I-Captopril Sandoz iyisidakamizwa esisebenzayo esisebenza ngokushesha esisebenza ekwelapheni umfutho wegazi ophakeme. Kuboniswa izifo ezinobungozi obukhulu bezinkinga zenhliziyo.
Igama elingabambeki emhlabeni jikelele
I-Captopril
Atkh
S09AA01
I-Captopril Sandoz iyisidakamizwa esisebenzayo esisebenza ngokushesha esisebenza ekwelapheni umfutho wegazi ophakeme.
Ukukhipha amafomu nokwakheka
Kuyatholakala kumathebulethi, kunezimpawu ezilandelayo:
- ukwakheka kuyindilinga noma ngendlela yeqabunga elinamahlamvu amane;
- umbala umhlophe;
- ingaphezulu alilungile;
- ingozi yokubethelwa kolunye uhlangothi noma zombili izinhlangothi.
Kukhiqizwa ngokuqukethwe okuhlukile kwengxenye eyinhloko. Amayunithi wokukhishwa, asuswe ku-6.25, 12,5, 100 mg, abe nomumo oyindilinga. Ngendlela yeqabunga elinamaqabunga amane, amafomu aqukethe u-50 no-25 mg wento esebenzayo ayatholakala.
Igcwele emabhulashini amayunithi omthamo ayi-10. Bakhishwa ngamaphakethe amakhadibhodi. Umyalo unamathiselwe.
Iyunithi ngayinye yokudedela iqukethe isithako esisebenzayo se-Captopril nezithako ezisizayo. Ukwakheka kwezinto ezingeziwe:
- isitashi sommbila;
- i-lactose monohydrate;
- i-microcrystalline cellulose;
- i-stearic acid.
Aliqukethe amakhambi ayingozi, ahlinzeka ngomphumela odingekile wokwelapha.
Isenzo semithi
Inomphumela we-hypotensive. Ivimbela ukwakheka kwe-vasoconstrictor angiotensin II kusuka ku-angodyotensin engasebenzi kahle kwe-hemodynam. I inciphisa ukucasulwa kwe-aldosterone.
Ikhuthaza ukunqwabelana kwe-bradykinin, okuthinta ukwakheka kwe-vasodilating prostaglandins.
Ngokusetshenziswa isikhathi eside inomphumela wenhliziyo:
- kunciphisa ngaphambi nangemva kokulayishwa;
- kuthuthukisa ukuhamba kwegazi kwezindawo ezingama-ischemic ze-myocardium;
- kwandisa ukugcinwa kwe-coronary;
- kubambezela ukwakheka kwe-hypertrophy, i-dilatation ye-ventricle yangakwesobunxele;
- Ivumela umsebenzi we-diastolic.
Akubangeli i-Reflex tachycardia. Iqinisa ukuhamba kwegazi lesitho, kunciphisa ukuhlanganiswa kweplatelet.
Imithamo eyanele yomuthi yokuhluleka kwenhliziyo ayibangeli ukuguquguquka kwengcindezi yegazi. Faka isandla ekonyeni lemizuzu, ukhulisa ukubekezelela umzimba.
Ukungathathi hlangothi. Inomphumela wokusindisa potassium. Kuthinta ukuzwela kwe-insulin.
Inomphumela we-nephroprotective. Ukwehlukaniswa kwemikhumbi yezinso esebenza kahle kusiza ukunciphisa ingcindezi ye-intraglomerular. Ivimbela ukusabela okuqhubekayo kwe-intravascular proliferative, normalizing isakhiwo kanye nemisebenzi ye-epithelium.
Umsebenzi wohlelo lwe-renin-angiotensin ulawula ukuthuthukiswa kokuphendula okuyinhloko komzimba ekuthatheni umuthi.
Ekhemisi
Umuthi unomsebenzi oqondile webhayoloji. Akuthinti amasistimu we-tisin renin-angiotensin. Umphumela we-hemodynamic uhlotshaniswa ne-vasodilation, akuxhomeki ezingeni le-renin egazini.
I-Captopril Sandoz ichazwe njengengxenye yokwelashwa okuyinkimbinkimbi kokuqina komfutho wegazi.
Kuxoshwe ngokushesha. Ukuqala kwesenzo kuphawulwa ngemuva kwemizuzu engama-30. I-bioavailability yomuthi iphezulu. Ukuphathwa ngomlomo kunikeza umphumela omkhulu ngemuva kwehora eli-1. Isikhathi sokusebenza sisuka emahoreni amane kuya kwayi-12.
