Isenzo se-Pharmacological kanye nemiyalo yokusetshenziswa kwesidakamizwa Jardins

Ekwelashweni kwesifo sikashukela, ukukhetha kwezidakamizwa kubaluleke kakhulu. Babekelwe odokotela, kepha iziguli ngeke zivinjelwe ekwazini izici zomuthi othile. Enye yezidakamizwa ezishiwo ku-radar futhi esetshenziselwa ukulawula amazinga kashukela yiJardins.

Imininingwane ejwayelekile, ukwakheka kanye nendlela yokukhululwa

Lo muthi wenziwa eJalimane. Iphilisi langaphakathi elibonakaliswa ngumphumela we-hypoglycemic. Kufanele isetshenziswe kuphela ekunconyweni kukadokotela ohambelayo, ngoba esimweni esihlukile, ukuwohloka kwenhlala-kahle kungabangelwa.

Kulokhu, udinga ukubhekisisa izinguquko esifundazweni, uqaphele ukwenzeka kwemiphumela engathandeki. Ukusetshenziswa okuyikho okulandela izincomo kusiza ukwehlisa inani loshukela egazini futhi kufinyelele amandla amahle.

Ithuluzi lethulwa ezibhebheni zezinhlobo ezimbili, elihlukile ngenani lezinto ezisebenzayo. Le nto yi-empagliflozin. Kwenziwa umuthi nge-10 noma 25 mg yale ngxenye kuwo.

Ithebhulethi ngayinye i-oval futhi ifakwe kumafilimu. Kuqoshwe okufakiwe kuso (ngakolunye uhlangothi kunophawu lomenzi, ngakolunye - umthamo wengxenye esebenzayo).

Ngaphezu kwe-Empagliflozin, iJardins ifaka ezinye izithako:

• i-microcrystalline cellulose;
• i-lactose monohydrate;
• i-magnesium stereate;
• i-colloidal silicon dioxide;
• i-hyprolosis;
• i-talc;
• titanium dioxide;
• udayi.

Umkhiqizo uthengiswa emaphaketheni amakhadibhodi, lapho kubekwa khona amalinge enamacwecwe (10 ama-PC.). Iphakethe liqukethe amanxeba ama-1 noma ama-3.

I-Mechanism yesenzo kanye ne-pharmacokinetics

I-Empagliflozin uhlobo 2 glucose transporter inhibitor. Umphumela wayo uhlinzeka ngokulawula inani ushukela onhlobo 2 sikashukela. Ngenxa yalokhu, ukuphindiselwa kabusha kweglucose yizinso kuncishisiwe.

Umsebenzi we-glucose excretion owenziwe izinso uyathintwa yizinga lokuqukethwe kwawo esegazini kanye nesilinganiso sokuhlunga kwegomerular. Ngenkathi kuthatha ikhambi kuma-diabetes, inqubo yokususa ushukela ngomchamo ishesha kakhulu, okuqinisekisa ukwehla ngokushesha kwenani layo.

Esinye isici seJardins umphumela waso omuhle emsebenzini wamaseli we-beta kanye nokwenza kusebenze kwezinqubo zokushiswa kwamafutha. Lokhu kuhlinzeka ukunciphisa umzimba, okuwusizo ezigulini eziphethwe ukukhuluphala.

Ukufakwa kwe-Empagliflozin kwenzeka ngokushesha, okwenziwa ezindongeni zepheshana lesisu. Umuthi ufinyelela ekuhlolweni okuphezulu kakhulu ngemuva kwamahora 1.5 ngemuva kokuthatha iphilisi. Ngaphezu kwalokho, inani layo ku-plasma lehla kakhulu, ngoba ukusatshalaliswa kwalo kwenzeka. I-Metabolism iyahamba kancane.

Umphumela ohleliwe wesidakamizwa uba mkhulu ngokwengeziwe ngomthamo owandayo. Ukuyithatha ngokudla okunamafutha kunciphisa kancane ukusebenza kwayo. Kepha lezi zinguquko azibalulekile, ngakho-ke umuthi ungadakwa ngaphambi nangemuva kokudla.

I-Empagliflozin yakha izibopho ezinzile namaprotheni egazi, enza izinhlobo ezintathu zama-metabolites. Kodwa okuqukethwe kwabo uma kuqhathaniswa nokuqoqwa kwento esebenzayo akunakwa. Ukuhoxiswa komuthi kwenzeka cishe kungashintshwa ngamanyongo nomchamo.

Izinkomba kanye ne-contraindication

Umsebenzi oyinhloko wemithi ubhekwa njengokulawulwa kweglucose egazini likashukela.

Kubekelwe uhlobo 2 lwesifo sikashukela ezimeni ezinjengokuthi:

• i-monotherapy (lapho kungekho khona imiphumela evela ekudleni nasekungabekezeleleni izidakamizwa ezisuselwa kwiMetformin);
• ukwelapha okuhlanganisiwe (inhlanganisela yalo muthi nabanye, kufaka phakathi i-insulin, uma ukudla kungasebenzi).

