Ungasisebenzisa kanjani isidakamizwa i-Biosulin P?

I-Biosulin P yi-ejenti ye-glycemic esekwe esenzweni se-insulin yomuntu. Lesi sakamuva senzelwe ukubonga kubuchwepheshe bokwenza izakhi zofuzo. Ngenxa yesakhiwo esifana ne-hormone yemvelo yama-pancreas, i-Biosulin ingasetjenziselwa uhlobo 1 nesifo sikashukela. Ingxenye esebenzayo ayiweli kwi-placenta, ngakho-ke, umuthi uvunyelwe ukuphatha ngesikhathi sokukhulelwa.

Igama Lezwe elingafanele

I-insulin yomuntu NgesiLatin - insulin yomuntu.

I-Biosulin P yi-ejenti ye-glycemic esekwe esenzweni se-insulin yomuntu.

I-ATX

A10AB01.

Khipha amafomu nokwakheka

Isixazululo somjovo sivezwa njengoketshezi ongenamabala, okhanyayo. Njengesakhi esisebenzayo, i-1 ml yokumiswa iqukethe i-100 IU ye-insulin eyenzelwe umuntu ngofuzo. Ukulungisa i-pH yewuketshezi futhi wandise i-bioavailability, isithako esisebenzayo sihambisana nalezi zinto ezilandelayo:

• metacresol;
• amanzi angaboli;
• 10% i-caustic soda solution;
• Isixazululo se-hydrochloric acid sokuhlushwa okungu-10%.

I-Biosulin iyatholakala emabhodleleni engilazi noma kuma-cartridges anamanani ama-3 ml, enzelwe ukuthi isetshenziswe ne-Biomatic pen pen syringe. Isixha sekhadibhodi siqukethe iziqukathi ezi-5 kwiphakheji yomugqa we blister.

Isenzo se-Pharmacological

I-insulin ilandela ukwakheka kwehomoni yomuntu pancreatic ngokusebenzisa ukuphindaphinda kwe-DNA. Umphumela we-hypoglycemic kungenxa yokubopha kwento esebenzayo kuma-receptors ngaphezulu kwangaphandle kolwelwesi lweseli. Ngenxa yalesi simo, kwakhiwa inhlanganisela yamaseli ane-insulin, ethuthukisa umsebenzi we-enzymatic we-hexose-6-phosphotransferase, synthesis kwesibindi ne-glucose. Ngenxa yalokhu, ukwehla kokuxineka kwegazi le-serum glucose kuyabonakala.

I-Biosulin P inyusa ukwakheka kwama-glycogen namafutha ashukela kusuka kushukela, ibambezela inqubo ye-gluconeogenesis esibindini.

Umphumela wokwelapha utholakala ngokwandisa ukumunca ushukela yizicubu zomzimba. Ukuhamba kwalo ngaphakathi kwamaseli kuyathuthukiswa. Ukwakheka kwe-glycogen namafutha acid aqhamuka ku-glucose kuyanda, futhi inqubo ye-gluconeogenesis esibindini iyancipha.

Isikhathi somphumela we-hypoglycemic sibalwa ngokuya ngesilinganiso sokutholwa, okubuye, kuncike endaweni nakwindlela yokuphatha i-insulin, izici zomuntu onesifo sikashukela. Ngemuva kokuphathwa kwe-subcutaneous, umphumela wokwelapha ubonwa ngemuva kwesigamu sehora futhi ufinyelela amandla aso aphezulu phakathi kwamahora amathathu no-4 ngemuva kokusebenzisa i-cartridge. Umphumela we-hypoglycemic uhlala amahora angama-6-8.

I-Pharmacokinetics

I-Bioavailability kanye nokuqala kokusebenza kokwelashwa kuncike kulezi zinto ezilandelayo:

• indlela yokufaka isicelo - ukujova okufakwayo noma okwenzeka emzimbeni
• inani le-hormone elimele;
• indawo yomjovo (i-rectus abdominis, ithanga le-anterior, i-gluteus maximus);
• ukuhlushwa kwe-insulin.

I-hormone yokwenziwa eyakhiwe isatshalaliswa ngokungalingani emzimbeni. Ikhompiyutha esebenzayo ibhujiswa kuma-hepatocytes nasezinso. Isigamu sempilo yimizuzu engu-5- 10. Into esebenzayo ishiya umzimba ngo-30-80% ngomchamo.