It is eyenziwe ngesibindi, kwakha metabolites engasebenzi. Ukhuliswe yizinso. Ingxenye yento edakwayo ikhishwe ingashintshiwe emzimbeni. Inganqwabelana uma kwenzeka umsebenzi wezinso ungasebenzi kahle. Isigamu sempilo ezimweni ezinjalo sikhuphuka sibe usuku olulodwa nengxenye.
Okusizayo
Ngokuvamile kubekwa njengengxenye yokwelashwa okuyinkimbinkimbi kwezifo ezilandelayo:
- umfutho wegazi ophakeme
- isifo sikashukela se-nephropathy;
- ukwehluleka kwenhliziyo okungapheli;
- acute coronary thrombosis.
Njengoba i-monotherapy isebenza ngempumelelo esigabeni sokuqala se-arterial hypertension, iqhubeka ngaphandle kwezinkinga.
Contraindication
Kufakwe ekukhulelweni, ukuncelisa. Ayisebenzi ezinganeni ezingaphansi kweminyaka engu-18.
Awukwazi ukusebenzisa lesi sidakamizwa nge-:
- umlando we-angioedema wanoma imuphi umsuka;
- I-hypersensitivity yezinto zokwakha noma ezinye izidakamizwa zaleli qembu;
- ukugula kwe-serum;
- i-aldosteronism eyinhloko;
- ukungabekezelelani kwe-lactose, ukuntuleka kwe-lactase emzimbeni;
- i-bilpatal renal stenosis noma i-artery stenosis yezinso olulodwa.
Umenzeli ohlukumezayo akakwazi ukusetshenziswa ngemuva kokufakwa kwezinso.
I-Captopril ayisetshenziswa ezinganeni ezingaphansi kweminyaka engu-18.
Ngokunakekela
Ukuqapha kufanele kusetshenziswe kulezi zifo ezilandelayo:
- i-hypertrophic obstriers cardiomyopathy;
- isifo sikashukela mellitus;
- i-scleroderma, systemic lupus erythematosus;
- i-mitral valve stenosis, i-oripice ye-aortic;
- isimo se-hypovolemia;
- ukwehluleka kwesibindi nezinso.
Lapho unquma umuthi, kubalulekile ukuthi unake ukusetshenziswa kokudla okungenasawoti, izithasiselo zokudla okunempilo.
Umthamo
Uhlobo lomthamo lumuntu ngamunye. Ngomqondo wezinso, kuyadingeka ukugxila kuzinkomba zokucaciswa kwe-creatinine. Ezimweni ezinjalo, kusetshenziswa imithamo esebenza ngempumelelo, izikhawu ezinde phakathi kwemithamo.
Nge-myocardial infarction
Ukunikezwa umuthi kokuqala kwesidakamizwa kukhonjiswa ngokufakelwa kwe-myocardial esimweni sesimo esizinzileyo sesiguli. Qala ukwelashwa ngomthamo omncane we-6.25 mg ngosuku. Ukuphindaphindwa kokwamukelwa kuyakhula kancane kancane, kufinyelela umphumela omuhle kakhulu.
Ekucindezelweni
Kuyadingeka ukuqala ukwelashwa ngomthamo osebenza kancane, olawula ukubekezelelwa komthamo wokuqala. Nikeza u-12.5 mg kabili ngosuku. Kukhuphuka umthamo wokuhamba kancane kancane ukuze kufinyelele ezingeni lokuqondiwe. Iziguli eziseqenjini labantu asebekhulile zinqunywe umthamo omncane womuthi.
Ekuhlulekeni kwenhliziyo okungapheli, ngaphambi kokuqala ukwelashwa, ama-diuretics akhanseliwe noma umthamo wawo uncishisiwe.
Ekuhlulekeni kwenhliziyo okungapheli
Ngaphambi kokuqala ukwelashwa, ama-diuretics akhanseliwe noma umthamo wawo uncishisiwe. Qala ngemithamo emincane evunyelwe, ekhula kancane kancane. Ukungabikho kokusabela okungekuhle kukuvumela ukuthi usebenzise umuthi isikhathi eside. Umthamo wansuku zonke uhlukaniswe ngemithamo emibili.
