IGlucophage neMetformin izidakamizwa ezivela eqenjini le-Biguanide ezinganciphisa ukugcwala kwe-glucose egazini ngaphandle kokuvusa izimo ze-hypoglycemic. Ingabekelwa iziguli ezindala nezingane ezingaphezulu kweminyaka eyi-10. Isibonakaliso sokusetshenziswa kwabo uhlobo lwe-2 sikashukela mellitus, kufaka phakathi nenkinga yokukhuluphala. Vumela ukuhlanganiswa kwale mithi nokwelashwa kwe-insulin.
Isici se-Glucophage
Umuthi ungumbukiso ohlanganyelwe weFrance neRussia, okhiqizwe ngesimo samathebhulethi amhlophe, efakwe kumafilimu. Amathebulethi aqukethe into esebenzayo, i-metformin hydrochloride, ngamanani alandelayo:
- 500 mg;
- 850 mg;
- 1000 mg
Ngokuya ngomthamo, amaphilisi ayindilinga noma awoli.
Ngokuya ngomthamo, amaphilisi ayindilinga noma awoli. Uphawu "M" lumakwe ngakolunye uhlangothi, kanti ngakolunye uhlangothi kungahle kube nenombolo ekhombisa inani lezinto ezisebenzayo.
Izici zeMetformin
Amathebhulethi akhiqizwa inani elikhulu lezinkampani zemithi zaseRussia. Kungenzeka ihlanganiswe nefilimu noma i-enteric coating noma kungenzeka ayinayo. Iqukethe isithako esisebenzayo esingu-1 - i-metformin hydrochloride kwimithamo:
- 500 mg;
- 850 mg;
- 1000 mg
Ukuqhathanisa kwe-Glucofage neMetformin
I-Glucophage neMetformin zinento efanayo esebenzayo, indlela efanayo yokukhipha nomthamo futhi ziyizifanekiselo eziphelele zomunye.
Ukufana
Le mishanguzo inomphumela ofanayo we-pharmacological, ovele uvule ukusebenza:
- ama-receptors asemaceleni futhi andise amathuba okuba ne-insulin;
- abathuthi be-transmembrane glucose;
- inqubo yokusebenzisa ushukela kwezicubu;
- inqubo yokuhlanganiswa kwe-glycogen.
IGlucophage neMetformin zinento efanayo esebenzayo.
Ngaphezu kwalokho, i-metformin hydrochloride yehlisa inani loshukela okhiqizwa isibindi, yehlisa i-cholesterol, i-lipoprotein engazweli kanye nama-hormone e-thyroid egazini, futhi inciphise ukungena kwe-carbohydrate emathunjini.
Le nto ine-bioavailability ka-50-60%, ecasulwa izinso icishe ingashintshiwe.
Umthamo ukhethwa ngudokotela ngawodwana. Abakhiqizi bancoma ukuqala ngo-500 mg izikhathi ezingama-2-3 ngosuku, uma kunesidingo, ukukhulisa umthamo owodwa njengoba umzimba uvumelana nezimo zawo zibekezelela. Inani lempahla esebenzayo ethathwe ngosuku akufanele yeqe i-3 g kubantu abadala ne-2 g ezinganeni.
Le mithi ingadala imiphumela emibi eminingana. Phakathi kwazo kukhona:
- i-lactic acidosis;
- ukumuncwa okungafanele i-Vitamin B12;
- ukwephula ukunambitheka, ukulahleka kwesifiso sokudla;
- ukuqubuka nokunye ukusabela kwesikhumba;
- ukuphazamiseka kwesibindi;
- Izimpawu ze-dyspeptic, kanye nokuhlanza kanye nohudo, okuholela ekuphelelwa ngumzimba emzimbeni.
Ukuze uthuthukise ukubekezelelana, kunconywa ukuthi wephule umthamo wansuku zonke uthathe imithamo eminingana. Abantu abangaphezu kweminyaka yobudala engama-60 futhi basebenza kanzima ngokomzimba basengozini enkulu yokuba nezinkinga.
Njengoba into esebenzayo yazo zombili lezi zidakamizwa idalulwa izinso, kuyadingeka ukuthi uhlole okungenani kanye ngonyaka ukusebenza kwawo, yize iqiniso lokuthi i-metformin hydrochloride ayibangeli i-polyuria kanye nezinye izinkinga zokuchama.
Le mithi ine-contraindication efanayo futhi yenqatshelwe ukusetshenziswa kulezi zimo ezilandelayo:
- ukungasebenzi kahle kwezinso noma ingozi enkulu yokukhula kwabo;
- izicubu hypoxia noma izifo eziholela ekukhuleni kwayo, njengokuhlaselwa yisifo senhliziyo, ukuhluleka kwenhliziyo;
- ukwehluleka kwesibindi;
- ukuhlinzwa uma kudingekile ukwelashwa kwe-insulin;
- ukudakwa okungapheli, ukudakwa ngokweqile;
- ukukhulelwa
- Ukudla kwe-hypocaloric;
- i-lactic acidosis;
- Izifundo ezisebenzisa ama-iodine aqukethe i-iodine agents.
Yomibili le mishanguzo inezinhlobo ezisebenza isikhathi eside, ekhonjiswa umaki omude. Umuthi onjalo uthathwa isikhathi esingu-1 ngosuku futhi ulawula izinga likashukela amahora angama-24.
