Umuthi we-antihypertensive Losacor usetshenziswa ekwelapheni umfutho wegazi ophakeme kanye nasekuvimbeleni izinkinga ze-vascular ezigulini ezisengozini. Ukubuyekezwa okuningi okuhle mayelana nomuthi kungenxa yomsebenzi wezidakamizwa eziphakeme nezindleko ezingabizi.
Igama Lezwe elingafanele
I-Losartan (ngesiLatini - iLozartanum).
Igama lomhlaba jikelele elingewona ophathi wezidakamizwa iLosacor iLosartan.
I-ATX
C09CA01.
Khipha amafomu nokwakheka
Uyathengiswa, umuthi usefomini lethebhulethi. Ithebhulethi ngayinye iqukethe i-12.5 mg ye-losartan potassium, esebenza njengesisekelo (into esebenzayo) yesidakamizwa. Ukuqanjwa Kwesibili:
- isitashi sommbila;
- isitashi pregelatinized;
- i-microcrystalline cellulose;
- i-magnesium stearate;
- i-anhydrous aerosil (i-colloidal silicon dioxide);
- cellulose (inhlanganisela ye-cellulose ne-lactose monohydrate).
Ukuhlanganiswa kwethebhulethi kufaka i-quinolone udayi ophuzi, i-titanium dioxide, i-propylene glycol, i-talc ne-hypromellose.
Kuqweqwe lwe-contour lamaphilisi ayi-7, 10 noma angu-14. Egcekeni lekhadibhodi lamapuleti e-1, 2, 3, 6 noma 9.
Ukuhlanganiswa kwethebhulethi kufaka i-quinolone udayi ophuzi, i-titanium dioxide, i-propylene glycol, i-talc ne-hypromellose.
Isenzo se-Pharmacological
Umuthi unomphumela obizwa ngokuthi yi-hypotensive effect futhi ungumphikisi we-angiotensin 2, onamathela kuma-receptors amaningi wezicubu futhi unemisebenzi eminingi ukusuka endaweni yokubukwa kwe-microbiology yemitholampilo, kufaka phakathi ukukhishwa kanye ne-vasoconstriction ye-aldosterone nokukhuthaza ukukhula kweseli kwemisipha ebushelelezi.
Ngaphezu kwalokho, umuthi wehlisela umfutho wegazi, uvimbela ukugcinwa kwamanzi nesodium emzimbeni, futhi futhi kwandisa ukumelana nokuzivocavoca ngokomzimba ezigulini ezinokwehluleka kwenhliziyo (ukuhluleka kwenhliziyo okungapheli).
I-Pharmacokinetics
ILosartan imunca kahle ngemuva kokuphathwa ngomlomo. Umuthi ungatholwa "i-main phase" ngesibindi.
Njengomphumela wale nqubo, kwakhiwa i-metabolite esebenzayo (i-carboxylated) nenqwaba yama-metabolites angasebenzi. Ingxenye ine-bioavailability ka-33%. I-plasma yokuhlushwa ephakeme kakhulu ifinyelelwa ihora eli-1 ngemuva kokungenisa. Ukudla akusithinti kakhulu iphrofayili ye-pharmacokinetic yezidakamizwa ze-antihypertensive.
ILosartan yakha izibopho eziqinile ngamaprotheni e-plasma (afika kuma-99%). Cishe i-14% yomthamo othathwe uguqulwa ube uhlobo olusebenzayo lwe-metabolite.
Into le ikhishwa yizinso namathumbu.
Izinkomba zokusetshenziswa
Amathebulethi angabhekelwa iziguli ezimweni ezinjalo:
- phambi kwe-hypertension ye-arterial;
- ukuze kuncishiswe izingozi zokufa nokufa komzimba ezigulini ezinobungozi (i-hypertrophy ye-ventricular kwesokunxele, i-arterial hypertension);
- ukwelashwa kwe-proteinuria ne-hypercreatinemia (ngesilinganiso se-umchamo we-mkoinine ne-albhamuin engaphezu kwama-300 mg / g) ezigulini ezinesifo sikashukela sohlobo lwe-2 mellitus kanye ne-hypertension ye-arterial;
- I-CHF ngokungabikho komphumela wokwelashwa nge-ACE inhibitors;
- ukuvimbela izinkinga ze-vascular in ukuhlinzwa.
