Izici zamakhemikhali zomuthi i-Methylethylpyridinol zivumela ukusetshenziswa kwayo ku-neurology, inhliziyo kanye ne-ophthalmology. Umuthi ungoweqembu lama-angioprotectors, abaluleke kakhulu ekwelashweni okuyinkimbinkimbi kwezimo ze-inhliziyo nezamaseli wezinzwa.
Igama Lezwe elingafanele
I-Methylethylpyridinol (Methylethylpiridinol).
Izici ze-pharmacological zesidakamizwa iMethylethylpyridinol zivumela ukusetshenziswa kwayo ku-neurology.
I-ATX
I-C05CX - ezinye izidakamizwa ezinciphisa ukuqina kwe-capillary.
Khipha amafomu nokwakheka
Umuthi uyatholakala ngendlela yesisombululo sokuphathwa kwabazali. Luwuketshezi olungenabala umbala. Isithako esisebenzayo yi-methylethylpyridinol hydrochloride. Nge-1 ml yesisombululo, 10 mg wento.
Izakhi ezisizayo yisisombululo se-hydrochloric acid namanzi omjovo.
Isixazululo sithengiswa ngama-ampoules, izingcezu ezi-5 noma eziyi-10 ngephakeji ngalinye.
Izindlwana ezinamaconsi wamehlo ziyatholakala ngaphansi kwamanye amagama okuhweba.
Isenzo se-Pharmacological
Umuthi unomphumela wokuvimbela izinqubo zamahhala zokukhululeka. Into esebenzayo ibonisa lezi zakhiwo ezilandelayo:
- Ukuvikelwa kwe-capillary. I-vasodilation iyenzeka, ikhwalithi ye-microcirculation iyathuthuka. Ukuvuleka kwezindonga ze-vascular kwenziwa okujwayelekile, i-metabolism kwezicubu zemithambo yegazi icushiwe, ukuvuvukala kwezicubu kuyasuswa.
- I-antioxidant. Izinqubo ze-lipid oxidation zivinjelwe. Izinga lokuthuthuka kwezinguquko ezihlobene nobudala liyancishiswa, ubungozi bokuthuthukisa ama-pathologies womdlavuza.
- I-Antiaggregant Amathuba wokuqhekeka kwegazi ancishisiwe. Umuthi osebenzayo uvimbela ukunamathela kwamapuleti, usiza ukuncibilika ukwakheka kwe-fibrin. Inomphumela we-hemorrhaging, uqinisa inkomba ye-prothrombin kanye ne-heestasis.
- I-Antihypoxic. Ukujikeleza kwegazi nokuthuthwa komoya-mpilo kwezicubu kwenziwa ngendlela ejwayelekile. Ekuphazamisekeni kokujikeleza okunamandla, ubulukhuni bokubonakaliswa kwemizwa buyancipha, ukumelana kwamaseli ku-ischemia ne-hypoxia kuyanda.
- Ukuphindisela kabusha. Kuthuthukisa i-microcirculation kanye nokubumba kabusha kwezicubu zomzimba ezithweni zeso. Umphumela omubi wokukhanya okukhulu kwi-retina uvinjelwe.
I-pharmacology yesidakamizwa kungenxa yokuqalwa kwezinqubo ze-metabolic ezibandakanyeka ku-metabolism. Kukhona ukushesha kokuphendula okune-biochemical, ukukhuthaza ukuvuselelwa kwezicubu.
Umuthi unomphumela wokuvimbela izinqubo zamahhala zokukhululeka.
I-Pharmacokinetics
Emzimbeni, into esebenzayo ingena kuwo wonke izicubu. It is metabolised in theibindi, izinsalela zidlulwa ngohlelo lomchamo. Ngokuphathwa kwe-intravenous, isikhathi sempilo siyimizuzu eyi-18.
Izinkomba zokusetshenziswa
Umuthi unqunywe ekwelapheni ngokuhlanganiswa. Umuthi usetshenziswa kulezi zindawo ezilandelayo:
- Kwi-cardiology, kunqunyelwe ukuvimbela ukuphindaphindeka kwe-syndrome ngokumelene nesizinda sokubuyiselwa kokugeleza kwegazi, ekwelapheni i-angina engazinzile kanye ne-acute myocardial infarction. Isidakamizwa sithuthukisa ukusebenza okuvumayo kanye nokuqina kwenhliziyo, sinciphisa ukulimala kwe-ischemic imisipha yenhliziyo. Umuthi unciphisa izehlakalo zokuhluleka kwenhliziyo.
- Isetshenziselwa i-neurosurgery ne-neurology for stroke ischemic kanye ne-hemorrhagic, ingozi engapheli futhi yesikhashana ye-cerebrovascular, ekwelapheni ukulimala kobuchopho obuhlukumezanayo. Kusetshenziswa esikhathini sokuvuselelwa ngemuva kokusebenza kwe-hematomas e-epidural and subdural. Ngomfutho wegazi ophakeme, umuthi unomphumela we-hypotensive, wehlisa ubungozi be-hemorrhage. Ukwephulwa kokungasebenzi kahle kwazimele kuyalungiswa, futhi ukubuyiselwa kokusebenza kobuchopho kuyasheshiswa.
