I-Xelevia ibhekisela kuma-ejenti we-hypoglycemic. Isetshenziswa njengengxenye eyinhloko yokwelapha okuyinkimbinkimbi yesifo sikashukela sohlobo 2. Inomphumela ophikelelayo we-hypoglycemic.
Igama Lezwe elingafanele
Isidakamizwa se-INN: Sitagliptin
Igama elingabambezeli lesidakamizwa i-Xelevia yiSitagliptin.
I-ATX
Ikhodi ye-ATX: A10VN01
Khipha amafomu nokwakheka
Kutholakala kumathebulethi ehlanganiswa ngefilimu. Amacwecwe anemibala kakhilimu, ngaphezulu kolwelwesi lwamafilimu ngakolunye uhlangothi aqoshwe "277", ngakolunye uhlangothi abushelelezi ngokuphelele.
Isithako esikhulu esisebenzayo yi-sitagliptin phosphate monohydrate kumthamo we-128,5 mg. Izinto ezingeziwe: i-microcrystalline cellulose, i-calcium hydrogen phosphate, i-croscarmellose sodium, i-magnesium stearate, i-magnesium stearyl fumarate. Ukuhlanganiswa kwefilimu kuqukethe i-polyvinyl alcohol, i-titanium dioxide, i-polyethylene glycol, i-talc, ophuzi nobomvu i-iron oxide.
Umuthi uyatholakala emabhulashini amaphilisi ayi-14. Kwiphakheji lekhadibhodi kukhona ama-2 blisters anjalo nemiyalo esetshenzisiwe.
Bheka futhi: Imiyalo yokusebenzisa umuthi iChitosan.
Yimaphi amamodeli we-glucometer eyodwa yokuthinta asebenza kangcono?
Kuphi futhi kanjani ukufaka i-insulin ku-mellitus yesifo sikashukela - funda kulesi sihloko.
Isenzo se-Pharmacological
Kuhloswe ukuthi kwelashwe ushukela ohlotsheni lwesibili. Indlela yokusebenza isebenza ngokususelwa ekuvinjelweni kwe-enzyme DPP-4. Umuthi osebenzayo wehluka esenzweni sawo kuma-insulin namanye ama-antiglycemic agents. Iqoqo lama-insulinotropic anciphisa i-glucose.
Kukhona ukucindezela kokukhululwa kwe-glucagon ngamaseli we-pancreatic. Lokhu kusiza ekunciphiseni ukwakheka kwe-glucose esibindini, ngenxa yalokho izimpawu ze-hypoglycemia zincishisiwe. Isenzo se-sitagliptin sihloselwe ukuvimbela i-hydrolysis yama-enzymes e-pancreatic. I-Glucagon secretion iyancishiswa, ngaleyo ndlela ikhuthaze ukukhululwa kwe-insulin. Kulokhu, inkomba ye-insulin ye-glycosylated kanye ne-glucose egazini iyancishiswa.
I-Xelevia kuhloswe ngayo ukwelapha isifo sikashukela sohlobo 2.
I-Pharmacokinetics
Ngemuva kokufaka iphilisi ngaphakathi, into esebenzayo imunwa masinyane emgodini wokugaya ukudla. Ukudla kuthinta ukumuncwa. Ukugxilisa kwayo okuphezulu egazini kunqunywa ngemuva kwamahora ambalwa. I-Bioavailability iphezulu, kepha amandla okubopha ezinhlakeni zamaprotheni aphansi. Metabolism kwenzeka esibindini. Umuthi ukhishwa emzimbeni kanye nomchamo ngokuhlunga kwe-renal kokubili okungashintshiwe nangendlela yama-metabolites ayisisekelo.
Izinkomba zokusetshenziswa
Kunezinkomba ezimbalwa eziqondile zokusetshenziswa kwalo muthi:
- i-monotherapy yokuthuthukisa i-glycemic metabolism ezigulini ezinesifo sikashukela sohlobo 2;
- ukuqala ukwelashwa okuyinkimbinkimbi ngohlobo lwe-metformin uhlobo 2 sikashukela;
- ukwelashwa kwesifo sikashukela sohlobo 2, lapho ukudla nokuzivocavoca kungasebenzi;
- ngaphezu kwe-insulin;
- ukwenza ngcono ukulawulwa kwe-glycemic kuhlanganiswe nokutholakala kwe-sulfonylurea;
- inhlanganisela yokwelashwa kwesifo sikashukela sohlobo lwesibili ne-thiazolidinediones.
Contraindication
Ukuphulwa okuqondile kokusetshenziswa kwesidakamizwa, okukhonjiswe kwimiyalo yokusetshenziswa, yile:
- hypersensitivity kuzakhi zomuthi;
- isikhathi sokukhulelwa nokukhulelwa;
- iminyaka efinyelela eminyakeni eyi-18;
- isifo sikashukela sikashukela;
- thayipha i-1 isifo sikashukela;
- umsebenzi wokuphazamiseka kwezinso.