Contraindication
Ithuluzi alisetshenziselwa ukwehluleka kwesibindi okunzima (amaphuzu angaphezu kwangu-9 ku-Child-Pugh), ukungabekezelelani kwe-lactose, ukukhipha isisu, ukukhulelwa, iminyaka yobusha, kanye ne-hypersensitivity to losartan kanye nezinto ezengeziwe ezivela emithini.
Ngokunakekela
I-ejenti ye-antihypertgency ichazwa ngokucophelela nge-BCC encishisiwe, i-arterial hypotension, nokuphazamiseka kokulingana kwe-electrolyte, kuhlangene ne-digoxin, i-diuretics, i-warfarin, i-lithium carbonate, i-fluconazole, i-erythromycin, neminye imithi eminingi.
Ungayithatha kanjani iLosacor
Amathebulethi angathathwa ngaphandle kokudla, agwinywe lonke futhi agezwa ngamanzi amaningi. Imvamisa yokusetshenziswa - isikhathi esingu-1 ngosuku.
I-arterial hypertension iphathwa ngemithamo ye-50 mg / ngosuku.
Kwesinye isikhathi umthamo ungandiswa ube ngu-100 mg kabili ngosuku. Umthamo omkhulu yi-150 mg / ngosuku.
Ukuvimbela izifo zohlelo lwethambo nenhliziyo.
Ngoshukela
Ukuze uvikele izinso ezigulini ezinesifo sikashukela sohlobo 2 sikashukela esine-proteinuria ehlanganayo, kukalwa imithamo engama-50 mg / ngosuku.
Umthamo wezidakamizwa zesifo sikashukela ungakhuphuka ufike ku-100 mg ngosuku, kucatshangelwa ukwehla kokwephulwa kwengcindezi yegazi.
Umthamo ungakhuphuka ube ngu-100 mg ngosuku, kucatshangelwa ubunzima bokuthi ukuphazamiseka kwengcindezi kwegazi.
Imiphumela emibi yeLosacor
Ezimweni eziningi, umuthi ubekezelelwa ngomoya ophansi. Izigameko zemiphumela emibi ziqhathaniswa nalokhu uma usebenzisa i-placebo.
Amapheshana wesisu
I-nausea engaba khona, izinhlungu ze-epigastric, unxusa ukuhlanza. Ezimweni ezingavamile kakhulu, kuba khona isifo sokusha kwesibindi.
Isistimu yezinzwa ephakathi
Ubuhlungu bekhanda, ukuphazamiseka kokulala kanye nesiyezi kungenzeka.
Engxenyeni yesikhumba
Izindawo ezibomvu zingabonakala ebusweni besikhumba.
Kusuka ohlelweni lwezinhliziyo
Ukushaya kwenhliziyo okubalulekile kungenzeka.
Ukuthatha umuthi kungadala ukushona kwenhliziyo.
Ngasohlangothini lwe-metabolism
Ezimweni ezingavamile, ukuphuma komzimba kanye nokwanda kokuxineka kwe-creatinine noma i-urea eplasma yegazi kuyabonakala.
Allergies
Ukuvuvukala, ukuqubuka, nokulunywa kungenzeka. Ezimweni ezingandile, i-edema kaQuincke iyakhula kanye nolwelwesi lwe-mucous, lomlomo nezinye izingxenye zomzimba kuyathinteka.
Umthelela ekhonweni lokulawula izindlela
Akukhange kube nokuhlolwa okukhethekile mayelana nokuhlolwa komphumela womuthi ekuphenduleni kwe-psychomotor kanye namandla okusebenzisa imoto.
Imiyalo ekhethekile
Ezigulini ezine-BCC encishisiwe, kungahle kube ne-hypotension izimpawu. Izimo ezinjalo zidinga ukusetshenziswa kwemithamo ephansi.
