I-Hypoglycemic ejenti Glucofage - imiyalo esetshenzisiwe

IGlucophage isidakamizwa se-hypoglycemic esisebenza kakhulu ekwelapheni isifo sikashukela sohlobo 2.

Ithuluzi lenza ushukela wegazi usheshe. Kuyathandwa futhi phakathi kweziguli ezikhuluphele.

Imininingwane ejwayelekile, ukwakheka kanye nendlela yokukhululwa

IGlucofage Long ilungiselelo likashukela lesigaba se-Biguanide ngesakhi esisebenzayo seMetformin hydrochloride. Kutholakala kwimithamo ye-500, 850, 1000 mg.

Uma igxilwe, ivele ikhangiswe ngokushesha. Ukuqongelela okuphezulu kwenzeka ngemuva kwamahora ama-2 ngemuva kokuphatha.

Lokhu kukuvumela ukuthi uzuze imiphumela elandelayo:

• yenza ushukela wegazi ube ngokwejwayelekile;
• khulisa ukuphendula kwezicubu kuyi-hormone ekhiqizwayo;
• ukukhiqizwa kweglue glucose ephansi;
• ukunciphisa ukumuncwa kwamathumbu eglucose;
• buyisela isisindo somzimba kokujwayelekile;
• thuthukisa i-lipid metabolism;
• cholesterol ephansi.

Amathebulethi ayasebenza ku-prediabetes.

Uyathengiswa, umuthi uvezwa ngendlela yethebhulethi, embozwe ngegobolvex igobolondo elimhlophe. Ukuqoqwa kwengxenye esebenzayo ngu-500, 850, 1000 mg. Ukuze kube lula isiguli, umthamo womuthi uqoshwe engxenyeni yepilisi.

I-Pharmacology ne-pharmacokinetics

Ukwakheka kwamacwecwe kufaka i-Metformin, eqinisekisa umphumela obizwa ngokuthi yi-hypoglycemic. Ezigulini ezinamazinga aphezulu kashukela, kuyanciphisa kokujwayelekile. Kubantu abanamazinga e-glucose ajwayelekile, ushukela wegazi uhlala ungashintshiwe.

Isenzo sengxenye esebenzayo sisekelwa ekuvinjelweni kwe-gluconeogeneis ne-glycogenolysis, amandla okwandisa ukuzwela kwe-insulin futhi kunciphise ukumuncwa emzimbeni wokugaya ukudla. Ngaphezu kwalokho, lo muthi usheshisa izinqubo ze-metabolic emzimbeni bese wehlisa i-cholesterol.

I-Massformin ephezulu kakhulu ibonwa ngemuva kwamahora ama-2-3 ngemuva kokuphathwa kwayo. Isici se-Glucophage Long yisilinganiso esiphansi sokubopha kumaprotheni e-plasma. Isakhi esisebenzayo esidalulwa yizinso namathumbu kungakapheli amahora ayi-6.5.

Ngemuva kokuthatha i-Glucofage, i-adsorption ephelele yeMetmorphine GIT iyaphawulwa. Ingxenye esebenzayo isatshalaliswa ngokushesha kuwo wonke izicubu. Iningi likhishwa ezinsweni, okusele emathunjini. Inqubo yokuhlanza umuthi iqala amahora angama-6.5 ngemuva kokuwuthatha. Ezigulini ezinezinkinga zezinso, isikhathi sempilo-siyakhuphuka, esandisa ubungozi be-Metformin cumulation.

Izinkomba kanye ne-contraindication

Ngokusho kwemiyalo enamathiselwe kwi-Glucofage, kukhonjiswa ngohlobo 2 lwesifo sikashukela, abanokukhuluphala yize bethola ukwelashwa kokudla.

Iziguli eziningi zisebenzisa i-Glucofage ukunciphisa umzimba. Kulokhu, kufanele ulandele ukudla okune-kilojoule encane futhi wenze isethi yokuzivocavoca yansuku zonke. Lokhu kukuvumela ukuthi uzuze imiphumela emihle ngesikhathi esifushane.

Njenganoma yimuphi umuthi, i-glucophage ine-contraindication.

Umuthi uvunyelwe:

• abantu abangabekezeleli enye yezakhi;
• nge-coma noma isifo sikashukela se-ketoacidosis;
• ukusebenza okungafanele kwezinso nenhliziyo;
• ngokwanda kwezifo ezingamahlalakhona nezingapheli;
• ukuphuza utshwala kanyekanye;
• ngokufaka ubuthi emzimbeni;
• ngesikhathi sokukhulelwa nokuqunjelwa;
• nge-lactic acidosis;
• Izinsuku ezi-2 ngaphambi kwe-radiology nezinsuku ezi-2 emva kwayo;
• abantu abangaphansi kweminyaka eyi-10;
• ngemuva kokuzikhandla komzimba.

Ukuthatha amaphilisi ngabantu asebekhulile kwenziwa ngaphansi kokuqondisa kukachwepheshe.