Nesifo sikashukela se-nephropathy
Umthamo wokuqala ungama-75-100 mg wesidakamizwa ngosuku. Imvamisa yokusetshenziswa ichazwa udokotela oholayo. Ukufeza umphumela omuhle kakhulu, ukuqokwa njengengxenye yokwelashwa okuhlanganisiwe kuyakhonjiswa.
Kanjani ukuthatha Captopril sandoz
Kunconywa ukuthatha umuthi ihora eli-1 ngaphambi kokudla. Umthamo ukhethiwe ngamunye ngokuya ngesifo.
Ngaphansi kolimi noma isiphuzo
Indlela yokuphuza umuthi inqunywa ubukhali balesi simo. Ngokulashwa okuhleliwe, umuthi kufanele ugwinywe wonke, ugezwe ngamanzi anele.
Esimweni senhlekelele, umuthi ongaphansi uvunyelwe.
Isenzo somuthi senzeka ngokushesha, ngemuva kwemizuzu engama-30. Umphumela omkhulu ngokuphathwa ngomlomo ubonwa ngehora lokuqala.
Kusebenza isikhathi esingakanani
Isenzo somuthi senzeka ngokushesha, ngemuva kwemizuzu engama-30. Umphumela omkhulu ngokuphathwa ngomlomo ubonwa ngehora lokuqala.
Ngingaphuza kangaki
Kuyikhambi elisebenza okwesikhashana. Umthamo owodwa uthathwa kabili ngosuku. Ngokubona kukadokotela, ukuvunyelwa kathathu kuvunyelwe. Umphumela oqhubekayo wokwelapha utholakala ngokusetshenziswa okuhlelekile nokuhlala isikhathi eside.
Imiphumela emibi ye-Captopril sandoz
Imiphumela emibi engathandeki ayivelakancane, kepha ingadala imiphumela emibi impela. Imiphumela eminingi engemihle ayidingi ukungenelela, inyamalala ngokuyekiswa komuthi.
Ipheshana emathunjini
Ukuthatha umuthi kungahle kuhambisane nenguquko yokunambitheka, ukuntuleka kwesifiso sokudla. Akuvamile ukuba kube nobuhlungu besisu, ukuphazamiseka kwesifo sokuqina. Kwesinye isikhathi kuba nokwanda kokuxwilwa kwe-bilirubin kanye ne-hepatic transaminases.
Izitho ze-hematopoietic
Ukusetshenziswa kwesidakamizwa isikhathi eside kuhambisana nokukhula kwe-neutropenia, i-thrombocytopenia, kanye nokwehla kwezinga le-hemoglobin. Ukusabela okunjalo kwenzeka kakhulu, kudlule ngokwabo.
Ukusetshenziswa kwesidakamizwa isikhathi eside kuhambisana nokwehla kwezinga le-hemoglobin. Ukusabela okunjalo kwenzeka kakhulu, kudlule ngokwabo.
Uhlelo lwangaphakathi lwezinzwa
Isiyezi, ikhanda elijwayelekile livame ngokwanele ezinsukwini zokuqala zokwamukelwa. Ukwelashwa okukhethekile akudingekile. Umphumela wesidakamizwa ungahle uhambisane nomuzwa wokukhathala, ukunganaki, ukuthuthukiswa kwe-paresthesia, asthenia.
Kusuka ohlelweni lomchamo
Umuthi ungadala ukwehla kokuhlunga kwe-glomerular. Isimo esinjalo sidinga ukuncishiswa kwamthamo noma ukuhoxiswa kwezidakamizwa, ukugada ngokucophelela kwezokwelapha.
Kusuka ohlelweni lokuphefumula
Ukukhwehlela owomile kuvela kaningi. Mhlawumbe ukuthuthukiswa kwe-rhinitis, umuzwa wokuntuleka komoya. Imiphumela emibi kakhulu ibandakanya i-bronchospasm. Kuyivelakancane.
Engxenyeni yesikhumba
Ukuthatha umuthi uvame ukuhambisana nokulunywa kwesikhumba, ukubonakala kokuqhuma. Ukusetshenziswa isikhathi eside kwalo muthi kubangela ukuthuthukiswa kwe-lymphadenopathy. Okungaphansi kakhulu i-dermatitis kanye ne-urticaria.