Amafushane noma amade

I-insulin inomphumela omfushane.

Isikhathi somphumela we-hypoglycemic sibalwa ngokuya ngesilinganiso sokutholwa.

Izinkomba zokusetshenziswa

Umuthi ungahanjiswa kulezi zimo ezilandelayo:

• isifo sikashukela esincike ku-insulin;
• isifo sikashukela esinga-insulin esingemuva kokusebenza okuphansi kokulashwa kokudla, ukusebenza ngokomzimba nezinye izindlela zokunciphisa isisindo;
• izimo eziphuthumayo ezigulini ezinesifo sikashukela i-mellitus, ebonakala ngokudilizwa kwe-saccharide metabolism.

Contraindication

Kwenqatshelwe ukusebenzisa umuthi we-hypoglycemia nokungabekezelelani ngakunye ezingxenyeni ezisebenzayo nezisizayo.

Ngokunakekela

Kuyadingeka ukubheka njalo izinga le-glucose futhi uthintane nodokotela kulezi zimo ezilandelayo:

• ukwehluleka okukhulu kwe-renal ngenxa yokwehla okungenzeka kwesidingo se-insulin ngokumelene nesizinda se-metabolism yayo ephazamisekile;
• ukukhula kweminyaka, ngoba ngokuhamba kweminyaka umsebenzi wezinso uyancipha;
• ukwehluleka kwenhliziyo okungapheli;
• izifo noma ukwehluleka kwesibindi okuholela ekunciphiseni kwe-gluconeogeneis;
• i-stenosis enzima yemithambo ye-coronary and cerebral;
• ukwehlulwa yi-retinopathy ekhulayo ngaphandle kokwelashwa okusekelayo nge-Photocoagulation, lesi sifo ngokuqalwa kwe-hypoglycemia sandisa ingozi yokungaboni ngokuphelele;
• izifo zesibili ezenza inkambo yesifo sikashukela futhi zandise isidingo se-insulin.

Ukwehluleka okukhulu kwezinso, umuthi kufanele uthathwe ngokuqapha.

Ukwehluleka kwenhliziyo okungapheli kuyisizathu sokusebenzisa ngokucophelela umuthi i-Rinsulin R.

Ngezifo noma ukwehluleka kwesibindi, iRinsulin P ithathwa ngokuqapha.

I-Rinsulin P ithathwa ngokuqapha uma isiguli sine-stenosis ye-coronary kanye ne-cerebral artery.

I-Rinsulin P kufanele ithathwe ngokuqapha lapho ikhula.

Ungayithatha kanjani i-Biosulin P

Umthamo we-insulin unqunywa uchwepheshe wezokwelapha ngamunye, kuye ngezinkomba zoshukela wegazi. I-Biosulin ivunyelwe ukuphathwa ngaphandle kokuzenzela, ezindaweni ezinesendlalelo esijulile semisipha futhi ngaphakathi. Ukudla okumaphakathi okunconyelwe nsuku zonke kumuntu omdala kungama-0.5-1 IU nge-1 kg yesisindo (amayunithi angama-30 kuya kwayi-30).

Ochwepheshe bezokwelapha baluleka ukusebenzisa lo muthi imizuzu engama-30 ngaphambi kokuqala kokudla okubangelwa i-carbohydrate. Kulokhu, izinga lokushisa lesidakamizwa esikhokhelwayo kufanele lifane lokushisa okukhona. Nge-monotherapy ene-Biosulin, i-ejenti ye-hypoglycemic iphathwa izikhathi ezi-3 ngosuku, lapho kukhona ukudla okulula phakathi kokudla, imvamisa yemijovo ikhuphuka izikhathi ezingama-5-6 ngosuku. Uma umthamo udlula i-0.6 IU nge-1 kg yesisindo somzimba, kuyadingeka ukwenza imijovo emi-2 ezingxenyeni ezihlukene zomzimba hhayi esifundeni esisodwa se-anatomical.

