Ukusetshenziswa kwe-glyformin kushukela

Ukwelashwa kwesifo sikashukela kudinga ukuhleleka. Izidakamizwa eziningi ezisetshenziselwa lesi sifo zenzelwe ukusetshenziswa isikhathi eside.

Phakathi kwazo kukhona umuthi onjengoGlatiniin.

Imininingwane ejwayelekile

I-Gliformin yi-ejenti ye-hypoglycemic ehloselwe ukusetshenziswa kwangaphakathi. Inconyelwe iziguli ezinesifo sikashukela. Ithebhulethi ye-oval emhlophe noma ekhilimu.

Ithuluzi liyatholakala eRussia. Igama layo lesiLatini yi-GLIFORMIN.

Lesi sidakamizwa sithengiswa ngomuthi kuphela, ngoba awulungele wonke umuntu onesifo sikashukela - kwezinye izimo, ukusetshenziswa kwaso kungaba yingozi. Ngakho-ke, akwamukeleki ukuthi uqale ukwelashwa ngokwakho.

Isithako esikhulu esisebenzayo eGlformin yiMetformin. Iyingxenye yesidakamizwa ngendlela ye-hydrochloride.

Ngaphezu kwalo, umuthi uqukethe izakhi ezisizayo:

• i-povidone;
• i-polyethylene glycol;
• i-sorbitol;
• i-acid entshontsha;
• calcium phosphate dihydrate.

IGlyformin ikhiqizwa kumathebhulethi anokuqukethwe okuhlukile kwengxenye esebenzayo. Kunamathebhulethi anomthamo ongu-500 mg, 800 mg no-1000 mg (Glodein Prolong). Imvamisa, umuthi ufakwa kumaseli we-contour, ngalinye liqukethe amayunithi ayi-10 omuthi. Iphakethe liqukethe amaseli ayi-6. Futhi, kukhona ukukhishwa emabhodleleni e-polypropylene, lapho kubekwa khona izibhebhe ezingama-60 zomuthi.

I-Pharmacology ne-pharmacokinetics

Umuthi ungoweqembu lama-Biguanides. Isenzo se-metformin ukucindezela i-gluconeogeneis. Iphinde ifake namafutha amafutha futhi ithuthukise ukwakheka kwamafutha acid yamahhala.

Ngokusetshenziswa kwayo, ama-receptors asemaceleni aya ngokuya ezwela ku-insulin, futhi amaseli omzimba adonsa ushukela ngokushesha, okunciphisa inani lawo.

Ngaphansi kwethonya leMetformin, okuqukethwe kwe-insulin akushintshi. Kukhona ushintsho kuma-pharmacodynamics aleli hormone. Ingxenye esebenzayo yeGlyformin ikhuthaza ukwenziwa kwe-glycogen. Lapho uthatha lo muthi, ukumuncwa kwamathumbu glucose kuyehla.

Ukufakwa kwezakhi ezisebenzayo kuvela endaweni yokugaya ukudla. Kuthatha cishe amahora angama-2,5 ukufinyelela inani eliphakeme leMetformin.

Le nto cishe ayihlanganisi namaprotheni e-plasma. Ukuqongelela kwayo kwenzeka ezinsweni nasezibindini, kanye nasezindongeni zezinto zokwenziwa ngamathe. Ama-metabolites lapho uthatha i-Gliformin awakhiwa.

I-excretion ye-metformin inikezwa izinso. Kwengxenye yempilo, kuthatha cishe amahora angama-4,5. Uma kukhona okungahambi kahle ezinso, ukubamba kungenzeka.

Izinkomba kanye ne-contraindication

Ukusetshenziswa kwe-Gliformin ngaphandle kwesidingo nokubalwa kwemiyalo kungaba yingozi empilweni nakwezempilo. Ngakho-ke, iziguli akufanele ziyisebenzise ngaphandle kokuqokwa udokotela.

Kuyadingeka ukubheka izinkomba kanye ne-contraindication - kuphela lapho ukwelashwa kuzoletha imiphumela edingekayo.

Nikeza leli thuluzi ezimweni ezilandelayo:

• thayipha isifo sikashukela esingu-2 mellitus (lapho kungekho khona imiphumela ekwelashweni kokudla nasekuphuzeni ezinye izidakamizwa);
• thayipha i-1 isifo sikashukela (kanye nokwelashwa kwe-insulin);

Umuthi lo ungasetjenziswa ngabantu abadala nabantwana kusukela eminyakeni eyi-10. Ukuphathwa okuhlukile komuthi nokusetshenziswa njengengxenye yokwelashwa okuhlanganayo kuyenziwa.

Ngaphambi kokunquma umuthi, udokotela kufanele afunde ama-anamnesis, ngoba ezinye izifo ziyisizathu sokwenqaba ukwelashwa nalesi sidakamizwa.

