IGentadueto ngenye yezidakamizwa ezisetshenziswa ekwelapheni isifo sikashukela. Inomphumela ophikelelayo we-hypoglycemic futhi ikuvumela ukuthi ulondoloze izinga elijwayelekile le-glucose isikhathi eside esanele.
Igama Lezwe elingafanele
INN: ILinagliptin + Metformil
IGentadueto ngenye yezidakamizwa ezisetshenziswa ekwelapheni isifo sikashukela.
I-ATX
A10BD11
Khipha amafomu nokwakheka
Umuthi uyatholakala ngesimo samathebulethi efilimu. Into esemqoka esebenzayo: linagliptin 2,5 mg ne-metformin hydrochloride emthanjeni ka-500, 850 noma we-1000 mg. Izici ezingeziwe zethulwe: i-arginine, isitashi sommbila, i-Copovidone, i-silicon dioxide, i-magnesium stearate. I-membrane yefilimu yakhiwa yi-titanium dioxide, udayi ophuzi nobomvu wensimbi, i-propylene glycol, hypromellose, talc.
Ithebhulethi i-2.5 + 500 mg: i-biconvex, i-oval, ehlanganiswe nefilimu yombala ophuzi. Ngakolunye uhlangothi kukhona umbhalo womkhiqizi, ngakolunye kukhona umbhalo othi "D2 / 500".
Izibhebhe ze-2,5 + 850 mg ziyefana, umbala wejazi lefilimu kuphela osawolintshi okhanyayo, kanti amaphilisi we-2.5 + 1000 mg anombala okhanyayo we-pink ganda.
Isenzo se-Pharmacological
ILinagliptin ingukuvimbela kwe-enzyme DPP-4. Inactivates ama -retretins kanye ne-insulinotropic polypeptide econsa. Ama-incretin abamba iqhaza ekugcineni amazinga eglucose ajwayelekile. Isakhi esisebenzayo sibopha ama-enzyme futhi sandisa ukugcwala kwama-incretins. Ukuqunjelwa kwe-insulin secretion kuyenyuka, futhi ukufihlakala kwe-glucagon kuyancipha, okulinganisa inani le-glucose.
I-Metformin iyi-greatuanide. Inomphumela ophikelelayo we-hypoglycemic. Ukuhlushwa kwe-glucose glucose kuyancipha. Kulokhu, ukukhiqizwa kwe-insulin akukhuthazeki, ngakho-ke i-hypoglycemia iba kuphela ezimweni ezingavamile. I-synthesis glucose yesibindi iyancipha ngenxa yokuvinjwa kwe-glycogeneis ne-gluconeogeneis. Ngenxa yokuzwela kwe-insulin okwandayo kwama-receptors angaphezulu, ukusetshenziswa kwe-glucose okungcono ngamaseli kwenzeka.
I-Metformin ivuselela ukwakheka kwe-glycogen ngaphakathi kwamaseli.
I-Metformin ivuselela ukwakheka kwe-glycogen ngaphakathi kwamaseli. Inomphumela omuhle kuma-lipid metabolism. Yehlisa ukugcwala kwe-cholesterol ne-triglycerides egazini. Ukusetshenziswa kwe-linagliptin kuhlangene ne-sulfonylurea derivatives kanye ne-metformin kunciphisa i-HbA1c (ngo-0,62% uma kuqhathaniswa ne-placebo; i-HbA1c yokuqala yayingama-8.14%).
I-Pharmacokinetics
Izinto ezisebenzayo zidonswa ngokushesha zivela emgodini wokugaya ukudla. Izitho zisatshalaliswa ngokungalingani. I-Bioavailability kanye namandla okubopha ezinhlakeni zamaprotheni aphansi impela. I-Excretion yenzeka ngemuva kokuhlunga kwe-renal ikakhulukazi okungashintshiwe.
Izinkomba zokusetshenziswa
Izinkomba eziqondile zokusetshenziswa kwalo muthi yilezi:
- ukwelashwa kohlobo 2 lwesifo sikashukela ezigulini ezinokulawulwa okunganele kwe-glycemic ngethamo elikhulu le-metformin;
- ukuhlanganiswa nezinye izidakamizwa kanye ne-insulin kubantu abadala abane-diabetesic pathology, uma ukusetshenziswa kwe-metformin kanye nalezi zidakamizwa akunikezeli ukulawulwa okwanele kwe-glycemic;
- Ukwelashwa kwabantu ngaphambili kokuthatha i-metformin ne-linagliptin ngokwehlukana.
Isibonakaliso esiqondile sokusetshenziswa kwalo muthi ukwelashwa kwesifo sikashukela sohlobo 2 ezigulini ezinokulawulwa okunganele kwe-glycemic ngethamo eliphakeme le-metformin.
Isetshenziswa njengesengezo sokudla nokuzivocavoca umzimba ukuze uthuthukise ukulawulwa kwe-glycemic kubantu abane-Type 2 pathology.