Kuyadingeka ukujova umuthi ngaphansi kwesikhumba ngaphezu kwemisipha ye-rectus abdominis, kulandela i-algorithm eyenziwe ngezenzo:

1. Esakhiweni sesingeniso esiphakanyisiwe, udinga ukuqoqa isikhumba ku-crease usebenzisa isithupha kanye nesikhanda sangaphambili. Inaliti yesirinji kufanele ifakwe esibayeni sesikhumba nge-angle engu-45 ° bese ipiston lehlisiwe.
2. Ngemuva kokufakwa kwe-insulin, udinga ukushiya inaliti ngaphansi kwesikhumba imizuzwana eyisithupha noma ngaphezulu ukuze uqiniseke ukuthi umuthi uphathwa ngokuphelele.
3. Ngemuva kokususa inaliti, igazi lingaphuma endaweni yomjovo. Indawo ethintekile kufanele icindezelwe ngomunwe noma ngoboya bekotini oswakanyiswe ngotshwala.

Ngaphezu kwalokho, umjovo ngamunye kufanele wenziwe ngaphakathi kwemingcele yesifunda se-anatomical, uguqula indawo yomjovo. Lokhu kuyadingeka ukunciphisa amathuba okuba ne-lipodystrophy. Ukujova kwe-Intramuscular and injinization in the vein kwenziwa kuphela ngochwepheshe bezokwelapha. I-insulin esebenza ngokufushane ihlanganiswa nolunye uhlobo lwe-insulin enomphumela omude wokwelapha.

Nge-monotherapy ene-Biosulin, i-ejenti ye-hypoglycemic ihanjiswa izikhathi ezi-3 ngosuku.

Imiphumela emibi ye-Biosulin P

Ukuvela kwemiphumela emibi kubangelwa ukusabela komuntu komzimba esenzweni somuthi, irekhodi lomthamo ongalungile noma ukwethulwa komjovo.

Ngasohlangothini lwe-metabolism

Isifo se-Hypoglycemic esibonakaliswa ngu:

• i-cyanosis;
• ukukhuphuka kokujuluka;
• i-tachycardia;
• ukuthuthumela;
• indlala;
• ukukhuphula okukhulu;
• ukunambitheka kwe-paresthesia;
• ikhanda;
• I-hypoglycemic coma.

Allergies

Ezigulini ezine-hypersensitivity yezicubu zomzimba ezihlanganisiwe zomuthi, i-angioedema yomphimbo nokuphendula kwesikhumba kungahle kukhule. Ezimweni ezingavamile, ukwethuka kwe-anaphylactic kungenzeka.

Ukunyuka kokujuluka kungumphumela ongemuhle wesidakamizwa i-Rinsulin R.

I-Rinsulin P ingadala i-tachycardia.

Kwesinye isikhathi iRinsulin P ibanga ikhanda.

I-Hypoglycemic coma ibonakala ngesifo se-hypoglycemic syndrome esenzeka lapho kuthatha uRinsulin R.

Ezimweni ezingavamile, ukwethuka kwe-anaphylactic kungavela ngokuthatha iRinsulin P.

Umthelela ekhonweni lokulawula izindlela

Umuthi awuthinti amandla okulawula izindlela eziyinkimbinkimbi. Ngakho-ke, ngesikhathi sokwelashwa kwe-glycemic, ukushayela noma ukusebenza namadivayisi wehadiwe akuvunyelwe.

Imiyalo ekhethekile

Awukwazi ukufaka isixazululo esinamafu, isidakamizwa esishintshe umbala noma siqukethe imizimba yangaphandle eqinile. Ngesikhathi sokwelashwa kwe-insulin, kuyadingeka ukulawula izinga loshukela wegazi.

Ingozi yesimo se-hypoglycemic iyanda kulezi zimo ezilandelayo:

• ukushintshela komunye umenzeli we-hypoglycemic noma olunye uhlobo lwe-insulin;
• ukweqa ukudla;
• ukomisa ngenxa yokuhlanza kanye nohudo;
• ukukhuphuka komzimba;
• izifo ezithathanayo;
• ukwehla kokukhululwa kwe-hormonal kwe-adrenal cortex;
• ushintsho endaweni yezokuphatha;
• ukusebenzisana neminye imithi.

Uma ukwelashwa okufanele kungenziwa, i-hyperglycemia kungaholela ekutholakaleni kwe-ketoacidosis yesifo sikashukela.

Izinqubo ze-pathological ezihambisanayo, ikakhulukazi zesimo esithathelwanayo, noma izimo ezibonakaliswa ukuthuthukiswa komkhuhlane, zandisa isidingo sezicubu ze-insulin. Ukwelashwa kokubuyiselwa kwe-Biosulin nolunye uhlobo lwe-insulin yomuntu kufanele kwenziwe ngaphansi kokulawulwa okuqinile kweshukela legazi le-serum.