Uyini umehluko?
Umehluko kumalungiselelo ubangelwa kuphela ukuthi zikhiqizwa yizinkampani ezahlukahlukene zemithi, futhi ziqukethe:
- ukwakheka kwalabo abathola ukulethwa ezibhebheni nasegobolondeni;
- inani.
Yikuphi okushibhile?
Kwelinye lamakhemikhali akwe-inthanethi, i-Glucofage ephakeji yamathebhulethi angama-60 ingathengwa ngalezi zindleko ezilandelayo:
- 500 mg - ama-ruble ayi-178.3;
- 850 mg - ama-ruble angama-225.0;
- I-1000 mg - ama-ruble angama-322,5.
Ngaso leso sikhathi, intengo yenani elifanayo leMetformin yile:
- 500 mg - kusuka kuma-ruble ayi-102.4. isidakamizwa esikhiqizwe yi-Ozone LLC, kuze kufike kuma-ruble angama-210.1. ngemithi eyenziwe nguGideon Richter;
- 850 mg - kusuka kuma-ruble ayi-169. (I-LLC Ozone) efinyelela kuma-ruble angama-262.1. (I-Biotech LLC);
- I-1000 mg - kusuka kuma-ruble angama-201. (Inkampani yakwaSanofi) efinyelela kuma-ruble angama-312.4 (Inkampani ye-Akrikhin).
Izindleko zezidakamizwa eziqukethe i-metformin hydrochloride azihambi ngegama lokuhweba, kepha kunqubomgomo yamanani womenzi. IMetformin ingathengwa ngo-30-40% oshibhile ngokukhetha amaphilisi enziwe i-Ozone LLC noma iSanofri.
Yini engcono - Glucofage noma Metformin?
IGlucophage neMetformin ziqukethe into efanayo esebenzayo kumithamo efanayo, ngakho-ke akunakwenzeka ukuphendula umbuzo wokuthi imiphi le mishanguzo engcono. Ukukhetha phakathi kwabo kufanele kwenziwe ngokususelwa kwinani lezimali kanye nezincomo zikadokotela, ezingase zihlangane, ngokwesibonelo, nabaqaphi abakhona ezibhebheni.
Ukukhetha phakathi kwezidakamizwa kumele kwenziwe ngokuya ngenani lezimali nezincomo zikadokotela.
Ngoshukela
Ngokwemiyalo yabakhiqizi, zombili lezi zidakamizwa zinconywa ukuthi zisetshenziswe kusifo sikashukela sohlobo 2.
Ukwehla kwesisindo
Umphumela wazo zombili izidakamizwa ekwehliseni isisindo ziyefana. Iziguli eziningi zibika ukwehla kwezidingo zokudla, ikakhulukazi ekudleni okuqukethe ushukela omningi.
Ukubuyekezwa kweziguli
UTaisiya, oneminyaka engama-42 ubudala, uLipetsk: "Ngikhetha umuthi i-Glucofage, ngoba ngithemba umenzi waseYurophu ngokwengeziwe. Ngingawubekezelela kahle lo muthi: izinga leshukela egazini lihlala liqinile, kepha imiphumela emibi ayiveli. Ngaphezu kwalokho, isifiso sami sokudla sehlile futhi nokulangazelela kwami amaswidi kunyamalale."
U-Elena, oneminyaka engama-33, eMoscow: "Udokotela wezifo zamazinyo unqume ukuthi i-Glucophage yehlise isisindo. Umuthi uyasebenza, kepha udla kuphela ekudleni. Umphumela omubi onjalo wokuwuthatha njengokwehlisa umdlavuza wenziwa isikhathi esifushane. Ngemuva kwesikhathi esithile, ukuze kusindiswe, kwanqunywa ukuba kususwe okunye nge Metformin. Angiphawulanga mehluko ekusebenzeni kahle nasekubekezelelekeni. "
Ukubuyekezwa kodokotela mayelana neGlucofage neMetformin
UVictor, umondli wezempilo, oneminyaka engu-43 ubudala, uNovosibirsk: "Ngaso sonke isikhathi ngikhumbuza isiguli sami ukuthi inhloso eyinhloko yezidakamizwa ezinjalo ukwenza ushukela wegazi kube ngokujwayelekile. Lezi zinto zisetshenziselwa ukwelapha isifo sikashukela. Ukulahleka kokudla, okusiza ukunciphisa isisindo, kuyindlela embi yomzimba "Into enamandla. Yabantu abaphilile, ukusetshenziswa kwayo akukaze kuboniswe, futhi ukudla nokuzivocavoca kuyizindlela ezinhle kakhulu zokunciphisa umzimba."
UTaisiya, i-endocrinologist, oneminyaka engama-35 ubudala, eMoscow: "I-Metformin hydrochloride iyithuluzi elisebenzayo ekulweni ne-insulin ukumelana nokunciphisa ukubekezelelwa kwe-glucose. Ngaphezu kwalokho, inamandla okwehlisa i-glycemia. Ngihlala ngichaza izidakamizwa eziqukethe ezigulini ezinesifo sikashukela, hhayi i-2 kuphela, kodwa futhi Uhlobo 1. Ukulimala okuyinhloko kwento yinto yemiphumela emibi ekhonjiswayo. "