Kunezimo lapho kwenqatshelwe ukusebenzisa ithuluzi:

• Uhlobo 1 sikashukela;
• ukuthuthukiswa kwe-ketoacidosis kushukela;
• ukwehluleka kwezinso;
• ukungabekezelelani kwe-lactose;
• ukuntuleka kwe-lactase;
• ukucaphuna nokukhulelwa;
• iminyaka ye-senile (kusuka eminyakeni engama-85);
• iminyaka yezingane (kuze kube iminyaka eyi-18);
• ukuba khona kokuzwela kuzakhi.

Ngaphezu kokuphulwa okuqinile, kunezimo lapho ukusetshenziswa komuthi kuvunyelwe, kodwa lapho kukhona ukubhekwa kwezokwelashwa.

Lokhu kufaka phakathi:

• izifo zamapheshana emathunjini, ezihambisana nokuthambekela komzimba;
• ukutheleleka ngofuzo;
• isidingo sokudla okuphansi kwe-carb;
• amathuba okuba ne-hypovolemia;
• ukuphazamiseka ekusebenzeni kwamaseli we-beta we-pancreas;
• umlando we-ketoacidosis yesifo sikashukela;
• iminyaka yesiguli ingaphezu kweminyaka engama-75.

Kulezi zimo nakwezinye ezifanayo, umuthi ungabekwa, kepha kuphela ngesizathu esihle salokhu.

Imiyalo yokusebenzisa

UJardins kufanele aphuzwe ngomlomo ngamanzi. Ukusetshenziswa kwayo kuvunyelwe ngaphambi nangemva kokudla.

Umthamo kumele ucaciswe ngudokotela ohambelayo, kepha lapho kungekho khona imiyalo ekhethekile, kubekwa ithebhulethi elilodwa (10 mg ngosuku).

Uma isheduli enjalo yokusebenzisa umuthi ingalethi umphumela oyifunayo, kunconywa ukusebenzisa ithuluzi lapho umthamo wento esebenzayo ungu-25 mg.

Ubuye futhi aphuze iyunithi elilodwa ngosuku. Umthamo omkhulu wesidakamizwa ngu-25 mg.

Ukusebenza kabili kweJardins akufanele kuthathwe, noma ngabe umuthi awudakwanga ngesikhathi. Kulokhu, kufanele ukuthi uthathe iphilisi ngokushesha nje lapho isiguli sikhumbula iphutha elenziwe.

Iziguli Ezikhethekile Nezinkomba

Emaqenjini athile eziguli, kusebenza imithetho ekhethekile.

Lokhu kufaka phakathi:

1. Abesifazane ngesikhathi sokukhulelwa nokuncelisa. Imininingwane yokuthi i-Empagliflozin yenza kanjani kulezi ziguli ingakatholakali, ngoba ucwaningo kule ndawo alwenziwanga. Lokhu kusho ukuvinjelwa kokusebenzisa kwabo umuthi.
2. Izingane nentsha. Ukusebenza kahle nezingozi ezingahle zenzelwe lo muthi nazo azikaphenywa nazo. Ukuphepha kweziguli ezinje, kunconywa ukuthi zisebenzise ezinye izidakamizwa.
3. Abantu beminyaka yobudala. Kusukela eminyakeni yobudala engama-75, iziguli zinamathuba amaningi okuthola ukomizwa ngesikhathi sokwelashwa nalesi sikhungo. Ngakho-ke, kufanele babheke izinyathelo zokuphepha. Udokotela angabeka uJardins njengeziguli ezinjalo, kodwa kufanele aqaphe impilo yakhe ngokucophelela. Esimweni esingaphezu kweminyaka engama-85, lo muthi uyagqitshwa.

Amanye amaqembu eziguli angawusebenzisa lo muthi ngaphandle kweminye imikhawulo futhi njengoba eyalelwe uchwepheshe.

Ukuba khona kwemiyalo ethile maqondana nalo muthi kuhlobene nomphumela wawo ezinso. Ngakho-ke, udokotela, ngaphambi kokunquma uJardins, kufanele aqinisekise ukuthi akukho ukwephulwa kulesi sitho.

Futhi, uma usebenzisa umuthi isikhathi eside, kufanele ukuthi ulawule ukuqaliswa kwemisebenzi yezintso ngokuhlola isiguli. Kwezinye izimo (ngisho nokulimala kwesibindi), izinguquko zomthamo azidingeki.

Imiphumela emibi kanye ne-overdose

Lapho usebenzisa lo muthi, imiphumela engafuneki kwesinye isikhathi ingavela.

Okusemqoka yile:

• i-hypoglycemia;
• isikhumba esikhanyayo;
• i-hypovolemia;
• ukuphazamiseka kokuchama (okusheshayo noma okungekho);
• i-candidiasis;
• izifo ezithinta umchamo;
• i-vulvovaginitis.

Umgomo wokusebenza ezimweni ezinjalo uxhomeke ekujuleni kwabo. Imvamisa, lapho zenzeka, uJardins ubuyiselwa amanye amaphilisi. Ngokuncipha kancane kancane kwemiphumela engafuneki noma amandla abo obuthaka, ukwelashwa kungaqhubeka.

