Umenzeli wokukhulula oguquliwe usiza ukunciphisa ushukela wegazi. Kubhekiswa kumalungiselelo wesulfonylurea wesizukulwane sesibili. Yabela ekwelapheni isifo sikashukela sohlobo 2.
Igama Lezwe elingafanele
I-Gliclazide.
I-Glidiab MV - isidakamizwa esikhululwa ngokuguqulwa kwesimo esisebenzayo sisiza ukunciphisa ushukela wegazi.
I-ATX
A10BB09.
Khipha amafomu nokwakheka
Umenzi ukhiqiza umkhiqizo ngesimo sezibhebhe zezingcezu eziyi-10 kwiphakeji yeseli. Iphakethe lekhadibhodi linamathebhulethi angama-60.
Into esemqoka yesidakamizwa yi-gliclazide ngesilinganiso esingu-30 mg. Ukwakheka kuqukethe i-microcrystalline cellulose, i-magnesium stearate, hypromellose.
Isenzo se-Pharmacological
Ngaphansi kwesenzo somuthi, amaseli we-pancreatic beta aqala ukukhiqiza i-insulin, kuthi izicubu eziwuzungezile zixakeke kakhulu eglucose. Ithuluzi linciphisa ushukela wegazi, livimbela ukunamathela kwe-platelet kanye nokuvela kwama-cholesterol deposits, athuthukisa imithambo yegazi. Umuthi wehlisa inani lamaprotheni kumchamo futhi ubangela ukuncipha kwesisindo.
I-Pharmacokinetics
Izakhi zomuthi zimunca ngokuphelele emgudwini wokugaya ukudla. Into esebenzayo idedelwa kancane kancane, kuthi ngemuva kwamahora angama-6 kuya kwe-12, ukugxila egazini kufinyelele kwinani layo eliphezulu. Ibopha amaprotheni ngo-95-97%. Iba phakathi kwe-biotransformation esibindini. Kuthuliswa izinso. Ukuqedwa kwesigamu sempilo kungamahora ayi-16.
Into esebenzayo isuswe yizinso.
Izinkomba zokusetshenziswa
IGlidiab MV inqunywe ukuthi inciphise ukugcwala kweglucose egazini ngohlobo 2 sikashukela.
Contraindication
Ungaqali ukwelashwa uma une-contraindication elandelayo:
- thayipha i-1 isifo sikashukela;
- ukwephulwa kwe-carbohydrate metabolism ngenxa yokushoda kwe-insulin;
- ukukhulelwa
- ukuncelisa;
- hypersensitivity kuzakhi zomuthi;
- i-precoma ne-coma;
- ukwephulwa okukhulu kwesibindi nezinso;
- ukuvinjwa kwamathumbu;
- isimo esidinga ukushintshwa nsuku zonke kokushoda kwe-insulin (ukuhlinzwa, ukushiswa);
- ukwephulwa komsebenzi wezimoto zesisu;
- i-hypoglycemia ngokumelene nesizinda sezifo ezithathelwanayo;
- ukwehla kwenani lama-leukocytes ku-plasma yegazi.
Kuyadingeka ukukhetha ngokucophelela umthamo lapho ukhona we-febrile syndrome, uphuzo oludakayo kanye nezifo ze-yegilo.
Ungayithatha kanjani i-Glidiab MV
Thatha umthamo onconyiwe ngokudla kokuqala 1 ngosuku.
Ngoshukela
Ngokwesifo sikashukela sohlobo 2, kubekwa ithebhulethi elilodwa (30 mg) ngosuku. Imithamo ingandiswa isikhathi esingu-1 emavikini ama-2. Ngokuya ngokuqhubeka kwesifo, udokotela angakunquma amaphilisi angafika kwangama-4 ngosuku (akusekho okunye). Ekwehlulekeni kwezinso okubucayi obukhulu, ukulinganiswa kwamthamo akudingeki uma imvume ye-creatinine isebangeni le-15 kuye ku-80 ml / min.
Imiphumela emibi yeGlidiab MV
Ukungezelela umthamo kungaholela ku-hypoglycemia. Lesi simo sihambisana nokukhishwa inyumbazana, isiyezi, ikhanda elibi, imizwa ekhathazayo yendlala, ukulahlekelwa ukwazi, ukuthuthumela, ubuthakathaka, ukujuluka. Ngenkathi ukuphuza amaphilisi, i-urticaria, ukuvimbela ukusebenza kwe-hepatic, i-anemia, isicanucanu, uhudo kungavela.