I-Xelevia isetshenziswa ekwelapheni isifo sikashukela sohlobo 2, lapho ukudla nokuzivocavoca kunganikeli mphumela.
Ngokukhathalela okukhulu, i-Xelevia ibekelwe abantu abaphethwe kabi futhi balinganiselwe ukuqina kwezinso, iziguli ezinomlando we-pancreatitis.
Ungayithatha kanjani iXelevia?
Imithamo nobude besikhathi sokwelashwa kuncike ekujuleni kwaleso simo.
Lapho wenza i-monotherapy, umuthi uthathwa ku-umthamo wokuqala nsuku zonke we-100 mg ngosuku. Umthamo ofanayo ubonwa lapho usebenzisa umuthi ngokuhlangene ne-metformin, insulin ne-sulfonylureas. Lapho wenza ukwelashwa okuyinkimbinkimbi, kungakuhle ukuthi unciphise umthamo we-insulin othathwe ukugwema ukuthuthukiswa kwe-hypoglycemia.
Ungathathi umthamo ophindwe kabili womuthi ngosuku olulodwa. Ngokushintshwa okubukhali empilweni ejwayelekile, ukulungiswa komthamo kungadingeka. Kwezinye izimo, amaphilisi wehafu noma wekota anqunyelwe, ikakhulukazi anomthelela we-placebo. Umthamo wansuku zonke ungahlukahluka ngokubheka ukubonakaliswa kwezifo zesifo kanye nokusebenza kokusetshenziswa kwalesi sidakamizwa.
Imiphumela emibi ye-Xelevia
Lapho uthatha i-Xelevia, imiphumela emibi elandelayo ingenzeka:
- ukungahambi kahle komzimba;
- ukulahleka kwesifiso
- ukuqunjelwa
- iminyakazo
- i-tachycardia;
- ukuqwasha
- i-paresthesia;
- ukungazinzi ngokomzwelo.
Ezimweni ezingavamile, ukwanda kwama-hemorrhoids kungenzeka. Ukwelashwa kuyimpawu. Ezimweni ezinzima, ezihambisana nokuqunjelwa, kwenziwa i-hemodialysis.
Umthelela ekhonweni lokulawula izindlela
Ucwaningo olunembile ngemiphumela yomuthi ezinga lokuphendula kanye nokuhlushwa alwenziwe. Umthelela ongemuhle ekuphatheni kwezindlela eziyinkimbinkimbi nezimoto awulindelekile.
Imiyalo ekhethekile
Kukhona ubungozi bokuthuthukisa i-hypoglycemia, ngakho-ke kuyalulekwa ukunciphisa kancane kancane isilinganiso se-insulin esetshenziswa yizimpawu ezibalulekile. Kuxwayiswa asebekhulile, iziguli ezinezifo zesibindi, izinso kanye nesifo senhliziyo.
Sebenzisa ebudaleni
Ngokuyisisekelo, iziguli esezikhulile azidingi ukulungiswa komthamo. Kepha uma isimo siba sibi kakhulu noma ukwelashwa kunganikeli imiphumela ebilindelekile, khona-ke kungcono ukuyeka ukuthatha amaphilisi noma ukuguqula umthamo wehle.
Iziguli asebekhulile azidingi ukuguqula umthamo wesidakamizwa i-Xelevia.
Isabelo sezingane
Ayisebenzi ekuziphatheni kwengane.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Akukho datha eqondile ngomphumela wento esebenzayo ku-fetus. Ngakho-ke, ukusetshenziswa kwalesi sidakamizwa ngesikhathi sokukhulelwa kwenqatshelwe.
Njengoba kungekho datha ethembekile yokuthi umuthi udlulela ubisi lwebele, kungcono ukuyeka ibele uma kudingeka ukwelashwa okunjalo.
Isicelo sokusebenza kokulimala kwezinso
Umuthi umuthi uzoncika ekuthini imvume ye-creatinine. Lapho ephakeme, yehlisa umthamo obekiwe. Uma kwenzeka umsebenzi wezinso onganele, umthamo wokuqala ungashintshwa ube ngu-50 mg ngosuku. Uma ukwelashwa kunganikeli umphumela owafunayo wokwelapha, udinga ukukhansela umuthi.
Sebenzisa umsebenzi wesibindi okhubazekile
Ngezinga eliphansi lokwehluleka kwezinso, ukulungiswa komthamo akudingeki. Umthamo wansuku zonke kuleli cala kufanele ube yi-100 mg. Kuphela ngesilinganiso esinzima sokwehluleka kwesibindi, ukwelashwa ngalo muthi akwenziwa.
Ngokwesilinganiso esinzima sokuhluleka kwesibindi, i-Xelevia ayinqunyelwe.
Ukweqisa kweXelevia
Azikho neze izimo zokweqisa. Isimo sobuthi obunzima bezidakamizwa singenzeka kuphela lapho uthatha umthamo owodwa ngaphezulu kwe-800 mg. Kulesi simo, izimpawu zemiphumela emibi ziyanda.