- Ku-ophthalmology, kunqunyelwe ukugcwala okuphathelene ne-subconjunctival kanye ne-intraocular hemorrhages, i-hemorrhage egumbini elingaphandle kwamehlo kanye ne-sclera, angioretinopathy, dystrophic keratitis, ifomu elomile lokuwohloka kwe-angiosselotic macular degeneration. Ekwelapheni i-retinal thrombosis, ubunzima be-myopia ne-myopia, i-chorioretinal dystrophy, ikhathalogu. Ibekelwe i-dystrophy, ukulimala kanye nokushiswa kokhokho, lapho igqoke amalensi wokuxhumana - ukuze kuvikeleke i-cornea ne-retina ekuchayelweni ukukhanya. Isidakamizwa sisetshenziswa ngemuva kokwelashwa kokuhlinzwa kwe-glaucoma nokunye ukungenelela okuhlinza.
Ukwelashwa ngomuthi wenziwa ngaphansi kokuqondisa kukadokotela oya khona.
Contraindication
Umuthi we-contraindicated ukuze uwusebenzise ngaphansi kweminyaka engu-18, abesifazane abakhulelwe futhi abancelayo. Umuthi awukwazi ukusetshenziselwa izimpawu ze-hypersensitivity.
Ngokunakekela
Isicelo sidinga ukuqaphela okukhethekile uma kwenzeka kunezifo ezikhipha ukopha, ukuthambekela kokubonakala komzimba, ngesikhathi sokuhlinzwa, lapho kunezimpawu zokopha kakhulu.
Ungayithatha kanjani i-methylethylpyridinol?
Ukusetshenziswa kwesidakamizwa kubandakanya imikhondo eminingana yokuphatha:
- intravenous;
- intramuscular
- subconjunctival;
- umugqa wesigcawu;
- ibha yokubuyisa;
- ukufaka ngaphakathi esifundeni se-conjunctival.
Ukufakwa kanye nokudonsa kwenziwa ngabasebenzi bezokwelapha abaqeqeshiwe. Nge-Drip, umuthi uvuthwa kuqala kusisombululo se-dextrose noma i-sodium chloride.
Ukulungiselela kuhambisana nemiyalo equkethe izincomo ezijwayelekile ngokusetshenziswa kwomuthi. Isikhathi senkambo yokwelashwa ezimeni ezihlukile sisukela ezinsukwini ezintathu kuya kwezingama-30. Uhlobo lokwelashwa kanye nemithamo yesisombululo kukhonjelwa udokotela ohambela yedwa.
Nge-Drip, umuthi uvuthwa kuqala kusisombululo se-dextrose noma i-sodium chloride.
Ngoshukela
Ekucwaningweni kwesayensi, kwembulwa ukuthi ukusetshenziswa kwekhambi ngokumelene nesizinda sohlobo I lwesifo sikashukela kuholele ekuzinzeni komsebenzi wokusebenza kwamaplatelet, amandla aphawulekayo aphawuleka maqondana nokungasebenzi kahle kwe-endothelial. Ngakho-ke, isidakamizwa sisetshenziswa ekwelapheni okuyinkimbinkimbi kwesifo sikashukela.
Imiphumela Emibi ye-Methylethylpyridinol
Ngokuphathwa kwe-intravenous, umuzwa ovuthayo ungazwakala. Ku-ophthalmology, umjovo ungaholela ku-conjunctival hyperemia, densification of the izicubu zepharaorbital zone. Lezi zimo zidlula ngokuzimela.
Ngokuphikisana nesizinda somuthi wokwelashwa nomuthi, ukungakhululeki esiswini kanye nasesifundeni se-epigastric kungenzeka, i-nausea kwesinye isikhathi iyaphawulwa.
Isistimu yezinzwa ephakathi
Ukuphazamiseka kwemizwa okwesikhashana kungenzeka, futhi kube nokuqunjelwa ikhanda nokuqina.
Kusuka ohlelweni lwezinhliziyo
Kwezinye izimo, kukhona ukwanda kwengcindezi yegazi, umuzwa wobuhlungu enhliziyweni.
Allergies
Ukuphendula komzimba wendawo kubonakaliswa ukuqhuma kwesikhumba, ukulunywa nokuvutha.
Umthelela ekhonweni lokulawula izindlela
Kunconywe ukulahla imisebenzi edinga ukunakwa okwandisiwe nesivinini sokuphendula isikhathi sokulashwa.
Imiyalo ekhethekile
Ngesikhathi sokulashwa nomuthi, kuyadingeka ukuqapha ukuqubuka kwegazi kanye nomfutho wegazi.