Umthelela ekhonweni lokulawula izindlela
Ithuluzi lithinta ukunakwa kokunakwa, ngakho-ke kungcono ukulahla ukuphathwa kwezindlela eziyinkimbinkimbi nezimoto.
Ngesikhathi sokwelashwa, kungcono ukulahla ukuphathwa kwezindlela eziyinkimbinkimbi nezimoto.
Imiyalo ekhethekile
Ushukela wegazi kufanele ulinganiswe ngaphambi nangemva kokudla. Ngesikhathi sokwelashwa, kunconywa ukulandela ukudla okune-limited carbohydrate ekudleni. Ukuzila ngokushesha kwandisa ingozi ye-hypoglycemia. Ngesikhathi sokuphatha, ukumelana kwezidakamizwa kwesibili kungaqala ukuvela.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Abesifazane ngesikhathi sokukhulelwa nokuncelisa ibele bayaphulwa.
Kunquma uGlidiab MV ezinganeni
Kuze kube yiminyaka eyi-18 ayinqunyelwe.
Sebenzisa ebudaleni
Ekwaluphaleni, umzimba uzwela kakhulu esenzweni sabaphatheli be-hypoglycemic. Ngaphambi kokusebenzisa, kungcono ukubonana nodokotela.
Ukweqisa kwe-Glidiab MV
Uma weqa umthamo ophakanyisiwe, kukhona ukwehla okukhulu kokuxineka koshukela egazini. Isiguli sizwa isiyezi, ukwesaba, indlala. Izandla ziqala ukuthuthumela ngokungananazi, ukujuluka kuya ngokuqina. Isimo singakhuphuka size sifinyelele ku-hypoglycemic coma. Ezimpawu zokuqala, udinga ukuthatha i-carbohydrate, edonswa kalula (ushukela). Uma ukuhlaselwa kuhambisana nokulahlekelwa ingqondo, isisombululo se-glucose siphathwa ngaphakathi, bese i-glucagon iphathwa ngendlela efanelekile.
Isiyezi singesinye sezimpawu zokweqisa.
Ukuxhumana nezinye izidakamizwa
Ezinye izidakamizwa zithinta umphumela wezidakamizwa ngezindlela ezahlukene:
- umphumela we-hypoglycemic uncishiswa ngokusetshenziswa kanyekanye kwama-hormone e-steroid kusukela ekuhambeni kwe-corticosteroids, "slow" calcium blockers, Barbituric acid derivatives, sympathomimetics, phenytoin, acetazolamide, diuretics, estrogen, nicotinic acid, chlorpromazine, lithiamu I-Baclofen, i-Diazoxide, iDanazole, iChlortalidone ne-Asparaginase;
- Ama-inhibitors e-ACE, ama-NSAIDs, cimetidine, fungus kanye nesifo sofuba, i-biguanides, ama-anabolic agents, ama-beta-blockers, ama-fibroic acid derivatives, i-salicylates, i-ethanol, i-coumarin anticoagulants, isenzo esingaqondile, i-Chloramphenicol, i-Cinimetinil, i-Cinimetinin I-Guanethidine, i-MAO inhibitors, i-Pentoxifylline, i-Theophylline, i-phosphamides, i-tetracycline antibiotic.
Ukuthatha i-glycosides yenhliziyo kungaholela ekuphazanyisweni kwesigqi senhliziyo.
Ukuhambisana notshwala
Ukusetshenziswa okuhlangana notshwala kungaholela ekwakhiweni kwe-hypoglycemia. Ingozi yokuthola ukuphazamiseka kwesistimu yezinzwa, ngesinye isikhathi kuze kuquleke, iyanda. Kunconywa ukulahla utshwala ngesikhathi sokwelashwa.
Ama-Analog
Kunezichasiselo ezingangena esikhundleni saleli thuluzi. Lokhu kufaka phakathi i-Diabeteson MB, Glidiab, Diabetesalong, Diabefarm MB, Gliclazide MB. Kungenzeka ukulawula ukusebenzisa i-Type 2 sikashukela, kepha umuthi awunawo umphumela wesikhathi eside.
Izidakamizwa zinokuphikisana kanye nemiphumela emibi. Ngaphambi kokufaka esikhundleni se-analogue, kufanele uvakashele udokotela futhi uhlolwe.