Contraindication
Kuyenqatshelwe ngokuphelele ukusebenzisa umuthi ezimeni ezinjalo:
- thayipha i-1 isifo sikashukela;
- hypersensitivity kwizakhi ngazinye;
- isifo sikashukela sikashukela;
- i-lactic acidosis;
- isimo sokukhubazeka kwesifo sikashukela;
- ukwehluleka okunzima kwezinso;
- izifo ezidala izicubu ze-izicubu: ukubola kokuhluleka kwemisipha yenhliziyo, ukuphefumula, ukushaya kwenhliziyo kwakamuva;
- ukwehluleka kwesibindi;
- ukudakwa kotshwala.
Ngokunakekela
Ukunakekelwa okuyisipesheli kumele kuthathwe ezigulini ezineminyaka engaphezu kwengama-80.
Ungayithatha kanjani iGentadueto?
Umuthi wenzelwe ukuphathwa ngomlomo. Ukuze unciphise ukubonakala kwemiphumela emibi engafuneki, kutuswa amaphilisi ukuthi adliwe neziphuzo.
Ukwelashwa kwesifo sikashukela
Umthamo wansuku zonke ngu-2.5 mg + 500 mg, 2,5 mg + 850 mg noma 2,5 mg + 1000 mg. Phuza amaphilisi kabili ngosuku. Umthamo ukhethiwe kucatshangelwa ubunzima bezimpawu zomtholampilo zesifo kanye nokuba sengozini kwezinto zezinto ezisebenzayo emzimbeni. Umthamo omkhulu wansuku zonke akufanele ube ngaphezulu kuka-5 mg + 2000 mg.
Imiphumela Emibi Gentadueto
Imvamisa, ngokusetshenziswa okuhlanganisiwe kwe-metformin ene-linagliptin, kuvela isifo sohudo. Lapho uthatha i-linagliptin ene-metformin ehambisana nezinto eziphuma ku-sulfonylurea, i-hypoglycemia ivame ukwenzeka. Kuvela futhi lapho uthatha i-linagliptin, i-metformin ene-insulin.
Izimpawu ezijwayelekile zezimpawu ezimbi:
- i-nasopharyngitis;
- ukuhlaselwa ukukhwehlela;
- ukwehla kwesifiso sokudla;
- isifo sohudo
- isicanucanu
- ukuqubuka kwesikhumba okuhambisana nokulunywa;
- ukukhuphuka kwegazi lipase;
- i-hypoglycemia;
- ukuqunjelwa
- ukungasebenzi kahle kwesibindi;
- i-lactic acidosis;
- ukwephula ukunambitheka;
- Ubuhlungu besisu.
Umthelela ekhonweni lokulawula izindlela
Akuthintekile.
Imiyalo ekhethekile
Ngokusho kocwaningo, uma uhlanganisa umuthi nokutholakala kwe-sulfonylurea, umphumela we-hypoglycemic wenzeka ngokushesha ukwedlula nokusabela kwe-placebo. Umuthi uqobo cishe awubangeli i-hypoglycemia. Uma isetshenziswe ngokungalungile, i-lactic acidosis ingavela, ebeka usongo empilweni yomuntu.
Ukuphathwa okuphindaphindiwe kwe-metformin ekwelapheni ukudakwa kungaholela ekukhuleni kwe-lactic acidosis, ikakhulukazi ngokubulawa yindlala isikhathi eside, ukungondleki, noma ukwehluleka kwesibindi okukhona.
Sebenzisa ebudaleni
Umuthi wamukeleka ukunquma abantu abaneminyaka engu-65 ubudala. Kepha ngasikhathi sinye, udinga ukubheka njalo ukusebenza kwezinso, ngoba esemdala, izingozi zokuthuthukisa i-renal pathologies ziphakeme, lapho ukusetshenziswa kwe-metformin kufakelwe khona.
Isabelo sezingane
Umuthi awusetshenziswa ekuziphatheni kwezingane.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Awukwazi ukuphuza amaphilisi ngesikhathi sokuzivocavoca. Ukuze uvikele izingozi zokulimala kwe-intrauterine fetus, udinga ukushintshela ku-insulin ejwayelekile ngokushesha okukhulu.
Kukhona ucwaningo olunganele lokuthi le nto esebenzayo idlula ngokushesha kanjani ebisini lwebele, kepha kukhona ubungozi enganeni esanda kuzalwa. Ngakho-ke, ngesikhathi sokwelashwa okunjalo kwezidakamizwa, kungcono ukuyeka ukuncelisa ibele.
Isicelo sokusebenza kokulimala kwezinso
Ngokukhishwa okuphezulu kwe-creatinine, isidakamizwa siyaphulwa. Lokhu kusebenza futhi nakokwehluleka okukhulu kwe-renal ngenkambo engapheli.
Sebenzisa umsebenzi wesibindi okhubazekile
Ngokunganeleki okungapheli, umuthi awuvunyelwe, ngoba lapho uthatha umuthi ohlelweni lwe-hepatobiliary, i-hepatitis and dysfunctions kungenzeka.
