeka. Kepha ngokwephulwa okukhulu kwemiyalo, isiguli singathola i-hypoglycemia yobunzima obuhlukahlukene. Ezimweni ezinzima ikakhulukazi, kudingeka usizo lodokotela oluphuthumayo.
Ukuxhumana neminye imithi kanye nama-analogues
Njengoba kunezinto ezimbili ezisebenzayo ekwakhiweni kwamacwecwe e-Combogliz, uma kunesidingo, hlanganisa lesi sidakamizwa nezinye izidakamizwa, kuyadingeka ukubheka ubuntu bokusebenzisana kwabo nesakhi ngasinye.
Eminye imishanguzo iholela ekunyukeni kokusebenza kwento.
Ngokuphathelene ne-saxagliptin, yilezi:
- I-Fluconazole;
- UVerapamil;
- I-Ketoconazole;
- I-Erythromycin.
KuMetformin lo mphumela usetshenziswa yi:
- imikhiqizo equkethe utshwala;
- Furosemide;
- INifedipine.
Ezimweni lapho le mithi isadinga ukuthathwa, imithamo yeCombogliz kumele inyuswe.
Ukunciphisa ukusebenza kahle kokwelashwa nge-saxagliptin can:
- I-pioglitazone;
- I-Rifampicin.
Isenzo seMetformin senziwe buthaka ngu:
- ama-estrogens;
- okokugcobisa;
- i-nicotinic acid;
- ama-audiathomimetics.
Lokhu kusho ukuthi uma uthatha noma yimuphi umuthi, udinga ukwazisa udokotela ngabo ukuze ahlelele ukwelashwa okusebenzayo.
Isidingo sokusetshenziswa kwezidakamizwa ze-analogue kwesinye isikhathi sibangelwa ukungabekezeleli umuthi okukhulunywa ngawo, imiphumela emibi noma imiphumela ephansi yokuvezwa kwayo.
Kaningi, udokotela angakwazi ukukhetha okunye okuvela kulolu hlu olulandelayo:
- Siofor;
- I-Glimecomb;
- Methadiene;
- UGlatiniin.
Ukukhetha okuzimele kwezihlobo zezidakamizwa akwamukeleki.
Izinto zevidiyo ekwelapheni isifo sikashukela sohlobo 2:
Imibono yesiguli
Ngemuva kokufunda ukubuyekezwa kweziguli eziningi, kungaphethwa ngokuthi umuthi i-Combogliz Prolong ubekezelelwa kahle futhi wehlisela ushukela wegazi ngempumelelo. Imiphumela emibi ayivelakancane. Lapho uthatha umuthi, ukuncipha kwesisindo kuyabonakala futhi.
Sekuyisikhathi eside ngisebenzisa izidakamizwa neMetformin. Bahlala baba nemiphumela emihle. Ngonyaka owedlule, uCombogliz Prolong waqala ukuphuza. Ushukela uhlala ezingeni elijwayelekile, kepha isisindo sami sehle kakhulu. Manje sengithola kudokotela ukuthi kungenzeka yini ukwenqaba ukuphuza amaphilisi ngokuphelele, nokulawula ushukela ngokudla.
U-Igor, oneminyaka engama-42
Sekuphele iminyaka emine ngihlala nesifo sikashukela. Ngalesi sikhathi ngizame izidakamizwa eziningi, kepha bekunezinkinga njalo - kungaba ukweqa ngamanani kashukela, bese kuba nemiphumela emibi. Ngonyaka owedlule, ngiqale ukuthatha i-Combogliz Prolong. Akukho ukusabela okungekuhle kukho, izivivinyo zinhle. Ngithanda yonke into.
UMaria, oneminyaka engama-34
Izindleko zaleli thuluzi zincike ekutheni imuphi umthamo obekwe udokotela, nokuthi mangaki amaphilisi aqukethwe kuphakethe. Izindleko zalo muthi ziqala kuma-ruble angama-2700 kuya kwangama-4100.