Lokhu kufaka phakathi:

• ketoacidosis;
• izifo zomsuka wokutheleleka;
• isifo sikashukela;
• imibandela esondele ekhendeni;
• ukulimala kwesibindi okunzima;
• isifo sezinso esinzima;
• ukwehluleka kwenhliziyo;
• ukwehluleka ukuphefumula;
• ukushaya kwenhliziyo;
• utshwala noma ubuthi obunobuthi;
• ukungenelela kokuhlinzwa nokulimala okukhulu;
• ukuzwela kuzakhi zomuthi;
• ukukhulelwa nokuqunjelwa;

Kuzona zonke lezi zimo, kunconywa ukuthi ukhethe omunye umuthi onomphumela ofanayo, kepha ungabangeli ubungozi.

Imiyalo yokusebenzisa

Umthamo kufanele ukhethwe ngudokotela, kucatshangelwa izici zesiguli ngasinye. Ngokuvamile, ekuqaleni kokwelashwa, kunconywa ukusetshenziswa kwe-0.5-1 g ngosuku.

Ngemuva kwamaviki amabili, umthamo ungandiswa. Inani eliphezulu lezinto ezisebenzayo akufanele lidlule i-3 g.

Ngokwelashwa kokulungiswa, kunconywa ukuthatha umuthi ongu-1.5-2 g. Leli nani kufanele lihlukaniswe ngezindlela eziningana.

Abantu asebekhulile, ikakhulukazi labo abazinga labo lokuzivocavoca liphezulu kakhulu, akufanele bathathe umthamo ongaphezu kwe-1 g ngosuku.

Isheduli yokuthatha i-Glyformin incike ezinkombeni eziningi, ngakho-ke udokotela kufanele aqaphele izinguquko kokuqukethwe ushukela. Uma kunesidingo, lungisa umthamo ukuze uzuze imiphumela engcono. Ngokushintshwa kwendlela yokuphila yesiguli, umthamo kufanele ubuyekezwe futhi.

Ukuphuza la maphilisi kufanele kube ngesikhathi sokudla noma ngokushesha emva kwawo. Akudingekile ukuwachoboza noma ukuwahlafuna - agwinywa ephelele, ahlanzwa ngamanzi.

Isikhathi senkambo yokwelashwa singase sehluke. Ukungabikho kwemiphumela emibi kanye nokusebenza kahle okuphezulu, lesi sidakamizwa singathathwa isikhathi eside kakhulu. Uma kutholakala izimpawu ezingezinhle, kungakuhle ukuthi usebenzise izikhala ukuze ungasizi isimo sesiguli.

Imiyalo ekhethekile

Kunamaqembu eziguli okufanele ziqashelwe lapho kunqunywa lo muthi.

Lokhu kufaka phakathi:

1. Abesifazane abakhulelwe. Ukuthi iMetformin iyingozi kangakanani kumama wakusasa nese-fetus akwaziwa, ngoba azikho izifundo ezenziwayo kule ndawo. Kepha le nto iyakwazi ukungena ku-placenta. Ngakho-ke, ukusetshenziswa kwe-Gliformin ngesikhathi sokukhulelwa kuvunyelwe kuphela ezimweni ezinzima.
2. Omama abahlengikazi. Into esebenzayo evela kulesi sidakamizwa ingadlulela ebisini. Yize iqiniso lokuthi ayikho imiphumela emibi ngenxa yalokhu etholakale ezinsaneni, akulungile ukusebenzisa lo muthi nge-lactation.
3. Izingane. Kubo, i-Glyformin akusona isidakamizwa esenqatshelwe, kodwa kusuka kuphela eminyakeni eyi-10. Ngaphezu kwalokho, kuyadingeka ukubala ngokucophelela umthamo.
4. Abantu abadala. Isiguli esingaphezu kweminyaka engama-60 ubudala, lesi sidakamizwa asifaneleki, ngoba kukhona ubungozi bezinkinga.

Kuyadingeka ukuthi unake lezi zici ukuze ungalimazi isiguli.

Ukuthatha i-Gliformin kudinga ukuhambisana nezindlela zokuqapha ezithile eziphathelene nezifo nemibandela yesiguli:

1. Awungeke uwusebenzise lo muthi uma isiguli sinokuphazamiseka okukhulu esibindini.
2. Ngokwehluleka kwezinso kanye nobunye ubunzima obukhona nabo, umuthi kufanele ulahlwe.
3. Uma ukuhlinzwa kuhlelwa, akunakufiseleka ukuthatha la mapilisi ngokushesha ngaphambi kwawo futhi kungakapheli izinsuku ezimbili ezizayo.
4. Ukwanda kwezifo ezingamahlalakhona zemvelaphi ethelelekile noma ukukhula kwesifo esibuhlungu nakho kuyisizathu sokuyeka ukusithatha.
5. Kuyadingeka ukuqapha ngokucophelela inhlala-kahle yeziguli ezisebenza kanzima ngokomzimba ngesikhathi sokwelashwa nomuthi.
6. Lapho usebenzisa lezi zibhebhe, kunconywa ukuthi uyeke ukuphuza utshwala.