I-Gentadueto overdose
Ayikho idatha ku-overdose. Ekuvivinyweni komtholampilo, i-overdose ye-linagliptin ayizange ibonwe. Ngomthamo owodwa we-metformin, i-hypoglycemia ayizange ibhekwe, kepha kunezimo ze-lactic acidosis. I-Lactic acidosis yisimo esiyinkimbinkimbi esidinga ukulaliswa esibhedlela ngokweqiniso. I-Metformin ikhishwa yi-hemodialysis.
Ukuxhumana nezinye izidakamizwa
Ukuphathwa okuphindaphindiwe kwesidakamizwa noma izingxenye ezisebenzayo zodwa aziguquli i-pharmacokinetics somuthi. Ungasisebenzisa lesi sidakamizwa ngokubambisana neGlibenclamide, iWarfarin, iDigoxin kanye neminye imishanguzo yokuvimbela inzalo.
Inhlanganisela ehlanganisiwe
Awukwazi ukusebenzisa umuthi ngokuhlangana ne-ritonavir, i-rifampicin nezinye izindlela zokuvimbela inzalo ngomlomo.
Awukwazi ukusebenzisa umuthi ngokuhlangana ne-ritonavir.
Akuhlanganisiwe ukuhlanganisa
Akunconyelwe ukuhlanganisa ukuthatha amaphilisi ne-thiazolidinediones nokuthile okuthathwe ku-sulfonylurea, ngoba baba nomthelela ekwehliseni okukhulu kwe-glucose futhi kuvuse i-glycemia.
Inhlanganisela edinga ukuqashelwa
Sebenzisa ngemithi esebenzayo ye-cationic, ngokwesibonelo, i-cimetidine. Ezimweni ezinjalo, kuyadingeka ukuqapha umsebenzi wezinhlelo zokuhambisa ezinama-renal tubular futhi uqaphele ngokucophelela inani le-glucose kwiplasma yegazi.
Ukuhambisana notshwala
Awukwazi ukuhlanganisa ukuphuza amaphilisi notshwala, ngoba umphumela wokwelapha uyancipha, nemiphumela yomuthi ezinhlotsheni zezinzwa nokugaya iyakhuphuka.
Awukwazi ukuhlanganisa ukuphuza amaphilisi notshwala, ngoba umphumela wokwelapha uyancishiswa.
Ama-Analog
Umuthi lo unama-analogues amaningi afana nawo entweni eyodwa noma ngaphezulu ezisebenzayo kanye nemiphumela yokwelapha:
- Avandamet;
- I-Amaryl;
- I-Douglimax;
- IVelmetia;
- UJanumet;
- IVokanamet;
- I-Galvusmet;
- I-Glibomet;
- I-Glybophor;
- Ama-Glucovans;
- IDuotrol;
- I-Dianorm-M;
- I-Dibizid-M;
- Casano;
- I-Comboglize;
- Sinjardi;
- I-Tripride.
Imibandela yekhefu lekhemisi
Kudingeka ukuthenga umuthi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Kukhishwe.
Intengo yeGentadueto
Imininingwane yamanani ayitholakali, njengoba Manje umuthi uthola isitifiketi kabusha.
Izimo zokugcina zomuthi
Kuyadingeka ukuthola indawo eyomile futhi emnyama, ngamazinga okushisa angaqedi + kuno-25 ° C.
Kuyadingeka ukuthola indawo eyomile futhi emnyama, ngamazinga okushisa angaqedi + kuno-25 ° C.
Isikhathi sokuphelelwa yisikhathi
Kungeqi ngaphezulu kweminyaka emi-3 kusuka ngosuku lokukhishwa olukhonjiswe kwiphakheji yangempela. Ungasebenzisi ngemuva kwalesi sikhathi.
Umkhiqizi
Inkampani ekhiqiza: Beringer Ingelheim Pharma GmbH & Co KG, eJalimane.
Ukubuyekezwa kwe-Gentadueto
U-Irina, oneminyaka engama-37, u-Ivanovo
Umuthi omuhle osiza ukugcina amazinga kashukela evamile kuze kube ngamahora ayi-12. Kuyadabukisa ukuthi manje akunakwenzeka ukuyithola emakhemisi, kuyadingeka ukuthi ukhethe ezinye izidakamizwa onomphumela ofanayo.
UVladimir, oneminyaka engama-64, uMurmansk
Ngithathe lo muthi iminyaka eminingana waze waphela ungathengiswa. Ushukela ugcine kulo, bekungekho miphumela emibi, kwakulula ukuthi wethule. Manje kwadingeka ngifune obambele.
U-Yaroslav, oneminyaka engama-57, uChelyabinsk
Wasebenzise lesi sidakamizwa ngokuhlanganiswa ne-insulin. Isifo sohudo sasinzima. Kwakufanele ngibuyise komunye umuthi.