Ngokuphikisana nesizinda sokulashwa kwezidakamizwa, udinga ukubheka ngokucophelela izinga le-potassium ku-serum yegazi, ikakhulukazi ezigulini esezikhulile kanye nomsebenzi wezinso ongasebenzi kahle.
Abantu asebekhulile abadingi ukulungiswa komthamo ngamunye komuthi okukhulunywa ngawo.
Sebenzisa ebudaleni
Lesi sigaba seziguli asidingi ukulungiswa komthamo ngamunye.
Isabelo sezingane
Ezinganeni ezingaphansi kweminyaka eyi-18, umuthi awuchaziwe.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi we-antihypertensive uhanjiswe ukuze usetshenziswe kuleli qembu leziguli.
Isicelo sokusebenza kokulimala kwezinso
Ukwehluleka kwezinso okunzima, i-antihypertensive ayinconywa.
Sebenzisa umsebenzi wesibindi okhubazekile
Uma kwenzeka kushoda kanye nokunye ukungasebenzi kahle kwesibindi (kufaka phakathi i-cirrhosis), kuthathwa umthamo omncane.
Ukweqisa kweLosacor
Imininingwane emayelana ne-overdose yesidakamizwa se-antihypertensive ilinganiselwe.
Nge-overdose yeLosacor, umfutho wegazi ungancipha.
Izimpawu: ukwehla okukhulu komfutho wegazi, i-tachycardia. Ukwelashwa kwezimpawu kunqunyelwe. I-Hemodialysis ayisebenzi.
Ukuxhumana nezinye izidakamizwa
Umuthi ukhulisa umphumela we-sympatholytics kanye ne-beta-blockers.
Ukuhlanganiswa kwesidakamizwa ngama-diuretic agents kungaholela kumphumela wokungezelela.
I-Fluconazole ne-rifampin yehlisa izinga le-plasma le-metabolite esebenzayo yento esebenzayo.
Ama-NSAIDs anganciphisa umphumela wezidakamizwa ze-antihypertensive. Ngokusetshenziswa ngasikhathi sinye kwale mishanguzo, ukulungiswa komthamo kuyadingeka.
I-Losacor yandisa umphumela we-sympatholytics kanye ne-beta-blockers.
Ukuhambisana notshwala
Ochwepheshe abancomi ukuphuza utshwala uma usebenzisa izidakamizwa ze-antihypertensive.
Ama-Analog
Esikhundleni eshibhile futhi esisebenzayo somuthi we-antihypertensive:
- Ama-Vasotens;
- IVasotens N;
- I-Losartan;
- I-Lozap;
- IXarten;
- I-Cantab;
- Edarby
- Angiakand;
- I-Hyposart;
- I-Sartavel.
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela
Akunakwenzeka ukuthenga umuthi ngaphandle kadokotela.
Intengo yeLosacor
Kusuka ku-102 rub. zamathebulethi ayi-10.
Izimo zokugcina zomuthi
Endaweni evikelwe umswakama ophezulu, emazingeni okushisa athambile.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umkhiqizi
Inkampani yaseBulgaria "Adifarm EAT".
Udinga ukugcina umuthi endaweni uvikelekile kumswakama ophezulu, emazingeni okushisa aphansi.
Ukubuyekezwa mayelana neLosacore
UVictoria Zherdelyaeva (udokotela wenhliziyo), oneminyaka engama-42. Ufa
Ukwelashwa okuhle. Umphumela wayo we-hypotensive ubonwa ngosuku lokuqala. Umuthi uvame ukukhonjelwa kakhulu nge-hypertension yempi engezansi. Izindleko ezingabizi. Ngaphambi kokusebenzisa umuthi, qiniseka ukuthi uthintana nochwepheshe wezokwelapha.
UValentina Struchkova, oneminyaka engama-23, eMoscow
Amaphilisi anqunyelwe ubaba ngudokotela wezifo zenhliziyo ukuvimbela izifo zenhliziyo. Uma sibheka imiphumela yezivivinyo asanda kuzithola emtholampilo wesifunda, lesi sidakamizwa "siyasebenza"