Amacala we-overdose ngokuhambisana nemiyalo awakhonjwa. Ngokweqile okukodwa komthamo kuze kufike ku-80 mg, ukuphambuka nakho akwenzekanga. Uma kutholakala izinkinga ezinzima ngenxa yokudlula umthamo, izici zokuqedwa kwazo zincike kuzimpawu.

Ukusebenzisana kwezidakamizwa kanye nama-analog

Indlela yokwelashwa efanelekile inciphisa ubungozi bezinkinga ngokuhlanganiswa kweJardins neminye imithi. Kuyinto engathandeki ukuhlanganisa lesi sidakamizwa ne-diuretics, ngoba kusiza ukuqinisa isenzo sabo, okuholela ekuphepheni komzimba nasekunciphiseni ingcindezi.

Uma kunezizathu zokwenqaba leli thuluzi, lingashintshwa ngama-analogues.

Okusemqoka yile:

1. Phendula. Isithako esisebenzayo kulezi zibhebhe yi-Repaglinide. Ithuluzi libhekene nomphumela ofanayo kanye ne-contraindication efanayo, lapho kufakwa khona ukwehluleka kwesibindi. Kufanele futhi ihlanganiswe ngokucophelela neminye imithi, njengoba kunemikhawulo eminye kuyo.
2. I-Novonorm. Umuthi ubuye usekelwe kwiRepaglinide. Ukuxhunyaniswa kwaleli thuluzi kuyafana naleyo ehlobene neJardins, ngaphandle komsebenzi wezinso okhubazekile (kuleli cala, lingasetshenziswa ngaphansi kokuqashwa kwezokwelashwa okusondele).
3. Attokana. Ithuluzi lilungele ukwelashwa kwesifo sikashukela sohlobo 2. Into yayo esebenzayo yiKaragliflozin. Umuthi ufana kakhulu nomphumela wawo kuJardins, uboniswa yi-contraindication efanayo nemiphumela emibi.

Umuthi kadokotela uyadingeka ukuthi usebenzise noma iyiphi yalezi ezinye izidakamizwa ze-analog.

Imibono yabathengi

Ukusuka kwezibuyekezo eziningi zeziguli ezithathe iJardins, singaphetha ngokuthi umuthi wehlisela ushukela wegazi kahle futhi kufanelekile ukuwusebenzisa, noma kunjalo, imiphumela emibi evela esinyeni nasezinso yaphawulwa, okwaphoqa abanye ukuba baphendukele emifanekisweni yomuthi. Intengo ephezulu yomuthi nayo iyabonakala.

Ngiqale ukuthatha uJardins ekuncomeni kwe-endocrinologist. Ngiyithandile imiphumela, kepha wabe esenyamalala emakhemisi, futhi kwadingeka ngisebenzise omunye umuthi. Ngokushesha nje lapho kungenzeka, wabuyela ukuthola uJardins, ngoba ulawula ushukela kahle. Inkinga kuphela intengo yesidakamizwa.

U-Igor, oneminyaka engama-49

Ekuqaleni, lo muthi ungifanele, ngoba wawugcina kahle ushukela. Kepha ngenxa yakhe, ngaba nezinkinga nge-bladder - kwadingeka ngiye endlini yangasese kaningi. Ngemuva kwalokho kwaqala ukuluma esithweni sangasese. Udokotela wathi le yimiphumela emibi. Ngazama ukujwayela, kodwa ngaphoqeleka ukuthi ngibuze omunye umuthi.

U-Irina, oneminyaka engama-36

Ngithanda ukuthi abakwaJardins babe nemithamo emibili. Phambilini, amaphilisi ayi-10 mg ayenele kimi, khona-ke bekufanele nginyuse umthamo. Ngiyethemba ukuthi ehlobo ngikwazi ukubuyela ekwelashweni okwedlule, ngoba ehlobo ngihlala ezweni. Kunomoya omusha, umsebenzi omningi, imifino evela engadini, ngakho-ke ukulawula ushukela kufanele kube lula. Umuthi ungifanele ngokuphelele, awubangeli imiphumela emibi futhi kulula ukuwuthatha - isikhathi esisodwa kuphela ngosuku.

UValentina, oneminyaka engama-57

Izinto zevidiyo ezimbangela zesifo sikashukela sohlobo 2:

Izindleko zesidakamizwa iJardins zincike kunani lezinto ezisebenzayo ezibhebheni. Ngomthamo we-10 mg, umuthi ungathengwa ngenani lama-ruble ayi-2000-2200. Uma udinga umuthi onomthamo we-25 mg, kuzodingeka usebenzise ama-ruble angama-2100-2600 kuwo. Lezi izintengo eziphakathi kwephakeji eliqukethe amaphilisi angama-30. Lapho uthenga iphakheji enamathebhulethi ayi-10, uzodinga ama-ruble angama-800-1000.

Lo muthi, uma uthathwe ngokungafanele, ungalimaza isiguli. Ngakho-ke, ukwamukelwa kwayo kuvunyelwe kuphela ngemvume kadokotela. Amakhemisi ayithengisa kuphela ngencwadi kadokotela.