Imiyalo yokusebenzisa

Umthamo wokuqala wokuqala ngu-500 noma 850 mg, ohlukaniswe ngemithamo eminingana. Amaphilisi athathwa kanye noma ngokushesha ngemuva kokudla. Ukuguqulwa komthamo kwenziwa ngemuva koshintsho kushukela.

Umthamo ophelele yi-3000 mg ngosuku, nayo ihlukaniswe ngemithamo eminingana (2-3). Ukuhamba kancane kokuhlushwa kwento esebenzayo egazini kuyanda, imiphumela emincane emincane evela emgudwini wesisu.

Lapho uhlanganisa i-Glucofage Long ne-insulin, umthamo onconywayo ngu-500, 750, 850 mg izikhathi ezingama-2-3 ngosuku. Umthamo we-insulin ulawulwa ngudokotela.

Amacwecwe asetshenziswa womabili ngokuhlanganiswa neminye imithi, futhi ngokuhlukile. Ezimweni ezihlukile, ukwamukelwa kuyamukeleka kusukela eminyakeni eyishumi. Umthamo udonswa udokotela ngokususelwa ekuhlolweni kashukela wegazi. Okuncane ngu-500 mg, okuphezulu ngu-2000 mg.

Iziguli Ezikhethekile Nezinkomba

Ngaphambi kokusebenzisa umuthi, kufanele ubonane nodokotela, ufunde imiphumela emibi, futhi uzijwayeze nezincomo zeziguli eziseqenjini elikhethekile:

1. Isikhathi sokukhulelwa. Ukwemukelwa kweGlucophage ngesikhathi sokuzala nengane kuyenqatshelwe ngokuphelele. Ushukela wegazi ugcinwa ngokujova i-insulin. Ukwenqatshelwa kwamaphilisi ngesikhathi sokuncelisa ibele kungenxa yokuntuleka kocwaningo.
2. Ubudala bezingane. Ukusetshenziswa kwe-glucophage yizingane ezingaphansi kweminyaka engu-18 kuyinto engathandeki. Inalo iqiniso lokusebenzisa umuthi ngabantwana beminyaka eyi-10. Ukulawulwa ngudokotela kuyimpoqo.
3. Abantu abadala. Ngokuqapha, kufanele uthathe umuthi kubantu asebekhulile abahlushwa izifo zezinso nezinhliziyo. Inkambo yokwelashwa kufanele ibhekelwe uchwepheshe.

Kwezifo noma izimo ezithile, umuthi uthathwa ngokuqapha, noma uvame ukukhanselwa:

1. I-Lactic acidosis. Ngesinye isikhathi, nokusetshenziswa kweMetformin, okuhambisana nokuba khona kokwehluleka kwezinso esigulini. Lesi sifo sihambisana nokuhlanekelwa kwemisipha, izinhlungu esiswini naku-hypoxia. Uma isifo sisolwa, ukuhoxiswa kwezidakamizwa nokubonisana ngochwepheshe kuyadingeka.
2. Isifo sezinso. Uma kwenzeka umsebenzi wezinso ongasebenzi kahle, kufanele kuqashelwe ngokwedlulele, ngoba umzimba uthatha wonke umthwalo wokususa iMetformin emzimbeni. Ngakho-ke, ngaphambi kokuqala ukusebenzisa umuthi, ukunakwa kufanele kukhokhwe kufinyelela ezingeni le-creatinine esegazini legazi.
3. Ukuhlinzwa. Iphilisi limiswa ezinsukwini ezimbili ngaphambi kokuhlinzwa. Ukuqala kabusha ukwelashwa kuqala ngemuva kwesikhathi esifanayo.

Ekukhatheni ngokweqile, ukuthatha amaphilisi kusiza ukuthayipha isifo sikashukela esi-2. Ngokwengxenye yesiguli, ukuhambisana nokudla okunempilo kuzodingeka lapho inani lamakhalori kufanele libe okungenani yi-1000 kcal ngosuku. Ukulethwa kokuhlolwa kwelebhu kuzokuvumela ukuthi uqaphe isimo somzimba kanye nokusebenza kwe-glucophage.

Imiphumela emibi kanye ne-overdose

Uhlu lwemiphumela emibi ekuphuzeni umuthi lususelwa kwizifundo eziningi zezokwelapha kanye nokubuyekezwa kweziguli:

1. Inciphise i-Vitamin Absorption I-B12 ibangela ukuthuthukiswa kwezifo ezinjenge-anemia ne-lactic acidosis.
2. Shintsha ekunambeni kokunambitha.
3. Ukusuka emgudwini wesisu, uhudo, izinhlungu esiswini, kanye nokuntuleka kokudla kuyabhekwa. Ukuzilolonga kukhombisa ukuthi i-Symbomatology echaziwe iyaphawulwa kuningi leziguli futhi lidlule ezinsukwini ezimbalwa.
4. Njengokusabela kwe-allergic, i-urticaria kungenzeka.
5. Ukwephulwa kwezinqubo ze-metabolic kungaholela ezimweni ezingalindelekile, ngenxa yalokho ukwesulwa okuphuthumayo kwamathebulethi kungenzeka.