Ingozi yesimo se-hypoglycemic iyanda uma kuhlangana neminye imithi.

Imithamo yomuthi kumele ilungiswe ngokucophelela kulezi zimo ezilandelayo:

• ukunciphisa umsebenzi wokusebenza kwe-gland yegilo;
• isifo sesibindi noma sezinso;
• Isifo sika-Addison;
• iminyaka engaphezu kwengu-60;
• ukukhuphuka komzimba noma ushintsho ekudleni.

Umuthi unciphisa ukubekezelela kwezicubu emiphumeleni ye-ethanol.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

I-insulin eklanyelwe izakhi zofuzo ayidluleli emgqonyeni we-placental, ongaphuli ukukhula kwemvelo kwe-embryonic. Ngakho-ke, ukwelashwa kwe-insulin akuvunyelwe ngesikhathi sokukhulelwa. Umuthi awungena emithanjeni yezilwane ezincelisayo futhi awudalulwanga ubisi lwebele, oluvumela abesifazane abakhipha izisu ukungena ku-Biosulin ngaphandle kokwesaba.

Sebenzisa ebudaleni

Abantu asebekhulile ngenxa yokuncipha okuhlobene nobudala bokusebenza kwezinso ngokuvamile badinga ukulawula amazinga kashukela egazini.

Ukunquma i-Biosulin P ezinganeni

Ebuntwaneni, kwethulwa amayunithi awu-8 womuthi kunconywa.

Ukweqisa kwe-Biosulin P

Ngokusetshenziswa okukodwa komthamo omkhulu we-insulin, i-hypoglycemia kungenzeka. Ukwehla okungatheni kwama-glucose kungaqedwa ngokwakho ngokudla ushukela noma ukudla okune-carbohydrate eningi. Ngenxa yalokhu, iziguli ezinesifo sikashukela sohlobo 2 ziyelulekwa ukuba ziphathe imikhiqizo kafulawa noma ye-confectionery, amajusi wezithelo noshukela.

Uma isiguli siphelelwa amandla, khona-ke kuvela i-hypoglycemia ngokweqile. Kulokhu, ukuphathwa ngokushesha kwekhambi le-glucose noma i-dextrose solution eyi-40%, i-1-2 mg ye-glucagon ngaphakathi, ngokufanele noma nge-intramuscularly kuyadingeka. Lapho uthola ukwazi kabusha, kuyadingeka ukuthi unikeze otholwayo ukudla okunama-carbohydrate amaningi ukuze anciphise ingozi yokuphinde futhi.

Uma isiguli siphelelwa amandla, khona-ke kuvela i-hypoglycemia ngokweqile.

Ukuxhumana nezinye izidakamizwa

Ukuhambisana notshwala

I-ethyl alcohol iyasithinta kabi isistimu yokujikeleza komsebenzi kanye nokusebenza kwesibindi nezinso. Ngenxa yalokho, i-insulin metabolism iyaphazamiseka, okungaholela ekulahlekelweni kokulawulwa kwe-glycemic. Amathuba okukhula kwe-hypoglycemia ayanda. Ngakho-ke, ngesikhathi sokulashwa nomuthi, kwenqatshelwe ukuphuza utshwala.

Ama-Analog

Umuthi ungathathelwa indawo yizinhlobo ezilandelayo ze-insulin ezisebenza ngokushesha:

• I-Insuman Rapid GT;
• I-Actrapid NM Penfill;
• IGensulin P;
• Humulin Njalo.

Imibandela yekhefu lekhemisi

Umuthi ungathengwa ngemithi kadokotela.

Ngingakwazi ukuthenga ngaphandle kadokotela

Umthamo ongalungile ungaholela ekuthuthukisweni kwe-hypoglycemia kuze kufike ekuqaleni kwesifo sikashukela, ngakho-ke, lesi sidakamizwa sithengiswa ngezizathu eziqondile zokwelashwa.

Intengo ye-Biosulin P

Izindleko ezijwayelekile zokufakwa ngamabhodlela ngama-ruble angama-1034.

Izimo zokugcina zomuthi

Kunconywe ukugcina ama-cartridge kanye nama-ampoules ane-insulin emazingeni okushisa we- + 2 ... + 8 ° C endaweni eseceleni kokukhanya nendawo enomswakama ophansi.