Lezi zinyathelo zizonciphisa ubungozi bezinkinga.

Imiphumela emibi kanye ne-overdose

Ukusetshenziswa kwe-Glyformin kwisifo sikashukela kungaholela emiphumeleni emibi.

Okusemqoka kufaka phakathi:

• ukuphefumula kwenhliziyo;
• ukungahambi kahle komzimba;
• ukunambitheka kwensimbi emlonyeni;
• Izinkinga ezisegayweni lokugaya ukudla.

Uma ungalandeli imiyalo, kungenzeka i-overdose. Umphumela wayo oyingozi kakhulu yi-lactic acidosis, ngenxa yokuthi isiguli singafa.

Ukuthuthukiswa kwayo kuboniswa yizimpawu ezinjengokuthi:

• ubuthakathaka
• lokushisa eliphansi
• isiyezi
• ingcindezi ephansi
• ukuphefumula ngokushesha
• ukungazi kahle.

Uma lezi zici zenzeka, kufanele uthintane nodokotela wakho. Uma kuyizimpawu ze-lactic acidosis, iGlatiniin kufanele ichithwe.

Ukusebenzisana kwezidakamizwa kanye nama-analog

Uma usebenzisa lesi sidakamizwa ngokuhambisana neminye imithi, izici zesenzo saso zingashintsha.

UGliformin uqala ukusebenza ngokuzikhandla uma kusetshenziswe kanye:

• insulin;
• izidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala;
• ama-beta-blockers;
• I-MAO ne-ACE inhibitors, njll.

Ukubuthakathaka komphumela wayo kubonakala lapho kusetshenziswa ama-glucocorticosteroids, izidakamizwa ze-hormonal, izindlela zokuvimbela ukuphathwa komlomo, njll.

Kuyinto engathandeki ukuthatha i-Gliformin nge-cimetidine, ngoba lokhu kunomthelela ekuthuthukiseni i-lactic acidosis.

Ukushintsha lesi sidakamizwa, ungasebenzisa amathuluzi anjenge:

1. I-Glucophage. Isakhi sayo esisebenzayo i-metformin nayo.
2. I-Metformin. Leli thuluzi lifana kakhulu ne-Gliformin, kodwa linentengo ephansi.
3. IFethethine. Ngenye ye-analogues eshibhile.

Akufanelekile ukukhetha umuthi ukuze ungene esikhundleni sikaGlatiniin ngokwakho - lokhu kudinga ukuqaphela. Kungcono ukubonana nochwepheshe.

Imibono yesiguli

Ukusuka ekubuyekezweni kweziguli ezithatha i-Gliformin, singaphetha ngokuthi umuthi wehlisela ushukela kahle kushukela, kodwa ukhulume imiphumela emibi, eyenza kungabi nangqondo ukuwuthatha ngaphandle kwesizathu (ukunciphisa umzimba).

Udokotela usanda kuthola ukuthi nginesifo sikashukela futhi wancomela uGlyformin. Ngiyiphuza izikhathi 2 ngosuku kwithebhulethi. Ukuphila kahle sekuthuthukile ngokubonakalayo, ushukela ubuyile kokujwayelekile, futhi wakwazi ukwehlisa isisindo.

U-Alexandra, oneminyaka engama-43

Ngibe nesifo sikashukela iminyaka engu-8, ngakho ngazama izidakamizwa eziningi. Ngisebenzisa i-Gliformin izinyanga ezimbili, ngizwa kahle. Kuqala bekuba nokuthambekela kanye nausea, kepha ngemuva kwamasonto ambalwa umzimba wakujwayela lokho futhi badlula. Kepha lo muthi awuzange umsize umfowethu - bekumele ngenqabe, ngoba unomdlavuza we-pancreatitis.

UVictor, oneminyaka engama-55

Anginaso isifo sikashukela, ngazama uGlatiniin ukuze wehlise isisindo. Umphumela wangishaqisa. Isisindo, yiqiniso, sehlile, kepha imiphumela emibi yahlushwa. Wenqabile ukusetshenziswa.

UTatyana, oneminyaka engama-23 ubudala

Ukubuyekezwa kwevidiyo kwento esetshenziswayo iMetmorfin evela kuDkt Malysheva:

Kumakhemisi ezifundeni ezihlukene, kungahlukahluka ngezindleko zalo muthi. Kukhona futhi umehluko wezindleko zeGlformin ngokuqukethwe okuhlukile kwento esebenzayo. Amanani aphakathi nalawa alandelayo: I-500 mg amaphilisi - ama-ruble ayi-115, ama-ruble ayi-850 mg - ama-210, ama-1000 mg - ama-ruble angama-485.