Sebenzisa ebudaleni
Ezigulini esezikhulile, umthamo ubhekwa udokotela ohambelayo. Umuthi uvame ukubekelwa ku-ophthalmology ekuvimbeleni nasekwelapheni i-cataralog, hemorrhages ku-sclera.
Isabelo sezingane
Ayabelwe abantu abangaphansi kweminyaka engu-18 ubudala.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukusetshenziswa kwekhambi ngabesifazane abakhulelwe nabakhanyayo akunikezwanga ngenxa yokuntuleka kwezifundo zemiphumela yento entusaneni nasezinganeni ngesikhathi sokuxunjelwa. Uma kwenzeka kunesidingo esikhulu sokwelashwa, amathuba okusebenzisa ayahlolwa udokotela oya khona.
Ukweqisa kwe-Methylethylpyridinol
Ukweqisa umthamo ovumelekile kwandisa ubulukhuni bemiphumela emibi. Ayikho i-antidote; ukwelashwa kufaka ukwelashwa okubonisa izimpawu, kubandakanya nokuthatha izidakamizwa ezinomphumela we-hypotensive. Ukuqapha umfutho wegazi kuyadingeka.
Umuthi akufanele uhlanganiswe nezinye izidakamizwa.
Ukuxhumana nezinye izidakamizwa
Umphumela we-antioxidant wesidakamizwa uthuthukisa izakhiwo ze-Vitamin E.
Umuthi akufanele uhlanganiswe nezinye izidakamizwa. Akukho ukuhlangana kwemithi nezinye izidakamizwa.
Ukuhambisana notshwala
Ukuphuza utshwala ngesikhathi sokwelashwa akufanele kukhishwe. I-Alcohol inethonya elengeziwe emithanjeni yegazi futhi ivimbela nohlelo lwezinzwa. Lokhu kusebenzisana kuhlanekezela ukusebenza futhi kunciphisa ukusebenza kwezokwelapha.
Ama-Analog
Kunenombolo yama-analogues wesakhiwo, afaka into efanayo esebenzayo:
- I-Emoxipin (umjovo kanye nokwehla kwamehlo);
- I-Vixipin (iso lehla ngo-5 ml);
- I-Emoxy optics (iso lehla ngo-5 ml);
- I-Emoxibel (iso lishiya u-5 ml, isixazululo somjovo 1% no-3%);
- I-Emoxipin-Acti (ikhambi lokufakwa).
Ama-Analogs ngokuya ngomshini wokusebenza ngamalungiselelo asuselwa ku-Ethylmethylhydroxypyridine prestig (Mexicoidol, Mexico, Neurox, njll).
Imithi ingaba nezici zokusetshenziswa. Amathuba okufaka ezinye izidakamizwa kufanele axoxwe nodokotela wakho.
Imibandela yekhefu lekhemisi
Umuthi ungowesiqhema semithi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Emakhemisi, ikhefu lingukuya kadokotela.
Intengo ye-methyl ethyl pyridinol
Izindleko ezijwayelekile zokupakishwa ngama-ruble angama-20-80.
Izimo zokugcina zomuthi
Umuthi kufanele ugcinwe endaweni emnyama emazingeni okushisa angeqi ku-25ºC.
Isikhathi sokuphelelwa yisikhathi
Impilo ye-Shelf iminyaka emi-3 kusukela ngosuku lokukhiqizwa.
Umkhiqizi
Umuthi lo ukhiqizwa yizinkampani ezimbalwa zaseRussia, ezifaka i-Eskom, Ozone, Atoll ne-Ellara.
Ukubuyekezwa mayelana neMethylethylpyridinol
UPetr Valerievich, udokotela wezifo zemizwa, eMoscow: "Emsebenzini wezokwelapha, umuthi uvame ukusetshenziselwa ukuphazamiseka kokujikeleza kwesidakamizwa. Umuthi ongabizi futhi osebenzayo."
UMarianna Alekseevna, udokotela wezifo zamehlo, uPenza: "Indlela yokujova yesisombululo iyindlela ephumelelayo yokwelapha izifo eziningi ku-ophthalmology. Amaconsi wamehlo angasetshenziswa isiguli ekhaya njengoba kushiwo udokotela. Nokho, athengiswa ngaphansi kwegama elihlukile."
UVitaliy, oneminyaka engama-50, uSaratov: "Udokotela unikeze inkambiso yemithi yokuphazamiseka kwengqondo uhlelo lodokotela. "
UJulia, oneminyaka engama-42 ubudala, uMurmansk: "Udokotela obekelwe umama ukuthi afake isisombululo emehlweni nge-chorioretinitis. Ngale ndlela, umuthi uthengiswa emakhemisi ngaphansi kwegama elihlukile lokuhweba. Izinzuzo zalo muthi ukwehla kalula, izindleko eziphansi."