Ukwelashwa kufaka ukwelashwa kwesisu, ukwelashwa okukhishwa emzimbeni kanye nokwelashwa kokulungiswa. Kuzokwazi ukususa ubuthi emzimbeni usebenzisa i-dialysis ende, ngoba i-hemodialysis ejwayelekile isebenza kuphela ezimweni ezithambile ze-overdose.
Ukuxhumana nezinye izidakamizwa
Umuthi ungahlanganiswa ne-metformin, i-warfarin, ezinye izindlela zokuvimbela inzalo ngomlomo. I-pharmacokinetics yento esebenzayo ayiguquki ekwelashweni okuhlangene ne-ACE inhibitors, ama-antiplatelet agents, izidakamizwa ezithoba i-lipid, i-beta-blockers ne-calcium blockers.
Lokhu kufaka nezidakamizwa ezingezona i-anti -idalidal anti-inflammatory, antidepressants, antihistamines, proton pump inhibitors, nezidakamizwa ezithile ukuqeda ukungasebenzi kwe-erectile.
Lapho kuhlanganiswa ne-Digoxin neCyclosporine, ukwanda okuncane kokuxineka kwento esebenzayo kuplasma yegazi kuyabonakala.
Ukuhambisana notshwala
Awukwazi ukuthatha lesi sidakamizwa notshwala. Umphumela womuthi uncishisiwe, kanti nezimpawu ze-dyspeptic zizokwanda kuphela.
Ama-Analog
Lo muthi une-analogues ethile efana nawo ngokuya ngento esebenzayo nomphumela onawo. Okuvame kakhulu phakathi kwabo yilezi:
- ISitagliptin;
- I-Sitagliptin phosphate monohydrate;
- UJanuvius;
- Yasitara.
Imibandela yekhefu lekhemisi
I-Xelevia ingathengwa emakhemisi kuphela ngemithi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Akunakwenzeka.
Intengo
Intengo isuka kuma-ruble ayi-1500 kuye kwangama-1700. iphakheji ngayinye futhi kuya ngesifunda sokuthengisa namamakethi ekhemisi.
Izimo zokugcina zomuthi
Khetha indawo eyomile nebumnyama, kude nezingane ezisencane, enamazinga okushisa angadluli + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Iminyaka engu-2 kusukela ngosuku lokukhipha olukhonjiswe kwiphakheji. Ungasebenzisi ngemuva kwalesi sikhathi.
Umkhiqizi
Inkampani yezokukhiqiza: "Berlin-Chemie", Germany.
Gcina i-Xelevia kude nezingane ezincane.
Ukubuyekezwa
UMikhail, oneminyaka engama-42, uBryansk
Udokotela weluleke ukuthatha i-Xelevia njengekhambi eliyinhloko. Ngemuva kwenyanga yokusetshenziswa, ushukela wokuzila usheshe wakhuphuka, ngaphambi kokuthi ungaphakathi kweminyaka engu-5, manje ufinyelela kuma-6,6,5. Ukusabela komzimba ekusebenzeni komzimba sekuguqukile. Phambilini, ngemuva kokuhamba noma ukudlala imidlalo, ushukela wehla kakhulu, futhi ngokuqinile, inkomba yayicishe ibe ngu-3. Lapho uthatha i-Xelevia, ushukela ngemuva kokuzivocavoca wehla kancane, kancane kancane, bese ubuyela kokujwayelekile. Waqala ukuzizwa engcono. Ngakho-ke ngincoma umuthi.
U-Alina, oneminyaka engama-38, uSmolensk
Ngemukela iXelevia njengesengezo se-insulin. Sekuphele iminyaka ngigula nginesifo sikashukela futhi ngazama nemithi eminingi kanye nezinhlanganisela. Ngiyithanda kakhulu le. Umuthi uphendula ushukela ophezulu. Uma manje sehlisiwe, isidakamizwa ngeke "siyithinte" bese siyiphakamisa kakhulu. Yenza kancane kancane. Akukho spikes ushukela phakathi nosuku. Kukhona elinye iphuzu elihle elingachazwanga emiyalweni yokusetshenziswa: indlela yokudla eguqukayo. Isifiso sokudla sincishiswa cishe yingxenye. Lokhu kuhle.
UMark, oneminyaka engama-54 ubudala, u-Irkutsk
Umuthi wafika ngaso leso sikhathi. Ngaphambi kwalapho, uthathe uJanuvia. Ngemuva kwakhe, bekungekuhle. Ngemuva kwezinyanga ezimbalwa zokuthatha i-Xelevia, hhayi nje kuphela ukuthi izinga likashukela lalifinyeziwe, kepha futhi nesimo jikelele sempilo. Ngizizwa nginamandla amaningi, asikho isidingo sokuhlala ngidla. Cishe ngikhohliwe ukuthi iyini i-hypoglycemia. Ushukela akaqhamuki, uyacwila futhi ukhuphuke kancane futhi kancane kancane, lapho umzimba uphendula kahle.