Ukusebenzisana kwezidakamizwa kanye nama-analog

Umphumela we-hyperglycemic wesidakamizwa uDanazol wenza kube nzima ukuwuhlanganisa ne-Glucofage. Uma kungenakwenzeka ukukhipha umuthi, umthamo uguqulwa udokotela.

Ama-tinctures aqukethe utshwala akhulisa ingozi ye-lactic acidosis.

Imithamo emikhulu ye-chlorpromazine (engaphezu kwe-100 mg / ngosuku) ingandisa i-glycemia futhi yehlise izinga lokukhishwa kwe-insulin. Ukulungiswa komthamo odokotela kuyadingeka.

Ukuphatha ngokubambisana kwama-diuretics kukhulisa ubungozi be-lactic acidosis. Kwenqatshelwe ukuthatha i-Glucofage ngenqanaba le-creatinine elingaphansi kwama-60 ml / min.

Izidakamizwa eziqukethe i-iodine ezisetshenziselwa i-fluoroscopy ezigulini ezinezinkinga zezinso zibangela i-lactic acidosis. Ngakho-ke, lapho kutholwa isiguli ngendlela ye-radiography, ukuhoxisa ithebhulethi kuyadingeka.

Umphumela we-hypoglycemic wesidakamizwa uvuselelwa yi-sulfonylurea, insulin, salicylates, acarbose.

Ama-Analogs aqondwa njengezidakamizwa ezihloselwe ukufaka esikhundleni somuthi oyinhloko, ukusetshenziswa kwawo kuvunyelwe nodokotela ohambelayo:

1. I-Bagomet. Idizayinelwe iziguli ezinesifo sikashukela sohlobo 2 esinokukhuluphala okubunjiwe Kusetshenziswa ku-monotherapy futhi kuhlangene ne-insulin.
2. I-Glycometer. Umuthi wohlobo lwesifo sikashukela sohlobo 2 othambekele ekukhuluphisweni. Ingasetshenziselwa isifo sikashukela sohlobo 1 ngokuhambisana ne-insulin.
3. I-Dianormet. Isiza ukuguquguqula amazinga e-hormone, ikakhulukazi ezigulini ezinamafutha emzimbeni.

Lawa ma-analogues afunwayo futhi athandwa phakathi kwesifo sikashukela sohlobo 2.

Imibono yabathengi

Ukusuka ekubuyekezweni kweziguli, kungaphethwa ngokuthi i-Glucofage iyasebenza impela ngokulungiswa koshukela wegazi, noma kunjalo, ukusetshenziswa kwayo kuphela kokunciphisa umzimba akunamsebenzi, ngoba ukuphatha kuhambisana nemiphumela emibi eminingana.

Okokuqala ngqa ukuzwa nge-Glucofage evela kugogo wethu, onesifo sikashukela sohlobo 2 futhi akakwazanga ukwehlisa ushukela nganoma yimuphi umuthi. Muva nje, udokotela oyi-endocrinologist unikeze uGlucophage kuye umthamo ka-500 mg kabili ngosuku. Ngokumangazayo, izinga likashukela lehlile ngesigamu, akukho miphumela emibi etholakele.

U-Ivan, oneminyaka engama-38, Khimki

Ngithatha i-glucophage muva nje. Ekuqaleni, ngangizizwa ngigula kancane futhi ngiba nomuzwa wokungakhululeki esiswini. Ngemuva kwamaviki amabili yonke yonke into ihambile. Inkomba kashukela yehle ukusuka ku-8,9 yaya ku-6.6. Umthamo wami ngu-850 mg ngosuku. Muva nje ngiqale ukuluma, mhlawumbe umthamo omkhulu.

UGalina, oneminyaka engama-42. I-Lipetsk

Ngamukela i-Glucofage Long ukunciphisa umzimba. Umthamo ulungiswa yi-endocrinologist. Ngiqale ngo-750. Ngidla njengenjwayelo, kepha isifiso sami sokudla sehlile. Ngiqale ukuya endlini yangasese kaningi. Kwenziwe kimi njenge-enema yokuhlanza.

U-Irina, oneminyaka engama-28, uPenza

IGlucophage ithathwa njengokuyalelwa uchwepheshe. Lesi sidakamizwa esibucayi sohlobo lwesifo sikashukela sohlobo 2, hhayi umkhiqizo wokunciphisa umzimba. Udokotela wami wangazisa ngalokhu. Ezinyangeni ezimbalwa bengilokhu ngithatha ku-1000 mg ngosuku. Amazinga kashukela ehle ngokushesha, futhi anciphisa 2 kg.

U-Alina, oneminyaka engama-33, eMoscow

Ividiyo evela kuDkt Kovalkov mayelana nesidakamizwa iGlucofage:

Izindleko ze-glucophage zincike kumthamo wento esebenzayo kanye nenani lamathebulethi amaphakethe. Intengo ephansi ngama-ruble angama-80., Okuphezulu ngama-ruble angama-300. Kuyaqapheleka ukuthi umehluko onjalo obonakalayo ngentengo kuya ngesimo sebhizinisi, isibonelelo sokuhweba kanye nenani labalamuli.