Komzimba
Kukhona ubungozi bokuthuthukisa i-Quincke edema. Ukuvela kwe-angioedema e-larynx kusongela ukuphazamiseka komoya. Umuthi uyakhanselwa, i-epinephrine ilawulwa ngokushesha, futhi umoya utholakala ngokukhululekile.
Lapho uthatha i-Captopril, kufanele ugweme ukushayela izimoto.
Nethonya kwikhono lokulawula izindlela
Gwema ukushayela izimoto. Ungazibandakanyi nomsebenzi ohambisana nokunaka ukunakwa kanye nokunemba okuphezulu kokubulawa.
Imiyalo ekhethekile
Ukwelapha ukwelashwa kudinga ukubhekwa njalo kwamakhemikhali we-hemodynamic nomsebenzi wezinso.
Kuyadingeka ukubheka ukuthi kungenzeka ukuthi kuthuthukiswe i-hypovolemia uma isetshenziswa ndawonye nama-diuretics. Isimo esifanayo sisongela ngokukhubazeka okukhulu kwamathambo, ngisho nokufa.
Ukugwema ukuthuthukiswa kwezinkinga kusiza:
- ukulungiswa kwamthamo;
- ukwesulwa okokuqala kwe-diuretics;
- ukufaniswa kwamakhemikhali we-hemodynamic.
I-Renal artery stenosis idinga ukunikezwa kwesilinganiso somuthi wesidakamizwa, ukuqapha isimo sohlelo lokuchama.
I-Proteinuria uma usebenzisa imithamo emikhulu iyancishiswa noma ihambe ngokwayo.
Kuyadingeka ukugwema ukuphathwa kanyekanye kwemithi equkethe i-potassium.
Ngokucophelela ngokucophelela kwe-pathology yezicubu ezithintekayo, okwenza ukwelashwa kwe-immunosuppression. Kubalulekile ukulawula okuqukethwe kwamaseli wegazi amhlophe namanye amaseli egazi.
Ukuqashwa njalo kwamazinga kashukela egazini kuyadingeka.
Ukuthuthukiswa kwe-cholestatic jaundice, ukwanda kwe-titer of hepatic transaminases kudinga ukuhoxiswa ngokushesha komuthi.
Ukwelashwa ngomuthi kumiswa usuku ngaphambi kokuqala kokungenelela okuhlinza okuhleliwe.
Ngesikhathi sokukhulelwa, i-Captopril ayikwazi ukusetshenziswa.
Sebenzisa ngesikhathi sokukhulelwa nokuqunjelwa
Umuthi unomphumela we-teratogenic. Ngesikhathi sokukhulelwa akukwazi ukusetshenziswa.
Ukuhlukaniswa nobisi lwebele kunciphisa ukusetshenziswa komuthi ngesikhathi sokukhulelwa.
Ukuhambelana notshwala
Ukusebenzisana notshwala kuphakamisa umphumela we-antihypertensive womuthi, okuholela ekuphulweni kokuhlinzekwa kwegazi ezithweni nasezithanjeni. Izimo ezifanayo zisongela ukuthuthukiswa kwezimo zokuqina kwemithambo.
Ukusetshenziswa kophuzo oludakayo kunomthelela ekususeni ngokushesha i-potassium emzimbeni, kuqeda imiphumela emihle yesidakamizwa emisipha yenhliziyo.
Utshwala bukhulisa i-dilatation yemithambo yegazi, bunomphumela onobuthi. Mhlawumbe ukuthuthukiswa kokuwohloka kwamathambo.
Overdose ye-Captopril sandoz
Ukuthatha imithamo emikhulu yezidakamizwa kudala ukuphazamiseka kwezitho, kusongela impilo. Ukwehla okukhulu komsebenzi wokumpompela kwenhliziyo kuhambisana nokuntuleka kwenhliziyo kwesokunxele, ukwehla kwe-hemodynamics, kanye nokuthuthukiswa kwesimo se-collaptoid. Kuvela izimpawu zokuhluleka kwezinso okunamandla.
Lesi simo sidinga ukwelashwa okuphuthumayo. Hlanza isisu. Nikeza abathakathi. Phindisela ukugeleza kwegazi, phatha ukwelashwa okubonakalayo.
Ukusetshenziswa okuhambisanayo ne-diuretics kungaholela ekuthuthukisweni kwe-hypotension, ukwehla kokuqukethwe kwe-potassium ku-serum yegazi, ne-hypovolemia.