Isikhathi sokuphelelwa yisikhathi

Izinyanga ezingama-24. Ngemuva kokuvula i-ampoule ingagcinwa izinsuku ezingama-42, ama-cartridge, izinsuku ezingama-28 ekushiseni kuka + 15 ... + 25 ° C.

Umkhiqizi

Marvel LifeSines, India.

Ukubuyekezwa mayelana neBiosulin P

Isidakamizwa sesizimele emakethe yemithi ngenxa yempendulo enhle evela kodokotela neziguli.

I-analog yeRinsulin P ibhekwa njenge-Insuman Rapid GT.

Humulin I-analogue ejwayelekile yesidakamizwa Rinsulin R.

I-Actrapid NM Penfill ithathwa njenge-analogue yesidakamizwa i-Gensulin R.

I-Gensulin R - i-analogue yesidakamizwa i-Rinsulin R.

Odokotela

U-Elena Kabluchkova, udokotela we-endocrinologist, uNizhny Novgorod

Ikhambi elisebenzayo le-insulin elisiza nge-hyperglycemia ephuthumayo kwizifo sikashukela. Ipeni lesirinji lilungele iziguli ezine-schedule eguquguqukayo yempilo nomsebenzi. Isenzo esifushane sisiza ukubhekana ngokushesha noshukela ophezulu. Ngokuthola ngokushesha umphumela wokwelapha, ungasebenzisa i-cartridge ngaphambi kokudla. I-Biosulin ivunyelwe ukusetshenziswa nezinye izidakamizwa ngokuya nge-insulin esebenza isikhathi eside. Iziguli zingathola umuthi ngesaphulelo.

U-Olga Atamanchenko, udokotela we-endocrinologist, uYaroslavl

Emkhakheni wezokwelapha, bengilokhu nginquma umuthi kusukela ngoMashi 2015. Ngokuqala kwalolu hlobo lwe-insulin kwabanesifo sikashukela, izinga lempilo lithuthuka, amathuba we-hyperglycemia ne-hypoglycemia ancipha. Kuvunyelwe ukusetshenziswa ezinganeni nakwabesifazane abakhulelwe. Ngenxa ye-insulin esebenza ngokufushane, isiguli singakwazi ukuphatha umuthi ezimweni eziphuthumayo (ngamazinga kashukela amaningi). Ngicabanga ukuthi iBiosulin isidakamizwa esisebenza ngokushesha, esezingeni eliphakeme.

Isifo sikashukela

UStanislav Kornilov, oneminyaka engama-53 ubudala, iLipetsk

I-insulin esebenza ngempumelelo. Ngisebenzise i-Gensulin ne-Farmasulin, kepha ngathola ukwehla okuhle kokuhlungwa koshukela ngenxa ye-Biosulin kuphela. Isidakamizwa sesizibonakalisile sihlanganiswa ne-Insuman Bazal - insulin esebenza isikhathi eside. Ngenxa yomphumela osheshayo, ngakwazi ukwandisa ukudla kwezithelo. Ngabona ukuthi ezidakamizweni ezidlule ikhanda lami lalihlala libuhlungu, kepha lo mphumela omubi awubonwa. Ngigculisekile ngomphumela, kepha into esemqoka ukulandela imiyalo yokusebenzisa kanye nokudla okunqunyelwe.

U-Oksana Rozhkova, oneminyaka engama-37, uVladivostok

Eminyakeni engu-5 eyedlule, ubesenkingeni yokunakekelwa okuhlobene nokwanda kwesifo sikashukela, angazi ngaso.Lapho esethole ukulawulwa kwe-glycemic, udokotela wakhuluma ngokuxilongwa futhi wanquma i-Biosulin njalo. Uthe kulula kakhulu ukusebenzisa ipeni lesirinji. Ngenkathi umuthi ufakiwe, amazinga kashukela ahlala emikhawulweni ejwayelekile. Kepha lolu hlobo lwe-insulin alusebenzi isikhathi esifushane, futhi kwakudingeka ukukhetha olunye uhlobo olunomphumela omude. Ngangesaba ukuthi le mishanguzo yayingahambisani, kepha ukungabaza bekungakaqinisekiswa. Kuhle ukuhlanganiswa nolunye uhlobo lwe-insulin.