Uyini umehluko phakathi kukaGlidiab noGlidiab MV
Umuthi onombhalo obhalwe i-MB kwiphakheji usebenza kakhulu. Into esebenzayo, engena emzimbeni, ikhishwa isikhathi eside. Ngakho-ke, lesi sidakamizwa sihlala isikhathi eside kunomlingani waso wegama elifanayo.
Imibandela yekhefu lekhemisi
Umuthi usatshalaliswa unikezwa umuthi, ongawuthola kudokotela wakho.
Intengo yeGlidiab MV
Intengo emakhemisi aseRussia isuka kuma-ruble ayi-130 kuye kwangama-150.
Izimo zokugcina zomuthi
Ukupakishwa kumele kubekwe endaweni eyomile futhi emnyama. Ukushisa okukhulu + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Impilo yeshelf iyiminyaka emi-2. Kuyenqatshelwa ukufaka isicelo ngemuva kwesikhathi esikhonjiswe kwiphakheji.
Ukwakheka okufanayo yiDiabeteson MV.
Umkhiqizi
I-JSC Amakhemikhali neZitshalo Zemithi i-Akrikhin, eRussia.
Ukubuyekezwa mayelana ne-Glidiab MV
Ithuluzi ekwelashweni okuyinkimbinkimbi ngokushesha futhi isikhathi eside kunciphisa izinga le-glucose egazini. Impendulo evumayo ishiywe yizo zombili iziguli nodokotela. Kubalulekile ukulandela imiyalo futhi ungeqi umthamo.
Odokotela
UGleb Mikhailovich, udokotela wobuchopho
Umuthi ubuyekeza izinqubo ze-metabolic, uvimbela ukubonakala kwe-atherosulinosis. Umuthi osebenzayo uvimbela ukwakheka kwe-glucose kusuka ezingxenyeni ezingezona ze-carbohydrate futhi kuthinta ukwenziwa kwe-insulin. Ezinye iziguli zingakhala ngokukhathala, ukozela, nokuphazamiseka kwendlela yomgudu wesisu. Ukugwema ukusabela okubi, umuthi kumele uthathwe ngokuya ngemiyalo. Kubalulekile ukugwema ukuzila ukudla nokuphuza utshwala.
U-Anna Yuryevna, udokotela wezifo zenhliziyo
Ithuluzi likhuthaza ukugcinwa kwe-insulin ngamaseli β-cell. Ukudla njalo amaphilisi kusiza ukukhulula iziguli ezinama-hypoglycemia. Ungawuzwa umphumela wokuphuza amaphilisi ngokushesha okukhulu uma udlala ezemidlalo, gwema ukucindezela bese ulandela ukudla okune-carb ephansi.
Kunconywa ukulahla utshwala ngesikhathi sokwelashwa.
Isifo sikashukela
UKarina, oneminyaka engama-36
Nikeza umuthi esikhundleni somuthi i-Diabeteson. Ekuqaleni, umthamo omncane awudalanga ukusabela. Ngiqale ukuphuza amaphilisi ama-2 ngosuku futhi umphumela waba muhle. Kamuva, udokotela wehlise umthamo ku-1 ithebhulethi. I-analogue esebenzayo futhi eshibhile. Into esebenzayo isebenzisa izinga leshukela ne-cholesterol egazini, isiza ukunciphisa isisindo somzimba. Ezinyangeni ezi-5, ulahlekelwe ngamandla i-8 kg.
UMaxim, iminyaka engama-29
Lesi sidakamizwa sinezinzuzo eziningi - umphumela wesikhathi eside, ukubekezelela ukukhuphuka kwe-glucose. Ekuqaleni kunzima ukukhetha umthamo, kepha owaqala ngobuncane. Ngemuva kwenyanga, ushukela wehle waya ku-4,5 futhi umuthi wasebenza cishe usuku. Ukuhlaziywa kukhombisa ukuthi kunamaplatifomu amancane egazini, inani lamaprotheni kumchamo lancishisiwe.
U-Alexander, oneminyaka engama-46
Ushukela wegazi ukhuphuke ngenxa yokudla izidakamizwa. Udokotela unqume ukuphuza lesi sidakamizwa kwithebhulethi eli-1 ngosuku esiswini esingenalutho. Ngayithatha ekuseni, futhi isimo sami saba ngcono. Izinga le-glucose elinganiselwe ngemuva kokuphathwa, yahlola umsoco. Kungcono ukungalethi umthamo ngenxa yokufiphala okungenzeka. Wanelisekile ngomphumela.