Ukusebenzisana nezinye izidakamizwa
Ukusetshenziswa okuhambisanayo ne-diuretics kungaholela ekuthuthukisweni kwe-hypotension, ukwehla kokuqukethwe kwe-potassium ku-serum yegazi, ne-hypovolemia.
Ukusetshenziswa kwamalungiselelo we-potassium, izithasiselo zokudla kuhlotshaniswa nokukhula kwe-hyperkalemia nokuphazamiseka kokusebenza kwezinso.
I-hypotension enkulu ibangelwa izidakamizwa ezisetshenziselwa i-anesthesia.
Akunakwenzeka ukuhlanganisa ukwamukela ne-Aliskiren namanye ama-inhibitors we-ACE.
Ukufaka isicelo nge-allopurinol kuholela ekubukekeni kwe-neutropenia, kwandisa ingozi yokuvela okukhulu komzimba.
Umphumela we-hypotensive womuthi uvuselelwa ngabakwa-beta-blockers, abamelene ne-calcium, ama-nitrate, amaphilisi okulala, ama-antipsychotic.
Umuthi ukhulisa ukuqina kwe-digoxin egazini.
Kukhona ubungozi be-hypoglycemia lapho uxhumana nama-hypoglycemic agents.
Ibambezela ukuqedwa kokulungiswa kwe-lithium, ikhulisa ukugxilisa ingqondo kwabo kwe-plasma.
Lapho uxhumana namalungiselelo wegolide, umphumela we-hypotensive uyathuthukiswa.
I-Indomethacin, ibuprofen inciphisa umphumela wesidakamizwa. Ukuphendula okufanayo kuyaphawulwa ngokusetshenziswa kwe-estrogen, izindlela zokuvimbela inzalo ngomlomo, ama-corticosteroids.
Ukusetshenziswa ngama-antacid nokudla kunciphisa i-bioavailability yesidakamizwa ngama-40%.
Izichazi
Ukufana kwezidakamizwa, okufanayo ekwakhekeni nasekwenziweni kwento:
- Kapoten;
- I-Captopril-Akos;
- I-Alkadil;
- I-Epsiron
- I-Captopril Hexal.
Hluka ezweni lemvelaphi, amagama, intengo. Khetha i-analogue ngemuva kokubonisana nodokotela.
Imigomo yekhefu ekhemisi
Ikhishwe ngumbhalo.
Ngingakwazi ukuthenga ngaphandle kadokotela
Kuvinjelwe ukuthengiswa kwamahhala.
Inani le-Captopril sandoz
Intengo iyahlukahluka kusuka kuma-ruble angama-83 kuya kwangama-135 ngephakeji ngalinye.
Izimo zokugcina umuthi
Gcina endaweni evikelwe ukukhanya nomswakama. Gwema kude nezingane. Ukushisa kwesitoreji kungabi ngaphezu kwe- + 25˚С.
Usuku lokuphelelwa isikhathi
Iminyaka emi-2 kusukela ngosuku lokukhishwa, olukhonjisiwe kwiphakheji.
Umkhiqizi
"USalutas Pharma GmbH" (Germany).
ISandoz, eSwitzerland.
Umenzi we-Captopril sandoz yinkampani yakwaSandoz, eSwitzerland.
Ukubuyekezwa kodokotela neziguli mayelana ne-Captopril sandoz
U-Eugene, udokotela wezifo zenhliziyo, oneminyaka engama-46, uKrasnodar
Umuthi uthatha isinyathelo esifushane, ubekezelelwa kahle. Intengo inengqondo. Ngincoma kuphela uma kunesimo esiphuthumayo. Ngezinye izinhloso, kungcono ukusebenzisa imikhiqizo esebenza isikhathi eside.
UNatalia, oneminyaka engama-46, uNovosibirsk
Ngokokuqala ngisebenzisa umuthi wokumisa inkinga yegazi. Isebenza ngokushesha, kwakungekho miphumela emibi. Manje ngithatha njengokuyalelwa udokotela.
ULika, oneminyaka engama-53, uRybinsk
Sengineminyaka eminingi ngihlushwa umfutho wegazi ophakeme. Ngathatha izindlela ezahlukahlukene. Umuthi lo uhamba phambili. Ngikwamukela ngaphansi kokuhlolwa udokotela. Ngokuphumelelayo nezinkinga ezinomfutho wegazi, kusheshe kube njalo isimo. Ukungaphenduki okungalungile akubangeli.
